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  1. Content type: Case report

    DNA methyltransferase 1 (EC 2.1.1.37), encoded by DNMT1 gene, is one of key enzymes in maintaining DNA methylation patterns of the human genome. It plays a crucial role in embryonic development, imprinting and...

    Authors: Wenxia Zheng, Zhenxing Yan, Rongni He, Yaowei Huang, Aiqun Lin, Wei Huang, Yuying Su, Shaoyuan Li, Victor Wei Zhang and Huifang Xie

    Citation: BMC Neurology 2018 18:174

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  2. Content type: Case report

    Progressive encephalomyelitis with rigidity and myoclonus (PERM) syndrome is a rare neurological condition. Its clinical characteristics include axial and limb muscle rigidity, myoclonus, painful spasms and hy...

    Authors: Aurélie Degeneffe, Marie Dagonnier, Alain D’hondt and Jose Antonio Elosegi

    Citation: BMC Neurology 2018 18:173

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  3. Content type: Research article

    Headache management is common within chiropractic clinical settings; however, little is yet known about how this provider group manage headache sufferers. The aim of this study is to report on the prevalence o...

    Authors: Craig Moore, Andrew Leaver, David Sibbritt and Jon Adams

    Citation: BMC Neurology 2018 18:171

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  4. Content type: Research article

    The validation of international cognitive batteries in different multiple sclerosis (MS) populations is essential. Our objective was to obtain normative data for the Portuguese population of the Brief Internat...

    Authors: Cláudia Sousa, Mariana Rigueiro-Neves, Telma Miranda, Paulo Alegria, José Vale, Ana Margarida Passos, Dawn Langdon and Maria José Sá

    Citation: BMC Neurology 2018 18:172

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  5. Content type: Research article

    Migraine and Attention Deficit and Hyperactivity Disorder (ADHD) have been found to be associated in child and adolescent cohorts; however, the association has not been assessed in adults or otherwise healthy ...

    Authors: Thomas Folkmann Hansen, Louise K. Hoeffding, Lisette Kogelman, Thilde Marie Haspang, Henrik Ullum, Erik Sørensen, Christian Erikstrup, Ole Birger Pedersen, Kaspar René Nielsen, Henrik Hjalgrim, Helene M. Paarup, Thomas Werge and Kristoffer Burgdorf

    Citation: BMC Neurology 2018 18:147

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  6. Content type: Research article

    About 30% of stroke patients suffer from aphasia. As aphasia strongly affects daily life, most patients request a prediction of outcome of their language function. Prognostic models provide predictions of outc...

    Authors: Femke Nouwens, Evy G. Visch-Brink, Hanane El Hachioui, Hester F. Lingsma, Mieke W. M. E. van de Sandt-Koenderman, Diederik W. J. Dippel, Peter J. Koudstaal and Lonneke M. L. de Lau

    Citation: BMC Neurology 2018 18:170

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  7. Content type: Research article

    Currently, it is challenging to detect the awareness of patients who suffer disorders of consciousness (DOC). Brain-computer interfaces (BCIs), which do not depend on the behavioral response of patients, may s...

    Authors: Qiuyou Xie, Jiahui Pan, Yan Chen, Yanbin He, Xiaoxiao Ni, Jiechun Zhang, Fei Wang, Yuanqing Li and Ronghao Yu

    Citation: BMC Neurology 2018 18:144

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  8. Content type: Case report

    Besides CSF-flow obstruction, syringomyelia is associated with inflammatory spinal cord lesions. However, syringomyelia-like syndrome concomitant with neuromyelitis optica spectrum disorder (NMOSD) and primary...

    Authors: Xiangling Li, Zhengqi Lu and Yanqiang Wang

    Citation: BMC Neurology 2018 18:168

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  9. Content type: Research article

    Recent studies have shown conflicting results regarding the effect of hydrogel coils for treating intracranial aneurysm compared to bare platinum coils. We implemented a meta-analysis to assess the value of hy...

