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  1. It is extremely rare to see cerebrospinal fluid dissemination of intraventricular meningioma, particularly with the development of acute, progressive brainstem/cerebellar dysfunction with an absence of mass fo...

    Authors: Motoki Fujimaki, Masashi Takanashi, Manami Kobayashi, Kei-ichiro Wada, Yutaka Machida, Akihide Kondo, Nobutaka Hattori and Hideto Miwa
    Citation: BMC Neurology 2016 16:82
    Content type: Case report Published on:

  2. In people with multiple sclerosis (MS) disabilities and limitations may negatively affect self-efficacy. Lowered self-efficacy has been associated with decreases in health-related quality of life, physical act...

    Authors: Peter Joseph Jongen, Marco Heerings, Rob Ruimschotel, Astrid Hussaarts, Silvia Evers, Lotte Duyverman, Joyce Valkenburg-Vissers, Job Cornelissen, Michel Bos, Maarten van Droffelaar, Wim A. Lemmens, Rogier Donders, Anneke van der Zande and Leo H. Visser
    Citation: BMC Neurology 2016 16:81
    Content type: Study protocol Published on:

  3. Living alone is associated with increased mortality after myocardial infarction but little data is available about whether this applies to prognosis after stroke. We aimed to examine the association between li...

    Authors: Petra Redfors, Daniella Isaksén, Georgios Lappas, Christian Blomstrand, Annika Rosengren, Katarina Jood and Christina Jern
    Citation: BMC Neurology 2016 16:80
    Content type: Research article Published on:

  4. The present study was carried out to evaluate cerebral perfusion in multiple sclerosis (MS) patients with a moderate to severe stage of disease. Some patients underwent hyperbaric oxygen therapy (HBOT) and bra...

    Authors: Mina Taghizadeh Asl, Reza Nemati, Negar Chabi, Hooman Salimipour, Iraj Nabipour and Majid Assadi
    Citation: BMC Neurology 2016 16:79
    Content type: Research article Published on:

  5. Limb-shaking transient ischemic attack (TIA) is a well-recognized, but rare observation in contralateral carotid steno-occlusive disease. Consequently, most clinicians have not had the chance to witness an att...

    Authors: Sverre Rosenbaum, Christian Ovesen, Nancy Futrell and Derk W. Krieger
    Citation: BMC Neurology 2016 16:78
    Content type: Case report Published on:

  6. Andrographis paniculata (A. paniculata), a medicinal plant, has shown anti-inflammatory, neuroprotective and antifibrotic effects in animal models as well as clinical efficacy in different studies, including an a...

    Authors: J. C. Bertoglio, M. Baumgartner, R. Palma, E. Ciampi, C. Carcamo, D. D. Cáceres, G. Acosta-Jamett, J. L. Hancke and R. A. Burgos
    Citation: BMC Neurology 2016 16:77
    Content type: Research article Published on:

  7. Accumulating evidences from experimental, epidemiologic and clinical studies support the potential linkage between poor vitamin D status and the risk of developing Multiple Sclerosis (MS), as well as, an adver...

    Authors: Soodeh Razeghi Jahromi, Mohammad Ali Sahraian, Mansoureh Togha, Behnaz Sedighi, Vahid Shayegannejad, Alireza Nickseresht, Shahriar Nafissi, Niayesh Mohebbi, Nastran Majdinasab, Mohsen Foroughipour, Masoud Etemadifar, Nahid Beladi Moghadam, Hormoz Ayramlou, Fereshteh Ashtari and Shekoofe Alaie
    Citation: BMC Neurology 2016 16:76
    Content type: Debate Published on:

  8. Studies have shown a slight excess risk in Guillain-Barré syndrome (GBS) incidence associated with A(H1N1)pdm09 vaccination campaign and seasonal trivalent influenza vaccine immunisations in 2009–2010. We aime...

