Clinical uses of Bupropion in patients with Parkinson’s disease and comorbid depressive or neuropsychiatric symptoms: a scoping review
BMC Neurology volume 22, Article number: 169 (2022)
Bupropion, an antidepressant inhibiting the reuptake of dopamine and noradrenaline, should be useful to treat depressive symptoms in patients with Parkinson’s disease (PD). Limited and conflicting literature data questioned its effectiveness and safety in depressed PD patients and extended its use to other neuropsychiatric symptoms associated with this disorder.
The databases PubMed, Embase, Web of Sciences, Cochrane Library, and the grey literature were searched. Following a scoping review methodology, articles focusing on Bupropion uses in PD patients who manifested depressive or other neuropsychiatric alterations were reviewed.
Twenty-three articles were selected, including 7 original articles, 3 systematic reviews or meta-analyses, 11 case reports, 1 clinical guideline, and 1 expert opinion. Bupropion showed considerable effectiveness in reducing depressive symptoms, particularly in relation to apathy. Solitary findings showed a restorative effect on compulsive behaviour secondary to treatment with dopamine as well as on anxiety symptoms. The effect on motor symptoms remains controversial. The safety profile of this medication seems positive, but additional precautions should be used in subjects with psychotic symptoms.
The available literature lacks good evidence to support the use of Bupropion in PD patients presenting depressive symptoms. Further investigations are needed to extend and confirm reported findings and to produce accurate clinical guidelines.
Motor symptoms are the cardinal manifestation of Parkinson’s disease (PD), however, the clinical picture typically also manifests with non-motor symptoms like neuropsychiatric alterations, autonomic dysfunctions, sleep disturbances, sensory deficits, and cognitive impairment [1, 2]. Non-motor symptoms often anticipate the diagnosis of PD and their underrecognition might lead to delay in the correct diagnosis and treatment . Additionally, the frequent overlap between neurological and psychiatric symptoms complicates the course of the illness and remains a real challenge in terms of differential diagnosis, management, and treatment approach [4, 5].
In PD patients, depressive symptoms are common, with a prevalence that varies from 35 to 50% of cases [6, 7] and are associated with greater disability, rapid progression of motor symptoms, and increased mortality [8, 9]. Despite the high prevalence, depressive symptoms remain frequently undiagnosed because they often mimic those of PD . Among different therapeutic strategies to target depressive symptoms in PD, antidepressants are the most used. However, the effectiveness and safety of these medications, particularly of “newer” compounds (beyond the selective serotonin reuptake inhibitors (SSRIs) and the serotonin–norepinephrine reuptake inhibitors (SNRIs)), is supported by limited scientific evidence [11, 12].
In the list of “newer” antidepressants, Bupropion has been described as a potential option for the treatment of depressive symptoms in PD . Compared to other classes of antidepressants, Bupropion has a unique mechanism of action targeting the dopaminergic and noradrenergic systems (through inhibition of the reuptake of these two neurotransmitters)  whose alterations are at the core of PD pathogenesis . Indeed, among other etiopathogenic factors responsible for depressive symptoms in PD, a specific loss of dopamine and noradrenaline innervation of cortical and subcortical components of the limbic system has been proposed. Hypofunction of these neurotransmitters might cause apathy, loss of interest, pleasure, and energy, impaired executive function, and concentration disturbances, that might be independent of a comorbid depressive disorder .
Remarkably, Bupropion does not affect the serotonergic system (with fewer side-effects such as drowsiness, weight gain, and sexual dysfunction) and potentially increases PD patients’ adherence to antidepressant treatment . For the same reason, the combination of Bupropion with monoamine-oxidase inhibitors (frequently prescribed in PD) is likely associated with an abated risk of serotonin syndrome . Lastly, a neuroprotective effect of Bupropion in patients with PD has been hypothesized, being possibly mediated by a reduction of dopaminergic toxicity in intracytoplasmic/extravesicular compartments .
Despite these theoretical properties, Bupropion efficacy on depressive symptoms in PD has been reported only in limited clinical investigations [17,18,19]. This presumably reflects the clinical practice that favors the use of other antidepressants (i.e., SSRIs or SNRIs) which are prescribed as first-line treatment in Major Depressive Disorder . Moreover, considering the Bupropion effect on the dopaminergic system, some concerns might be raised about its safety and tolerability. In this respect, the available clinical data showed controversial results. On one hand, Bupropion has been shown to ameliorate PD-related motor symptoms , while, on the other, some studies underlined the risk of Bupropion-induced movement disorders [22,23,24]. Apart from depressive symptoms, some investigations showed a positive effect of Bupropion on other neuropsychiatric manifestations often characteristic of individuals suffering from PD, for example, drowsiness and sleep problems [25, 26].
Considering this background, we primarily sought to review the current knowledge on the effectiveness and safety of Bupropion in patients with PD and comorbid depressive symptoms. Secondarily, we aimed to extend the knowledge on Bupropion additional uses in PD patients who manifested other neuropsychiatric alterations. This work primarily aimed to map and characterize the current literature on this topic. Additionally, it will help to draft specific recommendations which could guide clinicians to manage neuropsychiatric manifestations in patients with PD and, eventually, to delineate a PD patient’s profile more appropriate for treatment with Bupropion.
