Skip to main content

Paradoxical contralateral hemiparesis in spontaneous spinal epidural hematoma: a case report

Abstract

Background

Hemiparesis associated with spontaneous spinal epidural hematoma (SSEH) usually occurs ipsilateral to the hematoma. We here report the case of a patient with paradoxical hemiparesis contralateral to a spinal lesion due to SSEH.

Case presentation

A 70-year-old woman was identified in routine clinical practice; she presented with acute-onset neck pain and left hemiparesis. Neurological examination showed left-sided sensory-motor hemiparesis without facial involvement. Cervical MRI showed a dorsolateral epidural hematoma compressing the spinal cord at the C2 to C3 level. Axial imaging demonstrated a crescent hematoma on the right side, which is contralateral to the hemiparesis, and lateral displacement of the spinal cord. Spinal angiography revealed no abnormal vessels. Based on clinical presentation and MRI findings, a diagnosis of SSEH was made. The patient was managed conservatively. The symptoms completely resolved without any neurological deficits, and the hematoma disappeared on the follow-up MRI.

Conclusions

Paradoxical contralateral hemiparesis is one of the possible presenting symptoms in patients with SSEH. This case demonstrates the existence of the paradoxical contralateral hemiparesis associated with spinal compressive lesions. A plausible mechanism of the phenomenon is discussed.

Peer Review reports

Background

Spontaneous spinal epidural hematoma (SSEH) typically presents with features ranging from simple neck or back pain to hemiparesis, complete paraplegia or quadriplegia, corresponding to the spinal levels and severity of cord or nerve root compression [1, 2]. Hemiparesis associated with SSEH usually occurs ipsilateral to the hematoma. Here, we report an atypical case of SSEH with motor and sensory deficits in the upper and lower limbs contralateral to the lesion.

Case presentation

A 70-year-old woman presented to the emergency department with acute-onset neck pain and left hemiparesis. These symptoms occurred at rest without any specific trigger, and moving her neck exacerbated the pain. She had no history of recent trauma. Her medications included antihypertensive prescriptions and no antithrombotic agents. Her blood pressure on presentation was 230/129 mmHg. Physical examination revealed left-sided hemiparesis (manual muscle testing scores of 3/5 in upper and lower limbs), numbness and hypoesthesia on her left side, and no facial involvement. Laboratory studies showed no remarkable findings, including coagulopathy. Brain MRI and magnetic resonance angiography were performed to rule out stroke or vertebrobasilar artery dissection. Cervical MRI revealed an epidural hematoma localized to the dorsolateral spinal cord at the C2 to C3 level. Axial fluid-attenuated inversion recovery (FLAIR) imaging demonstrated a well-defined crescent hematoma on the right side, contralateral to the hemiparesis, and lateral displacement of the spinal cord (Fig. 1A, B). Spinal angiography revealed no abnormal vessels. Based on her clinical presentation and MRI findings, we diagnosed SSEH. Because of a remarkable improvement in her upper and lower limb symptoms within three hours after the onset, she was treated conservatively with a rigid cervical collar and antihypertensive agents. Her left-sided weakness and sensory deficits improved daily. Follow-up MRI on the sixth day showed that the hematoma had decreased in size. The hematoma had completely disappeared three weeks after the onset, the patient was fully recovered, and she was discharged without any neurological deficits.

Fig. 1
figure 1

A Sagittal T2-weighted MRI shows a dorsolateral epidural hematoma compressing the spinal cord at the C2 to C3 level. B Axial FLAIR MRI shows a crescent hematoma on the right side and lateral displacement of the spinal cord. C Possible mechanism of paradoxical contralateral hemiparesis.

Discussion and conclusions

Among spinal disorders other than SSEH, hemiparesis contralateral to the spinal lesion has also been reported in cervical disc herniation [3] and lumbar synovial cysts [4]. These reports note the existence of hemiparesis contralateral to the spinal lesion.

