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  1. Quality of life (QoL) in patients with Parkinson’s disease (PD) is increasingly used as an efficacy outcome in clinical studies of PD to evaluate the impact of treatment from the patient’s perspective. Studies...

    Authors: Tao Li, Shuang Zou, Zijuan Zhang, Meiruo Liu and Zhanhua Liang
    Citation: BMC Neurology 2022 22:320
  2. Excessive daytime sleepiness (EDS) is a cardinal symptom of narcolepsy and affects many patients with obstructive sleep apnoea (OSA). EDS is associated with reduced quality of life, increased accident risk, an...

    Authors: M. Janelle Cambron-Mellott, Sam Mettam, Vicky W. Li, John C. Rowland and JeanPierre Coaquira Castro
    Citation: BMC Neurology 2022 22:317
  3. Sinus pericranii is a rare cranial venous malformation resulting in a subcutaneous mass due to abnormal communication between intracranial and subperiosteal/interperiosteal veins. To date, to the best of our k...

    Authors: Shuhei Fujino, Mikako Enokizono, Satoshi Ihara, Tatsuo Kono and Sahoko Miyama
    Citation: BMC Neurology 2022 22:316
  4. Platelets play an important role in homeostasis however, they have also been associated with increased mortality after myocardial infarction. In the present study, we investigated whether platelet count is ass...

    Authors: Kazo Kanazawa, Nobukazu Miyamoto, Kenichiro Hira, Chikage Kijima, Yuji Ueno and Nobutaka Hattori
    Citation: BMC Neurology 2022 22:314
  5. Serum antibodies to myelin-oligodendrocyte glycoprotein (MOG) are biomarkers of MOG-IgG-associated disorder (MOGAD), a demyelinating disease distinct from both multiple sclerosis and aquaporin-4-IgG neuromyeli...

    Authors: Jan Kolcava, Aneta Rajdova, Eva Vlckova, Pavel Stourac and Josef Bednarik
    Citation: BMC Neurology 2022 22:313
  6. Impaired vision is one of the commonest and most disabling consequence following stroke. Among all visual impairments, eye movement disorders are found in 70% of stroke patients which include nystagmus, strabi...

    Authors: Sana Batool, Hamayun Zafar, Syed Amir Gilani, Ashfaq Ahmad and Asif Hanif
    Citation: BMC Neurology 2022 22:312
  7. As currently defined, recent small subcortical infarcts (RSSI) do not have a lower size boundary, and the smallest diffusion-weighted imaging (DWI) infarcts, which we term acute subcortical cerebral microinfar...

    Authors: Wendan Tao, Yajun Cheng, Wen Guo, William Robert Kwapong, Chen Ye, Bo Wu, Shuting Zhang and Ming Liu
    Citation: BMC Neurology 2022 22:311
  8. Childhood epilepsy causes a tremendous burden for the child, the family, society as well as the healthcare system. Adherence to anti-seizure medications (ASMs) is a key to treatment success. Poor adherence has...

    Authors: Hawi Mohammed, Kemal Lemnuro, Teferi Mekonnen and Tsegaye Melaku
    Citation: BMC Neurology 2022 22:310
  9. To prevent the spread of the novel coronavirus disease 2019 (COVID-19) infection, various vaccines have been developed and used in a large number of people worldwide. One of the most commonly used vaccines is ...

    Authors: Kentaro Nanatsue, Makoto Takahashi, Sakiko Itaya, Keisuke Abe and Akira Inaba
    Citation: BMC Neurology 2022 22:309
  10. Upper limb motor dysfunction is a common sequela of stroke, and its clinical efficacy needs to be improved. This protocol describes a trial to verify the clinical efficacy of robot-assisted virtual reality mir...

    Authors: Dong Wei, Xu-Yun Hua, Mou-Xiong Zheng, Jia-Jia Wu and Jian-Guang Xu
    Citation: BMC Neurology 2022 22:307
  11. Fingolimod is associated with an increased risk of developing progressive multifocal leukoencephalopathy (PML); however, its discontinuation may cause severe immune reconstitution inflammatory syndrome (IRIS)....

