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  1. DL-3-n-butylphthalide (NBP) was demonstrated to increase the cerebral blood flow (CBF) in the animal models, but there are no clinic studies to verify this. We aimed to explore the effect of NBP on improving c...

    Authors: Dawei Chen, Yanwei Yin, Jin Shi, Fen Yang, Kehua Wang, Faguo Zhao, Wenping Li and Bin Li
    Citation: BMC Neurology 2020 20:212
    Content type: Research article Published on:

  2. Vestibular migraine, a kind of acute vestibular syndrome, leads to both migraines and vertigo symptoms in a single patient. The occurrence of vestibular migraine has shown an obvious increase in female groups ...

    Authors: Ying Xin, Junyi Fu, Longchang Xie, Jie Yang and Guanhao Ke
    Citation: BMC Neurology 2020 20:211
    Content type: Case report Published on:

  4. Concussion is the most common type of TBI, yet reliable objective measures related to these injuries and associated recovery processes remain elusive, especially in military personnel. The purpose of this stud...

    Authors: Katie A. Edwards, Jessica M. Gill, Cassandra L. Pattinson, Chen Lai, Misha Brière, Nicholas J. Rogers, Denise Milhorn, Jonathan Elliot and Walter Carr
    Citation: BMC Neurology 2020 20:209
    Content type: Research article Published on:

  5. Cerebellar degeneration as a consequence of a malignancy is a rare condition most commonly related to the presence of anti-Yo, anti-Hu, and anti-Tr/DNER antibodies. In recent years, several reports have indica...

    Authors: Philipp A. Loehrer, Lars Timmermann, Anika Pehl, Corinna I. Bien, Andreas Pfestroff and David J. Pedrosa
    Citation: BMC Neurology 2020 20:208
    Content type: Case report Published on:

  6. Homozygous frameshift mutation in RUBCN (KIAA0226), known to result in endolysosomal machinery defects, has previously been reported in a single Saudi family with autosomal recessive spinocerebellar ataxia (Sa...

    Authors: Mohammed Z. Seidahmed, Muddathir H. Hamad, Albandary AlBakheet, Salah A. Elmalik, Abdulmajeed AlDrees, Jumanah Al-Sufayan, Ibrahim Alorainy, Ibrahim M. Ghozzi, Dilek Colak, Mustafa A. Salih and Namik Kaya
    Citation: BMC Neurology 2020 20:207
    Content type: Case report Published on:

  7. Stroke burden in young adults is growing associated with unique risk factors and devastating outcomes. We aimed to investigate the magnitude, risk factors and outcomes of first ever stroke in young adults ≤45 ...

    Authors: Sarah Shali Matuja, Patricia Munseri and Khuzeima Khanbhai
    Citation: BMC Neurology 2020 20:206
    Content type: Research article Published on:

  8. Multiple sclerosis (MS) causes significant economic burden to the patients, families, health systems and society. This study aimed to estimate the annual economic costs incurred by patients with multiple scler...

    Authors: Ali Imani, Farid Gharibi, Ali Khezri, Nasrin Joudyian and Koustuv Dalal
    Citation: BMC Neurology 2020 20:205
    Content type: Research article Published on:

  9. Cognitive dysfunction affects up to 70% of people with progressive MS (PMS). It can exert a deleterious effect on activities of daily living, employment and relationships. Preliminary evidence suggests that pe...

    Authors: Anthony Feinstein, Maria Pia Amato, Giampaolo Brichetto, Jeremy Chataway, Nancy Chiaravalloti, Ulrik Dalgas, John DeLuca, Peter Feys, Massimo Filippi, Jennifer Freeman, Cecilia Meza, Matilde Inglese, Robert W. Motl, Maria Assunta Rocca, Brian M. Sandroff, Amber Salter…
    Citation: BMC Neurology 2020 20:204
    Content type: Study protocol Published on:

  10. To our knowledge, the exposed nerve roots in thoracic spine are usually sacrificed to facilitate osteotomy during posterior vertebral column resection (PVCR) for severe spinal deformity. Currently we report a ...

    Authors: Shujie Wang, Zhifu Ren, Zhen Yang and Jianguo Zhang
    Citation: BMC Neurology 2020 20:203
    Content type: Case report Published on:

  11. A high multiple sclerosis activity while on alemtuzumab is rather uncommon compared to moderate-efficacy drugs. The purpose of this case report is to present a case of a 37-year-old female patient with bronchi...

    Authors: Martin Vališ, Pavel Ryška, Simona Halúsková, Blanka Klímová and Zbyšek Pavelek
    Citation: BMC Neurology 2020 20:202
    Content type: Case report Published on:

  12. Stress cardiomyopathy (Takotsubo cardiomyopathy) is very rare in the central nervous system (CNS) demyelinating disorders. Although this dysfunction of the heart-brain axis has been reported in several case se...

