Skip to main content

Neuroleptic malignant-like syndrome associated multiple system atrophy: report on three cases

Abstract

Background

Multiple system atrophy (MSA) associated with neuroleptic malignant-like syndrome (NMLS) is rare and few cases have been described in the literature.

Case presentation

In the present study, three patients with MSA associated with NMLS were analyzed from January 2012 to January 2020 to characterize their clinical presentations. Data collected from the patients for analysis included general patient history, the fluctuation and severity of disease symptoms, the indicated therapies and disease progression at follow-up. All patients had histories of sudden withdrawal or reduction of levodopa prior to the onset of symptoms. Clinical presentations were characterized by hyperthermia, autonomic dysfunction, worsening of extrapyramidal symptoms, and elevated serum creatine kinase (CK) levels. During hospitalization, one patient rapidly progressed and died, while the other two patients were successfully treated.

Conclusions

Early diagnosis and treatment are very important for patient outcomes in NMLS. Notably, the correct dose and time of administration of dopaminergic medication may be key in treating NMLS.

Peer Review reports

Background

In 1968, Delay et al. described the first case of Neuroleptic Malignant Syndrome (NMS), a potentially fatal condition characterized by hyperthermia, altered consciousness (agitation, delirium, or coma), autonomic dysfunction, extrapyramidal symptoms, muscle cramps or tremors, and elevated serum creatine kinase (CK) levels [1]. Although disturbances in the brain’s monoaminergic systems or rapid withdrawal of drugs for Parkinson’s disease may cause the condition, it is most frequently observed in patients receiving treatment with neuroleptic drugs [2, 3].

In 1981, Toru M. et al., reported a rare complication of sudden withdrawal or reduction of anti-parkinsonian treatment for Parkinson’s disease (PD), as well as of abrupt switching from one agent to another [4]. This condition was called parkinsonism hyperpyrexia syndrome or more commonly referred to as Neuroleptic malignant-like syndrome (NMLS). Clinical manifestations of NMLS are very similar to NMS, including hyperthermia, mental status change, muscular rigidity, respiratory failure, and autonomic instability [5, 6]. Like NMS, the pathophysiological mechanism of NMLS is still unclear. Due to the acute dopamine-deficient state frequently associated with NMLS, most hypotheses of its pathogenesis suspect dopamine receptor blockade and dysfunction of the dopamine receptor D2 [3, 7]. Published case series also speculate that other contributing factors including α-synuclein and ubiquitin-related diseases (Lewy body dementia and some lysosomal storage diseases), dehydration, physical exhaustion, and acute structural or functional brain disorders (including encephalitis, tumor, surgery, and trauma) are involved in NMLS [8,9,10,11].

Another ubiquitin and α-synuclein-related disease is multiple system atrophy (MSA). Its most common manifestation is autonomic dysfunction. However, its other signs and symptoms are mainly divided into two subtypes: parkinsonian manifestations (rigidity, tremors, bradykinesia, and postural instability) and cerebellar manifestation (unsteady gait, dysarthria, difficulty swallowing and double vision) [12]. The disease is termed MSA-P when there is a preponderance of parkinsonian symptoms and MSA-C when cerebellar symptoms are more dominant [12,13,14]. Previous studies have described catecholaminergic agents as potential therapies for MSA.

In our present study, we report three MSA patients who presented with NMLS. We analyzed their clinical features and summarized the therapeutic processes undertaken. Our aim is to improve awareness and effective treatment of this disease among clinicians.

Case presentation

Three cases of MSA associated-NMLS were identified in the Department of Geriatrics and Neurology (Qilu Hospital of Shandong University, Jinan, China) between 2012 and 2020. All three patients were diagnosed with MSA according to the clinical diagnostic criteria updated in 2008 [13]. The score for probability of NMLS consists of 8 symptoms based on international expert consensus (IEC) diagnostic criteria [15] (Supplementary Table 1). Shandong University’s Institutional Review Board ethics committee (Qilu Hospital, Jinan, China) reviewed and approved the study. All patients provided written informed consent prior to inclusion in the study.