    Authors: D. Mickeviciene, A. Baltusiene, B. Afanasjeva, D. Afanasjevas, R. Gleizniene, D. Rastenyte and JR. Berger
    Citation: BMC Neurology 2022 22:306
  12. As one of the leading causes of morbidity and mortality, stroke and its recurrence has attracted more and more attention. Dl-3-n-butylphthalidle(NBP) has been widely used for treating acute ischemic stroke in ...

    Authors: Junchao Lv, Di Zhao, Gang Zhao and Zhen Xie
    Citation: BMC Neurology 2022 22:305
  13. Neuropathic pain is a common complication in neuromyelitis optica spectrum disorder (NMOSD), which seriously affects the quality of life of NMOSD patients, with no satisfactory treatment. And risk factors of n...

    Authors: Xiaojun Li, Haoyou Xu, Zequan Zheng, Huiying Ouyang, Guixian Chen, Zhenzhen Lou, Haoxuan Chen, Jiahui Zhang, Yibo Zhan, Hui Mao, Changlin Zhang, Min Zhao and Yuanqi Zhao
    Citation: BMC Neurology 2022 22:304
  14. Polymicrogyria refers to the disruption of normal cerebral cortical development late in neuronal migration or in early cortical organization. Although patients with polymicrogyria feature relatively favorable ...

    Authors: Choong-Hee Roh, Da-Sol Kim, Gi-Wook Kim, Yu Hui Won, Myoung-Hwan Ko, Jeoung-Hwan Seo and Sung-Hee Park
    Citation: BMC Neurology 2022 22:303
  15. Tumor necrosis factor receptor-associated factor 6 (TRAF6) can regulate the activation of inflammatory signaling pathways by acting as an E3 ubiquitin ligase, which enhances B cell activation. This study aimed...

    Authors: Ting Li, Yue Li, Jia-Wen Li, Ying-Hui Qin, Hui Zhai, Bin Feng, He Li, Ning-Nannan Zhang and Chun-Sheng Yang
    Citation: BMC Neurology 2022 22:302
  16. Secondary progressive multiple sclerosis (SPMS) is a subtype of multiple sclerosis (MS), which is a chronic neurological disease, characterised by inflammation of the central nervous system. Most of MS patient...

    Authors: Vijayalakshmi Vasanthaprasad, Vivek Khurana, Sreelatha Vadapalle, Jackie Palace and Nicholas Adlard
    Citation: BMC Neurology 2022 22:301
  17. Aminoacyl tRNA-synthetases are ubiquitously-expressed enzymes that attach amino acids to their cognate tRNA molecules. Mutations in several genes encoding aminoacyl tRNA-synthetases, have been associated with ...

    Authors: Helle Høyer, Øyvind L. Busk, Q. Ying. Esbensen, Oddveig Røsby, Hilde T. Hilmarsen, Michael B. Russell, Tuula A. Nyman, Geir J. Braathen and Hilde L. Nilsen
    Citation: BMC Neurology 2022 22:299
  18. N-methyl-D-aspartate receptor (NMDAR) is an ionotropic glutamate (Glu) receptor that is widely expressed in the central nervous system (CNS), mainly in the hippocampus. We present a case in which the patient h...

    Authors: Xiaoling Li, Mengjiao Sun, Wei Liu, Ning Liu, Boyao Yuan and Xiaolu Su
    Citation: BMC Neurology 2022 22:298
  19. Homocysteine is correlated with several imaging features of cerebral small vessel disease including white matter hyperintensities, lacunes, and enlarged perivascular spaces (EPVS) in the basal ganglia. However...

    Authors: Yunting Fu, Wenwei Yun, Zhixiang Zhang, Yi Ma, Lulu Xiao, Min Zhang and Wusheng Zhu
    Citation: BMC Neurology 2022 22:296
  20. Trigeminal neuropathy is characterized by numbness in the region innervated by the trigeminal nerves, with or without neuropathic weakness in the muscles of mastication. Trigeminal neuritis is a form of trigem...