    Authors: Tao Xue, Zhouqing Chen, Weiwei Lin, Jiayi Xu, Xuming Shen and Zhong Wang

    Citation: BMC Neurology 2018 18:167

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  10. Content type: Case report

    Herpes zoster ophthalmicus (HZO) is an inflammation related to reactivation of the latent varicella zoster virus (VZV), involving the ophthalmic branch of the trigeminal nerve. Optic neuritis (ON), a rare ocul...

    Authors: Kavin Vanikieti, Anuchit Poonyathalang, Panitha Jindahra, Piyaphon Cheecharoen, Patchalin Patputtipong and Tanyatuth Padungkiatsagul

    Citation: BMC Neurology 2018 18:165

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  11. Content type: Research article

    We systematically reviewed the comparative effectiveness of injectable beta-interferons (IFN-β) and glatiramer acetate (GA) on annualised relapse rate (ARR), progression and discontinuation due to adverse even...

    Authors: G. J. Melendez-Torres, Xavier Armoiry, Rachel Court, Jacoby Patterson, Alan Kan, Peter Auguste, Jason Madan, Carl Counsell, Olga Ciccarelli and Aileen Clarke

    Citation: BMC Neurology 2018 18:162

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  12. Content type: Research article

    Neurodegenerative processes in the elderly damage the brain, leading to progressive, incapacitating cognitive, behavioral, and motor dysfunctions which culminate in dementia. Fully manifest dementia is likely ...

    Authors: Lorenzo Pasquini, Jorge Llibre Guerra, Martin Prince, Kia-Chong Chua and A. Matthew Prina

    Citation: BMC Neurology 2018 18:163

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  13. Content type: Research article

    Studying the impact of demographic changes and progress in the management of stroke patients is necessary in order to organize care structures for the coming years. Consequently, we analyzed the prognostic tre...

    Authors: Emilio Rodríguez-Castro, Iria López-Dequit, María Santamaría-Cadavid, Susana Arias-Rivas, Manuel Rodríguez-Yáñez, José Manuel Pumar, Pablo Hervella, Esteban López-Arias, Andrés da Silva-Candal, Ana Estany, María Piñeiro-Lamas, Tomás Sobrino, Francisco Campos, Manuel Portela, Manuel Vázquez-Lima, José Castillo…

    Citation: BMC Neurology 2018 18:164

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  14. Content type: Case report

    Crohn’s disease (CD) is associated with a variety of extra-intestinal manifestations. Most commonly these involve the eye, skin, joints, coagulation system and liver. Cerebral manifestations of CD have been re...

    Authors: Konrad Whittaker, Konstanze Guggenberger, Nils Venhoff, Soroush Doostkam, Hans-Eckart Schaefer and Brita Fritsch

    Citation: BMC Neurology 2018 18:161

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  15. Content type: Case report

    Catheter-related blood stream infection (CRBSI) is one of the most common intractable healthcare-associated infections because catheters can be easily contaminated by resistant bacteria, and is associated with...

    Authors: Nobuhiko Arai, Yutaka Mine, Hiroshi Kagami and Makoto Inaba

    Citation: BMC Neurology 2018 18:158

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  16. Content type: Case report

    Cerebral venous sinus thrombosis or stenosis (here collectively referred to as cerebral venous sinus occlusion, CVSO) can cause chronically-elevated intracranial pressure (ICP). Patients may have no neurologic...

    Authors: Tongtao Zhao, Gang Wang, Jiaman Dai, Yong Liu, Yi Wang and Shiying Li

    Citation: BMC Neurology 2018 18:159

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  17. Content type: Research article

    To investigate visual recovery after treatment of acute optic neuritis (ON) with either oral or intravenous high-dose methylprednisolone, in order to establish the best route of administration.

    Authors: Magdalena Naumovska, Rafi Sheikh, Boel Bengtsson, Malin Malmsjö and Björn Hammar

    Citation: BMC Neurology 2018 18:160

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  18. Content type: Case report

    The computed tomography (CT) finding of a pseudo-subarachnoid hemorrhage (SAH) may lead the treating physician into a diagnostic dilemma. We present a case of a pseudo-SAH in a patient with post-resuscitative ...

