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225 result(s) for 'advanced multiple sclerosis' within BMC Neurology

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  1. Traditionally, multiple sclerosis has been viewed as a disease predominantly ... within the grey matter has arisen. This advance was driven mainly by novel imaging techniques, ... physical and cognitive disabilit...

    Authors: Dana Horakova, Tomas Kalincik, Jana Blahova Dusankova and Ondrej Dolezal
    Citation: BMC Neurology 2012 12:10
    Content type: Review Published on:

  2. Although the precise etiology of multiple sclerosis is largely unknown, there is some speculation that a prior history of surgery may be associated with the subsequent risk for developing the disease. Therefor...

    Authors: Carole Lunny, Jennifer A Knopp-Sihota and Shawn N Fraser
    Citation: BMC Neurology 2013 13:41
    Content type: Research article Published on:

  4. Exercise has consistently yielded short-term, positive effects on health outcomes in people with multiple sclerosis (MS). However, these effects have not been maintained in the long-term. Behaviour change inte...

    Authors: Susan Coote, Stephen Gallagher, Rachel Msetfi, Aidan Larkin, John Newell, Robert W Motl and Sara Hayes
    Citation: BMC Neurology 2014 14:241
    Content type: Study protocol Published on:

  5. Multiple sclerosis (MS) is the most common disabling neurological disease in young adults worldwide with majority of patients manifest symptoms between 20 and 40 years of age. The aims of this study are to exp...

    Authors: Hussain Abdulrahman Al-Omar, Nada Alsowaida, Lama Aldosari, Ahmed Mayet, Reem Bunyan and Mohammed Aljumah
    Citation: BMC Neurology 2023 23:135
    Content type: Research Published on:

  6. The Brief Repeatable Battery of Neuropsychological Tests (BRBN-T) is one of the most sensitive and used measures for detecting cognitive impairment in Multiple Sclerosis (MS).

    Authors: Claudia Sousa, Mariana Rigueiro-Neves, Ana Margarida Passos, Aristides Ferreira and Maria José Sá
    Citation: BMC Neurology 2021 21:170
    Content type: Research article Published on:

  8. We designed a new multi-modal version of the MSmonitor, called the MSmonitor-Plus and Video calling Care (MPVC), a self-management and education program with e-health interventions that combines frequent use o...

    Authors: M. Hoving, P. J. Jongen, S. M. A. A. Evers, M. A. Edens and E. M. P. E. Zeinstra
    Citation: BMC Neurology 2022 22:423
    Content type: Study protocol Published on:

  9. Some recent experimental data suggest a possible role of LINGO-1 in the pathogenesis of multiple sclerosis (MS). In an attempt to identify genetic biomarkers related to MS susceptibility, we genotyped two comm...

    Authors: Elena García-Martín, Oswaldo Lorenzo-Betancor, Carmen Martínez, Pau Pastor, Julián Benito-León, Jorge Millán-Pascual, Patricia Calleja, María Díaz-Sánchez, Diana Pisa, Laura Turpín-Fenoll, Hortensia Alonso-Navarro, Lucía Ayuso-Peralta, Dolores Torrecillas, Elena Lorenzo, José Francisco Plaza-Nieto, José A G Agúndez…
    Citation: BMC Neurology 2013 13:34
    Content type: Research article Published on:

  10. Care for People with Multiple Sclerosis (PwMS) is increasingly complex, requiring innovations in care. Canada has high rates of MS; it is challenging for general neurologists to optimally care for PwMS with bu...

    Authors: Penelope Smyth, Kaitlyn E. Watson, Yazid N. Al Hamarneh and Ross T. Tsuyuki
    Citation: BMC Neurology 2022 22:275
    Content type: Research Published on:

  11. A possible method of finding physiological markers of multiple sclerosis (MS) is the application of EEG quantification (QEEG) of brain activity when the subject is stressed by the demands of a cognitive task. ...

    Authors: Manuel Vazquez-Marrufo, Javier J Gonzalez-Rosa, Encarnacion Vaquero, Pablo Duque, Monica Borges, Carlos Gomez and Guillermo Izquierdo
    Citation: BMC Neurology 2008 8:44
    Content type: Research article Published on:

  12. Many individuals afflicted with multiple sclerosis (MS) experience a transient worsening of symptoms when body temperature increases due to ambient conditions or physical activity. Resulting symptom exacerbati...