    Authors: Sungsik An, Hyeo-il Ma, Jooyeon Song, Hong-Mi Choi and Young Eun Kim
    Citation: BMC Neurology 2020 20:201
    Content type: Case report Published on:

  14. Direct evidence of intimal flaps, double lumen and intramural haematomas (IMH) is difficult to detect on conventional angiography in most intracranial vertebrobasilar dissecting aneurysms (VBDAs). Our purpose ...

    Authors: Xianjin Zhu, Hancheng Qiu, Ferdinand K. Hui, Yiqun Zhang, Yun-e Liu, Fengyuan Man and Wei-Jian Jiang
    Citation: BMC Neurology 2020 20:199
    Content type: Research article Published on:

  15. We investigated the clinical course of patients with prolonged disorders of consciousness (PDoC), predictors of emergence from PDoC (EDoC), and the temporal dynamics of six neurobehavior domains based on the J...

    Authors: Hoo Young Lee, Jung Hyun Park, Ae Ryoung Kim, Misun Park and Tae-Woo Kim
    Citation: BMC Neurology 2020 20:198
    Content type: Research article Published on:

  16. Acute ischemic stroke attack with and without a recent TIA may differ in clinical risk factors, and this may affect treatment outcomes following thrombolytic therapy. We examined whether the odds of exclusion ...

    Authors: Nicolas Poupore, Dan Strat, Tristan Mackey, Ashley Snell and Thomas Nathaniel
    Citation: BMC Neurology 2020 20:197
    Content type: Research article Published on:

  17. Pathogenic variants in the FKRP gene cause impaired glycosylation of α-dystroglycan in muscle, producing a limb-girdle muscular dystrophy with cardiomyopathy. Despite advances in understanding the pathophysiol...

    Authors: Doris G. Leung, Alex E. Bocchieri, Shivani Ahlawat, Michael A. Jacobs, Vishwa S. Parekh, Vladimir Braverman, Katherine Summerton, Jennifer Mansour, Genila Bibat, Carl Morris, Shannon Marraffino and Kathryn R. Wagner
    Citation: BMC Neurology 2020 20:196
    Content type: Research article Published on:

  18. The prevalence of Multiple Sclerosis (MS) has been increasing worldwide and the north–south gradient of prevalence may be disappearing in the Northern hemisphere. The few previous prevalence studies performed ...

    Authors: Mariana Branco, Ivânia Alves, Ana Martins da Silva, Joaquim Pinheiro, Maria José Sá, Inês Correia, Lívia Sousa, Eva Brandão, Carlos Veira, Bernardo Gomes and Luis Ruano
    Citation: BMC Neurology 2020 20:195
    Content type: Research article Published on:

  19. Injection-site reactions have been reported with biologicals. In this post hoc analysis of Phase 3 studies in participants with migraine, we provide a comprehensive overview and detailed summary of injection-s...

    Authors: Virginia L. Stauffer, Shufang Wang, Jo Bonner, ByungKun Kim, Rohit Bhandari, Kathleen A. Day and Angelo Camporeale
    Citation: BMC Neurology 2020 20:194
    Content type: Research article Published on:

  20. Cognitive impairment is common in patients with multiple sclerosis (MS). Accurate and repeatable measures of cognition have the potential to be used as markers of disease activity.

    Authors: Seyed-Mahdi Khaligh-Razavi, Maryam Sadeghi, Mahdiyeh Khanbagi, Chris Kalafatis and Seyed Massood Nabavi
    Citation: BMC Neurology 2020 20:193
    Content type: Research article Published on:

  23. To explore the underlying mechanisms leading to the occurrence of hyponatremia and enhanced urinary sodium excretion in brain trauma patients using sodium balance and urinary biochemical analysis.

    Authors: Alexandre Lannou, Cedric Carrie, Sebastien Rubin, Gregoire Cane, Vincent Cottenceau, Laurent Petit and Matthieu Biais
    Citation: BMC Neurology 2020 20:190
    Content type: Research article Published on:

  24. Endovascular therapy (EVT) is increasingly used to improve cerebral reperfusion after moderate-to-severe acute ischemic stroke (AIS). However, the influence of hemodynamic factors on clinical outcome is still ...

    Authors: Ge Tian, Zhong Ji, Kaibin Huang, Zhenzhou Lin, Suyue Pan and Yongming Wu
    Citation: BMC Neurology 2020 20:189
    Content type: Research article Published on:

  27. Parkinson’s disease is one of the most frequent causes of disability among the older adults. It is a chronic-progressive neuro-degenerative disease, characterized by several motor disorders. Balance disorders ...

