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An open-label, multicenter study to evaluate the safe and effective use of the single-use autoinjector with an Avonex® prefilled syringe in multiple sclerosis subjects
© Phillips et al; licensee BioMed Central Ltd. 2011
Received: 26 July 2011
Accepted: 14 October 2011
Published: 14 October 2011
The ability to self-inject in patients with multiple sclerosis (MS) has been associated with a reduced risk of missed injections and drug discontinuation, and a beneficial effect on patients' independence. However, injection anxiety, needle phobia and disease-related disability are major barriers to a patient's ability to self-administer treatment. Use of an autoinjector may improve patients' ability to self-inject. This study evaluated the safe and effective use of Avonex Pen™ (prefilled pen), a single use autoinjector, for intramuscular delivery of interferon beta-1a (IM IFNβ-1a, Avonex) in MS patients.
This was a Phase IIIb, open-label, single-country, multicenter trial in MS patients currently using IM IFNβ-1a prefilled syringes. Patients received weekly 30 mcg IM IFNβ-1a treatment over 4 weeks. On Day 1, patients self-administered IM IFNβ-1a using a prefilled syringe at the clinic. On Day 8, patients received training on the prefilled pen and self-administered IM IFNβ-1a using the device. On Day 15, patients self-administered IM IFNβ-1a at home using the prefilled pen. A final injection occurred at the clinic on Day 22 when patients self-administered IM IFNβ-1a using the prefilled pen while clinic staff observed and completed a detailed questionnaire documenting patients' ability to self-inject with the device. Serum neopterin levels were evaluated pre and post-injection on Days 1 and 8. Adverse events were monitored throughout.
Seventy-one (96%) patients completed the study. The overall success rate in safely and effectively using the prefilled pen was 89%. No device malfunctions occurred. One unsuccessful administration occurred at Day 22 due to patient error; no patient injury resulted. Patients gave the prefilled pen high ratings (8.7-9.3) on a 10-point scale for ease of use (0 = extremely difficult, 10 = extremely easy). Ninety-four percent of patients preferred the prefilled pen over the prefilled syringe. Induction of serum neopterin levels, serving as a biomarker for type 1 interferon action, was similar to that of the prefilled syringe. The prefilled pen demonstrated a safety profile comparable to the prefilled syringe.
The prefilled pen is a safe and effective device for administration of IM IFNβ-1a and represents an alternative method for self-injection for MS patients using this therapy.
This study is registered at clinicaltrials.gov, identifier: NCT00828204
Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system that can lead to extensive neurodegeneration and subsequent irreversible disability. Symptoms of MS affect motor, sensory, visual, and autonomic systems but are not limited to these areas alone . While there is no cure for MS, treatment with disease modifying therapies (DMTs) can reduce the frequency of relapses and disability associated with the disease [2–5].
For patients prescribed injectable DMTs, self-administration has been associated with a reduced risk of missed injections and drug discontinuation, and a beneficial effect on patients' sense of independence [6–8]. However, patients with MS face a variety of challenges that limit their ability to self-administer treatment . Injection anxiety, including anticipation of pain, fear of hitting bone, inability to complete the injection effectively and fear of needle breakage, is an important barrier to self-injection . Needle phobia, a component of injection anxiety, occurs in approximately 50% of patients with MS and therefore presents a significant concern for patients using injectable therapies . Furthermore, as MS is a disease that affects the CNS, additional challenges to self-injection develop as the disease progresses and disability accumulates. Impairment of fine motor skills and decreased coordination present obstacles to the independent use of self-injected MS therapies .
The clinical importance of enabling self-injection is supported by various studies that have shown that the injection process can be made easier for patients through the use of automated injectors [13–16]. Autoinjectors have been shown to improve treatment adherence, reduce injection related adverse events (AEs) such as pain, and decrease injection anxiety [17–19]. Given these clinical benefits and recognizing the frequency at which barriers to self-injection are encountered by MS patients, including those using intramuscular interferon beta-1a (IM IFNβ-1a, Avonex) [11, 20], it is evident that a mechanism to facilitate a patient's ability to self-inject IM IFNβ-1a is needed.