    Authors: Mohamad Syafeeq Faeez Md Noh and Anna Misyail Abdul Rashid

    Citation: BMC Neurology 2018 18:157

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  19. Content type: Research article

    Though genetic and environmental determinants of systemic haemodynamic have been reported, surprisingly little is known about their influences on cerebral haemodynamics. We assessed the potential geographical ...

    Authors: Angela S. M. Salinet, Ronney B. Panerai, Juliana Caldas, Ricardo C. Nogueira, Adriana B. Conforto, Manoel J. Texeira, Edson Bor-Seng-Shu and Thompson G. Robinson

    Citation: BMC Neurology 2018 18:156

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  20. Content type: Research article

    Peripheral diagnostics for Alzheimer’s disease (AD) continue to be developed. Diagnostics capable of detecting AD before the onset of symptoms are particularly desirable, and, given the fact that early detecti...

    Authors: Marwan N Sabbagh, Jiong Shi, Moonhee Lee, Lisa Arnold, Yazan Al-Hasan, Jennifer Heim and Patrick McGeer

    Citation: BMC Neurology 2018 18:155

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  21. Content type: Case report

    Autosomal recessive Myotonia congenita (Becker’s disease) is caused by mutations in the CLCN1 gene. The condition is characterized by muscle stiffness during sustained muscle contraction and variable degree of mu...

    Authors: Jing Miao, Xiao-jing Wei, Xue-mei Liu, Zhi-xia Kang, Yan-lu Gao and Xue-fan Yu

    Citation: BMC Neurology 2018 18:154

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  22. Content type: Research article

    Strategies are needed to improve adherence to the blood pressure (BP) and low-density lipoprotein cholesterol (LDL-C) level recommendations after stroke and transient ischemic attack (TIA). We investigated whe...

    Authors: Joachim Ögren, Anna-Lotta Irewall, Lars Söderström and Thomas Mooe

    Citation: BMC Neurology 2018 18:153

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  23. Content type: Research article

    The evaluation of children with cerebral palsy (CP) focuses on activity level measurement to examine the effect of health-care interventions on their physical functioning in the home, school, and community set...

    Authors: Soojung Chae, Eun-Young Park and Yoo-Im Choi

    Citation: BMC Neurology 2018 18:151

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  24. Content type: Case report

    Noonan syndrome-like disorder with loose anagen hair-2 (NSLH2) is an extremely rare disease caused by a heterozygous mutation in the PPP1CB gene on chromosome 2p23. The syndrome causes not only numerous dysmor...

    Authors: Chien-Heng Lin, Wei-De Lin, I-Ching Chou, Inn-Chi Lee, Hueng-Chuen Fan and Syuan-Yu Hong

    Citation: BMC Neurology 2018 18:150

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  25. Content type: Case report

    Only five patients have previously been reported to harbor mutations in the MT-TT gene encoding mitochondrial tRNA threonine. The m.15923A > G mutation has been found in three severely affected children. One of t...

    Authors: Mikko Kärppä, Laura Kytövuori, Markku Saari and Kari Majamaa

    Citation: BMC Neurology 2018 18:149

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  26. Content type: Research article

    Autonomic nervous system dysfunction, common in patients with Parkinson’s disease (PD), causes significant morbidity and it is correlated with poor quality of life. To assess frequency of urinary symptoms in p...

    Authors: Francesca Valentino, Tommaso Vincenzo Bartolotta, Giuseppe Cosentino, Sergio Mastrilli, Valentina Arnao, Paolo Aridon, Salvatore Scurria, Alice Pavone, Carlo Pavone and Marco D’Amelio

    Citation: BMC Neurology 2018 18:148

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  27. Content type: Research article

    Due to brain plasticity a transection of a median or ulnar nerve results in profound changes in the somatosensory areas in the brain. The permanent sensory deprivation after a peripheral nerve injury might inf...

    Authors: Pernilla Vikström, Anders Björkman, Ingela K. Carlsson, Anna-Karin Olsson and Birgitta Rosén

    Citation: BMC Neurology 2018 18:146

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  28. Content type: Case report

    The cardinal symptoms of auto-immune myasthenia gravis are fatigue and weakness. Endurance events such as marathon running would seem incompatible with this chronic disease. Many patients stop sport altogether...