    Authors: Dennis A Grahn, Julie vLS Murray and H Craig Heller
    Citation: BMC Neurology 2008 8:14
    Content type: Research article Published on:

  13. The aim of this study was to evaluate the safety, feasibility and preliminary effects of a high-intensity rehabilitative task-oriented circuit training (TOCT) in a sample of multiple sclerosis (MS) subjects on...

    Authors: Sofia Straudi, Carlotta Martinuzzi, Claudia Pavarelli, Amira Sabbagh Charabati, Maria Grazia Benedetti, Calogero Foti, Michela Bonato, Eleonora Zancato and Nino Basaglia
    Citation: BMC Neurology 2014 14:124
    Content type: Research article Published on:

  14. Early infratentorial and focal spinal cord lesions on magnetic resonance imaging (MRI) are associated with a higher risk of long-term disability in patients with multiple sclerosis (MS). The role of diffuse sp...

    Authors: Michaela Andelova, Karolina Vodehnalova, Jan Krasensky, Eliska Hardubejova, Tereza Hrnciarova, Barbora Srpova, Tomas Uher, Ingrid Menkyova, Dominika Stastna, Lucie Friedova, Jiri Motyl, Jana Lizrova Preiningerova, Eva Kubala Havrdova, Bénédicte Maréchal, Mário João Fartaria, Tobias Kober…
    Citation: BMC Neurology 2022 22:270
    Content type: Research article Published on:

  15. Multiple sclerosis (MS) is a chronic disease that requires lifelong treatment. A highly effective drug not only for relapsing but also for progressive forms of MS with a favorable safety profile is needed to f...

    Authors: Petra Dirks, Vera Zingler, Jost Leemhuis, Heike Berthold, Stefanie Hieke-Schulz, David Wormser and Tjalf Ziemssen
    Citation: BMC Neurology 2020 20:95
    Content type: Study protocol Published on:

  16. Glatiramer acetate (GA) is one of the first therapies approved for multiple sclerosis (MS). We prospectively included and monitored drug-naïve and pre-treated MS patients who had been prescribed GA for 1 year,...

    Authors: Chiara Zecca, Giulio Disanto, Rosaria Sacco, Gianna C. Riccitelli and Claudio Gobbi
    Citation: BMC Neurology 2019 19:159
    Content type: Research article Published on:

  17. Cognitive problems frequently occur in patients with multiple sclerosis (MS) and profoundly affect their quality of life. So far, the best cognitive treatment options for MS patients are a matter of debate. Th...

    Authors: Ilse M. Nauta, Anne E. M. Speckens, Roy P. C. Kessels, Jeroen J. G. Geurts, Vincent de Groot, Bernard M. J. Uitdehaag, Luciano Fasotti and Brigit A. de Jong
    Citation: BMC Neurology 2017 17:201
    Content type: Study protocol Published on:

  18. Anxiety, depression and functional impairments are commonly reported by persons with multiple sclerosis (PwMS) but no data, to our knowledge, has emerged from an Arab Islamic population. The study aims to inve...

    Authors: Abdullah Al-Asmi, Salim Al-Rawahi, Zahir Saif Al-Moqbali, Yahya Al-Farsi, Musthafa M. Essa, May El-Bouri, Roopa P. Koshy, Arunodaya R. Gujjar, PC Jacob, Abeer Al-Hodar and Samir Al Adawi
    Citation: BMC Neurology 2015 15:131
    Content type: Research article Published on:

  19. Most patients with multiple sclerosis (MS) suffer from bladder dysfunction during the course of the disease. This study was conducted to examine the prevalence of these complications among patients with MS.

    Authors: Fatemeh Nazari, Vahid Shaygannejad, Mehrdad Mohammadi Sichani, Marjan Mansourian and Valiollah Hajhashemi
    Citation: BMC Neurology 2020 20:24
    Content type: Research article Published on:

  20. Due to lack of any curative therapy for ALS, symptomatic treatment and maintenance of quality of life (QoL) is very important. We aimed to characterize the affected domains of QoL in ALS patients and to identi...

    Authors: Sonja Körner, Katja Kollewe, Susanne Abdulla, Antonia Zapf, Reinhard Dengler and Susanne Petri
    Citation: BMC Neurology 2015 15:84
    Content type: Research article Published on:

  21. Registry to Evaluate Novantrone Effects in Worsening Multiple Sclerosis (RENEW) was a 5-year, phase IV study in which the safety of Mitoxantrone was monitored in a patient cohort from the United States (US). T...