A scoping review method was deemed appropriate for our research question considering the lack of univocal findings and the paucity of data on Bupropion use in patients with PD . We followed the modified scoping review procedures as outlined by Arskey and O’Malley  and further elaborated by Levac and colleagues . Accordingly, the present review followed the proposed five-stage methodological framework: developing the research question, identifying relevant articles, selecting articles, extracting data, and collating results (the sixth step - engaging stakeholders through consultation - was not adopted, as considered optional by the above-mentioned approach ).
Definitions and search strategies
The authors discussed and reached a consensus on the research question and the target of the investigation. The research question consisted of investigating the therapeutical uses of Bupropion in patients with a diagnosis of PD (or parkinsonism) who manifested depressive symptoms or other neuropsychiatric alterations (e.g., sleep disturbances, anxiety symptoms). Therefore, we included studies where Bupropion was primarily prescribed as an antidepressant (considering its main clinical indication) but also studies that investigated its use for potentially any other therapeutical reason in PD patients. Considering scoping review’s methodology, we decided to search for studies that differed on several variables, including sample characteristics, Bupropion dosage, or outcomes investigated.
To identify relevant studies, we searched electronic databases PubMed, Embase, Web of sciences, Cochrane Library from inception to May 2021. An inclusive search strategy was performed using the terms “Bupropion” AND “Parkinson” OR “parkinsonism”. Considering the original generic name of Bupropion (i.e., amfebutamone), an additional research was performed using this term. To identify further references not captured in the published medical literature, we also searched Opengrey (SIGLE) and Google Scholar, screening the first 100 results for relevance to our clinical question. Additional articles potentially relevant to our objectives were identified through reviewing reference lists of selected articles.
Pre-defined inclusion criteria were used to select articles relevant to study objectives identified through the search strategy. Due to the broad nature of scoping reviews, we did not limit our research question to a particular type of article. Indeed, case reports, original articles, guidelines, expert opinions, or posters at conferences/congresses were all eligible for inclusion in order to capture all the results in this area. Based on predetermined criteria, we excluded records investigating non-human samples. Two authors (MV and GN) independently selected the articles according to study question and exclusion criteria. Disagreements were resolved by discussion and the involvement of a third assessor (BB). A consensus was reached in all cases. A relevant number of narrative reviews were selected during the search strategy but were subsequently excluded considering these were referring to one or few previously published reports (i.e., [13, 17, 21]) and, therefore, the strength of the recommendation would have been biased. Therefore, we decided to include only systematic reviews or meta-analyses considering the higher reliability of these methodologies. PRISMA guidelines for scoping review were followed in the selection procedures (Fig. 1). Study quality was not systematically measured; indicators of quality were assessed during selection and have been reported in Tables 1 and 2.
Data charting and collating, summarizing, and reporting results
The research team investigators (MV, GN, BB) collectively developed the data-charting form to determine which variables to extract. This form was revised during meetings throughout the stages of the review, and uncertainty was resolved with periodic team meetings and the involvement of a fourth investigator (BD). The following variables were extracted from each study: author, year and country of publication, characteristics of patients investigated (i.e., number, age, gender, and clinical variables related to PD or comorbid illnesses), Bupropion primarily indication and dosage, results on effectiveness and safety.
Our literature search produced 1319 records reduced to 738 after duplicates were removed. Review of titles and abstracts led to the inclusion of 77 articles for assessment; 54 narrative reviews were excluded (Fig. 1). Ultimately, 23 articles were included.
Description of articles
Selected articles were published between 1984 and 2021 and this result reflects the commercialization (firstly approved as an antidepressant in the United States in 1985) and subsequent use of Bupropion in clinical practice. An increasing trend towards growing publications in this field emerged since then (1984–1995: n = 1; 1996–2007: n = 7; 2008–2021: n = 15). Reports came primarily from North America (n = 8, 34.8%) and Europe (n = 8, 34.8%).
Most selected articles included case reports (n = 11, 47.8%) [17,18,19, 29, 30, 32,33,34,35, 38, 42] for a total of 12 patients with PD and one with parkinsonism. Seven original articles were selected [21, 31, 36, 37, 39,40,41], most of which were published only in the form of poster presentations [36, 37, 40, 41]. These included interventional studies of which one randomized controlled trial (RCT) (only in the form of poster presentation) , one with a mixed design (some patients were compared with a placebo-controlled group while others were treated with an open label fashion) , and three with an open-label design (all in the form of poster presentations) [36, 37, 41]. Two cross-sectional studies included a 12-month prospective investigation  and one retrospective analysis of clinical charts . Most articles were relatively small in sample (n < 50 patients), except for one study based on a national sample , with overall 7868 patients with PD being investigated.
With respect to review articles, two were systematic literature reviews and included a meta-analysis of the results [44, 47]. Another meta-analysis  included six RCTs but did not conduct a systematic revision of the literature (only in the form of poster presentation).
Original articles - randomized controlled trials
Only one double-blind RCT has been conducted thus far  which included 46 patients with PD and comorbid depression (according to the Diagnostic and Statistical Manual of Mental Disorders, IV edition criteria) who were divided into two arms: 23 patients treated with Bupropion 300 mg/day and 23 with Sertraline 100 mg/day as the control condition. The main outcomes were to assess the improvement, after a 6-week trial, of depressive symptoms (as assessed on the Hamilton Depression Rating Scale (HAM-D), as well as the efficacy of treatments as measured with the Clinical Global Impression Scale (CGI)) and in relation to motor symptoms (clinically measured). Patients on Bupropion showed a significant improvement in all outcome measures compared with Sertraline, and the side effect profile (clinically assessed) was approximately equal. Despite this being one of the few RCTs conducted in the field, only the abstract was published as a conference poster and, therefore, the role of potential influencing variables (e.g., comorbidities, concurrent medications) and the strictness of the methodology could not be assessed.