The Avonex Pen™ (prefilled pen) is a single use autoinjector containing the commercially available Avonex® Prefilled Syringe for once-weekly intramuscular (IM) injection. The prefilled pen has been developed as the first IM autoinjector available for long-term treatment with IM IFNβ-1a. Features of the prefilled pen have been specifically designed to overcome the barriers to self-injection and facilitate the technical aspects of the injection process. These features include a protective sheath that conceals the needle within the device prior to injection, automated needle insertion and medication dispensing, a diameter and length designed to stabilize the device during the injection process, a safety mechanism which prevents accidental injection, and a visual indicator to confirm the full dose has been administered.
The prefilled pen has the potential to improve injection methods and simplify the self-injection process, thereby addressing an unmet need in patients using IM IFNβ-1a. This study was conducted to evaluate the safe and effective use of the prefilled pen for IM delivery of IFNβ-1a in patients with MS.
This was a Phase IIIb, open-label, single-arm, multicenter study to evaluate the safe and effective use of the prefilled pen. A total of 17 sites in the United States participated. Investigators at each site obtained institutional review board (IRB) approval for the study protocol. This study was performed in accordance with all international, federal and local regulations, and written informed consent was obtained from each patient prior to eligibility evaluations. Study duration was 6 weeks, including a 14-day screening period and a 4 week IM IFNβ-1a treatment period. There were a total of 9 scheduled clinic visits per patient.
Study participants were 18 to 65 years of age. Eligibility criteria required patients to have been self-administering the prefilled syringes to treat MS for the 12 weeks prior to the screening visit. Key exclusion criteria included concomitant treatment with prescribed immunomodulators or immunosuppressants, and unwillingness or inability to comply with the requirements of the protocol, including the presence of any condition (physical, mental, or social) that was likely to affect a patient's ability to return for follow up visits on schedule.
For the manual injection with the prefilled syringe (Injection 1), patients used their own supply of IM IFNβ-1a prefilled syringes. The needle size used for Injection 1 was not recorded for each patient since the needle size used for manual injection of the prefilled syringe can vary between patients. A 23 G × 1.25 inch (32 mm) needle is included in the commercially available IM IFNβ-1a prefilled syringe package, however a different needle size (25 G × 1 inch) is also approved for use with the IM IFNβ-1a prefilled syringe. The decision of which needle a patient should use is based on the needs of the patient and left to the discretion of the prescribing physician, per IM IFNβ-1a prescribing information.
All patients received 30 mcg doses of IM IFNβ-1a once weekly over 4 weeks. Patients who were taking prophylactic therapy for flu-like symptoms at the start of the study continued the same medication and dose until their participation in the study was completed. If MS relapses occurred during the study, these were treated at the Investigator's discretion following standard medical practice, as long as treatment did not involve any of the protocol excluded concomitant medications. Treatment for spasticity, fatigue, or other MS associated symptoms was not restricted.
Patients who met the eligibility criteria during the 14-day screening period entered into a 4-week IM IFNβ-1a treatment period. Injection 1 took place on Day 1 and was administered at the study clinic by the patient using a prefilled syringe from their own supply of IM IFNβ-1a prefilled syringes and needles as prescribed by their physician.
Injection 2 occurred on Day 8 and was administered at the study clinic by the patient using the prefilled pen following training provided by the clinic site Trainer/Observer. During this injection, the Trainer/Observer observed patient use of the prefilled pen and reinforced training as needed. Injection 3 occurred on Day 15 and was self-administered by the patient at home using the prefilled pen. The final injection, Injection 4, occurred on Day 22 and was administered at the study clinic by the patient using the prefilled pen. At this clinic visit the Trainer/Observer observed patient use of the prefilled pen and completed a detailed questionnaire documenting patients' ability to self-inject with the device. The Trainer/Observer completed the observation in a hands off manner; no assistance or correction was provided to the patient during this final injection. In total, patients were to receive one injection with the prefilled syringe and three injections with the prefilled pen.