    Authors: Victor M Rivera, Douglas R Jeffery, Bianca Weinstock-Guttman, Daena Bock and Fernando Dangond
    Citation: BMC Neurology 2013 13:80
    Content type: Research article Published on:

  22. To reduce injection pain and improve satisfaction, a thinner (29-gauge [29G]), sharper (5-bevel) needle than the 27G/3-bevel needle used previously to inject interferon (IFN) beta-1a, 44 or 22 mcg subcutaneous...

    Authors: Amer Jaber, Gian B Bozzato, Lionel Vedrine, Wes A Prais, Julie Berube and Philippe E Laurent
    Citation: BMC Neurology 2008 8:38
    Content type: Technical advance Published on:

  23. Interferon (IFN) beta drugs have been approved for the treatment of relapsing forms of multiple sclerosis (RMS) for more than 20 years ... products in MS. In the Phase 3 ADVANCE trial peginterferon beta-1a demons...

    Authors: Annette Kolb-Mäurer, Cord Sunderkötter, Borries Kukowski and Sven G. Meuth
    Citation: BMC Neurology 2019 19:130
    Content type: Debate Published on:

  24. Despite the commonly known benefits of exercise and physical activity evidence shows that persons Multiple Sclerosis (MS) are relatively inactive yet physical activity may be even more important in a populatio...

    Authors: Nancy E Mayo, Mark Bayley, Pierre Duquette, Yves Lapierre, Ross Anderson and Susan Bartlett
    Citation: BMC Neurology 2013 13:69
    Content type: Study protocol Published on:

  25. Comparisons between neurological conditions have the potential to inform service providers by identifying particular areas of difficulty experienced by affected individuals. This study aimed to identify predic...

    Authors: David Morley, Sarah Dummett, Laura Kelly, Ray Fitzpatrick and Crispin Jenkinson
    Citation: BMC Neurology 2018 18:19
    Content type: Research article Published on:

  26. Continuation of interferon (IFN) β-based therapies is important for maximum treatment effectiveness in patients with multiple sclerosis (MS); however, few real-world data are available on discontinuation from ...

    Authors: Meritxell Sabidó-Espin and Rick Munschauer
    Citation: BMC Neurology 2017 17:57
    Content type: Research article Published on:

  27. Comprehensive epidemiologic data for multiple sclerosis (MS) in Poland are limited. The aim of this cross-sectional population-based study was to determine the incidence and prevalence of MS in the Swietokrzys...

    Authors: Waldemar Brola, Piotr Sobolewski, Stanisław Flaga, Małgorzata Fudala, Wiktor Szczuchniak, Jan Stoiński, Anita Rosołowska, Jacek Wójcik, Katarzyna Kapica-Topczewska and Danuta Ryglewicz
    Citation: BMC Neurology 2016 16:134
    Content type: Research article Published on:

  28. Aerobic training has the potential to restore function, stimulate brain repair, and reduce inflammation in people with Multiple Sclerosis (MS). However, disability, fatigue, and heat sensitivity are major barr...

    Authors: Augustine J. Devasahayam, Arthur R. Chaves, Wendy O. Lasisi, Marie E. Curtis, Katie P. Wadden, Liam P. Kelly, Ryan Pretty, Alice Chen, Elizabeth M. Wallack, Caitlin J. Newell, John B. Williams, Hannah Kenny, Matthew B. Downer, Jason McCarthy, Craig S. Moore and Michelle Ploughman
    Citation: BMC Neurology 2020 20:33
    Content type: Research article Published on:

  29. The management of multiple sclerosis (MS) is rapidly changing by the ... by different risk score systems. Despite these advances, we know very little about medical decisions...

    Authors: Gustavo Saposnik, Angel Perez Sempere, Roula Raptis, Daniel Prefasi, Daniel Selchen and Jorge Maurino
    Citation: BMC Neurology 2016 16:58
    Content type: Study protocol Published on:

  30. Decision-making is an essential function of everyday life. Decision-making under explicit risk requires developing advantageous decision strategies based on fixed outcomes (e.g., probabilities of winning or lo...

    Authors: Ashley D Radomski, Christopher Power, Scot E Purdon, Derek J Emery, Gregg Blevins, Kenneth G Warren and Esther Fujiwara
    Citation: BMC Neurology 2015 15:61
    Content type: Research article Published on:

  31. Neuroinflammation might be involved in the degeneration and progression of Amyotrophic Lateral Sclerosis (ALS). Here, we studied the role of the circulating lymphocytes in ALS, in particular the NK cells. We f...