The investigation from Goetz and colleagues  adopted a mixed design. Indeed, 14 patients were enrolled in a double-blind parallel protocol, 8 of whom received Bupropion in the first phase and 6 received placebo. Moreover, 12 patients received Bupropion in an open-label fashion, 6 as crossovers from the double-blind placebo group and 6 were treated outside the double-blind protocol. The primary aim of this investigation was to assess the efficacy of Bupropion on motor symptoms in patients with PD (n = 20). At the same time, its effects on depressive symptoms were assessed in a specific subgroup of patients (n = 12/20) who manifested depressive symptoms at the baseline. After 9 weeks, all patients reported a significant improvement in motor symptoms (as measured on the North-western University Disability Scale or New York University Parkinson Disease Scale) and 41.7% of the whole sample reported an improvement of depressive symptoms (measured on a generic “global impression scales for both parkinsonism and depression”). Of note, antiparkinsonian and antidepressant effects of Bupropion were unrelated. Reported findings seem to support the efficacy of Bupropion in subjects with PD with or without comorbid depression, while the limited sample size and the lack of a control group limit the confidence in the results. Additionally, the endpoint was set at 9 weeks, which seems quite short for a clinical trial. Side effects were frequent (nausea and vomiting, excitement, restlessness, and postural tremor were dose-limiting in five patients; hallucinations or confusional states occurred as new phenomena in one patient and recurred or resulted to be exacerbated in two subjects; dyskinesia was exacerbated in one patient).
Original articles - open-label design studies
Two open-label studies specifically investigated the antidepressant effect of Bupropion in patients with PD [36, 41]. Despite the limited sample size (≤20 patients), a significant improvement of depressive symptoms (as measured on the HAM-D  or the Montgomery-Asberg Depression Rating Scale ) emerged in both studies after a 6-month trial with Bupropion (150–300 mg/day). With respect to other PD symptoms, the study from Vasile and colleagues showed an improvement on the “non-motor experiences of daily living” dimension on the Unified Parkinson’s disease rating scale  while the other investigation showed no changes . Additionally, the investigation from Vasile and colleagues  showed an improvement in measures of global functioning and quality of life (on the 36-item Short Form survey). With respect to safety, both studies showed a safe profile of Bupropion, with mild and self-limiting side effects being reported (anxiety, insomnia, sweating , dizziness, or nausea ).
Another 12-week open-label study addressed the use of Bupropion (300 mg/day) on freezing of gait in 9 patients with PD . At the endpoint, freezing of gait (as measured on the Gait and Balance Scale) was reduced, but not at a significant level, and, therefore, authors concluded this medication was not efficacious in PD patients with this motor alteration.
Original articles – observational studies
Considering safety concerns of monoamine oxidase type B (MAO-B) inhibitors in PD, Ritter and colleagues  retrospectively reviewed the clinical charts of 28 patients with PD, who were prescribed Selegiline in association with antidepressants (including 3 patients taking Bupropion), with the aim to investigate the safety of different combinations. Among the investigated combinations (n = 40), only one interaction emerged (serotonin syndrome with Fluoxetine). With respect to Bupropion, authors considered the medication an appropriate first choice in subjects prescribed Selegiline, whereas tricyclic antidepressants and Trazodone may be reserved as second-line treatments .
A cross-sectional prospective study collected data from a national database of veterans who attended clinical visits for depression, followed up for the following 12 months to compare different antidepressants in patients with versus without PD . Results showed interesting data on antidepressant approaches in the two subgroups (which had the same chance to start an antidepressant prescription: SSRIs were the most prescribed and the PD group had slightly higher rates to use newer non-SSRI drugs). Bupropion’s prescription accounted for 6.8% of patients with PD, a percentage similar to Venlafaxine (6.8%) but lower compared to other “classic” serotonergic antidepressants (e.g., Sertraline 28.9%) .
Eleven case reports describing the use of Bupropion in patients with PD were selected. Bupropion daily dosage varied in a range included in the therapeutic dose (150–300 mg). In all case reports, the compound was used to treat depressive symptoms or Major Depression in patients with PD [17,18,19, 29, 30, 32,33,34,35, 38, 42]. The effects of Bupropion on depressive symptoms were measured, when reported, at different endpoints, from 8 weeks  to 1 year [19, 35].
The majority of these reports that measured changes in depressive symptoms (n = 6, 86%) observed a variable degree of improvement of depressive symptoms [17,18,19, 30, 32, 35], based on a standardized assessment measure (i.e., the HAM-D) [17, 19, 30, 32] or on clinical evaluation [18, 35]. Conversely, the case of a patient with mood fluctuations (i.e., depressive symptoms worsened when Levodopa medication wore off and opposite “euphoric” symptoms manifested during the peak dose) with no improvement after antidepressant treatment, including an 8-week trial with Bupropion, was reported . The remaining case reports (n = 4) did not measure changes in depressive symptoms, as they were primarily focusing on Bupropion’s side effects or on other topics [29, 33, 34, 42].