    Authors: Enrique Alcalde-Cabero, Javier Almazán-Isla, Fernando J. García López, José Ramón Ara-Callizo, Fuencisla Avellanal, Carlos Casasnovas, Carlos Cemillán, José Ignacio Cuadrado, Jacinto Duarte, María Dolores Fernández-Pérez, Óscar Fernández, Juan Antonio García Merino, Rosa García Montero, Dolores Montero, Julio Pardo, Francisco Javier Rodríguez-Rivera…
    Citation: BMC Neurology 2016 16:75
    Content type: Research article Published on:

  9. Mutations in proteins involved in the glycosylphosphatidylinositol anchor biosynthesis and remodeling pathway are associated with autosomal recessive forms of intellectual disability. Recently mutations in the PG...

    Authors: Matthias Kettwig, Orly Elpeleg, Eike Wegener, Steffi Dreha-Kulaczewski, Marco Henneke, Jutta Gärtner and Peter Huppke
    Citation: BMC Neurology 2016 16:74
    Content type: Case report Published on:

  10. The aim of this study was to develop an assessment tool for activities of daily living (ADL) from the perspective of patients with Parkinson’s disease (PD) and examine the validity and reliability of the asses...

    Authors: Su-Yun Lee, Sung Kwan Kim, Sang-Myung Cheon, Jung-Wook Seo, Min Ah Kim and Jae Woo Kim
    Citation: BMC Neurology 2016 16:73
    Content type: Research article Published on:

  11. Primary central nervous system lymphoma (PCNSL) may rarely be preceded by “sentinel demyelination,” a pathologic entity characterized by histologically confirmed demyelinating inflammatory brain lesions that m...

    Authors: Mark D. Kvarta, Deva Sharma, Rudolph J. Castellani, Robert E. Morales, Stephen G. Reich, Amy S. Kimball and Robert K. Shin
    Citation: BMC Neurology 2016 16:72
    Content type: Case report Published on:

  12. Three main genes are described as causative genes for early-onset Alzheimer dementia (EOAD): APP, PSEN1 and PSEN2. We describe a woman with EOAD had a novel PSEN1 mutation.

    Authors: Seong Soo A. An, Eva Bagyinszky, Hye Ryoun Kim, Ju-Won Seok, Hae-Won Shin, SeunOh Bae, SangYun Kim and Young Chul Youn
    Citation: BMC Neurology 2016 16:71
    Content type: Case report Published on:

  15. In recent randomized controlled trials (RCTs) intra-arterial treatment (IAT) has been proven effective and safe for patients with acute ischemic stroke (AIS). So far, there seemed to be no interaction between ...

    Authors: Debbie Beumer, Anouk D. Rozeman, Geert J. Lycklama à Nijeholt, Patrick A. Brouwer, Sjoerd F. M. Jenniskens, Ale Algra, Jelis Boiten, Wouter Schonewille, Robert J. van Oostenbrugge, Diederik W. J. Dippel and Wim H. van Zwam
    Citation: BMC Neurology 2016 16:68
    Content type: Research article Published on:

  17. Our previous randomized double-blind study showed that drinking hydrogen (H2) water for 48 weeks significantly improved the total Unified Parkinson’s Disease Rating Scale (UPDRS) score of Parkinson’s disease (PD)...

    Authors: Asako Yoritaka, Takashi Abe, Chigumi Ohtsuka, Tetsuya Maeda, Masaaki Hirayama, Hirohisa Watanabe, Hidemoto Saiki, Genko Oyama, Jiro Fukae, Yasushi Shimo, Taku Hatano, Sumihiro Kawajiri, Yasuyuki Okuma, Yutaka Machida, Hideto Miwa, Chikako Suzuki…
    Citation: BMC Neurology 2016 16:66
    Content type: Study protocol Published on:

  18. Cognitive impairment and neuropsychiatric syndromes, like depression and apathy, are frequent residual consequences of stroke. These have a large impact on quality of life and long-term prognosis. Several fact...

    Authors: Elles Douven, Syenna H. J. Schievink, Frans R. J. Verhey, Robert J. van Oostenbrugge, Pauline Aalten, Julie Staals and Sebastian Köhler
    Citation: BMC Neurology 2016 16:65
    Content type: Study protocol Published on:

  19. The ε4 allele of the Apolipoprotein E gene (APOE-ε4) is a potent genetic risk factor for sporadic Alzheimer’s disease (AD). Amnestic mild cognitive impairment (aMCI) is an intermediate state between normal cog...

