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  1. Content type: Research article

    It is essential to investigate cognitive deficits in multiple sclerosis (MS) to develop evidence-based cognitive rehabilitation strategies. Here we refined cognitive decline assessment using the automated test...

    Authors: Hideraldo Luis Souza Cabeça, Luciano Chaves Rocha, Amanda Ferreira Sabbá, Alessandra Mendonça Tomás, Natali Valim Oliver Bento-Torres, Daniel Clive Anthony and Cristovam Wanderley Picanço Diniz

    Citation: BMC Neurology 2018 18:140

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  2. Content type: Case report

    Rheumatoid meningitis presenting with a stroke-like attack (RMSA) is a rare manifestation of rheumatoid arthritis (RA). When the patients arrive within the time-window for recombinant tissue plasminogen activa...

    Authors: Masashi Akamatsu, Futaba Maki, Hisanao Akiyama, Daisuke Hara, Masashi Hoshino and Yasuhiro Hasegawa

    Citation: BMC Neurology 2018 18:139

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  3. Content type: Research article

    Early mobilization has been an important part of acute stroke unit treatment. However, early and intense mobilization within the first 24 h post stroke may cause an unfavorable outcome. Recently, objective mea...

    Authors: Ole Petter Norvang, Anne Hokstad, Kristin Taraldsen, Xiangchun Tan, Stian Lydersen, Bent Indredavik and Torunn Askim

    Citation: BMC Neurology 2018 18:138

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    The Correction to this article has been published in BMC Neurology 2019 19:8

  4. Content type: Case report

    Ocular neuromyotonia (ONM) is characterized by episodic diplopia, which is usually triggered by prolonged eccentric gaze of the affected extraocular muscles. The spell is characterized by involuntary, occasion...

    Authors: Tanyatuth Padungkiatsagul, Panitha Jindahra, Anuchit Poonyathalang, Narong Samipak and Kavin Vanikieti

    Citation: BMC Neurology 2018 18:137

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  5. Content type: Research article

    Recently, minimal invasive surgery (MIS) has been applied as a common therapeutic approach for treatment of hypertensive intracerebral hemorrhage (HICH). However, the efficacy and safety of MIS is still contro...

    Authors: Yiping Tang, Fengqiong Yin, Dengli Fu, Xinhai Gao, Zhengchao Lv and Xuetao Li

    Citation: BMC Neurology 2018 18:136

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  6. Content type: Research article

    Little is known of how accurately a first-time seizure witness can provide reliable details of a semiology. Our goal was to determine how accurately first-time seizure witnesses could identify key elements of ...

    Authors: Taim A. Muayqil, Mohammed H. Alanazy, Hassan M. Almalak, Hussain Khaled Alsalman, Faroq Walid Abdulfattah, Abdullah Ibrahim Aldraihem, Fawaz Al-hussain and Bandar N. Aljafen

    Citation: BMC Neurology 2018 18:135

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  7. Content type: Case report

    Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is characterized clinically by central nervous system dysfunctions. It is unclear whether CADASIL is involve...

    Authors: Yusuke Sakiyama, Eiji Matsuura, Yoshimitsu Maki, Akiko Yoshimura, Masahiro Ando, Miwa Nomura, Kazuya Shinohara, Ryuji Saigo, Tomonori Nakamura, Akihiro Hashiguchi and Hiroshi Takashima

    Citation: BMC Neurology 2018 18:134

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  8. Content type: Research article

    Glioma metastasis, invasion, epithelial-mesenchymal transition (EMT) and chemoresistance indicate poor prognosis. Accumulating evidence reveals that Notch1 is an important factor in tumour progression. However...

    Authors: Jianlong Li, Qingbin Li, Lin Lin, Rui Wang, Lingchao Chen, Wenzhong Du, Chuanlu Jiang and Ruiyan Li

    Citation: BMC Neurology 2018 18:133

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  9. Content type: Research article

    Down syndrome (DS) is a common developmental disorder resulting from the presence of an additional copy of chromosome 21. Abnormalities in dopamine signaling are suggested to be involved in cognitive dysfuncti...