Some of these reports described Bupropion’s effect on other neuropsychiatric manifestations. Indeed, a case report showed its effectiveness in reducing food intake within 3–4 weeks and promoting weight loss in three patients with PD that developed compulsive eating as a side effect of dopaminergic medications . Another study showed an improvement of anxiety symptoms after a treatment trial with Bupropion . In another study of a woman with late-stage PD, severe recurrent depression, psychosis, and chronic pain (diffuse and burning at the lower limbs) were described . After several unsuccessful treatment strategies to reduce chronic pain and unstable motor and depressive symptoms, switching from Paroxetine to Bupropion – combined with the introduction of sustained-release Carbidopa/Levodopa - reduced fluctuations in mood and mobility and improved overall functioning.
With respect to the safety profile, the majority of cases that reported this measure (n = 7, 70%) confirmed Bupropion overall safety [32, 35] showing no negative motor side-effects [17, 30] or limited improvement in PD symptoms [18, 35]. No psychotic symptoms were registered in a female patient with a positive history of hallucinosis , despite the reported risk of this medication to cause this symptom.
On the other hand, some reports (n = 3, 30%) described potential side effects that occurred during the administration of Bupropion. A 78-old patient with a severe stage of PD developed dyskinesias and dystonia two days after Bupropion initiation that reduced and disappeared after its discontinuation . Similarly, Ahn and colleagues described the occurrence of propriospinal myoclonus a few days after Bupropion introduction and Memantine increase, which improved when the two drugs were discontinued . Another case report described a patient with PD and comorbid Major Depressive Disorder who developed hyponatremia (119.5 mEq/L) 18 days after Bupropion initiation; the alteration normalized by 7 days after drug discontinuation .
Lastly, one case report described Bupropion’s interference with neuroimaging test in a patient with a long history of depression who developed parkinsonism (mild bradykinesia in the left hand, mild slowness in his foot-tapping rate, and reduced stride length) . In particular, 1 week after Bupropion discontinuation (according to the usual time indicated for washout in imaging centers) the patient performed a brain imaging ([123I]FP-CIT SPECT) which resulted in abnormal (reduced binding bilaterally but particularly in the left putamen) and suggestive for dopamine transporter binding defect. Indeed, a Levodopa treatment trial was started, without clinical response. Eleven months later (this time, four weeks after Bupropion discontinuation) a new SPECT was performed and resulted normal, suggesting that medication might have been the reason for misdiagnosis in the brain dopamine transporter imaging .
Systematic reviews, meta-analyses, and other reports
Despite the vast number of literature reviews focusing on treatment approaches in patients with PD who manifest neuropsychiatric symptoms, only two systematic reviews mentioned Bupropion [44, 47]. Both reports focused on antidepressants use in patients with PD and the review from Mills and colleagues included only RCTs . In these reviews, two articles were included, the one from Goetz, 1984 (in Weintraub, 2005) and the one from Trivedi, 2002 (in Mills, 2018), which have been already discussed the previous paragraph. In both cases, a meta-analysis was performed, but the specific studies on Bupropion were not included in further analyses, so additional data on this medication were not available.
Similarly, Paumier and colleagues  conducted a meta-analysis on six RCTs investigating the effect of antidepressants (including Bupropion) on PD progression. This is the only investigation that showed how antidepressant-treated subjects had a lower probability of requiring dopaminergic therapy compared with those individuals not taking antidepressants (HR = 0.6, p < 0.001). Of note, this effect was not specific to a particular class of antidepressants. Additionally, mean change in the UPDRS (Unified Parkinson’s disease rating scale) scores was significantly lower (i.e., a lesser degree of motor impairment and disability) in subjects treated with “atypical” antidepressants than those not taking antidepressants (p < 0.05). Bupropion was included in this class of “atypical” antidepressants, even though a direct effect of Bupropion cannot be drawn considering how these drugs were grouped (with Mirtazapine and Trazodone).
The “Neurological Association of Madrid”, thanks to a review of the literature and the results of a movement disorder study group survey, issued a series of recommendations on the use of antidepressants in patients with PD . These clinical guidelines state that SSRIs are usually the drugs of first choice, as they are perceived as being well tolerated, having few drug interactions, and being suitable for patients with comorbidities. In relation to Bupropion, the Authors concluded that clinicians should consider it to treat apathy in patients with PD with the following degree of evidence: class IV (data based on other studies, including consensus or expert opinion) and recommendation U (inadequate or conflicting data).
Lastly, using a Delphi methodology, an original article collected the opinion of 37 experts in psychiatry, neurology, and geriatrics on different topics related to depression in PD . Forty-nine items revisiting some fundamental clinical aspects of depression in PD were included, including specific ones on Bupropion (i.e., “the dopamine and norepinephrine reuptake inhibitor Bupropion is effective in PD patients?”; and “Given its PD-specific efficacy and tolerability, Bupropion is a good treatment option for depression in PD patients?”). Seeing experts’ agreement, this medication was considered an efficacious and well-tolerated pharmacological option for depressive symptoms in PD .
Effectiveness on depressive symptoms
Considering the results of the present scoping review, the first question that can be answered relates to Bupropion antidepressant effectiveness in patients with PD. Overall, most of the retrieved reports seem to support its use. Indeed, the RCT  and three reviewed open-label studies [21, 36, 41] demonstrated a variable degree of the antidepressant effectiveness of Bupropion in patients with PD. Similarly, the majority of case reports who measured depressive outcomes [17,18,19, 30, 32, 35] showed improvement of depressive symptoms, while only one  reported no changes. Despite diverse methodology (e.g., different measures of depressive symptoms, different Bupropion dosage, and duration of therapy) and publication biases (i.e., negative findings remain often unpublished ), we can conclude that Bupropion is potentially a valuable treatment option to target depressive symptoms in patients with PD. This recommendation is supported by the treatment guidelines from the Neurological Association of Madrid , specifically indicating Bupropion for the treatment of apathy associated with PD, though with a low level of evidence and grade of recommendation (class IV, recommendation U). Apathy is a common symptom in PD patients, with a frequency reported between 16.5% and 42% of cases of PD . According to these guidelines, Bupropion is the only antidepressant recommended for apathy: thus, it might be particularly useful in PD patients who manifest an intense lack of feelings, emotions, or interests.
