Table 1 Data extracted from studies
Study ID | Author name | Year | Country | Study design | Number of participants | Age of menopause | Disease duration | Disease type | Follow up time | Annual relapse rate | EDSS | NOS score | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Before | After | Before | After | |||||||||||
1 | Baroncini et al [21]. | 2019 | Italy | Retrospective Cohort | 148 | 50.3 ± 3.8 | - | - | 3.7 ± 0.6 years before and 3.5 ± 0.7 years after menopause onset | 0.21 ± 0.31 | 0.13 ± 0.24 | 2 ± 1.2 | 2.6 ± 1.4 | 7/9 |
2 | Baroncini et al [26]. | 2017 | Italy | Retrospective Cohort | 84 | 50.2 ± 3.2 | 14.6 ± 7.8 | - | 2–4 years pre and post- final menstrual period | 0.23 ± 0.28 | 0.13 ± 0.23 | - | ||
14 | Ladeira et al [22]. | 2018 | Portugal | Retrospective Cohort | 37 | 49.8 ± 4.06 | 14.0 ± 8.64 | 28 RR, 2 PP, 7 SP | At least 1 year before and after menopause | 0.37 ± 0.35 | 0.08 ± 0.18 | 2 ± 1.06 | 3.1 ± 1.93 | 7/9 |
16 | Otero-Romero [27] | 2020 | Spain | Prospective Cohort | 74 | 47.2 ± 5.6 | - | 74 CIS | Median follow-up from onset of 13.3 years (SD 4.4) and a median postmenopause observation pe-riod of 6.03 years (SD 4.7) | Median (IQR) 1.5(1-1.5) | Median (IQR) 2(1.1–2.5) | 6/9 | ||