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Fig. 1 | BMC Neurology

Fig. 1

From: Disease severity and mortality in Alzheimer's disease: an analysis using the U.S. National Alzheimer’s Coordinating Center Uniform Data Set

Fig. 1

Overall survival of participants progressing to a particular stage of AD. Shaded areas show 95% confidence intervals. Some participants contribute to several stages upon progression. Please note, any comparison across stages underestimates the uncertainty because some participants contribute to several cohorts. The curve of cognitively normal lacks a relevant clinical interpretation as the starting point is their first visit at ≥ 50 years of age. Kaplan–Meier estimators were not stratified by age or other predictors; they describe the overall survival of participants with the age distribution of our sample cohorts. Numbers at risk at 0, 5, 10, and 15 years respectively: CN: 11458, 4185, 1272, 64; MCI due to AD: 937, 249, 50, 0; mild AD dementia: 522, 139, 11, 0; moderate AD dementia: 457, 77, 2, 0; severe AD dementia: 85, 8, 0, 0. AD Alzheimer’s disease, CN cognitively normal, MCI mild cognitive impairment

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BMC Neurology

ISSN: 1471-2377

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