Table 3 Performance of various MRI areas on screening for recent seizure in neonates with HIE
From: Restricted diffusion of the callosal splenium is highly specific for seizures in neonates
Areas | Number (%) of positive MRIs | Sensitivity | Specificity | PPV | NPV | Positive LR | Negative LR |
|---|---|---|---|---|---|---|---|
Splenium | 26 (21.1%) | 53.85% | 94.05% | 80.77% | 81.44% | 9.05 | 0.49 |
Cortex | 34 (27.6%) | 58.97% | 86.90% | 67.65% | 82.02% | 4.50 | 0.47 |
Deep gray matter | 22 (17.9%) | 41.03% | 92.86% | 72.73% | 77.23% | 5.74 | 0.64 |
Subcortical white matter | 27 (22.0%) | 43.59% | 88.10% | 62.96% | 77.08% | 3.66 | 0.64 |
Any change | 50 (40.7%) | 69.23% | 72.62% | 54.00% | 83.56% | 2.53 | 0.42 |