Patient 1

In Nov 2012, a female patient aged 62 was diagnosed as having probable MSA. She had presented with a syndrome of muscular rigidity and ataxia for 2 years. In addition, she had also developed glossolalia, vegetative nerve functional disturbance, sebaceous gland secretions, alternating high and low body temperatures, incontinence, and constipation over 6 months. Brain MRI suggested a diagnosis of MSA, which showed atrophy of the brainstem and cerebellum, enlarged lateral ventricles, putaminal iron deposition, and a hyperintense putaminal rim (Fig. 1). The patient had been on levodopa (480 mg/day), comprised of Madopar (175 mg, twice a day) and Sinemet (250 mg, at night), but her clinical syndromes gradually deteriorated. The patient gradually tapered down medications over 11 months and, by October 2013, had discontinued all dopaminergic drugs.

Fig. 1
figure 1

MRI showed atrophy of the brainstem and cerebellum, enlarged bilateral ventricle, iron deposition in the bilateral putamen, and a hyperintense putaminal rim. a and d Contrast-enhanced T1-weighted image. b and e Contrast-enhanced T2-weighted image. c and f T2/FLAIR image. MRI: Magnetic resonance imaging; FLAIR: Fluid attenuation inversion recovery

On November 25 in 2013, she was hospitalized for hyperthermia. Initial investigations showed her blood pressure to be in the normal range (125/61 mmHg), while her body temperature was raised to 39.3 °C with the whole-body sweating. On admission, hematologic tests showed a raised leukocyte count of 6.81 × 109/L (normal: 3.5–9.5 × 109/L), a slightly raised CK of 472 U/L (normal: 26–178 U/L), and hyponatremia (sodium, 125 mmol/L, normal range 137–147 U/L). The admission sputum, urine, and blood cultures were all negative, eliminating the presence of intercurrent infections. Both serum levels of tumor markers (including:α-fetoprotein, squamous cell carcinoma, and carcinoembryonic antigen) and autoimmune antibody tests were within the normal range, suggesting that malignant and immune-related diseases were also absent. Computer tomography (CT) of the chest, abdomen, and pelvic cavity showed coronary artery calcification and pulmonary fibrosis.

The patient’s symptoms progressed to laryngospasm, shortness of breath, and rigidity on the second day following hospital admission. The respiratory rate ranged from 25 to 30 beats/min and the pulse rate was 120 beats/min. Analysis of blood gases from the patient’s arteries revealed a pH of 7.5 (normal: 7.35–7.45), indicating respiratory alkalosis. Moreover, the carbon dioxide and oxygen partial pressures were 27 mmHg (pCO2, normal: 35–45 mmHg) and 93 mmHg (pO2, normal: 80–100 mmHg) respectively. Blood results also showed that the lactic acid was 4.7 mmol/L (0.5–1.8 mmol/L), the total carbon dioxide was 21.9 (22–29 mmol/L), the standard base excess was − 2.1 mmol/L, and the actual base excess was − 0.8 mmol/L (− 2–3 mmol/L).

On day 3, her temperature rose to 39.3 °C which led to a working diagnosis of NMLS at the time. The patient’s levodopa dosage was therefore raised to 680 mg/day. The CK decreased to 252 U/L on the fourth day while the leukocyte count was still in the normal range. After increasing the dose of levodopa for 3 days, the patient’s temperature decreased to 37.5 °C. In tandem, the CK level also fell to 212 U/L. Two days later, the temperature was normal without any changes in therapy. This patient showed good health without recurrence over 5-year follow up.

Patient 2

A female patient aged 63 with a history of bradykinesia and dysautonomia spanning 6 years was also examined. In 2013, she had developed glossolalia. Although she suffered serious ataxia with dystonia, her movements were voluntary. She was diagnosed as possible MSA in 2014. In the subsequent 2 years, she gradually started experiencing tremor, constipation, and retention of urine. The symptoms progressively worsened resulting her being unable to walk unaided.