    Authors: Simone Birnbaum, Tarek Sharshar, Bruno Eymard, Marie Theaudin, Pierre Portero and Jean-Yves Hogrel

    Citation: BMC Neurology 2018 18:145

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  29. Content type: Research article

    Patients with ischemic cerebrovascular diseases are more likely to suffer from intracranial aneurysms, and their surgical treatment has a growing controversy in this condition. The current case series was aime...

    Authors: Yangrui Zheng and Chen Wu

    Citation: BMC Neurology 2018 18:142

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  30. Content type: Research article

    In the PRISMS study, interferon beta-1a subcutaneously (IFN β-1a SC) reduced clinical and radiological disease burden at 2 years in patients with relapsing–remitting multiple sclerosis. The study aimed to char...

    Authors: Anthony Traboulsee, David K. B. Li, Mark Cascione, Juanzhi Fang, Fernando Dangond and Aaron Miller

    Citation: BMC Neurology 2018 18:143

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  31. Content type: Research article

    Various outcome measures are used for the assessment of balance and mobility in patients with stroke. The purpose of the present study was to examine test-retest reliability, construct validity, and responsive...

    Authors: Ahmad H. Alghadir, Einas S. Al-Eisa, Shahnawaz Anwer and Bibhuti Sarkar

    Citation: BMC Neurology 2018 18:141

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  32. Content type: Research article

    It is essential to investigate cognitive deficits in multiple sclerosis (MS) to develop evidence-based cognitive rehabilitation strategies. Here we refined cognitive decline assessment using the automated test...

    Authors: Hideraldo Luis Souza Cabeça, Luciano Chaves Rocha, Amanda Ferreira Sabbá, Alessandra Mendonça Tomás, Natali Valim Oliver Bento-Torres, Daniel Clive Anthony and Cristovam Wanderley Picanço Diniz

    Citation: BMC Neurology 2018 18:140

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  33. Content type: Case report

    Rheumatoid meningitis presenting with a stroke-like attack (RMSA) is a rare manifestation of rheumatoid arthritis (RA). When the patients arrive within the time-window for recombinant tissue plasminogen activa...

    Authors: Masashi Akamatsu, Futaba Maki, Hisanao Akiyama, Daisuke Hara, Masashi Hoshino and Yasuhiro Hasegawa

    Citation: BMC Neurology 2018 18:139

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  34. Content type: Research article

    Early mobilization has been an important part of acute stroke unit treatment. However, early and intense mobilization within the first 24 h post stroke may cause an unfavorable outcome. Recently, objective mea...

    Authors: Ole Petter Norvang, Anne Hokstad, Kristin Taraldsen, Xiangchun Tan, Stian Lydersen, Bent Indredavik and Torunn Askim

    Citation: BMC Neurology 2018 18:138

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  35. Content type: Research article

    Recently, minimal invasive surgery (MIS) has been applied as a common therapeutic approach for treatment of hypertensive intracerebral hemorrhage (HICH). However, the efficacy and safety of MIS is still contro...

    Authors: Yiping Tang, Fengqiong Yin, Dengli Fu, Xinhai Gao, Zhengchao Lv and Xuetao Li

    Citation: BMC Neurology 2018 18:136

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  36. Content type: Case report

    Ocular neuromyotonia (ONM) is characterized by episodic diplopia, which is usually triggered by prolonged eccentric gaze of the affected extraocular muscles. The spell is characterized by involuntary, occasion...

    Authors: Tanyatuth Padungkiatsagul, Panitha Jindahra, Anuchit Poonyathalang, Narong Samipak and Kavin Vanikieti

    Citation: BMC Neurology 2018 18:137

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  37. Content type: Research article

    Little is known of how accurately a first-time seizure witness can provide reliable details of a semiology. Our goal was to determine how accurately first-time seizure witnesses could identify key elements of ...

    Authors: Taim A. Muayqil, Mohammed H. Alanazy, Hassan M. Almalak, Hussain Khaled Alsalman, Faroq Walid Abdulfattah, Abdullah Ibrahim Aldraihem, Fawaz Al-hussain and Bandar N. Aljafen

    Citation: BMC Neurology 2018 18:135

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  38. Content type: Research article

    Down syndrome (DS) is a common developmental disorder resulting from the presence of an additional copy of chromosome 21. Abnormalities in dopamine signaling are suggested to be involved in cognitive dysfuncti...