    Authors: Thanh Thi Mai Pham, Hiroki Kato, Haruyoshi Yamaza, Keiji Masuda, Yuta Hirofuji, Hiroshi Sato, Huong Thi Nguyen Nguyen, Xu Han, Yu Zhang, Tomoaki Taguchi and Kazuaki Nonaka

    Citation: BMC Neurology 2018 18:132

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  10. Content type: Research article

    There is evidence that uric acid may have antioxidant and neuroprotective effects and might therefore alter the risk for neurodegenerative diseases such as dementia. So far, the relation between serum uric aci...

    Authors: Bettina Engel, Willy Gomm, Karl Broich, Wolfgang Maier, Klaus Weckbecker and Britta Haenisch

    Citation: BMC Neurology 2018 18:131

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  12. Content type: Research article

    The SPAN-100 index adds patient age and baseline NIHSS-score and was introduced to predict clinical outcome after acute ischemic stroke (AIS). Even with high NIHSS-scores younger patients cannot reach a SPAN-1...

    Authors: Cornelia Möbius, Christian Blinzler, Stefan Schwab, Martin Köhrmann and Lorenz Breuer

    Citation: BMC Neurology 2018 18:129

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  13. Content type: Research article

    Our aim was to compare the perioperative time courses of matrix metalloproteinase-9 (MMP-9) and its inhibitor (TIMP-1) in during carotid endarterectomy (CEA) and carotid artery stenting (CAS).

    Authors: Ákos Mérei, Bálint Nagy, Gábor Woth, János Lantos, Ferenc Kövér, Lajos Bogár and Diána Mühl

    Citation: BMC Neurology 2018 18:128

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  14. Content type: Research article

    Critical care covers multiple disciplines. However, the causes of critical illness in the ICU, particularly the most common causes, remain unclear. We aimed to investigate the incidence and the most common cau...

    Authors: Ye-Ting Zhou, Dao-Ming Tong, Shao-Dan Wang, Song Ye, Ben-Wen Xu and Chen-Xi Yang

    Citation: BMC Neurology 2018 18:127

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  15. Content type: Research article

    Cardiac autonomic neuropathy (CAN) in diabetes is among the strongest risk markers for future global and cardiovascular mortality. The aim of this study was to analyse CAN prevalence and to compare the associatio...

    Authors: Anca Moţăţăianu, Smaranda Maier, Zoltan Bajko, Septimiu Voidazan, Rodica Bălaşa and Adina Stoian

    Citation: BMC Neurology 2018 18:126

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  16. Content type: Research article

    Neurogenic orthostatic hypotension (nOH) results from impaired vasoconstriction due to dysfunction of the autonomic nervous system and is commonly associated with Parkinson disease (PD), multiple system atroph...

    Authors: Daniel O. Claassen, Charles H. Adler, L. Arthur Hewitt and Christopher Gibbons

    Citation: BMC Neurology 2018 18:125

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  17. Content type: Research article

    Respiratory system elastance (ERS) is an important determinant of the responsiveness of intracranial pressure (ICP) to positive end-expiratory pressure (PEEP). However, lung elastance (EL) and chest wall elastanc...

    Authors: Han Chen, Kai Chen, Jing-Qing Xu, Ying-Rui Zhang, Rong-Guo Yu and Jian-Xin Zhou

    Citation: BMC Neurology 2018 18:124

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  18. Content type: Research article

    Sleep disorders and fatigue are common in multiple sclerosis (MS). The underlying causes are not fully understood, and prospective studies are lacking. Therefore, we conducted a prospective, observational coho...

    Authors: Sylvia Kotterba, Thomas Neusser, Christiane Norenberg, Patrick Bussfeld, Thomas Glaser, Martin Dörner and Markus Schürks

    Citation: BMC Neurology 2018 18:123

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  19. Content type: Research article

    Chinese guidelines for management of Parkinson’s disease (PD) have been issued and updated regularly since 2006. We undertook a cross-sectional survey to evaluate the impact of the latest edition (2014) on cur...

    Authors: Gang Wang, Hai-Lun Cui, Jun Liu, Qin Xiao, Ying Wang, Jian-Fang Ma, Hai-Yan Zhou, Jing Pan, Yu-Yan Tan and Sheng-Di Chen

    Citation: BMC Neurology 2018 18:122

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  20. Content type: Research article

    Segmental zoster paresis (SZP) of limbs, characterized by focal weakness of extremity, is recognized as a rare complication of herpes zoster (HZ). The following study analyzes the clinical characteristics and ...

