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  1. Amyotrophic lateral sclerosis (ALS) is an incurable and rapidly progressive neurological disorder. Biomarkers are critical to understanding disease causation, monitoring disease progression and assessing the e...

    Authors: Maize C. Cao, Erin E. Cawston, Grace Chen, Collin Brooks, Jeroen Douwes, Dave McLean, E. Scott Graham, Mike Dragunow and Emma L. Scotter
    Citation: BMC Neurology 2022 22:216
  2. Wake-up ischemic stroke (IS) has been usually excluded from acute stroke therapy options for being outside of the safe treatment window. We identified risk factors, and clinical or molecular biomarkers that co...

    Authors: Pablo Hervella, María Luz Alonso-Alonso, María Pérez-Mato, Manuel Rodríguez-Yáñez, Susana Arias-Rivas, Iria López-Dequidt, José M. Pumar, Tomás Sobrino, Francisco Campos, José Castillo and Ramón Iglesias-Rey
    Citation: BMC Neurology 2022 22:215
  3. Missense mutations in the mitochondrial alanyl-tRNA synthetase 2 (AARS2) gene are clinically associated with infantile mitochondrial cardiomyopathy or adult-onset leukoencephalopathy with early ovarian failure. T...

    Authors: Yan Fan, Jinming Han, Yanyan Yang and Tuanzhi Chen
    Citation: BMC Neurology 2022 22:214
  4. We aimed to investigate the risk factors of early neurological deterioration (END) after intravenous thrombolysis with recombinant tissue-type plasminogen activator (rt-PA) and the relationship between END and...

    Authors: Fengli Che, Anxin Wang, Yi Ju, Yarong Ding, Honglian Duan, Xiaokun Geng, Xingquan Zhao and Yongjun Wang
    Citation: BMC Neurology 2022 22:212

    The Correction to this article has been published in BMC Neurology 2022 22:343

  5. Over a dozen disease-modifying therapies (DMTs) have been approved for treatment of multiple sclerosis (MS). Treatment guidelines focus on when to initiate, change, and discontinue treatment but provide little...

    Authors: Robert J. Fox, Rina Mehta, Timothy Pham, Julie Park, Kathleen Wilson and Machaon Bonafede
    Citation: BMC Neurology 2022 22:211
  6. A subgroup of individuals experienced stroke-like symptoms after receiving an inactivated COVID-19 vaccine. We present clinical characteristics, neuroimaging, and outcome of these patients.

    Authors: Duangnapa Roongpiboonsopit, Chichaya Nithisathienchai, Wasan Akarathanawat, Krittanon Lertutsahakul, Jarturon Tantivattana, Anand Viswanathan and Nijasri Charnnarong Suwanwela
    Citation: BMC Neurology 2022 22:210
  7. The present strategies regarding poststent management for cerebral venous sinus stenosis (CVSS) are inconsistent. Herein, we compared the safety and efficacy of oral anticoagulants (OACs) plus single antiplate...

    Authors: Chaobo Bai, Zhiying Chen, Xiaoqin Wu, Roxanne Ilagan, Yuchuan Ding, Xunming Ji and Ran Meng
    Citation: BMC Neurology 2022 22:209
  8. So far, the diagnosis of acute artery of percheron (AOP) infarction is uncommon. In this study, patients with acute AOP infarction were studied to explore the relationship of imaging findings, clinical manifes...

    Authors: Bei Zhang, Xiaoxun Wang, Chen Gang and Jiping Wang
    Citation: BMC Neurology 2022 22:207
  9. The development of tools that could help emergency department clinicians recognize stroke during triage could reduce treatment delays and improve patient outcomes. Growing evidence suggests that stroke is asso...

    Authors: Grant C. O’Connell, Kyle B. Walsh, Christine G. Smothers, Suebsarn Ruksakulpiwat, Bethany L. Armentrout, Chris Winkelman, Truman J. Milling, Steven J. Warach and Taura L. Barr
    Citation: BMC Neurology 2022 22:206
  10. Eptinezumab is an anti-calcitonin gene-related peptide (CGRP) monoclonal antibody approved for the preventive treatment of migraine. In the phase 3 RELIEF study, eptinezumab resulted in shorter time to headach...