On June 25, 2016, the patient complained of low-grade fever, and was admitted to our hospital. She had been on levodopa 800 mg/day, including 250 mg Sinemet four times a day, and had 50 mg piribedil twice a day, but showed poor response to these medications. Due to the poor response, the patient was withdrawn these drugs over 2 months. On admission, her body temperature was 37.8 °C. The initial blood examination showed that the leukocyte count was 6.51 × 109/L, the serum level of sodium was 129 mmol/L, and the CK level was normal. Over the subsequent 3 days, she suffered pyrexia with a temperature of 40.9 °C, whole-body sweating and rigidity. The CK level rose gradually from 210 U/L to 976 U/L. Admission cultures of blood, sputum, and urine were negative, and intercurrent infections were ruled out. Results of tests for rheumatic, neoplastic, and immune markers, as well as thyroid hormones were within normal ranges. Empiric therapy was administered at all admissions. The antibiotics used ranged from third generation cephalosporins to Meropenem, but the temperature could not be controlled. On the fifth day she suddenly developed acute respiratory failure. Arterial blood gas analysis showed that the pO2 was 68 mmHg and the pCO2 was 32 mmHg. Although her breathing stabilized after endotracheal intubation, she finally died of disseminated intravascular coagulation (DIC) 1 day later.

Patient 3

A male patient aged 78 presented with frozen gait, autonomic dysfunction, and parkinsonism over 10 years. Brain MRI demonstrated cortical subtentorial and cerebellar atrophy. He was diagnosed as probable MSA in 2016 because of the clinical features and imaging manifestations. After the diagnosis, he commenced taking anti-parkinsonian drugs. He had been kept in bed for 3 years and had not been able to communicate with family members for 2 years. He had thought that the drugs did not give much response, so had stopped all anti-parkinsonian drugs for the previous year. During the past month, he developed intermittent fever (sometimes up to 38.5 °C) which usually persisted for several days and then gradually resolved without any obvious cause.

Recently, a persistent fever resulted in his admission to our hospital. The patient manifested generalized muscular rigidity and sweating. Routine blood tests revealed his white blood cell count to be 8.86 × 109/L, the serum level of sodium was 130 mmol/L, and the CK level was 418 U/L. The admission cultures of blood, sputum, and urine were negative. CT of his chest showed fibrosis at the base of the lungs. His progress worsened continuously after the administration of different levels of antibiotics. He was given levodopa at a dose of 300 mg/day (125 mg Madopar three times a day). This resulted in gradual control of his body temperature. The patient continued taking anti-parkinsonian drugs after discharge and the fever did not appear again.

Discussion and conclusions

The prevalence of NMLS is high and it often requires rapid medical attention as it has a concomitantly high mortality rate. While mortality has reduced over the last few decades due to earlier diagnosis and aggressive intervention, the overall mortality of NMLS reported in the literature is still between 10 and 30% [16]. In the clinic, NMLS is sometimes referred to as parkinsonism hyperpyrexia syndrome. Manifestations usually include hyperthermia, altered consciousness, rigidity, sweating, fast heart rate, and autonomic imbalance [17, 18]. Other signs may include tachycardia, tachypnea, acidosis, incontinence, and elevated serum CK [18]. Accurate NMLS detection and therapy often relies upon its suspicion by a knowledgeable clinician rather than systematic diagnosis.

Previous studies have suggested that causes of NMLS include sudden withdrawal of anti-parkinsonian drugs, reduction or withdrawal of dopamine agonist therapy, and the substitution of anti-parkinsonian drugs with alternatives over a short space of time [18, 19]. Moreover, infection, trauma and surgery have also been implicated [2, 10]. Since dopaminergic drugs are also commonly used to treat MSA, in theory, NMLS conditions may also occur in patients with MSA.

Despite its low prevalence, MSA is associated with a variety of symptoms making it a progressive, degenerative neurological disease that is worthy of serious attention. Symptoms include general autonomic dysfunction (blood pressure, heart rate, sweating, and bladder function), parkinsonism symptoms, and cerebellar ataxia signs [12, 20]. MSA typically affects individuals in their 50s and 60s and the average survival following symptomatic onset is 6–10 years [21]. Causes of MSA are still unclear. Some scholars have proposed that an inherited component or environmental toxin may be responsible, but this remains controversial [22].

Microscopically, the brain tissue of patients shows neuronal destruction and contains abnormal filamentous α-synuclein aggregates in the glial cell and neuronal cytoplasm [12, 20, 23].

