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Table 4 Medians (inter-quartile ranges) of outcome measures, before and after PBM treatment for group B (n = 6)

From: Improvements in clinical signs of Parkinson’s disease using photobiomodulation: a prospective proof-of-concept study

 

On enrolment

Before PBM treatment

After 4 weeks PBM treatment

After 12 weeks PBM treatment

Mobility tests

 10MWT walk speed (m/s)

1.21 (0.24)

1.82 (0.30)*

1.94 (0.28)*

1.93 (0.27)

 10MWT stride length (m)

0.52 (0.09)

0.67(0.11)

0.71 (0.08)

0.70 (0.08)

 TUG (s)

7.9 (1.6)

7.4 (1.4)*

6.6 (0.8)*

6.9 (1.1)

 TUG motor (s)

8.6(1.2)

8.2 (1.4)

7.1 (0.7)

6.9 (1.4)

 TUG cognitive (s)

9.6 (1.8)

7.5 (1.1)

7.0 (1.3)*

6.8 (1.3)

Dynamic Balance test

 Step test - affected leg (n)

10.0 (4.3)

14.0 (2.0)*

15.0 (2.3)

15.5 (4.0)

 Step test - unaffected leg (n)

11.5 (1.8)

12.5 (3.3)

15.0 (2.3)

16.0 (5.0)

Cognition test

 MoCA

26.0 (2.3)

27.5 (2.5)

28.0 (1.5)

29.0 (1.5)

Fine Motor Skill tests

 NHPT - affected hand (s)

24.6 (6.3)

22.5 (7.0)

24.0 (4.1)

26.0 (9.7)

 NHPT - unaffected hand (s)

22.1 (2.1)

25.4 (7.2)

23.9 (4.7)

24.0 (6.9)

 Spiral test - dominant hand (s)

35.2 (4.4)

33.9 (10.9)

27.3 (10.6)

29.0 (6.2)

Static Balance tests

 TS affected leg behind (s)

2.0 (3.0)

5.6 (6.2)

19.5 (24.2)*

5.8 (10.6)

 TS unaffected leg behind (s)

1.0 (3.0)

4.2 (7.0)

3.2 (20.3)

2.3 (13.6)

 SLS affected leg raised (s)

1.5 (1.8)

1.6 (1.0)

1.2 (1.2)

0.8 (4.5)

 SLS unaffected leg raised (s)

1.0 (0.8)

2.1 (1.8)

0.1 (1.2)

0.9 (4.8)

  1. Significant improvement in outcome measure - * p < 0.05
  2. 10MWT 10 metre walk test, TUG timed up-and-go, MoCA Montreal Cognitive Assessment, NHPT nine-hole peg test, TS tandem stance (eyes closed), SLS single leg stance (eyes closed)