    Authors: Roberta Bevilacqua, Elvira Maranesi, Mirko Di Rosa, Riccardo Luzi, Elisa Casoni, Nadia Rinaldi, Renato Baldoni, Fabrizia Lattanzio, Valentina Di Donna, Giuseppe Pelliccioni and Giovanni Renato Riccardi
    Citation: BMC Neurology 2020 20:186
    Content type: Study protocol Published on:

  28. To explore the feasibility of the metrics of diffusion kurtosis imaging (DKI) for investigations of the microstructural changes of spinal cord injury in patients with degenerative cervical myelopathy (DCM) and...

    Authors: Zhuohang Liu, Bingyang Bian, Gang Wang, Cheukying Tian, Zhenshan Lv, Zhiqing Shao and Dan Li
    Citation: BMC Neurology 2020 20:185
    Content type: Research article Published on:

  29. In individuals with neuromuscular diseases (NMD), symptoms of muscle weakness, fatigue and pain may limit physical activity. Inactivity leads to reduced physical fitness, which further complicates daily life f...

    Authors: Sander Oorschot, Merel A. Brehm, Annerieke C. van Groenestijn, Fieke S. Koopman, Camiel Verhamme, Filip Eftimov, Judith G. M. Jelsma, Harald T. Jorstad, Frans Nollet and Eric L. Voorn
    Citation: BMC Neurology 2020 20:184
    Content type: Study protocol Published on:

  30. Pisa syndrome (PS) is characterized by an abnormally sustained posture, with flexion of the body and head to one side and slight rotation of the trunk. Although PS most commonly arises as an adverse effect of ...

    Authors: Yu Mimura, Shin Kurose, Taketo Takata, Hajime Tabuchi, Masaru Mimura and Michitaka Funayama
    Citation: BMC Neurology 2020 20:183
    Content type: Case report Published on:

  31. To describe the clinical phenotype of paroxysmal extreme pain disorder, an autosomal dominant condition in four members in one family with the mutation NM_002977.3:c.3892G > T (p.Val1298Phe) in the SCN9A gene. Cl...

    Authors: Adam Stępień, Daria Sałacińska, Jacek Staszewski, Marta Durka-Kęsy and Jan Dobrogowski
    Citation: BMC Neurology 2020 20:182
    Content type: Case report Published on:

  32. Recovery patterns of motor function and activity capacity of the upper extremity after stroke have been described, but less is known about longitudinal changes of perceived manual activity performance. The aim...

    Authors: Elisabeth Ekstrand, Katharina S. Sunnerhagen, Hanna C. Persson, Åsa Lundgren-Nilsson and Margit Alt Murphy
    Citation: BMC Neurology 2020 20:181
    Content type: Research article Published on:

  33. The etiologic determinants of cryptogenic stroke remain a diagnostic challenge in clinical practice. Fabry disease (FD) is one of the monogenic causes of stroke that may remain unrecognized as a potential cont...

    Authors: Shuai Jiang, Lei Wang, Yuying Yan, Qiange Zhu, Jincheng Wan, Jiayu Sun and Bo Wu
    Citation: BMC Neurology 2020 20:180
    Content type: Case report Published on:

  34. Diverse mechanisms including infections, autoimmune inflammatory reactions, neoplasms, and degeneration are involved in the central nervous system in cases of acquired immune deficiency syndrome. In such cases...

    Authors: Mayu Ishiguro, Yuji Ueno, Yuta Ishiguro, Masashi Takanashi, Kenji Murai, Guillaume Taieb, Kensuke Daida, Akimitsu Suda, Kazumasa Yokoyama, Toshio Naito and Nobutaka Hattori
    Citation: BMC Neurology 2020 20:179
    Content type: Case report Published on:

  35. Glioblastoma multiforme (GBM) is one of the most aggressive malignant brain tumors. Intracranial GBM metastases to the spine are rarely detected clinically. Secondary gliosarcomas after treatment of primary GB...

    Authors: Bing-Hung Hsu, Wei-Hwa Lee, Shun-Tai Yang, Cheng-Ta Han and Yuan-Yun Tseng
    Citation: BMC Neurology 2020 20:178
    Content type: Case report Published on:

  36. Neurodegeneration, rather than inflammation, plays a key role in the progressive phase of multiple sclerosis (MS). Current disease modifying treatment options for people with progressive MS (PMS) do not specif...

    Authors: A. S. Gravesteijn, H. Beckerman, B. A. de Jong, H. E. Hulst and V. de Groot
    Citation: BMC Neurology 2020 20:177
    Content type: Study protocol Published on:

  37. Narcolepsy is a rare chronic sleep disorder that typically begins in youth. Excessive daytime sleepiness is the main disabling symptom, but the disease is often associated with severe endocrine-metabolic and p...