The present study reported on the clinical manifestations and laboratory examinations of three MSA cases associated with NMLS. Based on clinical experience, hyperthermia is recorded as an initial symptom [24]. In most cases, the temperatures exceed 38 °C. However, even higher temperatures above 40 °C can sometimes appear [18]. NMLS cases without hyperthermia have been rarely been reported [25]. The cause of hyperthermia in NMLS is still unclear. Some researchers have proposed that central dopamine receptor blockade in the hypothalamus impairs thermoregulation resulting in high fever [3]. In our study, all three patients presented the symptom of hyperthermia. Another common clinical feature of the three patients was hyponatremia. We have found only a few reports in the literature describing hyponatremia in patients with MSA or NMLS [26,27,28]. We speculate that hyponatremia was perhaps related to the feverish conditions experienced by the patients.

Severe rigidity of most body muscles is frequently seen at diagnosis. In parallel, the CK levels are almost always raised early in the progression of NMLS, indicating that CK may be a potential diagnostic marker for the condition [5, 17]. Generally CK elevation was mild to moderate and usually did not exceed 1000 U/L. CK levels, however, can remain normal if there is only mild muscle rigidity [29]. For our investigation, all three patients had normal or slightly increased CK levels. Other studies have reported that the onset of muscle rigidity and rise in CK level may not be simultaneous [30]. Indeed, the CK levels usually return to normal following an episode of NMLS.

Due to its mimicry of other syndromes, distinguishing NMLS from other neurological diseases in the early stages can be very difficult. As the possibility of NMLS is often overlooked and immediate treatment for the syndrome is delayed, expert judgment is required to differentiate it from other diseases. Initially, we did not recognize Patient 2 as having NMLS, which delayed the first treatment. Some of the most common misdiagnoses are encephalitis, toxic encephalopathy, status epilepticus, acute spinal cord injury, heat stroke, and malignant hyperthermia [31,32,33].

NMLS is a medical emergency that may rapidly lead to death if left untreated. The treatment for patients with NMLS should be based on three aspects: reinstating anti-parkinsonian drugs, supportive care, and specific treatments [16]. Doctors should remind MSA patients not to withdraw or reduce doses of anti-parkinsonian medications without a doctor’s supervision. Once NMLS appears, levodopa or dopamine agonists must be administered immediately [34]. In terms of supportive care, the following measures should be provided: cardiorespiratory function must be preserved (by using anti-arrhythmic drugs, mechanical ventilation, or pacemakers); euvolemia preservation with intravenous fluids; fever dissipation using cooling blankets; blood pressure reduction if markedly elevate and heparin or low-molecular weight heparin for the prevention of deep venous thrombosis. Dantrolene sodium as a muscle relaxant that can be used to reduced heat production and muscle rigidity [35]. Bromocriptine, Amantadine, Lorazepam, Phenytoin, Apomorphine, Aripiprazole, and anticholinergic agents have also been previously reported to be useful for NMLS [36,37,38,39].

Consideration of these patient cases will serve as a useful reminder that it is essential to consider NMLS in MSA. When a patient has a history of dopamine withdrawal and presents with two or more of the following primary symptoms: rigidity, mental status change, dysautonomia, or fever, NMLS should be suspected. The correct dose and timing of administration of dopaminergic medication is vital and should start as soon as possible.

Availability of data and materials

All data related to this case report are documented within this manuscript.

Abbreviations

MSA:

Multiple system atrophy

NMLS:

Neuroleptic malignant like syndrome

CK:

Creatine kinase

NMS:

Neuroleptic Malignant Syndrome

PD:

Parkinson’s disease

CT:

Computer tomography

DIC:

Disseminated intravascular coagulation

References

  1. Delay J, Deniker P. Drug-induced extrapyramidal syndromes. In: Vinken PJ, Bruyn GW, editors. Handbook of Clinical Neurology; Diseases of the Basal Ganglia, vol. 6; 1968. p. 248–66.

    Google Scholar 

  2. Oruch R, Pryme IF, Engelsen BA, Lund A. Neuroleptic malignant syndrome: an easily overlooked neurologic emergency. Neuropsychiatr Dis Treat. 2017;13:161–75. https://doi.org/10.2147/ndt.S118438.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  3. Gillman PK. Neuroleptic malignant syndrome: mechanisms, interactions, and causality. Mov Disord. 2010;25(12):1780–90. https://doi.org/10.1002/mds.23220.