    Authors: Ying Liu, Bing-Yun Wu, Zhen-Shen Ma, Juan-Juan Xu, Bing Yang, Heng Li and Rui-Sheng Duan

    Citation: BMC Neurology 2018 18:121

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  21. Content type: Case report

    The motor and sensory symptoms caused by compressive radial neuropathy are well-known, but the involvement of the autonomic nervous system or the dermatologic symptoms are less well known. We report an unusual...

    Authors: Jong Hyeon Ahn, Dae Joong Kim, Jung-Joon Sung, Yoon-Ho Hong, Suk-Won Ahn, Jeong Jin Park and Byung-Nam Yoon

    Citation: BMC Neurology 2018 18:120

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  22. Content type: Case report

    Benign gynecologic tumor, such as uterine adenomyosis, has been suggested to develop hypercoagulability. Although some cases of cerebral infarction associated with adenomyosis have been reported, the mechanism...

    Authors: Yasuhiro Aso, Ryo Chikazawa, Yuki Kimura, Noriyuki Kimura and Etsuro Matsubara

    Citation: BMC Neurology 2018 18:119

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  24. Content type: Case report

    Niemann-Pick disease type C (NPC) is a lysosomal storage disorder with severe prognosis. Disease-specific therapy is crucial to prevent disease progression; however, diagnosing NPC is quite difficult because o...

    Authors: Tomoya Kawazoe, Toshiyuki Yamamoto, Aya Narita, Kousaku Ohno, Kaori Adachi, Eiji Nanba, Atsuko Noguchi, Tsutomu Takahashi, Masamitsu Maekawa, Yoshikatsu Eto, Masafumi Ogawa, Miho Murata and Yuji Takahashi

    Citation: BMC Neurology 2018 18:117

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  25. Content type: Research article

    Post-translational modifications (PTMs) generate a tremendous protein diversity from the ~ 20,000 protein-coding genes of the human genome. In chronic pain conditions, exposure to pathological processes in the...

    Authors: Emmanuel Bäckryd, Sofia Edström, Björn Gerdle and Bijar Ghafouri

    Citation: BMC Neurology 2018 18:116

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  26. Content type: Research article

    Dysphagia and other eating and drinking difficulties are common in progressive neurological diseases. Mealtimes can become a major source of difficulty and anxiety for patients and their families. Decisions ab...

    Authors: Gemma Clarke, Elizabeth Fistein, Anthony Holland, Jake Tobin, Sam Barclay and Stephen Barclay

    Citation: BMC Neurology 2018 18:115

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  27. Content type: Research article

    Deficits in gait and balance are common among neurological inpatients. Currently, assessment of these patients is mainly subjective. New assessment options using wearables may provide complementary and more ob...

    Authors: Felix P. Bernhard, Jennifer Sartor, Kristina Bettecken, Markus A. Hobert, Carina Arnold, Yvonne G. Weber, Sven Poli, Nils G. Margraf, Christian Schlenstedt, Clint Hansen and Walter Maetzler

    Citation: BMC Neurology 2018 18:114

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  28. Content type: Case report

    We present a patient fulfilling the electrophysiological criteria for definite chronic inflammatory demyelinating polyneuropathy (CIDP), antibody-positive myasthenia gravis (MG), and membranous glomerulonephri...

    Authors: Saskia Bolz, Andreas Totzeck, Kerstin Amann, Mark Stettner, Christoph Kleinschnitz and Tim Hagenacker

    Citation: BMC Neurology 2018 18:113

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  29. Content type: Case report

    Cutaneous and systemic plasmacytosis are skin disorders characterized by cutaneous polyclonal plasma cell infiltration accompanied by polyclonal hypergammaglobulinemia. Cutaneous plasmacytosis involvement is l...

    Authors: Taku Hatano, Masashi Takanashi, Hitoshi Tsuchihashi, Shin-Ichi Ueno, Arisa Hayashida, Yutaka Tsukune, Kazuaki Kanai, Yasushi Shimo and Nobutaka Hattori

    Citation: BMC Neurology 2018 18:112

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  30. Content type: Study protocol

    Multiple sclerosis (MS) is one of the most frequently observed neurological conditions in Switzerland, but data sources for country-wide epidemiological trend monitoring are lacking. Moreover, while clinical a...