Treatment period and evaluation schedule
Injection using the prefilled syringe
Injections using the prefilled
Treatment and evaluations
Injection using the prefilled syringe
Neopterin serum sample collection
Prefilled pen training
Injection using the prefilled pen
Patient assessment of the prefilled pen training materials
Patient assessment of injection site pain
Patient assessment of ease of use
Patient assessment of injection procedure
Clinician assessment of injection site
Patient assessment and dosing information forms dispensed
Concomitant therapy and adverse events
Monitor and record throughout study
The primary assessment of the safe and effective use of the prefilled pen was to evaluate the overall success rate as measured by the proportion of patients who successfully used the device. Data for determining the overall success rate were generated from an observation form that was completed by the Trainer/Observer during the final injection (Day 22). The observation form was composed of a series of questions organized around the three key steps of the injection process: device setup, self-administration of injection, and capping and disposal of the device. All actions captured in the observation form that would define the patient's handling of the prefilled pen as a failure were pre-defined in the protocol. Failure was further categorized as "failure patient induced" or "failure-possible device malfunction." Overall success was defined as no failures occurring during the patient's use of the device.
Additional endpoints in this study included patient assessments, clinician assessments, a pharmacodynamic evaluation, and safety monitoring.
Patient Preference Assessment
A preference questionnaire was administered to the patients on the last clinic visit (either Day 23 or the final visit if patient was withdrawing early from the study). The questionnaire investigated whether patients preferred the prefilled pen or the prefilled syringe, and scored patient preference for specific features of the prefilled pen compared to the prefilled syringe using a grading scale ranging from 0 (defined on the form as "much worse") to 10 (defined on the form as "much better"); definitions for integers 2-9 on the scale were not specified.
Patient Assessment of Injection Procedure
The injection procedure was assessed by each patient in order to evaluate whether patients experienced any difficulty with the processes of preparing, injecting, removing, and disposing after each of the 4 injections (Days 1, 8, 15, 22).
Patient Assessment of Injection Site Pain
Injection site pain was evaluated pre and post injection by patients for each of the 4 injections (Days 1, 8, 15, 22). Pain was evaluated on a scale from 0 (no pain) to 10 (extremely painful).
Patient Assessment of Ease of Use
Patients evaluated the "ease of use" for each of the 4 injections performed (Days 1, 8, 15, 22) by using the Ease-of-Use Grading Scale to indicate how easy it was for the patient to perform the injection. The scale ranged from 0 (extremely difficult) to 10 (extremely easy).
Patient Assessment of Training Materials
For each use of the prefilled pen (Days 8, 15, 22), patients evaluated how easy or difficult it was to read and understand the training materials.
Clinician Injection Site Assessment
Clinicians at the study site assessed injection sites 1 hour before injection and 24 hours following injection for each administration that took place at the clinic (Days 1, 8, 22). The injection site was examined for erythema, induration, temperature, and tenderness.
In order to evaluate levels of neopterin, a well-established biological marker of pharmacodynamic response to activation of the Type 1 interferon receptor, blood samples were collected from patients one hour prior to injection and 24 and 48 hours following injection for Injection 1 (Day 1, prefilled syringe) and Injection 2 (Day 8, prefilled pen).
Adverse events were monitored throughout the study.
A 10% dropout rate was assumed for this study. A sample size of 70 patients was required to provide a 95% confidence interval of the success rate [82.6%, 97.4%] based on the assumption that 90% of patients would successfully use the prefilled pen. The population used to evaluate the primary outcome consisted of those patients who received Injection 1 with the prefilled syringe, received at least one injection with the prefilled pen, and had a completed observation form.
Summary and descriptive statistics were used in this study. No formal statistical testing was preplanned in the protocol.
Of the 74 enrolled patients, 64 (86%) were female. Mean patient age was 49.6 years (range: 22 to 65 years). The mean body mass index (BMI) of the study population was 28.92 kg/m2 (range: 17.9 to 42.2 kg/m2).