    Article  PubMed  Google Scholar 

  4. Toru M, Matsuda O, Makiguchi K, Sugano K. Neuroleptic malignant syndrome-like state following a withdrawal of antiparkinsonian drugs. J Nerv Ment Dis. 1981;169(5):324–7. https://doi.org/10.1097/00005053-198105000-00011.

    Article  CAS  PubMed  Google Scholar 

  5. Modi S, Dharaiya D, Schultz L, Varelas P. Neuroleptic malignant syndrome: complications, outcomes, and mortality. Neurocrit Care. 2016;24(1):97–103. https://doi.org/10.1007/s12028-015-0162-5.

    Article  PubMed  Google Scholar 

  6. Velamoor R. Neuroleptic malignant syndrome: a neuro-psychiatric emergency: recognition, prevention, and management. J Asian J Psychiatry. 2017;29:106–9. https://doi.org/10.1016/j.ajp.2017.05.004.

    Article  Google Scholar 

  7. Ueda M, Hamamoto M, Nagayama H, Okubo S, Amemiya S, Katayama Y. Biochemical alterations during medication withdrawal in Parkinson's disease with and without neuroleptic malignant-like syndrome. J Neurol Neurosurg Psychiatry. 2001;71(1):111–3. https://doi.org/10.1136/jnnp.71.1.111.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  8. Jussen D, Sprung C, Buchert R, Braun JS. Hydrocephalus-induced neuroleptic malignant-like syndrome with reduced dopamine transporters. J Neurol. 2013;260(8):2182–4. https://doi.org/10.1007/s00415-013-7026-8.

    Article  PubMed  Google Scholar 

  9. Eiden C, Capdevielle D, Deddouche C, Boulenger JP, Blayac JP, Peyrière H. Neuroleptic malignant syndrome-like reaction precipitated by antipsychotics in a patient with gamma-butyrolactone withdrawal. J Addict Med. 2011;5(4):302–3. https://doi.org/10.1097/ADM.0b013e3182236730.

    Article  CAS  PubMed  Google Scholar 

  10. Bonnici A, Ruiner CE, St-Laurent L, Hornstein D. An interaction between levodopa and enteral nutrition resulting in neuroleptic malignant-like syndrome and prolonged ICU stay. Ann Pharmacother. 2010;44(9):1504–7. https://doi.org/10.1345/aph.1P242.

    Article  PubMed  Google Scholar 

  11. Caroff SN, Campbell EC. Risk of neuroleptic malignant syndrome in patients with NMDAR encephalitis. Neurol Sci. 2015;36(3):479–80. https://doi.org/10.1007/s10072-014-2022-z.

    Article  PubMed  Google Scholar 

  12. Koga S, Dickson DW. Recent advances in neuropathology, biomarkers and therapeutic approach of multiple system atrophy. J Neurol Neurosurg Psychiatry. 2018;89(2):175–84. https://doi.org/10.1136/jnnp-2017-315813.

    Article  PubMed  Google Scholar 

  13. Gilman S, Wenning GK, Low PA, Brooks DJ, Mathias CJ, Trojanowski JQ, et al. Second consensus statement on the diagnosis of multiple system atrophy. 2008;71(9):670–6. https://doi.org/10.1212/01.wnl.0000324625.00404.15.

  14. Lieto M, Roca A, Bruzzese D, Antenora A, Alfieri G, Saccà F, et al. Longitudinal study of a cohort of MSA-C patients in South Italy: survival and clinical features. Neurol Sci. 2019;40(10):2105–9. https://doi.org/10.1007/s10072-019-03948-7.

    Article  PubMed  Google Scholar 

  15. Gurrera RJ, Mortillaro G, Velamoor V, Caroff SN. A validation study of the international consensus diagnostic criteria for neuroleptic malignant syndrome. J Clin Psychopharmacol. 2017;37(1):67–71. https://doi.org/10.1097/jcp.0000000000000640.

    Article  PubMed  Google Scholar 

  16. Ghosh R, Liddle BJ. Emergency presentations of Parkinson's disease: early recognition and treatment are crucial for optimum outcome. Postgrad Med J. 2011;87(1024):125–31. https://doi.org/10.1136/pgmj.2010.104976.

    Article  CAS  PubMed  Google Scholar 

  17. Wei L, Chen Y. Neuroleptic malignant-like syndrome with a slight elevation of creatine-kinase levels and respiratory failure in a patient with Parkinson's disease. Patient Preference Adherence. 2014;8:271–3. https://doi.org/10.2147/ppa.S59150.

