Fig. 6

Peri-operative contralateral thalamus Cho/Cr and NAA/Cr change in TN patients 1-week following surgical treatment. (A) A strong trend suggests that Cho/Cr decreases in non-responders (NR—dark grey bars) 1-week after surgery (p = 0.063), at which point Cho/Cr differs (p = 0.038) from responders (R—light grey bars). (B) Cho/Cr either increases or decreases in responders at the individual-subject level, while (C) all non-responders show a decrease in Cho/Cr. (D) A strong trend suggests that NAA/Cr decreases in non-responders 1-week after surgery (p = 0.063), at which point NAA/Cr differs (p = 0.038) from responders. (E) NAA/Cr either increases or decreases in responders at the individual-subject level, while (F) all non-responders show a decrease in NAA/Cr. Mann–Whitney tests were used to perform between-group comparisons, while Wilcoxon sign-rank tests were used to compare thalamus volumes within-groups. Statistical significance (p < 0.05) is indicated with *. Medians with interquartile ranges are displayed