Patient Exposure to Study Treatment
Of 74 enrolled patients, 71 patients (96%) completed the study. All 74 enrolled patients received a self-injection using the prefilled syringe. Two patients discontinued from the study following the injection with the prefilled syringe prior to receiving an injection with the prefilled pen (one patient was withdrawn after missing two clinic visits and the other patient was withdrawn due to a MS relapse). Seventy two patients received at least one self- injection with the prefilled pen and 71 patients completed all three injections with the device. One patient completed the final injection but did not have a completed observation form. As a result, the observation form was only completed for 70 patients. In total, 215 injections were administered with the prefilled pen.
Overall Success Rate
Patient success at each self-administration step using the prefilled pen (analysis population, n = 70)
Steps in self-administration using the prefilled pen
Patients who completed step correctly and in an optional manner, n(%)
Holds device in an upright position and removes tamper-evident cap
Holds device in an upright position and attaches needle
Extends injector shield all the way, while pointing device away from body
Places and holds prefilled pen perpendicularly to anterior lateral thigh (injection site)
Applies firm downward pressure on the body of the prefilled pen and releases the safety lock and fires device by depressing blue activation button
Holds device for a count of 10 seconds before removing needle from thigh
Lifts device straight out, perpendicular to thigh
Visually confirms delivery via circular display window
Capping and disposal
Caps the device with blue cover
Does not hold blue cover in place while capping prefilled pen
Patient Preference Assessment
Patient Assessment of Injection Site Pain
Following injection with the prefilled syringe, the mean pain score was low, 1.7 (out of 10). The mean pain score for each of the 3 injections with the prefilled pen was also low: 1.0, 1.3, and 0.7 for injections on Days 8, 15, and 22, respectively.
Patient Assessment of Injection Procedure
Eighty-nine percent of patients reported having no difficulty with administration using the prefilled syringe. For each of the injections using the prefilled pen, 90% of patients reported having no difficulty.
Patient Assessment of Ease of Use
The mean ease of use score for the injection administered with the prefilled syringe was 8.1 (out of 10). For each administration with the prefilled pen, the mean ease of use score was as follows: 8.9 on Day 8, 8.7 on Day 15, and 9.3 for the final injection with the prefilled pen.
Patient Assessment of Training Materials
Patients referred to the written instructions and DVD less with each subsequent injection using the prefilled pen. Of the patients who used the written instructions and DVD, the majority rated them as "very effective" in educating on how to use the prefilled pen (90%-93% for written instructions; 88%-90% for DVD instructions).
Clinician Injection Site Assessment
Clinical injection site assessments made before and after injection were similar between the prefilled syringe and the prefilled pen. For the majority of patients, the clinician found no presence of induration, no temperature variation, and no tenderness at the site following injection with the prefilled syringe or the prefilled pen. Mild erythema was reported in 26% of patients after using the prefilled syringe and in 25% and 23% of patients on Days 8 and 22 after using the prefilled pen. Mild induration and mild tenderness were reported in less than 8% of patients following injections with both the prefilled syringe and the prefilled pen. There were no severe reports of erythema, induration, tenderness and temperature following any injection.
Similar increases in mean neopterin serum levels were observed over time following administration with the prefilled pen (6.2 ng/ml before injection, 12.6 ng/mL 24 hours after injection, and 13.7 ng/mL 48 hours after injection) as were seen with the injection using the prefilled syringe (5.6 ng/mL before injection, 10.0 ng/mL 24 hours after injection, and 11.0 ng/mL 48 hours after injection). The mean neopterin induction ratios were similar for injection with the prefilled syringe and the prefilled pen (2.149 and 2.514, respectively).
Safety - Adverse Events
The most common (≥3%) treatment-emergent prefilled pen injection site-related adverse events
Number of patients who received at least 1 injection with prefilled pen
Injection site-related adverse event
Injection site pain
Injection site hematoma
Injection site erythema
Injection site hemorrhage
Injection site induration
This open-label study evaluated the safe and effective use of the prefilled pen in patients currently self-administering IM IFNβ-1a via the prefilled syringe. These patients represent the population expected to use the prefilled pen and as such, were believed to be well suited to evaluate the prefilled pen.