    Authors: Hyunsoo Kim, Kyung Wook Kang, Jae-Myung Kim and Man-Seok Park
    Citation: BMC Neurology 2022 22:294
  21. Chronic Inflammatory Demyelinating Polyradiculoneuropathy (CIDP), a rare disorder affecting young adults, causes gradual weakness of the limbs, areflexia and impaired sensory function. New CIDP phenotypes with...

    Authors: O. Moranne, IM. Ion, R. Cezar, Z. Messikh, C. Prelipcean, S. Chkair, E. Thouvenot, Tu Anh Tran, P. Corbeau and T. Chevallier
    Citation: BMC Neurology 2022 22:293
  22. Congenital myasthenic syndromes (CMSs) are rare genetic diseases due to abnormalities of the neuromuscular junction leading to permanent or transient muscle fatigability and weakness. To date, 32 genes were fo...

    Authors: Youssef El Kadiri, Ilham Ratbi, Abdelaziz Sefiani and Jaber Lyahyai
    Citation: BMC Neurology 2022 22:292
  23. Early detection of acute ischemic stroke (AIS) may provide patients with benefits against harmful health and financial impacts. The use of non-contrast computed tomography images for early detect of the infarc...

    Authors: Jianping Yu, Zhi Zhang, Qingping Xue, Tao He, Chun Luo, Kaimin Zhuo, Qian Yang, Tianzhu Xu, Jing Zhang and Fan Xu
    Citation: BMC Neurology 2022 22:291
  24. Even with high standards of acute care and neurological early rehabilitation (NER) a substantial number of patients with neurological conditions still need mechanical ventilation and/or airway protection by tr...

    Authors: Thomas Platz, Thomas Kohlmann, Steffen Fleßa, Bernadette Einhäupl, Martha Koppelow, Lina Willacker, Hans-Jürgen Gdynia, Esther Henning, Jürgen Herzog, Friedemann Müller, Dennis A. Nowak, Romy Pletz, Felix Schlachetzki, Tobias Schmidt-Wilcke, Michael Schüttler, Andreas Straube…
    Citation: BMC Neurology 2022 22:290
  25. Patients with a transient ischemic attack (TIA) or ischemic stroke are at increased risk of developing cognitive impairment in the subacute phase. At present, the effects of exercise on cognitive functioning f...

    Authors: Inger A. Deijle, Roelofjan Hemmes, H. Myrthe Boss, Edwin C. de Melker, Bob T. J. van den Berg, Gert Kwakkel, Erwin van Wegen, Wendy M. Bosboom, Henry C. Weinstein, Sander M. van Schaik and Renske M. Van den Berg-Vos
    Citation: BMC Neurology 2022 22:289
  26. The objective of this report is to share the clinicopathological features of chemotherapy-induced toxic leukoencephalopathy, which is a rare and under-recognized disease, clinically characterized by rapidly pr...

    Authors: Ka Young Lim, Seong-Ik Kim, Hyunhee Kim, Jeongwan Kang, Jin Woo Park, Jae Kyung Won, Dong-Yeop Shin and Sung-Hye Park
    Citation: BMC Neurology 2022 22:288
  27. Traumatic acute subdural haematoma is a debilitating condition. Laterality intuitively influences management and outcome. However, in contrast to stroke, this research area is rarely studied. The aim is to inv...

    Authors: V. D. N. Hoogslag, T. A. van Essen, M. D. Dijkman, W. Moudrous, G. G. Schoonman and W. C. Peul
    Citation: BMC Neurology 2022 22:287
  28. Liver abscess is a common emergency in the emergency department. However, cerebral venous sinus thrombosis (CVST) is a rare and serious cerebrovascular disease. Cases of CVST in patients with Klebsiella pneumonia...