    Authors: Nina Steinemann, Jens Kuhle, Pasquale Calabrese, Jürg Kesselring, Giulio Disanto, Doron Merkler, Caroline Pot, Vladeta Ajdacic-Gross, Stephanie Rodgers, Milo Alan Puhan and Viktor von Wyl

    Citation: BMC Neurology 2018 18:111

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  31. Content type: Research article

    Seizures arising from the precuneus are rare, and few studies have aimed at characterizing the clinical presentation of such seizures within the anatomic context of the frontoparietal circuits. We aimed to cha...

    Authors: Yanfeng Yang, Haixiang Wang, Wenjing Zhou, Tianyi Qian, Wei Sun and Guoguang Zhao

    Citation: BMC Neurology 2018 18:110

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  32. Content type: Case report

    Semantic variant primary progressive aphasia (svPPA) is a subtype of primary progressive aphasia characterized by two-way anomia and disturbance in word comprehension, with focal atrophy in the left temporal l...

    Authors: Ryota Kobayashi, Hiroshi Hayashi, Shinobu Kawakatsu, Aiko Ishiki, Nobuyuki Okamura, Hiroyuki Arai and Koichi Otani

    Citation: BMC Neurology 2018 18:109

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  33. Content type: Research article

    Diffusion kurtosis imaging (DKI) has the potential to provide microstructural insights into myelin and axonal pathology with additional kurtosis parameters. To our knowledge, few studies are available in the c...

    Authors: Hai Qing Li, Bo Yin, Chao Quan, Dao Ying Geng, Hai Yu, Yi Fang Bao, Jun Liu and Yu Xin Li

    Citation: BMC Neurology 2018 18:108

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  34. Content type: Research article

    Nocturia is a common urinary symptom of multiple sclerosis (MS) which can affect quality of life (QoL) adversely. Melatonin is a hormone known to regulate circadian rhythm and reduce smooth muscle activity suc...

    Authors: Marcus J. Drake, Luke Canham, Nikki Cotterill, Debbie Delgado, Jenny Homewood, Kirsty Inglis, Lyndsey Johnson, Mary C. Kisanga, Denise Owen, Paul White and David Cottrell

    Citation: BMC Neurology 2018 18:107

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  35. Content type: Research article

    Insulin-like growth factor I (IGF-I) has neuroprotective effects in experimental ischemic stroke (IS). However, in patients who have suffered IS, various associations between the levels of serum IGF-I (s-IGF-I...

    Authors: N. David Åberg, Daniel Åberg, Katarina Jood, Michael Nilsson, Christian Blomstrand, H. Georg Kuhn, Johan Svensson, Christina Jern and Jörgen Isgaard

    Citation: BMC Neurology 2018 18:106

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  37. Content type: Study protocol

    After stroke, spasticity of the rectus femoris (RF) and triceps surae (TS) muscles frequently alters the gait pattern. Knee flexion and ankle dorsiflexion in swing are often reduced, respectively called Stiff ...

    Authors: Anthony Supiot, Maxime Geiger, Djamel Bensmail, Phillippe Aegerter, Didier Pradon and Nicolas Roche

    Citation: BMC Neurology 2018 18:104

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  38. Content type: Study protocol

    Mild cognitive impairment is an early stage of Alzheimer’s disease. Increasing evidence has indicated that cognitive training could improve cognitive abilities of MCI patients in multiple cognitive domains, ma...

    Authors: Yiqi Lin, Binyin Li, Huidong Tang, Qun Xu, Yuncheng Wu, Qi Cheng, Chunbo Li, Shifu Xiao, Lu Shen, Weiguo Tang, Hui Yu, Naying He, Huawei Lin, Fuhua Yan, Wenwei Cao, Shilin Yang…

    Citation: BMC Neurology 2018 18:103

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  39. Content type: Research article

    Perinatal stroke (PS) affects up to 1/2300 infants and frequently leads to unilateral cerebral palsy (UCP). Preterm-born infants affected by unilateral haemorrhagic parenchymal infarction (HPI) are also at ris...