Similarly, Aguera-Ortiz and colleagues  showed that clinicians considered Bupropion as an efficacious and safe pharmacological option in the treatment of depression in PD patients. Available treatment guidelines about depression in PD  are inconclusive and underline the lack of robust literature data, as emerged in the systematic reviews included in the present paper [44, 47]. Therefore, clinicians presumably base their therapeutic decisions on clinical experience, which seems to favor Bupropion use in PD patients with depressive symptoms.
Effectiveness on motor symptoms
Considering Bupropion’s pro-dopaminergic effect, its potential parallel role in ameliorating motor symptoms in PD is the second issue that can be discussed in light of the results of the present review. Among selected articles that measured motor outcomes, the two RCTs [21, 40], one original article  and two case reports [18, 35] showed an improvement in motor symptoms following treatment with Bupropion. Additionally, using a meta-analytic approach, Paumier reported that, in subjects with early PD, antidepressant therapy (including but not specific on Bupropion) reduced the probability of requiring dopaminergic therapy compared with subjects not taking antidepressants . However, these investigations adopted questionnaires that measured generic changes in motor symptoms, so the effect of Bupropion on a specific PD-related motor symptom cannot be surveyed. Only the investigation from Kim and colleagues  specifically showed a reduction of gait freezing in PD patients treated with Bupropion, although this difference was not significant when compared with baseline. In this respect, although the exact mechanism of action of Bupropion is not fully understood, this improvement in motor symptoms is likely associated with increased dopaminergic levels in the dopaminergic pathways involved in PD .
On the other hand, among investigated studies, two case reports reported dyskinesias and dystonia  and propriospinal myoclonus  occurring after Bupropion start: these adverse events improved and disappeared after its discontinuation. Indeed, they might be considered similar to dopamine-induced peak dose dystonia given Bupropion’s mechanism of increasing the availability of dopamine  or, in the circumstance of myoclonus, possibly produced by the concomitant use of Memantine .
Overall, the present scoping review seems to support a certain degree of efficacy of Bupropion also on motor symptoms, even though additional investigations with larger samples and with a strict methodology are needed to confirm this conclusion. In the attempt to analyze motor side effects in patients on Bupropion, a recent systematic review (non specific on PD patients, with Bupropion prescribed for different reasons) collected 710 cases describing Bupropion-associated movement disorders. The three most commonly reported were tremors, slurred speech, and falls, but also dystonia, dyskinesia, parkinsonism and myoclonus were variably reported. However, the Authors concluded Bupropion was uncommonly related to abnormal movements and that the majority of literature cases did not clearly report the clinical neurological examination and lacked electrodiagnostic tests: therefore, the reported alterations might be not primary a consequence of Bupropion .
Effectiveness of Bupropion on other neuropsychiatric manifestations
In the general population, Bupropion is approved for depression, seasonal affective disorder, and smoking cessation, while off-label uses often include antidepressant-induced sexual dysfunction, attention-deficit/hyperactivity disorder, depression associated with bipolar disorder, and obesity . In the context of PD, the articles examined in the present review supported Bupropion use to reduce compulsive eating as a consequence of dopaminergic medications  and to improve panic symptoms . Although these results represent solitary findings, they might reflect the pharmacodynamics of Bupropion. Indeed, the inhibition of dopamine reuptake in the ventral striatum might lead to a stabilization of dopaminergic transmission in the mesolimbic system (as observed in nicotine addiction where Bupropion showed to be effective) . Moreover, Bupropion-mediated inhibition of norepinephrine reuptake in the prefrontal cortex may contribute to further stabilizing cortical-subcortical prefrontal limbic circuitries involved in addictive and compulsive behaviors. The same neurotransmitter might be responsible for the anxiolytic effect, even though an improvement of anxiety symptoms as secondary to improvement of depression might be another potential explanation.
The third important issue addressed in the present review is about Bupropion safety in patients with PD. This medication is contraindicated in patients with epilepsy and eating disorders, and the most common side effects occurring in more than 10% of the patients are headache, dry mouth, nausea, weight loss, insomnia, agitation, dizziness. However, Bupropion lacks typical antidepressant-associated side effects such as sexual dysfunction, weight gain, and sedation .
The motor side effects described in the reviewed articles have been already discussed in a previous paragraph. Considering non-motor side effects, Bupropion has been considered a safe medication by the majority of the articles [17, 19, 30, 32, 35, 36, 39,40,41]. Additionally, one investigation showed an improvement in measures of global functioning and quality of life as secondary to Bupropion treatment . Moreover, Bupropion was considered to be safe in combination with Selegiline therapy . Another reviewed case report did not show an increased risk of psychotic symptoms in a female patient with a positive history of hallucinosis , whereas hallucinosis was reported in 3 patients (15%) in another selected paper . Some previous reports alerted on the risk of psychosis associated with Bupropion, with incomplete, and in some cases mixed, results as observed by a systematic review of the literature . The side effects reported in selected articles were anxiety, insomnia and sweating , dizziness [36, 37], nausea [17, 21, 36], vomiting, excitement and restlessness, postural tremor, dyskinesia, hallucinations, and confusion . Another report described the occurrence of hyponatremia in a PD patient on Bupropion, which was found to be resolved after Bupropion withdrawal . Hyponatremia is reported to be associated with the use of various antidepressants, especially SSRIs, and in 0.41% of subjects prescribed Bupropion in a phase IV clinical study analysis .
