Disease severity and mortality in Alzheimer's disease: an analysis using the U.S. National Alzheimer’s Coordinating Center Uniform Data Set

Table 1 Number of participants per cohort, their progressions, deaths, and median Survival (95% CI)

	Time of entry into cohort		Progression from study entry^c						All observations from start of stage^d
Cohort	Study entry n^a	Progression n^b	Did not progress	MCI due to AD	Mild AD dementia	Moderate AD dementia	Severe AD dementia	Death	Total N	Deaths	Median survival (95% CI)
Cognitively normal	11,458	0	10,210	613	29	21	0	585	11,458	686	NA
MCI due to AD	324	613	761	-	53	21	0	102	937	132	12.27 (11.83–NA)
Mild AD dementia	440	82	227	-	-	228	16	51	522	167	6.32 (5.99–7.46)
Moderate AD dementia	187	270	275	-	-	-	64	118	457	162	5.21 (4.88–6.1)
Severe AD dementia	5	80	24	-	-	-	-	61	85	61	3.06 (2.68–3.84)

Data were NA because median survival was not reached during observation period
AD Alzheimer's disease, CI Confidence interval, MCI Mild cognitive impairment, NA Not available
^aUnique participants assigned at the start of the study
^bParticipants progressing from their original cohort, adding observation time to one or more additional cohorts upon progression
^cOnly the immediate progression of a participant is shown on each row
^dSome participants included in several cohorts if progressing

ISSN: 1471-2377