    Authors: Guan-Qun Chen, Can Sheng, Yu-Xia Li, Yang Yu, Xiao-Ni Wang, Yu Sun, Hong-Yan Li, Xuan-Yu Li, Yun-Yan Xie and Ying Han
    Citation: BMC Neurology 2016 16:64
    Content type: Study protocol Published on:

  20. Patients affected by progressive long-term neurological conditions might benefit from specialist palliative care involvement. However, little is known on how neurology and specialist palliative care services i...

    Authors: Liesbeth M. van Vliet, Wei Gao, Daniel DiFrancesco, Vincent Crosby, Andrew Wilcock, Anthony Byrne, Ammar Al-Chalabi, K. Ray Chaudhuri, Catherine Evans, Eli Silber, Carolyn Young, Farida Malik, Rachel Quibell and Irene J. Higginson
    Citation: BMC Neurology 2016 16:63
    Content type: Research article Published on:

  21. Multiple sclerosis (MS) is an incurable, unpredictable but typically progressive neurological condition. It is the most common cause of neurological disability in young adults. Within 15 years of diagnosis, ap...

    Authors: J. A. Freeman, W. Hendrie, S. Creanor, L. Jarrett, A. Barton, C. Green, J. Marsden, E. Rogers and J. Zajicek
    Citation: BMC Neurology 2016 16:62
    Content type: Study protocol Published on:

  22. Patients with a history of mild TBI (post-mTBI-patients) have an unexplained increase in long-term mortality which might be related to central autonomic dysregulation (CAD). We investigated whether standardize...

    Authors: Max J. Hilz, Mao Liu, Julia Koehn, Ruihao Wang, Fabian Ammon, Steven R. Flanagan and Katharina M. Hösl
    Citation: BMC Neurology 2016 16:61
    Content type: Research article Published on:

  24. The purpose of this study is to determine whether intracerebral hemorrhage and subarachnoid hemorrhage have different incidence patterns based on monthly variations in meteorological and air pollution paramete...

    Authors: Myung-Hoon Han, Hyeong-Joong Yi, Yong Ko, Young-Soo Kim and Young-Jun Lee
    Citation: BMC Neurology 2016 16:59
    Content type: Research article Published on:

  25. The management of multiple sclerosis (MS) is rapidly changing by the introduction of new and more effective disease-modifying agents. The importance of risk stratification was confirmed by results on disease p...

    Authors: Gustavo Saposnik, Angel Perez Sempere, Roula Raptis, Daniel Prefasi, Daniel Selchen and Jorge Maurino
    Citation: BMC Neurology 2016 16:58
    Content type: Study protocol Published on:

  28. Cerebral palsy (CP) is the main cause of severe physical impairment during childhood and has commonly shown oral motor association. It has been considered as the main cause of the high prevalence of problems i...

    Authors: Vanessa Vieira Pinto, Levy Anderson César Alves, Fausto M. Mendes and Ana Lídia Ciamponi
    Citation: BMC Neurology 2016 16:55
    Content type: Research article Published on:

  30. Intravenous thrombolytic therapy after ischaemic stroke significantly reduces mortality and morbidity. Actual thrombolysis rates are disappointingly low in many western countries. It has been suggested that hi...

    Authors: S. Scherf, M. Limburg, R. Wimmers, I. Middelkoop and H. Lingsma
    Citation: BMC Neurology 2016 16:53
    Content type: Research article Published on:

  31. Considerable variability exists in international prevalence and incidence estimates of dementia. The accuracy of estimates of dementia in the oldest-old and the controversial question of whether dementia incid...

    Authors: Henry Brodaty, Claudia Woolf, Stacy Andersen, Nir Barzilai, Carol Brayne, Karen Siu-Lan Cheung, Maria M. Corrada, John D. Crawford, Catriona Daly, Yasuyuki Gondo, Bo Hagberg, Nobuyoshi Hirose, Henne Holstege, Claudia Kawas, Jeffrey Kaye, Nicole A. Kochan…
    Citation: BMC Neurology 2016 16:52
    Content type: Study protocol Published on:

  33. Carotid artery stenosis is a frequent cause of ischemic stroke. While any degree of stenosis can cause embolic stroke, a higher degree of stenosis can also cause hemodynamic infarction. The hemodynamic effect ...