    Authors: Jessica Ailani, Peter McAllister, Paul K. Winner, George Chakhava, Mette Krog Josiassen, Annika Lindsten, Bjørn Sperling, Anders Ettrup and Roger Cady
    Citation: BMC Neurology 2022 22:205
  11. It is important to assess the degree of brain injury and predict long-term outcomes in neonates diagnosed with hypoxic-ischemic encephalopathy (HIE). However, routine studies, including magnetic resonance imag...

    Authors: Kwang Yeon Kim, Joo-Young Lee, Ja-Un Moon, Tae-Hoon Eom and Young-Hoon Kim
    Citation: BMC Neurology 2022 22:204
  12. To explore the expression relationship and significance of long chain non-coding RNA nuclear-enriched abundant transcript 1 (LncRNA NEAT1) and miR-27a-3p in serum and cerebrospinal fluid of patients with Alzhe...

    Authors: Lijie He, Zongnan Chen, Jing Wang and Heqiang Feng
    Citation: BMC Neurology 2022 22:203
  13. Neural tube defects (NTDs) are associated with high rates of neonatal mortality and morbidity worldwide. The promotion of folic acid fortification and supplementation in pregnant women by the Food and Drug Adm...

    Authors: Paddy Ssentongo, Emily S. Heilbrunn, Anna E. Ssentongo, Lydia V. N. Ssenyonga and Alain Lekoubou
    Citation: BMC Neurology 2022 22:202
  14. For patients with aneurysmal subarachnoid hemorrhages (SAHs) and multiple intracranial aneurysms (MIAs), a simple and fast imaging method that can identify ruptured intracranial aneurysms (RIAs) may have great...

    Authors: Xue-hua Zhang, Xiao-yan Zhao, Lan-lan Liu, Li Wen and Guang-xian Wang
    Citation: BMC Neurology 2022 22:201
  15. Hereditary spastic paraplegia 7 (SPG7) is one of the subtypes of autosomal-recessive hereditary spastic paraplegia, which is a clinically heterogeneous neurodegenerative disorder. SPG7 often displays a complic...

    Authors: Shan Wang, Yaye Wang, Yue Wu, Jinru Zhang, Weilin Zhang, Chang Li and Xueqin Song
    Citation: BMC Neurology 2022 22:200
  16. Specific dietary recommendations for migraine patients with comorbid irritable bowel syndrome (IBS) are lacking. This work aimed to study the severity scores of such two common pain-related disorders in relati...

    Authors: Rehab Magdy, Ragaey A Eid, Mahmoud Hassan, Mohamed Abdelghaffar, Asmaa F El Sayed, Zeinab Mohammed and Mona Hussein
    Citation: BMC Neurology 2022 22:199
  17. Alzheimer’s disease (AD) is closely related to aging, showing an increasing incidence rate for years. As one of the main brain regions involved in AD, hippocampus has been extensively studied due to its associ...

    Authors: Pengcheng Xia, Jing Chen, Xiaohui Bai, Ming Li, Le Wang and Zhiming Lu
    Citation: BMC Neurology 2022 22:198
  18. Convulsive status epilepticus (CSE) is a common neurologic emergency with high morbidity and mortality. This single center study is aimed to assess changes of serum biochemical biomarkers after seizure, and th...

    Authors: Manli Wang, Jian Yu, Xiao Xiao, Bingbing Zhang and Jihong Tang
    Citation: BMC Neurology 2022 22:196
  19. We aimed to develop and validate machine learning (ML) models for 30-day stroke mortality for mortality risk stratification and as benchmarking models for quality improvement in stroke care.

    Authors: Wenjuan Wang, Anthony G. Rudd, Yanzhong Wang, Vasa Curcin, Charles D. Wolfe, Niels Peek and Benjamin Bray
    Citation: BMC Neurology 2022 22:195

    The Correction to this article has been published in BMC Neurology 2022 22:319

  20. Stroke is one of the most frequent causes of death in Germany and the developed countries. After a stroke, those affected often suffer particularly from functional motor restrictions of the upper extremities. ...