    Authors: Thanh Thi Mai Pham, Hiroki Kato, Haruyoshi Yamaza, Keiji Masuda, Yuta Hirofuji, Hiroshi Sato, Huong Thi Nguyen Nguyen, Xu Han, Yu Zhang, Tomoaki Taguchi and Kazuaki Nonaka

    Citation: BMC Neurology 2018 18:132

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  39. Content type: Research article

    Glioma metastasis, invasion, epithelial-mesenchymal transition (EMT) and chemoresistance indicate poor prognosis. Accumulating evidence reveals that Notch1 is an important factor in tumour progression. However...

    Authors: Jianlong Li, Qingbin Li, Lin Lin, Rui Wang, Lingchao Chen, Wenzhong Du, Chuanlu Jiang and Ruiyan Li

    Citation: BMC Neurology 2018 18:133

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  40. Content type: Research article

    There is evidence that uric acid may have antioxidant and neuroprotective effects and might therefore alter the risk for neurodegenerative diseases such as dementia. So far, the relation between serum uric aci...

    Authors: Bettina Engel, Willy Gomm, Karl Broich, Wolfgang Maier, Klaus Weckbecker and Britta Haenisch

    Citation: BMC Neurology 2018 18:131

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  41. Content type: Case report

    Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is characterized clinically by central nervous system dysfunctions. It is unclear whether CADASIL is involve...

    Authors: Yusuke Sakiyama, Eiji Matsuura, Yoshimitsu Maki, Akiko Yoshimura, Masahiro Ando, Miwa Nomura, Kazuya Shinohara, Ryuji Saigo, Tomonori Nakamura, Akihiro Hashiguchi and Hiroshi Takashima

    Citation: BMC Neurology 2018 18:134

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  42. Content type: Research article

    Our aim was to compare the perioperative time courses of matrix metalloproteinase-9 (MMP-9) and its inhibitor (TIMP-1) in during carotid endarterectomy (CEA) and carotid artery stenting (CAS).

    Authors: Ákos Mérei, Bálint Nagy, Gábor Woth, János Lantos, Ferenc Kövér, Lajos Bogár and Diána Mühl

    Citation: BMC Neurology 2018 18:128

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  43. Content type: Research article

    The SPAN-100 index adds patient age and baseline NIHSS-score and was introduced to predict clinical outcome after acute ischemic stroke (AIS). Even with high NIHSS-scores younger patients cannot reach a SPAN-1...

    Authors: Cornelia Möbius, Christian Blinzler, Stefan Schwab, Martin Köhrmann and Lorenz Breuer

    Citation: BMC Neurology 2018 18:129

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  44. Content type: Research article

    Cardiac autonomic neuropathy (CAN) in diabetes is among the strongest risk markers for future global and cardiovascular mortality. The aim of this study was to analyse CAN prevalence and to compare the associatio...

    Authors: Anca Moţăţăianu, Smaranda Maier, Zoltan Bajko, Septimiu Voidazan, Rodica Bălaşa and Adina Stoian

    Citation: BMC Neurology 2018 18:126

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  45. Content type: Research article

    Critical care covers multiple disciplines. However, the causes of critical illness in the ICU, particularly the most common causes, remain unclear. We aimed to investigate the incidence and the most common cau...

    Authors: Ye-Ting Zhou, Dao-Ming Tong, Shao-Dan Wang, Song Ye, Ben-Wen Xu and Chen-Xi Yang

    Citation: BMC Neurology 2018 18:127

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  46. Content type: Research article

    Neurogenic orthostatic hypotension (nOH) results from impaired vasoconstriction due to dysfunction of the autonomic nervous system and is commonly associated with Parkinson disease (PD), multiple system atroph...

    Authors: Daniel O. Claassen, Charles H. Adler, L. Arthur Hewitt and Christopher Gibbons

    Citation: BMC Neurology 2018 18:125

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