Safe and effective use of the prefilled pen was assessed from data captured in the observation form completed by the Trainer/Observer. The comprehensive list of questions in the observation form was developed to provide an overall evaluation of the patients' ability to properly self-inject with the device during the final injection using the prefilled pen. There were no device malfunctions and the overall success rate of the prefilled pen was high (89%), demonstrating that it provides a safe and effective alternative method of administering IM IFNβ-1a. Patients also gave high ratings to the related training materials and injection procedure.
The prefilled pen was specifically designed to overcome multiple challenges of self-injection faced by patients with MS. Features designed to reduce injection anxiety include a protective shield that conceals the needle and automated needle insertion and medication dispensing, which reduces the number of steps involved in the dosing process. Safety features include a mechanism to prevent early injection as well as a visual indicator that allows for confirmation of injection process completion. The diameter and length dimensions are designed to help stabilize the device during the injection process so as to improve ease of use for patients with impaired motor coordination. In this study, 94% of patients preferred the prefilled pen over the prefilled syringe. Reasons for patient preference for the prefilled pen were related to ease of holding and gripping, ease of injection, level of pain, and needle anxiety, confirming that the design of the prefilled pen was successful in making the injection process easier. In addition, although the study was not originally designed to compare the prefilled syringe to the prefilled pen, a post hoc paired t test was performed to compare the ease of use assessment at Injection 1 (Day 1, with the prefilled syringe) with Injection 4 (Day 22, with the prefilled pen). Results demonstrated that patients found the prefilled pen statistically significantly easier to use after 3 injections compared to the prefilled syringe after at least 12 uses, as required by study entry criteria (mean ease of use scores 8.1 and 9.3, respectively).
Automated injection devices offer a means to potentially reduce injection site pain. In this study, patient assessment of pain was low for the injection with the prefilled syringe (1.7 out of 10), and numerically lower for each of the three injections with the prefilled pen. A post hoc comparison of the pain assessment at Injection 1 (Day 1, with the prefilled syringe) and Injection 4 (Day 22, with the prefilled pen) was performed by paired t test and showed that patients experienced statistically significantly less pain with the prefilled pen by the third use than with the prefilled syringe after at least 12 uses, as required by study entry criteria (mean pain scores 1.7 and 0.7, respectively). The incidence of pain through safety monitoring was also low for both methods of administration. Seven percent of patients reported an AE of pain related to use of the prefilled pen and none of the reports were severe. In addition to pain assessments, the injection site was assessed at multiple time points during the study by the clinician. Mild erythema was observed at a similar frequency following injection with the prefilled syringe and injection with the prefilled pen. The incidence of other injection site reactions such as temperature, induration, and tenderness were infrequent, and rates were similar for the two injection methods.
Importantly, there were no new safety concerns raised in this study. The safety profile observed with the prefilled pen was similar to the known safety profile of IM IFNβ-1a from the prescribing information and post marketing data.
Although IM injections are frequently administered via a manual syringe with a longer needle, the 25 G × 5/8 inch (16 mm) needle was determined to be the appropriate size for use with the prefilled pen. Earlier development of the prefilled pen using a 23 G × 1.25 inch (30 mm) needle indicated that this length was not appropriate for use with the device due to needle bends, which did not occur in this study with use of the shorter needle. The ability of the needle used in this study to deliver an IM injection is supported by published reports indicating that a 5/8 inch needle (16 mm) can be expected to access the IM space in the majority of patients when applied with a manual syringe [21–23]. Considering the compressive effects related to the forceful application of the prefilled pen to the cutaneous tissue, the shorter needle is likely appropriate for general use [22, 24].
As discussed earlier, reduction in needle anxiety and injection pain were amongst the subjective benefits specifically sought in the design of the prefilled pen. We note that the shorter needle length of the prefilled pen may, in addition to its other features, contribute to the observed patient preferences for this device over the prefilled syringe. Our observation that neopterin induction was similar following injection with the prefilled syringe and with the prefilled pen further supports that the 25 G × 5/8 inch (16 mm) needle is the appropriate size to effectively deliver the full dose of IM IFNβ-1a with the prefilled pen as designed.