    Authors: Tommaso Piccoli, Francesca Castro, Vincenzo La Bella, Serena Meraviglia, Marta Di Simone, Giuseppe Salemi, Francesco Dieli and Rossella Spataro
    Citation: BMC Neurology 2023 23:222
    Content type: Research Published on:

  32. Nocturia (the symptom of needing to wake up to pass urine) is common in progressive Multiple Sclerosis (MS) patients. Moderate-to-severe nocturia affects quality of life, can exacerbate fatigue and may affect ...

    Authors: D. Delgado, L. Canham, N. Cotterill, D. Cottrell, M. J. Drake, K. Inglis, D. Owen and P. White
    Citation: BMC Neurology 2017 17:63
    Content type: Study protocol Published on:

  33. Biochemical changes associated with multiple sclerosis (MS), and its various clinical forms have not been characterized well. Therefore, we investigated the biochemistry of MS in relation to its natural histor...

    Authors: Vijitha K. Senanayake, Wei Jin, Asuka Mochizuki, Bassirou Chitou and Dayan B. Goodenowe
    Citation: BMC Neurology 2015 15:154
    Content type: Research article Published on:

  34. The Paced Auditory Serial Addition Test (PASAT) is a useful cognitive test in patients with multiple sclerosis (MS), assessing sustained attention and information processing speed. However, the neural underpin...

    Authors: Jordi A. Matias-Guiu, Ana Cortés-Martínez, Paloma Montero, Vanesa Pytel, Teresa Moreno-Ramos, Manuela Jorquera, Miguel Yus, Juan Arrazola and Jorge Matías-Guiu
    Citation: BMC Neurology 2018 18:214
    Content type: Research article Published on:

  35. Disease modifying treatments (DMT) for MS such as interferon beta (IFNβ) have been shown to reduce the risk for disease progression. Therefore adherence to treatment is essential for treatment outcome.Here we ...

    Authors: Zaza Katsarava, Birgit Ehlken, Volker Limmroth, Kirsi Taipale, Sarita Noemi Patel, Gabriele Niemczyk, Karin Rehberg-Weber and Colin Wernsdörfer
    Citation: BMC Neurology 2015 15:170
    Content type: Research article Published on:

  36. Multiple sclerosis (MS) is a stressful condition. Mental health comorbidity is common. Stress can increase the risk of depression, reduce quality of life (QOL), and possibly exacerbate disease activity in MS. ...

    Authors: Robert Simpson, Frances S. Mair and Stewart W. Mercer
    Citation: BMC Neurology 2017 17:94
    Content type: Research article Published on:

  37. Recent exercise guidelines for people with multiple sclerosis (MS) recommend a minimum of 30 min moderate intensity aerobic exercise and resistance exercise twice per week. This trial compared the secondary ou...

    Authors: Susan Coote, Marcin Uszynski, Matthew P. Herring, Sara Hayes, Carl Scarrott, John Newell, Stephen Gallagher, Aidan Larkin and Robert W Motl
    Citation: BMC Neurology 2017 17:119
    Content type: Research article Published on:

  38. No longitudinal, long-term, follow-up studies have explored the association between presence and severity of variations in extracranial venous anatomy, and clinical outcomes in patients with multiple sclerosis...

    Authors: Sirin Gandhi, Karen Marr, Marcello Mancini, Maria Grazia Caprio, Dejan Jakimovski, Avinash Chandra, Jesper Hagemeier, David Hojnacki, Channa Kolb, Bianca Weinstock-Guttman and Robert Zivadinov
    Citation: BMC Neurology 2019 19:121
    Content type: Research article Published on:

  39. Besides the defining involvement of upper and lower motor neurons, the involvement of extramotor structures has been increasingly acknowledged in amyotrophic lateral sclerosis (ALS).

    Authors: Johannes Thorns, Henk Jansma, Thomas Peschel, Julian Grosskreutz, Bahram Mohammadi, Reinhard Dengler and Thomas F Münte
    Citation: BMC Neurology 2013 13:148
    Content type: Research article Published on:

  40. Weight loss is a frequent feature in the motor neuron disease Amyotrophic lateral sclerosis (ALS). In this study we investigated possible causes of weight loss in ALS, its impact on mood/quality of life (QOL) ...

    Authors: Sonja Körner, Melanie Hendricks, Katja Kollewe, Antonia Zapf, Reinhard Dengler, Vincenzo Silani and Susanne Petri
    Citation: BMC Neurology 2013 13:84
    Content type: Research article Published on:

  41. Baló’s Concentric Sclerosis (BCS) is a rare heterogeneous demyelinating disease with a variety of phenotypes on Magnetic Resonance Imaging (MRI). Existing literature lacks data especially on the therapeutic ap...