    Article  PubMed  PubMed Central  Google Scholar 

  18. Serrano-Dueñas M. Neuroleptic malignant syndrome-like, or--dopaminergic malignant syndrome--due to levodopa therapy withdrawal. Clinical features in 11 patients. Parkinsonism Relat Disord. 2003;9(3):175–8. https://doi.org/10.1016/s1353-8020(02)00035-4.

    Article  PubMed  Google Scholar 

  19. Reimer J, Kuhlmann A, Müller T. Neuroleptic malignant-like syndrome after rapid switch from bromocriptine to pergolide. Parkinsonism Relat Disord. 2002;9(2):115–6. https://doi.org/10.1016/s1353-8020(01)00045-1.

    Article  PubMed  Google Scholar 

  20. Jellinger KA. Multiple system atrophy: an Oligodendroglioneural Synucleinopathy1. J Alzheimers Dis. 2018;62(3):1141–79. https://doi.org/10.3233/jad-170397.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  21. Glasmacher SA, Leigh PN, Saha RA. Predictors of survival in progressive supranuclear palsy and multiple system atrophy: a systematic review and meta-analysis. J Neurol Neurosurg Psychiatry. 2017;88(5):402–11. https://doi.org/10.1136/jnnp-2016-314956.

    Article  PubMed  Google Scholar 

  22. Curry-Hyde A, Chen BJ, Ueberham U, Arendt T, Janitz M. Multiple system atrophy: many lessons from the Transcriptome. Neuroscientist. 2018;24(3):294–307. https://doi.org/10.1177/1073858417723915.

    Article  CAS  PubMed  Google Scholar 

  23. Guerrero-Ferreira R, Kovacik L, Ni D, Stahlberg H. New insights on the structure of alpha-synuclein fibrils using cryo-electron microscopy. Curr Opin Neurobiol. 2020;61:89–95. https://doi.org/10.1016/j.conb.2020.01.014.

    Article  CAS  PubMed  Google Scholar 

  24. Douglas A, Morris J. It was not just a heatwave! Neuroleptic malignant-like syndrome in a patient with Parkinson's disease. Age Ageing. 2006;35(6):640–1. https://doi.org/10.1093/ageing/afl096.

    Article  PubMed  Google Scholar 

  25. Hashimoto T, Tokuda T, Hanyu N, Tabata K, Yanagisawa N. Withdrawal of levodopa and other risk factors for malignant syndrome in Parkinson's disease. J Parkinsonism Relat Disord. 2003:S25–30. https://doi.org/10.1016/s1353-8020(02)00119-0.

  26. Sechi G, Manca S, Deiana GA, Corda DG, Pisu A, Rosati G. Acute hyponatremia and neuroleptic malignant syndrome in Parkinson's disease. Prog Neuropsychopharmacol Biol Psychiatry. 1996;20(3):533–42. https://doi.org/10.1016/0278-5846(96)00015-2.

    Article  CAS  PubMed  Google Scholar 

  27. Sone H, Okuda Y, Bannai C, Suzuki S, Yamaoka T, Asakura Y, et al. Syndrome of inappropriate secretion of antidiuretic hormone (SIADH) and Gerhardt syndrome associated with shy-Drager syndrome. Intern Med. 1994;33(12):773–8. https://doi.org/10.2169/internalmedicine.33.773.

    Article  CAS  PubMed  Google Scholar 

  28. Samukawa M, Hirano M, Sakamoto H, Kitada M, Kusunoki S, Nakamura Y. Risks of inappropriate secretion of antidiuretic hormone in multiple system atrophy. Mov Disord. 2011;26(14):2572–3. https://doi.org/10.1002/mds.23904.

    Article  PubMed  Google Scholar 

  29. Nisijima K, Shioda K. A rare case of neuroleptic malignant syndrome without elevated serum creatine kinase. Neuropsychiatr Dis Treat. 2014;10:403–7. https://doi.org/10.2147/ndt.S58677.