There are limitations to consider when interpreting the results of this study. First, we acknowledge that the questionnaires and assessments used in the study have not been formally validated. However, they were specifically developed to capture information relevant to the robust evaluation of the safety and efficacy of the prefilled pen.
In addition, several features of the study design and population should be emphasized. We enrolled only patients actively interested in the prefilled pen. In this regard, we are not able to speculate on the outcomes of a similar study conducted in patients who were not interested in a self-injection device. Given the nature of the study, it was also impossible to blind patients and study staff regarding injection method. As such, the data derived from the subjective assessments made in this study may partially reflect patients' and clinicians' expectations for the prefilled pen. The partial crossover study design in which patients switched from injections with the prefilled syringe to injections with the prefilled pen (and not from the prefilled pen to the prefilled syringe) does not allow us to exclude an impact of treatment order on our findings. Additionally, patients evaluated the prefilled syringe injection experience only once, whereas they evaluated the prefilled pen injection experience a total of three times. It could be argued that patient responses may have varied when assessing the different methods since there were repeat evaluations for only one of the methods. However, since the patients in the population selected for this study were currently using the prefilled syringe, it is unlikely that the single assessment of the prefilled syringe would have differed significantly if that assessment had been repeated.
While we acknowledge that this study evaluated the prefilled pen in patients currently self-administering IM IFNβ-1a via the prefilled syringe and therefore does not address its suitability in treatment-naïve patients or when utilized by caregivers, the patient preference and ease of use results indicate the prefilled pen would also be an attractive option for use in these populations.
Injection anxiety and physical limitations are major barriers to self-injection for many patients with MS. These barriers may contribute to poor treatment adherence that may result in a reduction in the clinical benefits of MS therapy.
Results from this study support the safe and effective use of the prefilled pen for self-administration of IM IFNβ-1a by patients with MS. Patients preferred the prefilled pen over the prefilled syringe for reasons related to ease of use, injection pain, needle anxiety, and sense of independence. Data from this study demonstrate the potential for the prefilled pen to fulfil an unmet need in patients using IM IFNβ-1a by offering an alternative method for IM delivery that simplifies the injection process. The prefilled pen provides patients the opportunity to gain the clinical benefits of IM IFNβ-1a treatment while improving their ability to independently manage their disease.
The authors thank Kimberly Cushing of Biogen Idec for her assistance in writing the manuscript, and Infusion, An InforMed Group Company, for their assistance in developing the graphics.
The authors would also like to thank the lead investigator and staff at each study site: Jeffrey English, MD (MS Center of Atlanta, Atlanta, GA), Warren Felton, III, MD (Virginia Commonwealth University Medical Center, Richmond, VA), John Foley, MD (Rocky Mountain MS Clinic, Salt Lake City, UT), Lawrence Goldstick, MD (Neurology Specialists, Inc., Dayton, OH), Mark Gudesblatt, MD (Comprehensive Multiple Sclerosis Care Center, Patchogue, NY), Barry Hendin, MD (Phoenix Neurological Associates LTD, Phoenix, AZ), David Hojnacki, MD (Buffalo General Hospital, Buffalo, NY), William Honeycutt, MD (Neurological Associates, P.A., Maitland, FL), DeRen Huang, MD (Neurology & Neuroscience Associates, Inc., Akron, OH), Michael Kaufman, MD (Carolinas Healthcare System Neuroscience & Spine Institute, Charlotte, NC), Kiren Kresa-Reahl, MD (Capitol Neurology, Charleston, WV), Ellen Lathi, MD (Caritas St. Elizabeth's Medical Center, Boston, MA), Howard Rossman, D.O., F.A.C.N. (Michigan Institute for Neurological Disorders, Farmington Hills, MI), James C. Stevens, MD (Fort Wayne Neurological Center, Fort Wayne, IN).