    Authors: Lingyu Zhou, Chao Wang, Jialan Bian, Siyuan Xu, Minjie Yang and Mingquan Chen
    Citation: BMC Neurology 2022 22:286
  29. Cognitive complaints are common in patients recovering from Coronavirus Disease 2019 (COVID-19), yet their etiology is often unclear. We assess factors that contribute to cognitive impairment in ambulatory ver...

    Authors: Karen Blackmon, Gregory S. Day, Harry Ross Powers, Wendelyn Bosch, Divya Prabhakaran, Dixie Woolston and Otto Pedraza
    Citation: BMC Neurology 2022 22:285
  30. Evaluation of the current physical therapy practice for German stroke rehabilitation with respect to the ‘Rehabilitation of Mobility after Stroke (ReMoS)’ guideline recommendations and the associated implement...

    Authors: Bettina Scheffler, Florian Schimböck, Almut Schöler, Katrin Rösner, Jacob Spallek and Christian Kopkow
    Citation: BMC Neurology 2022 22:284
  31. Lymphoplasmacyte-rich meningioma (LPRM) is a rare form of meningioma characterized by prominent lymphoplasmacytic infiltrates into the tumor. Report of flat growth of LPRM mimicking pachymeningitis is rare in ...

    Authors: Yue Zhang, Xiang Zhang, Abhijeet Kumar Bhekharee, Zunguo Du and Shuguang Chu
    Citation: BMC Neurology 2022 22:283
  32. The widespread use of brain magnetic resonance imaging (MRI) has revealed the correlation between enlarged perivascular spaces (EPVS) and cognitive impairment (CI). However, few studies have examined the corre...

    Authors: Yu Tu, Wenyan Zhuo, Jiewei Peng, Rong Huang, Baizhu Li, Yuqi Liu, Chengtao Zhang, Xiuli Zeng and Li’an Huang
    Citation: BMC Neurology 2022 22:282
  33. Anti-leucine-rich glioma-inactivated 1 (LGI1) encephalitis, an autoimmune disorder, is characterized by faciobrachial dystonic seizures, epilepsy, memory deficits and altered mental status while hiccup is not ...

    Authors: Lan Hou, Li Wan, Hongshan Li, Zhehui Wang, Hongzhi Guan, Haitao Ren and Pei Wang
    Citation: BMC Neurology 2022 22:281
  34. The recanalization rate after intravenous thrombolysis (IVT) is not enough and there is still the possibility of re-occlusion. We aim to investigate the effectiveness and safety of infusing tirofiban after IVT.

    Authors: Zhigang Liang, Junliang Zhang, Shuangfeng Huang, Shaowan Yang, Luyao Xu, Wei Xiang and Manman Zhang
    Citation: BMC Neurology 2022 22:280
  35. While several studies investigated the epidemiology and burden of stroke in the North Africa and Middle East region, no study has comprehensively evaluated the age-standardized attributable burden to all strok...

    Authors: Ataollah Shahbandi, Parnian Shobeiri, Sina Azadnajafabad, Sahar Saeedi Moghaddam, Yeganeh Sharifnejad Tehrani, Narges Ebrahimi, Nazila Rezaei, Mohammad-Mahdi Rashidi, Seyyed-Hadi Ghamari, Mohsen Abbasi-Kangevari, Sogol Koolaji, Rosa Haghshenas, Negar Rezaei, Bagher Larijani and Farshad Farzadfar
    Citation: BMC Neurology 2022 22:279
  36. Migraine is a neurological condition characterized by chronic inflammation. However, not much is known about the potential role of peripheral blood immune cells in the pathophysiology of migraine.

    Authors: Hongtao Li, Qiang Fu, Kamaira Philips, Yufei Sun, Keturah R. Faurot, Susan A. Gaylord and John Douglas Mann
    Citation: BMC Neurology 2022 22:278
  37. While numerous neuroimaging studies have demonstrated that glaucoma is associated with smaller volumes of the visual cortices in the brain, only a few studies have linked glaucoma with brain structures beyond ...