    Authors: Sibu Mundiyanapurath, Peter Arthur Ringleb, Sascha Diatschuk, Oliver Eidel, Sina Burth, Ralf Floca, Markus Möhlenbruch, Wolfgang Wick, Martin Bendszus and Alexander Radbruch
    Citation: BMC Neurology 2016 16:50
    Content type: Research article Published on:

  34. Reversible splenial lesion syndrome (RESLES) is a disorder radiologically characterized by reversible lesion in the splenium of the corpus callosum (SCC). Most of patients with RESLES associated with encephali...

    Authors: Yuanzhao Zhu, Junjun Zheng, Ling Zhang, Zhenguo Zeng, Min Zhu, Xiaobin Li, Xiaoliang Lou, Hui Wan and Daojun Hong
    Citation: BMC Neurology 2016 16:49
    Content type: Research article Published on:

  35. Mechanisms of inflammation and protein accumulation are crucial in inclusion body myositis (IBM). Recent evidence demonstrated that intravenous immunoglobulin failed to suppress cell-stress mediators in IBM. H...

    Authors: Karsten Schmidt, Konstanze Kleinschnitz, Goran Rakocevic, Marinos C. Dalakas and Jens Schmidt
    Citation: BMC Neurology 2016 16:48
    Content type: Research article Published on:

  36. Leakage of the blood–brain barrier (BBB) is a common pathological feature in multiple sclerosis (MS). Following a breach of the BBB, albumin, the most abundant protein in plasma, gains access to CNS tissue whe...

    Authors: Steven M. LeVine
    Citation: BMC Neurology 2016 16:47
    Content type: Review Published on:

  37. The predictive ability of National Institute of Neurological Disease and Stroke-Canadian Stroke Network (NINDS-CSN) 5-minute protocol and Montreal Cognitive Assessment (MoCA) administered sub-acutely and at th...

    Authors: YanHong Dong, Jing Xu, Bernard Poon-Lap Chan, Raymond Chee Seong Seet, Narayanaswamy Venketasubramanian, Hock Luen Teoh, Vijay Kumar Sharma and Christopher Li-Hsian Chen
    Citation: BMC Neurology 2016 16:46
    Content type: Research article Published on:

  38. Mutant rodent models have highlighted the importance of the ventricular ependymal cells and the subcommissural organ (a brain gland secreting glycoproteins into the cerebrospinal fluid) in the development of f...

    Authors: Eduardo Ortega, Rosa I. Muñoz, Nelly Luza, Francisco Guerra, Monserrat Guerra, Karin Vio, Roberto Henzi, Jaime Jaque, Sara Rodriguez, James P. McAllister and Esteban Rodriguez
    Citation: BMC Neurology 2016 16:45
    Content type: Case report Published on:

  39. Authors: Diego Santos-García, Pablo Mir, Esther Cubo, Lydia Vela, Mari Cruz Rodríguez-Oroz, Maria José Martí, José Matías Arbelo, Jon Infante, Jaime Kulisevsky and Pablo Martínez-Martín
    Citation: BMC Neurology 2016 16:44
    Content type: Erratum Published on:

    The original article was published in BMC Neurology 2016 16:26

  40. The noble gas xenon is considered as a neuroprotective agent, but availability of the gas is limited. Studies on neuroprotection with the abundant noble gases helium and argon demonstrated mixed results, and d...

    Authors: Patrick Zuercher, Dirk Springe, Denis Grandgirard, Stephen L. Leib, Marius Grossholz, Stephan Jakob, Jukka Takala and Matthias Haenggi
    Citation: BMC Neurology 2016 16:43
    Content type: Research article Published on:

  41. Sitting ability and function are commonly impaired after stroke. Balance training has been shown to be helpful, but abundant repetitions are required for optimal recovery and patients must be motivated to perf...