This study was funded by Biogen Idec.
- Compston A, Coles A: Multiple sclerosis. Lancet. 2008, 372: 1502-1517. 10.1016/S0140-6736(08)61620-7.View ArticlePubMedGoogle Scholar
- The IFNB Multiple Sclerosis Study Group: Interferon beta-1b is effective in relapsing-remitting multiple sclerosis. I. Clinical results of a multicenter, randomized, double-blind, placebo-controlled trial. Neurology. 1993, 43: 655-661.View ArticleGoogle Scholar
- Jacobs LD, Cookfair DL, Rudick RA, Herndon RM, Richert JR, Salazar AM, Fischer JS, Goodkin DE, Granger CV, Simon JH, et al: Intramuscular interferon beta-1a for disease progression in relapsing multiple sclerosis. Ann Neurol. 1996, The Multiple Sclerosis Collaborative Research Group (MSCRG), 39: 285-294. 10.1002/ana.410390304.Google Scholar
- Johnson KP, Brooks BR, Cohen JA, Ford CC, Goldstein J, Lisak RP, Myers LW, Panitch HS, Rose JW, Schiffer RB: Copolymer 1 reduces relapse rate and improves disability in relapsing-remitting multiple sclerosis: results of a phase III multicenter, double-blind placebo-controlled trial. Neurology. 1995, The Copolymer 1 Multiple Sclerosis Study Group, 45: 1268-1276.Google Scholar
- PRISMS (Prevention of Relapses and Disability by Interferon b-1a Subcutaneously in Multiple Sclerosis) Study Group: Randomised doubleblind placebo-controlled study of interferon b-1a in relapsing/remitting multiple sclerosis. Lancet. 1998, 352: 1498-504. 10.1016/S0140-6736(98)03334-0. [Erratum, Lancet 1999; 353:678.]View ArticleGoogle Scholar
- Mohr DC, Cox D, Merluzzi N: Self-injection anxiety training: a treatment for patients unable to self-inject injectable medications. Mult Scler. 2005, 11: 182-185. 10.1191/1352458505ms1146oa.View ArticlePubMedGoogle Scholar
- Buhse M: Efficacy of EMLA cream to reduce fear and pain associated with interferon beta-1a injection in patients with multiple sclerosis. J Neurosci Nurs. 2006, 38: 222-226. 10.1097/01376517-200608000-00004.View ArticlePubMedGoogle Scholar
- Turner AP, Williams RM, Sloan AP, Haselkorn JK: Injection anxiety remains a long-term barrier to medication adherence in multiple sclerosis. Rehabil Psychol. 2009, 54: 116-121.View ArticlePubMedGoogle Scholar
- Patti F: Optimizing the benefit of multiple sclerosis therapy: the importance of treatment adherence. Patient Prefer Adherence. 2010, 4: 1-9.View ArticlePubMedPubMed CentralGoogle Scholar
- Cox D, Stone J: Managing self-injection difficulties in patients with relapsing-remitting multiple sclerosis. J Neurosci Nurs. 2006, 38: 167-171. 10.1097/01376517-200606000-00005.View ArticlePubMedGoogle Scholar
- Mohr DC, Boudewyn AC, Likosky W, Levine E, Goodkin DE: Injectable medication for the treatment of multiple sclerosis: the influence of self efficacy expectations and injection anxiety on adherence and ability to self-inject. Ann Behav Med. 2001, 23: 125-132. 10.1207/S15324796ABM2302_7.View ArticlePubMedGoogle Scholar
- Lugaresi A: Addressing the need for increased adherence to multiple sclerosis therapy: can delivery technology enhance patient motivation?. Expert Opin Drug Deliv. 2009, 6: 995-1002. 10.1517/17425240903134769.View ArticlePubMedGoogle Scholar
- Rubin RR, Peyrot M: Quality of life, treatment satisfaction, and treatment preference associated with use of a pen device delivering a premixed 70/30 insulin aspart suspension (aspart protamine suspension/soluble aspart) versus alternative treatment strategies. Diabetes Care. 2004, 27: 2495-2497. 10.2337/diacare.27.10.2495.View ArticlePubMedGoogle Scholar