    Authors: Yae Won Ha, Heeseon Jang, Sang-Baek Koh, Young Noh, Seung-Koo Lee, Sang Won Seo, Jaelim Cho and Changsoo Kim
    Citation: BMC Neurology 2022 22:277
  38. Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis is a type of autoimmune encephalitis. The underlying mechanism(s) remain largely unknown. Recent evidence has indicated that the gut microbiome may be in...

    Authors: Jingya Wei, Xiao Zhang, Fang Yang, Xiaodan Shi, Xuan Wang, Rong Chen, Fang Du, Ming Shi and Wen Jiang
    Citation: BMC Neurology 2022 22:276
  39. Care for People with Multiple Sclerosis (PwMS) is increasingly complex, requiring innovations in care. Canada has high rates of MS; it is challenging for general neurologists to optimally care for PwMS with bu...

    Authors: Penelope Smyth, Kaitlyn E. Watson, Yazid N. Al Hamarneh and Ross T. Tsuyuki
    Citation: BMC Neurology 2022 22:275
  40. Our previous study explored Amphotericin B (AMB) plus 5-flucytosine (5-FC) combined with fluconazole (FLU) therapy in the induction period, which seemed to be better than the previous AMB + 5-FC antifungal the...

    Authors: Junyu Liu, Jia Liu, Xiaohong Su, Lu Yang, Yijie Wang, Anni Wang, Xiaofeng Xu, Min Li, Ying Jiang and Fuhua Peng
    Citation: BMC Neurology 2022 22:274
  41. Automated infrared pupillometry (AIP) and the Neurological Pupil index (NPi) provide an objective means of assessing and trending the pupillary light reflex (PLR) across a broad spectrum of neurological diseas...

    Authors: Claudio M. Privitera, Sanjay V. Neerukonda, Venkatesh Aiyagari, Shoji Yokobori, Ava M. Puccio, Nathan J. Schneider, Sonja E. Stutzman and DaiWai M. Olson
    Citation: BMC Neurology 2022 22:273
  42. Circadian rhythm disorders (CRDs) are closely associated with the occurrence and development of various diseases, such as inflammatory and cardiovascular diseases, as well as tumors. The impact of a CRD on bod...

    Authors: Xiaoli Chen, Dongze Li, Yu Jia, Yanmei Liu, Yan Ma, Rui Zeng, Zhi Wan and Lei Ye
    Citation: BMC Neurology 2022 22:272
  43. Early infratentorial and focal spinal cord lesions on magnetic resonance imaging (MRI) are associated with a higher risk of long-term disability in patients with multiple sclerosis (MS). The role of diffuse sp...

    Authors: Michaela Andelova, Karolina Vodehnalova, Jan Krasensky, Eliska Hardubejova, Tereza Hrnciarova, Barbora Srpova, Tomas Uher, Ingrid Menkyova, Dominika Stastna, Lucie Friedova, Jiri Motyl, Jana Lizrova Preiningerova, Eva Kubala Havrdova, Bénédicte Maréchal, Mário João Fartaria, Tobias Kober…
    Citation: BMC Neurology 2022 22:270
  44. Myalgic encephalomyelitis / chronic fatigue syndrome (ME/CFS) is a common, long-term condition characterised by post-exertional malaise, often with fatigue that is not significantly relieved by rest. ME/CFS ha...

    Authors: Andy Devereux-Cooke, Sian Leary, Simon J. McGrath, Emma Northwood, Anna Redshaw, Charles Shepherd, Pippa Stacey, Claire Tripp, Jim Wilson, Margaret Mar, Danielle Boobyer, Sam Bromiley, Sonya Chowdhury, Claire Dransfield, Mohammed Almas, Øyvind Almelid…
    Citation: BMC Neurology 2022 22:269
  45. A small lateral medullary lesion could produce isolated impairment of temperature sensation without concomitant impaired pain sensation. However, only one such case has ever been reported, and there are no rep...

    Authors: Keisuke Hanada, Kayoko Yokoi, Natsuko Kashida, Ryota Shimomura, Daiki Murata and Kazumi Hirayama
    Citation: BMC Neurology 2022 22:268

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