    Authors: Anna Purna Basu, Janice Pearse, Rose Watson, Pat Dulson, Jessica Baggaley, Blythe Wright, Denise Howel, Luke Vale, Dipayan Mitra, Nick Embleton and Tim Rapley

    Citation: BMC Neurology 2018 18:102

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  40. Content type: Case report

    Miller Fisher syndrome (MFS) and Bickerstaff’s Brainstem Encephalitis (BBE) share some clinical features and a common immunological profile characterized by anti-GQ1b antibodies. Some MFS patients overlap with...

    Authors: Angela Puma, Jeanne Benoit, Sabrina Sacconi and Antonino Uncini

    Citation: BMC Neurology 2018 18:101

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  41. Content type: Case report

    Epileptic seizures can lead to cardiac arrhythmias. The arrhythmias may be in the form of tachycardia, bradycardia or asystole. Ictal bradycardia and asystole can lead to sudden unexpected death.

    Authors: Nirmeen Kishk, Amani Nawito, Ahmed El-Damaty and Amany Ragab

    Citation: BMC Neurology 2018 18:100

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  42. Content type: Case report

    Leigh Syndrome (LS, OMIM 256000) is an early-onset, progressive neurodegenerative disorder characterized by broad clinical and genetic heterogeneity; it is the most frequent disorder of mitochondrial energy pr...

    Authors: Paolo Aretini, Chiara Maria Mazzanti, Marco La Ferla, Sara Franceschi, Francesca Lessi, Veronica De Gregorio, Claudia Nesti, Angelo Valetto, Veronica Bertini, Benedetta Toschi, Roberta Battini and Maria Adelaide Caligo

    Citation: BMC Neurology 2018 18:99

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  43. Content type: Research article

    Brief measures of health-related quality of life (HRQOL) that assess both patient-reported functioning and well-being after stroke are scarce. The objective of this study was to examine reliability and validit...

    Authors: Guri Heiberg, Synne Garder Pedersen, Oddgeir Friborg, Jørgen Feldbæk Nielsen, Henriette Stabel Holm, Nicole Steinbüchel von, Cathrine Arntzen and Audny Anke

    Citation: BMC Neurology 2018 18:98

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  44. Content type: Case report

    Immunoglobulin associated meningitis is a rare disease that mimics infectious meningitis. This is, to our knowledge, the first case of Immunoglobulin-associated meningitis described in a patient with Systemic ...

    Authors: Luísa Graça, Joana Alves, João Nuak and António Sarmento

    Citation: BMC Neurology 2018 18:97

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  45. Content type: Research article

    Recently, most reports of Leucine-rich glioma-inactivated 1 (LGI1) antibody encephalitis are from Europe and the US, while the short term outcome and clinical characteristics of Chinese patients are rarely rep...

    Authors: Weishuai Li, Si Wu, Qingping Meng, Xiaotian Zhang, Yang Guo, Lin Cong, Shuyan Cong and Dongming Zheng

    Citation: BMC Neurology 2018 18:96

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  47. Content type: Research article

    Migraine is considered a disease with diurnal and 24 h pattern, though the existence of a prevalent circadian rhythm associated to migraine frequency and severity is still not clear. This observational cross-s...

    Authors: Marina de Tommaso and Marianna Delussi

    Citation: BMC Neurology 2018 18:94

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  48. Content type: Research article

    White matter hyperintensities (WMHs) are frequently detected in migraine patients. However, their significance and correlation to migraine disease burden remain unclear. This study aims to examine the correlat...

    Authors: Hui Xie, Qiang Zhang, Kang Huo, Rui Liu, Zhi-Jie Jian, Yi-Tong Bian, Guo-Liang Li, Dan Zhu, Li-Hui Zhang, Jian Yang and Guo-Gang Luo

    Citation: BMC Neurology 2018 18:93

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  50. Content type: Research article

    Neuropathic pain is defined as pain caused by a lesion or disease of the somatosensory nervous system and is a major therapeutic challenge. Several screening tools have been developed to help physicians detect...

    Authors: Hans Timmerman, André P. Wolff, Ewald M. Bronkhorst, Oliver H. G. Wilder-Smith, Marcel J. Schenkels, Nick T. van Dasselaar, Frank J. P. M. Huygen, Monique A. H. Steegers and Kris C. P. Vissers

    Citation: BMC Neurology 2018 18:91

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