    Authors: L. Sheehy, A. Taillon-Hobson, H. Sveistrup, M. Bilodeau, D. Fergusson, D. Levac and H. Finestone
    Citation: BMC Neurology 2016 16:42
    Content type: Study protocol Published on:

  42. Internal carotid artery (ICA) occlusion mainly manifests as ischemia of the anterior circulation. There are very few reports of ICA occlusion manifesting as only ischemia of the posterior circulation related t...

    Authors: Ryo Hiramatsu, Hiroyuki Ohnishi, Shinji Kawabata, Shigeru Miyachi and Toshihiko Kuroiwa
    Citation: BMC Neurology 2016 16:41
    Content type: Case report Published on:

  43. Primary dystonia is a chronic neurological movement disorder that causes abnormal muscle movements. Pain and emotional distress may accompany these physical symptoms. Behavioural interventions are used to help...

    Authors: C. J. Bernstein, D. R. Ellard, G. Davies, E. Hertenstein, N. K. Y. Tang, M. Underwood and H. Sandhu
    Citation: BMC Neurology 2016 16:40
    Content type: Research article Published on:

  44. Collateral pathways are important in maintaining adequate cerebral blood flow in patients with carotid stenosis. We aimed to evaluate the hemodynamic patterns in relation to carotid stenosis in acute stroke pa...

    Authors: Hui Fang, Bo Song, Bo Cheng, Ka Sing Wong, Yu Ming Xu, Stella Sin Yee Ho and Xiang Yan Chen
    Citation: BMC Neurology 2016 16:39
    Content type: Research article Published on:

  45. Tinnitus is a result of hyper-activity/hyper-synchrony of auditory neurons coding the tinnitus frequency, which has developed due to synchronous mass activity owing to the lack of inhibition. We assume that re...

    Authors: Alwina Stein, Robert Wunderlich, Pia Lau, Alva Engell, Andreas Wollbrink, Alex Shaykevich, Jörg-Tobias Kuhn, Heinz Holling, Claudia Rudack and Christo Pantev
    Citation: BMC Neurology 2016 16:38
    Content type: Research article Published on:

  46. Morvan syndrome is a rare disorder characterized by the combination of peripheral nerve hyperexcitability, encephalopathy and dysautonomia with marked insomnia. It was reported to have association to antibodie...

    Authors: Li Zhang, Qiang Lu, Hong-Zhi Guan, Jun-Hua Mei, Hai-Tao Ren, Ming-Sheng Liu, Bin Peng and Li-Ying Cui
    Citation: BMC Neurology 2016 16:37
    Content type: Case report Published on:

  47. Total cholesterol is a well-documented risk factor for coronary disease. Previous studies have shown that high total cholesterol level is associated with better stroke outcomes, but the association of low tota...

    Authors: Wenjuan Zhao, Zhongping An, Yan Hong, Guanen Zhou, Jingjing Guo, Yongli Zhang, Yuanju Yang, Xianjia Ning and Jinghua Wang
    Citation: BMC Neurology 2016 16:36
    Content type: Research article Published on:

  48. In addition to its role in cell adhesion and gene expression in the canonical Wingless/integrated Wnt signaling pathway, β-catenin also regulates genes that underlie the transmission of nerve impulses. Mutatio...

    Authors: Anna Winczewska-Wiktor, Magdalena Badura-Stronka, Anna Monies-Nowicka, Michal Maciej Nowicki, Barbara Steinborn, Anna Latos-Bieleńska and Dorota Monies
    Citation: BMC Neurology 2016 16:35
    Content type: Case report Published on:

  49. Alemtuzumab (Lemtrada®) is a newly approved therapeutic agent for relapsing-remitting multiple sclerosis (RRMS). In previous phase II and III clinical trials, alemtuzumab has proven superior efficacy to subcut...

    Authors: Tobias Ruck, Ali Maisam Afzali, Karl-Friedrich Lukat, Maria Eveslage, Catharina C. Gross, Steffen Pfeuffer, Stefan Bittner, Luisa Klotz, Nico Melzer, Heinz Wiendl and Sven G. Meuth
    Citation: BMC Neurology 2016 16:34
    Content type: Study protocol Published on:
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BMC Neurology

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