Overall, Bupropion use is likely associated with a favorable safety profile in subjects with PD, considering the absence or the nonsignificant nature of side effects that emerged in reviewed articles. Apart from specific contraindications, Bupropion might be cautiously used in PD patients with a positive history of psychotic symptoms. Once more, the nature of the reviewed reports and the limited number of included patients must be considered. The work from Agüera-Ortiz supports this recommendation, with a consensus of experts about the good tolerability of Bupropion in patients with PD .
Potential study limitations must be kept in mind. First, our search may not have been exhaustive, despite using multiple databases and grey literature sources. Using a systematic review methodology was not possible (considering the limited investigations on the topic); however, the present scoping review has been conducted after a systematic revision of the literature and according to a strict methodology (i.e., PRISMA Guidelines). Second, the authors decided to not include narrative reviews, commentaries, and perspectives which represent a considerable number of sources, but, as already stated, are based on limited reports. Third, a quality assessment of the selected studies was not conducted with a standardized tool, but the authors critically evaluated and indicated in Tables 1 and 2 the most relevant methodological limitations. Lastly, the 22% (N = 5) of records selected were missing the full-text article being posters at conferences/congresses. This issue potentially reflects a limitation of the current knowledge on this topic as it seems that some investigations were conducted and published only as poster presentations/conference abstracts but not in the extended form, likely due to bias that did not allow publishing the trials or other reasons that we are not aware of. Despite the lack of the full-text might limit the confidence in the results, this more inclusive approach is in accordance with the nature of a scoping review, that includes researches and publications that would be characterized as having lower levels of evidence in hierarchies but, on the other hand, includes the kind of evidence that inform clinicians in the decision-making [59, 60] and design of future RCTs needed to produce accurate clinical guidelines.
The present scoping review sought to provide a comprehensive and updated overview of Bupropion clinical uses in patients with PD who manifested depression or other neuropsychiatric symptoms. Figure 2 describes the main findings and related recommendations that emerged from the present work.
Considering the current literature limitations and the scarce number of patients with non-motor symptoms treated with Bupropion, it was not possible to stratify them according to specific disease variables, like severity, duration, or pharmacotherapy. However, we tentatively delineated a patient’s profile more suitable for treatment with Bupropion. Patients with PD and depressive symptoms in particular apathy seem to favor the use of this medication, which should preferably not be used in subjects who present a history of psychosis and in ones with a long history of PD or unstable response to treatment with dopamine.
Considering the unique mechanism of action of the medication and the encouraging results emerged in the present scoping review, further investigations in this area, in particular RCTs with larger sample sizes, are encouraged and needed to overcome current literature limitations and to better understand the efficacy and safety profile of the compound in this specific population.
Availability of data and materials
All data generated or analyzed during this study are included in this article/manuscript.
Schapira AH, Jenner P. Etiology and pathogenesis of Parkinson’s disease. Mov Disord. 2011;26:1049–55.
Balestrino R, Martinez-Martin P. Neuropsychiatric symptoms, behavioural disorders, and quality of life in Parkinson’s disease. J Neurol Sci. 2017;373:173–8.
Szatmari S, Min-Woo Illigens B, Siepmann T, Pinter A, Takats A, Bereczki D. Neuropsychiatric symptoms in untreated Parkinson’s disease. Neuropsychiatr Dis Treat. 2017;13:815–26.
Vismara M, Cirnigliaro G, Piccoli E, Giorgetti F, Molteni L, Cremaschi L, et al. Crossing borders between frontotemporal dementia and psychiatric disorders: an updated overview. J Alzheimers Dis. 2020;75:661–73.
Altamura AC, Serati M, Albano A, Paoli RA, Glick ID, Dell’Osso B. An epidemiologic and clinical overview of medical and psychopathological comorbidities in major psychoses. Eur Arch Psychiatry Clin Neurosci. 2011;261:489–508.
Cummings JL. Understanding Parkinson Disease. JAMA. 1999;281:376.
Aarsland D, Marsh L, Schrag A. Neuropsychiatric symptoms in Parkinson’s disease. Mov Disord. 2009;24:2175–86.
Borek LL, Chou KL, Friedman JH. Management of the behavioral aspects of Parkinson’s disease. Expert Rev Neurother. 2007;7:711–25.
Lemke MR. Depressive symptoms in Parkinson’s disease. Eur J Neurol. 2008;15:21–5.
Shulman L, Taback R, Rabinstein A, Weiner W. Non-recognition of depression and other non-motor symptoms in Parkinson’s disease. Parkinsonism Relat Disord. 2002;8:193–7.
Dyduch A, Załuska M. Depression in Parkinson’s disease: the effectiveness and risk of pharmacotherapy. Clinical review. Psychogeriatrics. 2015;15:147–53.
Ryan M, Eatmon CV, Slevin JT. Drug treatment strategies for depression in Parkinson disease. Expert Opin Pharmacother. 2019;20:1351–63.
