Variable | Sample size | n (%) | |
---|---|---|---|
Age (year), Median (IQR) | 22 | 64 (50, 74) | |
Gender, n (%) male | 18 (82%) | ||
Generalized Myasthenia Gravis | 12 (55%) | ||
mRNA-based vaccinea | 1st dose / 2nd dose / Booster | 14 | 5 (36%) / 5 (36%) / 4 (28%) |
Vector-based vaccineb | 1st dose / 2nd dose | 8 | 7 (88%) / 1 (12%) |
Presenting symptoms | Diplopia / Ptosisc / Dysarthria / Dysphagia / Extremity asthenia | 13 | 10(77%)/ 6(46%)/ 3(23%)/ 3(23%)/ 1(8%) |
Time from vaccine to symptom (days), Median (IQR) | 22 | 6 (2, 8.5) | |
Tests | |||
Imaging | Normal Brain CT scan | 5 | 5 (100%) |
Normal Brain MRI | 6 | 5 (83%) | |
Thymus hyperplasia on Chest CT scan | 8 | 2 (25%) | |
Tests in the clinic | Positive Ice pack test | 2 | 2 (100%) |
Positive IM neostigmine test | 4 | 3 (75%) | |
EMG | Positive RNS | 15 | 13 (87%) |
Positive SFEMG | 4 | 4 (100%) | |
Seropositivity | Only AChR Ab positive (MuSK not tested) | 16 | 14 (87%) |
AChR positive & MuSK negative | 4 | 2 (50%) | |
AChR negative & MuSK negative | 2 (50%) | ||
Treatment | |||
Pyr only / + Pred / + IVIG / or + PLEX | 19 | 7 (33%) / 7 (33%) / 1 (5%) / 1 (5%) | |
Pyr + Pred + IVIG / Pyr + Pred + PLEX / Pred + PLEX | 2 (10%) / 2 (10%) / 1 (5%) | ||
Clinical outcomes | |||
Partial / Complete improvement at discharge or 1-month follow-up | 14 | 7 (50%) / 4 (29%) | |
Myasthenic crisis/symptoms unchanged at 3-months follow-up | 2 (14%) / 1 (7%) |