    Authors: D. Tzanetakos, A. G. Vakrakou, J. S. Tzartos, G. Velonakis, M. E. Evangelopoulos, M. Anagnostouli, G. Koutsis, E. Dardiotis, E. Karavasilis, P. Toulas, L. Stefanis and C. Kilidireas
    Citation: BMC Neurology 2020 20:400
    Content type: Research article Published on:

  42. Daclizumab is a humanized monoclonal antibody against CD25 that modulates interleukin 2 signaling. The SELECT TRILOGY of clinical studies (SELECT/SELECTION/SELECTED) evaluated the safety and efficacy of dacliz...

    Authors: Ralf Gold, Ernst-Wilhelm Radue, Gavin Giovannoni, Krzysztof Selmaj, Eva Havrdova, Dusan Stefoski, Till Sprenger, Xavier Montalban, Stanley Cohan, Kimberly Umans, Steven J. Greenberg, Gulden Ozen and Jacob Elkins
    Citation: BMC Neurology 2016 16:117
    Content type: Research article Published on:

  43. Extracellular adenosine 5'-triphosphate (ATP) has been suggested to cause neuroinflammation and motor neuron degeneration by activating microglia and astrocytes in amyotrophic lateral sclerosis (ALS). Since we...

    Authors: Takamasa Nukui, Atsushi Matsui, Hideki Niimi, Tomoyuki Sugimoto, Tomohiro Hayashi, Nobuhiro Dougu, Hirofumi Konishi, Mamoru Yamamoto, Ryoko Anada, Noriyuki Matsuda, Isao Kitajima and Yuji Nakatsuji
    Citation: BMC Neurology 2021 21:255
    Content type: Research Published on:

  44. Personalized ENCALS survival prediction model reliably estimates the personalized prognosis of patients with amyotrophic lateral sclerosis. Concerns were raised on discussing personalized prognosis without causin...

    Authors: Remko M. van Eenennaam, Willeke J. Kruithof, Michael A. van Es, Esther T. Kruitwagen-van Reenen, Henk-Jan Westeneng, Johanna M. A. Visser-Meily, Leonard H. van den Berg and Anita Beelen
    Citation: BMC Neurology 2020 20:446
    Content type: Research article Published on:

  45. We systematically reviewed the comparative effectiveness of injectable beta-interferons (IFN-β) and glatiramer acetate (GA) on annualised relapse rate (ARR), progression and discontinuation due to adverse even...

    Authors: G. J. Melendez-Torres, Xavier Armoiry, Rachel Court, Jacoby Patterson, Alan Kan, Peter Auguste, Jason Madan, Carl Counsell, Olga Ciccarelli and Aileen Clarke
    Citation: BMC Neurology 2018 18:162
    Content type: Research article Published on:

  46. Leakage of the blood–brain barrier (BBB) is a common pathological feature in multiple sclerosis (MS). Following a breach of the BBB, albumin, the most abundant protein in plasma, gains access to CNS tissue whe...

    Authors: Steven M. LeVine
    Citation: BMC Neurology 2016 16:47
    Content type: Review Published on:

  47. Disease severity is tremendously variable in tuberous sclerosis complex (TSC). In contrast with the detailed guidelines available for TSC diagnosis and management, clinical practice lacks adequate tools to eva...

    Authors: Valérie Mongrain, Nicolaas H. van Doesburg, Françoise Rypens, Catherine Fallet-Bianco, Justine Maassen, Julien Dufort-Gervais, Lucie Côté and Philippe Major
    Citation: BMC Neurology 2020 20:324
    Content type: Case report Published on:

  49. Initial symptoms of amyotrophic lateral sclerosis (ALS) are often subtle and can delay diagnosis. This exploratory analysis was conducted to better characterize the pre-diagnosis pathway undertaken by patients...

    Authors: James R Williams, David Fitzhenry, Lauren Grant, Derek Martyn and Douglas A Kerr
    Citation: BMC Neurology 2013 13:160
    Content type: Research article Published on:

  50. Palliative sedation has become widely accepted as a method to alleviate refractory symptoms in terminally ill patients. Controversies regarding this topic especially concern the use of palliative sedation for ...

    Authors: Laura Salzmann, Bernd Alt-Epping and Alfred Simon
    Citation: BMC Neurology 2022 22:161
    Content type: Research Published on:

    The Correction to this article has been published in BMC Neurology 2022 22:188

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