Raskin S, Durst R. Bupropion as the treatment of choice in depression associated with Parkinson’s disease and it’s various treatments. Med Hypotheses. 2010;75:544–6.
Jefferson JW, Pradko JF, Muir KT. Bupropion for major depressive disorder: Pharmacokinetic and formulation considerations. Clin Ther. 2005;27:1685–95.
Remy P, Doder M, Lees A, Turjanski N, Brooks D. Depression in Parkinson’s disease: loss of dopamine and noradrenaline innervation in the limbic system. Brain. 2005;128:1314–22.
Uhl GR. Dopamine compartmentalization, selective dopaminergic vulnerabilities in Parkinson’s disease and therapeutic opportunities. Ann Clin Transl Neurol. 2019;6:406–15.
Leentjens AF, Verhey FR, Vreeling FW. Successful treatment of depression in a Parkinson disease patient with bupropion. Ned Tijdschr Geneeskd. 2000;144:2157–9.
Stein WM, Read S. Chronic pain in the setting of Parkinson’s disease and depression. J Pain Symptom Manag. 1997;14:255–8.
Załuska M, Dyduch A. Bupropion in the treatment of depression in Parkinson’s disease. Int Psychogeriatr. 2011;23:325–7.
NICE. Depression in adults: recognition and management. National Institute for Health and Care Excellence. 2009. https://www.nice.org.uk/guidance/cg90.
Goetz CG, Tanner CM, Klawans HL. Bupropion in Parkinson’s disease. Neurology. 1984;34:1092.
Jerome L. Bupropion and Drug-Induced Parkinsonism. Can J Psychiatr. 2001;46:560–1.
Grandas F, López-Manzanares L. Bupropion-induced parkinsonism. Mov Disord. 2007;22:1830–1.
Pitton Rissardo J, Fornari CA. Bupropion-associated movement disorders: A systematic review. Ann Mov Disord. 2020;3:86.
Rye DB. Excessive daytime sleepiness and unintended sleep in Parkinson’s disease. Curr Neurol Neurosci Rep. 2006;6:169–76.
Monderer R, Thorpy M. Sleep disorders and daytime sleepiness in Parkinson’s disease. Curr Neurol Neurosci Rep. 2009;9:173–80.
Levac D, Colquhoun H, O’Brien KK. Scoping studies: advancing the methodology. Implement Sci. 2010;5:69.
Arskey OH. Scoping studies: towards a methodological framework. Int J Soc Res Methodol. 2007;8:19–32.
Ahn BJ, Kwon KY. Elderly woman presenting with unusual propriospinal myoclonus triggered by drug-induced nausea and vomiting. Geriatr Gerontol Int. 2018;18:504–5.
Benincasa D, Pellicano C, Fanciulli A, Pontieri FE. Bupropion abates dopamine agonist-mediated compulsive behaviors in Parkinson’s disease. Mov Disord. 2011;26:355–7.
Chen P, Kales HC, Weintraub D, Blow FC, Jiang L, Mellow AM. Antidepressant treatment of veterans with Parkinson’s disease and depression: Analysis of a national sample. J Geriatr Psychiatry Neurol. 2007;20:161–5.
Gebhardt S, Röttgers H, Bäcker A, Schu U, Krieg J-C. Treatment of panic disorder with bupropion in a patient with Parkinson’s disease. J Clin Pharm Ther. 2008;33:575–7.
Honkanen EA, Kemppainen N, Noponen T, Seppänen M, Joutsa J, Kaasinen V. Bupropion Causes Misdiagnosis in Brain Dopamine Transporter Imaging for Parkinsonism. Clin Neuropharmacol. 2019;42:181–3.
Kate N, Grover S, Kumar S, Modi M. Bupropion-induced hyponatremia. Gen Hosp Psychiatry. 2013;35:681.e11–2.
Kaur N, Madan R, Sharma A. Successful use of rasagiline in combination with two antidepressants: A case report. Innov Clin Neurosci. 2012;9:39–41.
Kim W, Kim H, Oh S, Kim O, Lee M. Effects of bupropion on depression of Parkinson’s disease: Open-label 12-week trial in Korea - Poster 4-021. Mov Disord. 2009:S241–1.
Kim W, Oh S, Kim H, Kim O. Bupropion on freezing of gait in Parkinson’s Disease - Poster 2.270. Parkinsonism Relat Disord. 2012:S81–159.
Kummer A, Maia DP, Salgado JV, Cardoso FEC, Teixeira AL. Dopamine dysregulation syndrome in Parkinson’s disease: case report. Arq Neuropsiquiatr. 2006;64:1019–22.
Ritter JL, Alexander B. Retrospective study of selegiline-antidepressant drug interactions and a review of the literature. Ann Clin Psychiatry. 1997;9:7–13.
Trivedi A, Srivastava T, Batra D. Comparative study of efficacy for Bupropion vs Sertraline (SSRI) in depression with Parkinson’s disease. Yokohama, Japan. XII World Congress of Psychiatry, Aug 24–9. 2002.
Vasile D, Macovei RA, Vasiliu O. Efficacy and tolerability of bupropion in major depressive disorder associated with Parkinson’s disease Poster 2.b.007. Eur Neuropsychopharmacol. 2013:S322–3.
Vegda M, Panda S. Bupropion-Induced Dystonia in a Patient with Parkinson’s Disease. J Mov Disord. 2020;13:241–3.