    Authors: Francesca Ingravallo, Luca Vignatelli, Uberto Pagotto, Stefano Vandi, Monica Moresco, Anastasia Mangiaruga, Claudia Oriolo, Corrado Zenesini, Fabio Pizza and Giuseppe Plazzi
    Citation: BMC Neurology 2020 20:176
    Content type: Study protocol Published on:

  38. We propose two new concepts, the Filum Disease (FD) and the Neuro-cranio-vertebral syndrome (NCVS), that group together conditions thus far considered idiopathic, such as Arnold-Chiari Syndrome Type I (ACSI), ...

    Authors: Miguel B. Royo-Salvador, Marco V. Fiallos-Rivera, Horia C. Salca and Gabriel Ollé-Fortuny
    Citation: BMC Neurology 2020 20:175
    Content type: Research article Published on:

  39. Cognitive impairment (CI) with mixed vascular and neurodegenerative pathologies after stroke is common. The role of amyloid pathology in post-stroke CI is unclear. We hypothesize that amyloid deposition, measu...

    Authors: Guri Hagberg, Hege Ihle-Hansen, Brynjar Fure, Bente Thommessen, Håkon Ihle-Hansen, Anne Rita Øksengård, Mona K. Beyer, Torgeir B. Wyller, Ebba Gløersen Müller, Sarah T. Pendlebury and Per Selnes
    Citation: BMC Neurology 2020 20:174
    Content type: Research article Published on:

  40. Multiple sclerosis (MS) is a chronic immune mediated disease and the progressive phase appears to have significant neurodegenerative mechanisms. The classification of the course of progressive MS (PMS) has bee...

    Authors: Ethel Ciampi, Reinaldo Uribe-San-Martin, Claudia Cárcamo, Juan Pablo Cruz, Ana Reyes, Diego Reyes, Carmen Pinto, Macarena Vásquez, Rafael A. Burgos and Juan Hancke
    Citation: BMC Neurology 2020 20:173
    Content type: Research article Published on:

  42. Perinatal asphyxia, more appropriately known as hypoxic-ischemic encephalopathy (HIE), is a condition characterized by clinical and laboratory evidence of acute or sub-acute brain injury resulting from systemi...

    Authors: Beatrice Ezenwa, Chinyere Ezeaka, Iretiola Fajolu, Anne Ogbenna, Omodele Olowoyeye, Obiyo Nwaiwu, Zainab Opoola and Gbenga Olorunfemi
    Citation: BMC Neurology 2020 20:171
    Content type: Study protocol Published on:

  44. The epidemiological characteristics of multiple sclerosis (MS) have been investigated in various studies, which have revealed that the prevalence of MS varies across countries. The present study was conducted ...

    Authors: Amir Almasi-Hashiani, Mohammad Ali Sahraian and Sharareh Eskandarieh
    Citation: BMC Neurology 2020 20:169
    Content type: Research article Published on:

  45. Insufficient amounts of physical activity is a risk factor for (recurrent) stroke. People with a stroke or transient ischemic attack (TIA) have a high risk of recurrent stroke and have lower levels of physical...

    Authors: Wendy Hendrickx, Lara Vlietstra, Karin Valkenet, Roderick Wondergem, Cindy Veenhof, Coralie English and Martijn Frits Pisters
    Citation: BMC Neurology 2020 20:168
    Content type: Research article Published on:

  46. Stroke-like episodes (SLEs) in mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes (MELAS) with m.3243A > G mutation usually develop in the cerebral cortex. Few reports have docum...

    Authors: Munenori Oyama, Takahiro Iizuka, Jin Nakahara and Yoshikane Izawa
    Citation: BMC Neurology 2020 20:167
    Content type: Case report Published on:

  48. Short-chain enoyl-CoA hydratase (ECHS1) is a multifunctional mitochondrial matrix enzyme involved in the second step of mitochondrial fatty acid β-oxidation. Mitochondrial diseases resulting from ECHS1 mutations ...

    Authors: Miaojuan Wu, Wenqi Gao, Zhifang Deng, Zhisheng Liu, Jiehui Ma, Han Xiao, Yu Xu and Dan Sun
    Citation: BMC Neurology 2020 20:165
    Content type: Case report Published on:

  49. Lithium is primarily used to treat bipolar disorder and is known to cause several acute neurological complications. Reversible splenial lesions (RSLs) may be evident in antiepileptic drug toxicity or withdrawa...

    Authors: Han Uk Ryu, Ji Yeon Chung, Byoung-Soo Shin and Hyun Goo Kang
    Citation: BMC Neurology 2020 20:164
    Content type: Case report Published on:

  50. Research is needed to examine differences in multiple sclerosis (MS) prevalence by race-ethnicity. The goal of this study was to quantify MS prevalence in a health care system in Northern California and examin...

    Authors: Robert J. Romanelli, Qiwen Huang, Joseph Lacy, Lobat Hashemi, Alana Wong and Alden Smith
    Citation: BMC Neurology 2020 20:163
    Content type: Research article Published on:
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