    Article  PubMed  PubMed Central  Google Scholar 

  30. Nisijima K. Elevated creatine kinase does not necessarily correspond temporally with onset of muscle rigidity in neuroleptic malignant syndrome: a report of two cases. Neuropsychiatr Dis Treat. 2012;8:615–8. https://doi.org/10.2147/ndt.S38638.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  31. Rehman T, deBoisblanc BP. Persistent fever in the ICU. Chest. 2014;145(1):158–65. https://doi.org/10.1378/chest.12-2843.

    Article  PubMed  Google Scholar 

  32. Onofrj M, Bonanni L, Cossu G, Manca D, Stocchi F, Thomas A. Emergencies in parkinsonism: akinetic crisis, life-threatening dyskinesias, and polyneuropathy during L-Dopa gel treatment. Parkinsonism Relat Disord. 2009:S233–6. https://doi.org/10.1016/s1353-8020(09)70821-1.

  33. Wang HY, Li T, Li XL, Zhang XX, Yan ZR, Xu Y. Anti-N-methyl-D-aspartate receptor encephalitis mimics neuroleptic malignant syndrome: case report and literature review. Neuropsychiatr Dis Treat. 2019;15:773–8. https://doi.org/10.2147/ndt.S195706.

    Article  PubMed  PubMed Central  Google Scholar 

  34. Fiore S, Persichino L, Anticoli S, De Pandis MF. A neuroleptic malignant-like syndrome (NMLS) in a patient with Parkinson's disease resolved with rotigotine: a case report. Acta biomed Atenei Parmensis. 2014;85(3):281–4.

    Google Scholar 

  35. Man SP. An uncommon adverse effect of levodopa withdrawal in a patient taking antipsychotic medication: neuroleptic malignant-like syndrome. Hong Kong Med J. 2011;17(1):74–6.

    CAS  PubMed  Google Scholar 

  36. Auffret M, Drapier S, Vérin M. New tricks for an old dog: a repurposing approach of apomorphine. Eur J Pharmacol. 2019;843:66–79. https://doi.org/10.1016/j.ejphar.2018.10.052.

    Article  CAS  PubMed  Google Scholar 

  37. Kishimoto S, Nakamura K, Arai T, Yukimasa O, Fukami N. Postoperative neuroleptic malignant syndrome-like symptoms improved with intravenous diazepam: a case report. J Anesth. 2013;27(5):768–70. https://doi.org/10.1007/s00540-013-1602-z.

    Article  PubMed  PubMed Central  Google Scholar 

  38. Azuma H, Negi A, Hattori M, Masayasu T, Akechi T, Furukawa TA. Neuroleptic malignant syndrome-like state in an epileptic patient with organic brain comorbidity treated with zonisamide and carbamazepine. Epilepsia. 2007;48(10):1999–2001. https://doi.org/10.1111/j.1528-1167.2007.01165_2.x.

    Article  PubMed  Google Scholar 

  39. Shin HW, Youn YC. Neuroleptic malignant syndrome induced by phenytoin in a patient with drug-induced parkinsonism. Neurol Sci. 2014;35(10):1641–3. https://doi.org/10.1007/s10072-014-1826-1.

    Article  PubMed  Google Scholar 

Download references

Acknowledgments

We are grateful to the patients who were willing to share their medical data.

Funding

This study was supported by the National Natural Science Foundation of China (No.81100972).

Author information

Authors and Affiliations

Authors

Contributions

YL: Writing original draft. LM: Substantively revised the manuscript. NZ and RL: Data Collection. WJ: Review the final manuscript. All authors have read and approved the manuscript.

Corresponding author

Correspondence to Wenjing Jiang.

Ethics declarations

Ethics approval and consent to participate

Informed consent was obtained from the patients to publish these cases, and approval for this study was provided by the Research Ethics Committee of Qilu Hospital of Shandong University.

Consent for publication

The written informed consent for publication was obtained from the patients. The copy of the consent is available for the journal.

Competing interests

The authors declare no conflicts of interest.

Additional information

Publisher’s Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Supplementary Information

Rights and permissions

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Lin, Y., Ma, L., Zhang, N. et al. Neuroleptic malignant-like syndrome associated multiple system atrophy: report on three cases. BMC Neurol 22, 67 (2022). https://doi.org/10.1186/s12883-022-02583-8

Download citation

  • Received:

  • Accepted:

  • Published:

  • DOI: https://doi.org/10.1186/s12883-022-02583-8

Keywords