Agüera-Ortiz L, García-Ramos R, Grandas Pérez FJ, López-Álvarez J, Montes Rodríguez JM, Olazarán Rodríguez FJ, et al. Focus on Depression in Parkinson’s Disease: A Delphi Consensus of Experts in Psychiatry, Neurology, and Geriatrics. Parkinsons Dis. 2021;2021:1–11.
Mills KA, Greene MC, Dezube R, Goodson C, Karmarkar T, Pontone GM. Efficacy and tolerability of antidepressants in Parkinson’s disease: A systematic review and network meta-analysis. Int J Geriatr Psychiatry. 2018;33:642–51.
Paumier KL, Siderowf AD, Auinger P, Oakes D, Espay AJ, Revilla FJ, et al. Antidepressant treatment may have disease modifying-effects in early Parkinson’s disease: A patient-level meta-analysis - Poster. Mov Disord. 2010:III.
Peña E, Mata M, López-Manzanares L, Kurtis M, Eimil M, Martínez-Castrillo JC, et al. Antidepresivos en la enfermedad de Parkinson. Recomendaciones del grupo de trastornos del movimiento de la Asociación Madrileña de Neurología. Neurología. 2018;33:395–402.
Weintraub D, Morales KH, Moberg PJ, Bilker WB, Balderston C, Duda JE, et al. Antidepressant studies in Parkinson’s disease: A review and meta-analysis. Mov Disord. 2005;20:1161–9.
Mlinarić A, Horvat M, Šupak Smolčić V. Dealing with the positive publication bias: Why you should really publish your negative results. Biochem Med (Zagreb). 2017;27(3):030201.
Pluck GC, Brown RG. Apathy in Parkinson’s disease. J Neurol Neurosurg Psychiatry. 2002;73:636–42.
NICE. Parkinson’s Disease [CG35]: National clinical guideline for diagnosis and management in primary and secondary care. London: Royal College of Physicians; 2006. p. 35.
Costa R, Oliveira NG, Dinis-Oliveira RJ. Pharmacokinetic and pharmacodynamic of bupropion: integrative overview of relevant clinical and forensic aspects. Drug Metab Rev. 2019;51:293–313.
Naranjo CA, Busto U, Sellers EM, Sandor P, Ruiz I, Roberts EA, et al. A method for estimating the probability of adverse drug reactions. Clin Pharmacol Ther. 1981;30:239–45.
Kitagawa N, Takeuchi A. Memantine-induced myoclonus. Neurology. 2014;83:1387.
Huecker MR, Smiley A, Saadabadi A. Bupropion. 2021. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2022.
Robles GI, Singh-Franco D, Ghin HL. A review of the efficacy of smoking-cessation pharmacotherapies in nonwhite populations. Clin Ther. 2008;30:800–12.
Stahl SM, Pradko JF, Haight BR, Modell JG, Rockett CB, Learned-Coughlin S. A Review of the Neuropharmacology of Bupropion, a Dual Norepinephrine and Dopamine Reuptake Inhibitor. Prim Care Companion J Clin Psychiatry. 2004;06:159–66.
Kumar S, Kodela S, Detweiler JG, Kim KY, Detweiler MB. Bupropion-induced psychosis: folklore or a fact? A systematic review of the literature. Gen Hosp Psychiatry. 2011;33:612–7.
eHealth Me. Wellbutrin and Hyponatraemia - a phase IV clinical study of FDA data. 2021. http://www.ehealthme.com/ds/wellbutrin/hyponatraemia.
Atkins D, Best D, Briss P, Eccles M, Falck-Ytter Y, Flottorp S, et al. Grading quality of evidence and strength of recommendations. Br Med J. 2004;328:1490–4.
Oxford Centre for Evidence-Based Medicine. OCEBM Levels of Evidence Working Group. “The Oxford Levels of Evidence 2”. 2011. https://www.cebm.ox.ac.uk/resources/levels-of-evidence/ocebm-levels-of-evidence.
The authors acknowledge the support from the University of Milan through the APC initiative.
This research was funded by the project “Bupropion for depression in Parkinson’s disease: clinical and epigenetic correlates”- Codice Progetto U-Gov: CCE_FON16_CNBT_RAVELLI_PJ1 - by the “Aldo Ravelli” Center for Neurotechnology and Brain Therapeutic, University of Milan, Milan.
Ethics approval and consent to participate
Consent for publication
Dr. Vismara is the Principal Investigator of the study “Bupropion for depression in Parkinson’s disease: clinical and epigenetic correlates” sponsored by “Aldo Ravelli” Center for Neurotechnology and Brain Therapeutic, University of Milan, Milan.
Prof. Dell’Osso has received Grant/Research Support from LivaNova, Inc., Angelini and Lundbeck and Lecture Honoraria from Angelini, FB Health and Lundbeck.
Prof. Priori, Dr. Nicolini, Dr. Benatti, Dr. Cova, Dr. Di Fonzo, Dr. Monfrini, Dr. Fetoni, and Dr. Viganò report no financial relationships with commercial interests.
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
About this article
Cite this article
Vismara, M., Benatti, B., Nicolini, G. et al. Clinical uses of Bupropion in patients with Parkinson’s disease and comorbid depressive or neuropsychiatric symptoms: a scoping review. BMC Neurol 22, 169 (2022). https://doi.org/10.1186/s12883-022-02668-4
- Parkinson’s disease
- Neuropsychiatric symptoms
- Pharmacological treatment