Intracranial lesions, mostly those supratentorial and expanding, occasionally yield neurological signs not directly related to the location of the lesion. Hemiparesis ipsilateral to an intracranial lesion, referred to as false localizing signs or paradoxical hemiparesis, often led to wrong-site exploratory surgery in the pre-brain-imaging era [5]. Compelling candidate mechanisms of paradoxical hemiparesis due to intracranial lesions are (1) compression of the contralateral cerebral peduncle against the tentorial edge, referred to as Kernohan’s notch phenomenon; (2) vascular involvement of the contralateral hemisphere; or (3) impaired functional activation of the contralateral hemisphere [5].

In our case involving a spinal lesion, the mechanism of paradoxical contralateral hemiparesis may be analogous to Kernohan’s notch type injury, similar to that of a previously reported case with cervical disc herniation [3]. Pressure produced by the spinal hematoma could have been transferred across the spinal cord, and lateral displacement of the cord may have affected the contralateral corticospinal tract (descending motor pathway) and dorsal column, with direct compression of the ipsilateral spinothalamic tract (major ascending sensory pathway), causing the sensory-motor hemiparesis mimicking stroke (Fig. 1C).

We now note that contralateral hemiparesis is a possible presenting symptom in patients with SSEH. Our case suggests the rare occurrence of direct (ipsilateral) and indirect (contralateral) compression mechanism resulting in paradoxical hemiparesis, supplementing the few previous reports of similar contralateral hemiparesis associated with spinal compressive lesions.

Data Availability

The data and images used in this case report are available from the corresponding author on request.

Abbreviations

SSEH:

Spontaneous spinal epidural hematoma

MRI:

Magnetic resonance imaging

FLAIR:

Fluid-attenuated inversion recovery.

References

  1. Bakker NA, Veeger NJ, Vergeer RA, Groen RJ. Prognosis after spinal cord and cauda compression in spontaneous spinal epidural hematomas. Neurology. 2015;84:1894–903.

    Article  PubMed  Google Scholar 

  2. Raasck K, Habis AA, Aoude A, et al. Spontaneous spinal epidural hematoma management: a case series and literature review. Spinal Cord Ser Cases. 2017;2:316043. https://doi.org/10.1038/scandc.2016.43.

    Article  Google Scholar 

  3. Yeung JT, Johnson JI, Karim AS. Cervical disc herniation presenting with neck pain and contralateral symptoms: a case report. J Med Case Rep. 2012;6:166. https://doi.org/10.1186/1752-1947-6-166.

    Article  PubMed Central  Google Scholar 

  4. Lyons MK, Atkinson JL, Wharen RE, Deen HG, Zimmerman RS, Lemens SM. Surgical evaluation and management of lumbar synovial cysts: the Mayo Clinic experience. J Neurosurg. 2000;93:53–7.

    CAS  PubMed  Google Scholar 

  5. Carrasco-Moro R, Castro-Dufourny I, Martínez-San Millán JS, Cabañes-Martínez L, Pascual JM. Ipsilateral hemiparesis: the forgotten history of this paradoxical neurological sign. Neurosurg Focus. 2019;47:3.

    Article  Google Scholar 

Download references

Acknowledgements

Not applicable.

Funding

No funding was obtained for this study.

Author information

Authors and Affiliations

Authors

Contributions

All authors contributed to the study conception. Material preparation, data collection were performed by KO and RK. Imaging analysis were performed by RK and YF. The first draft of the manuscript was written by KO, and all authors commented on previous versions of the manuscript. All authors read and approved the final manuscript.

Corresponding author

Correspondence to Kazuhiro Okada.

Ethics declarations

Ethics approval and consent to participate

Approval was obtained from the ethics committee of Kaga Medical Center(#R4-1), and written informed consent was obtained from the patient.

Consent for publication

Written informed consent was obtained from the patient for publication of this case report and CARE guidelines were followed.

Competing interests

The authors declare that there are no competing interests.

Additional information

Publisher’s Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Okada, K., Fujita, Y. & Kitai, R. Paradoxical contralateral hemiparesis in spontaneous spinal epidural hematoma: a case report. BMC Neurol 23, 138 (2023). https://doi.org/10.1186/s12883-023-03179-6

Download citation

  • Received:

  • Accepted:

  • Published:

  • DOI: https://doi.org/10.1186/s12883-023-03179-6

Keywords