- Summers KH, Szeinbach SL, Lenox SM: Preference for insulin delivery systems among current insulin users and nonusers. Clin Ther. 2004, 26: 1498-1505. 10.1016/j.clinthera.2004.09.009.View ArticlePubMedGoogle Scholar
- Hornquist JO, Wikby A, Andersson PO, Dufva AM: Insulin-pen treatment, quality of life and metabolic control: retrospective intra-group evaluations. Diabetes Res Clin Pract. 1990, 10: 221-230. 10.1016/0168-8227(90)90065-2.View ArticlePubMedGoogle Scholar
- Mikol D, Lopez-Bresnahan M, Taraskiewicz S, Chang P, Rangnow J: A randomized, multicentre, open-label, parallel-group trial of the tolerability of interferon beta-1a (Rebif) administered by autoinjection or manual injection in relapsing-remitting multiple sclerosis. Mult Scler. 2005, 11: 585-591. 10.1191/1352458505ms1197oa.View ArticlePubMedGoogle Scholar
- Kozubski W: Autoinjector Improves Injection-related Tolerability Issues in Patients with Multiple Sclerosis - Exploring the New ExtaviJect™ 30G System for the Injection of Interferon Beta-1b. Eur Neurol Rev. 2010, 5 (2): 77-81.View ArticleGoogle Scholar
- Lugaresi A, Durastanti V, Gasperini C, Lai M, Pozzilli C, Orefice G, Sotgiu S, Pucci E, Ardito B, Millefiorini E: Safety and tolerability in relapsing-remitting multiple sclerosis patients treated with high-dose subcutaneous interferon-beta by Rebiject autoinjection over a 1-year period: the CoSa study. Clin Neuropharmacol. 2008, 31: 167-172. 10.1097/wnf.0b013e3181571a8e.View ArticlePubMedGoogle Scholar
- Brochet B, Lemaire G, Beddiaf A: Reduction of injection site reactions in multiple sclerosis (MS) patients newly started on interferon beta 1b therapy with two different devices. Rev Neurol (Paris). 2006, 162: 735-740. 10.1016/S0035-3787(06)75071-8.View ArticleGoogle Scholar
- Freedman SM, Cox D, Rosebrough T: A prospective baseline versus on treatment study assessing patient perceptions of using a smaller needle when injecting intramuscular interferon beta-1 a (Avonex). J Neurosci Nurs. 2008, 40: 350-355. 10.1097/01376517-200812000-00007.View ArticlePubMedGoogle Scholar
- Poland GA, Borrud A, Jacobson RM, McDermott K, Wollan PC, Brakke D, Charboneau JW: Determination of deltoid fat pad thickness. Implications for needle length in adult immunization. JAMA. 1997, 277: 1709-1711. 10.1001/jama.277.21.1709.View ArticlePubMedGoogle Scholar
- Song TT, Nelson MR, Chang JH, Engler RJ, Chowdhury BA: Adequacy of the epinephrine autoinjector needle length in delivering epinephrine to the intramuscular tissues. Ann Allergy Asthma Immunol. 2005, 94: 539-542. 10.1016/S1081-1206(10)61130-1.View ArticlePubMedGoogle Scholar
- Gibney MA, Arce CH, Byron KJ, Hirsch LJ: Skin and subcutaneous adipose layer thickness in adults with diabetes at sites used for insulin injections: implications for needle length recommendations. Curr Med Res Opin. 2010, 26: 1519-1530. 10.1185/03007995.2010.481203.View ArticlePubMedGoogle Scholar
- Frid A, Hardebo JE: The thigh may not be suitable as an injection site for patients self-injecting sumatriptan. Neurology. 1997, 49 (2): 559-61.View ArticlePubMedGoogle Scholar
- The pre-publication history for this paper can be accessed here:http://www.biomedcentral.com/1471-2377/11/126/prepub
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