    Authors: Stefanie Liebl, Tim Tischendorf, Julia Winterlich and Tom Schaal
    Citation: BMC Neurology 2022 22:194
  21. Cerebrotendinous xanthomatosis (CTX) is an autosomal-recessive lipid storage disorder caused by mutations in the CYP27A1 gene encoding the key enzyme in the bile acid synthesis, sterol 27-hydroxylase. Here, we re...

    Authors: Shingo Koyama, Yuma Okabe, Yuya Suzuki, Ryosuke Igari, Hiroyasu Sato, Chifumi Iseki, Kazuyo Tanji, Kyoko Suzuki and Yasuyuki Ohta
    Citation: BMC Neurology 2022 22:193
  22. Glioma is the most common brain tumor in adults and is characterized by a short survival time and high resistance to chemotherapy. It is imperative to determine the prognosis and therapy-related targets for gl...

    Authors: Lianxin Li, Zhihao Yang, Yinfei Zheng, Zhigang Chen, Xiaoyu Yue, Erbao Bian and Bing Zhao
    Citation: BMC Neurology 2022 22:192
  23. Red cell distribution width (RDW) is a parameter that indsicates the heterogeneity of red blood cell size and could be a prognostic factor in some diseases. Also, intracerebral hemorrhage (ICH) is considered a...

    Authors: Sheida Shaafi, Ehsan Bonakdari, Yalda Sadeghpour and Seyed Aria Nejadghaderi
    Citation: BMC Neurology 2022 22:191
  24. Electrocardiogram (ECG) patterns can change, especially in patients with central nervous system disorders such as spontaneous subarachnoid hemorrhage. However, the association between the prognosis of traumati...

    Authors: Ji Ho Lee, Dong Hun Lee, Byung Kook Lee, Yong Soo Cho, Dong Ki Kim and Yong Hun Jung
    Citation: BMC Neurology 2022 22:190
  25. Postural abnormality is one of the main symptoms of Parkinson’s disease (PD). The erector spinae muscles play an important role in maintaining an upright posture, but the fatigability of the erector spinae in ...

    Authors: Yukihide Nishimura, Hiroyuki Tsuboi, Ken-Ya Murata, Yuta Minoshima, Hideyuki Sato, Yuichi Umezu and Fumihiro Tajima
    Citation: BMC Neurology 2022 22:189
  26. Recent evidence suggests a merging role of immunothrombosis in the formation of arterial thrombosis. Our study aims to investigate its relevance in stroke patients.

    Authors: Angeliki Datsi, Laura Piotrowski, Markella Markou, Thomas Köster, Isabelle Kohtz, Kerstin Lang, Sabine Plöttner, Heiko Udo Käfferlein, Burkhard Pleger, Ramon Martinez, Bogdan Pintea, Roland Fried, Marcus Müller, Rene Chapot and Konstantinos Gousias
    Citation: BMC Neurology 2022 22:186
  27. Since the beginning of the COVID-19 pandemic and development of new vaccines, the issue of post-vaccination exacerbation or manifestation of demyelinating central nervous system (CNS) disorders has gained incr...

    Authors: Lisa Lohmann, Felix Glaser, Gabriel Möddel, Jan D. Lünemann, Heinz Wiendl and Luisa Klotz
    Citation: BMC Neurology 2022 22:185
  28. It is critical for stroke survivors in working age to develop skills and confidence for long-term self-management of physical activity and exercise training to maintain a healthy lifestyle and decrease the ris...

    Authors: Kirsti S. Roaldsen, Charlotte Walter, Johan Gäverth and Ing-Mari Dohrn
    Citation: BMC Neurology 2022 22:183
  29. Congenital absence of the internal carotid artery (ICA) is a highly infrequent congenital incidence and occurs in less than 0.01% of the population; bilateral absence is exceedingly rare, diagnosed below 10% o...

    Authors: Ivana Markovic, Zoran Milenkovic, Bosanka Jocic-Jakubi, Amna Al Futaisi, Kakaria Anupam Kakaria and Yasser Walli
    Citation: BMC Neurology 2022 22:182
  30. Bromine compounds are used in several drugs, including over-the-counter drugs. They sometimes cause intoxication known as bromism. Although the acute neurological symptoms and sequelae of bromism vary, few rep...

    Authors: Masahiro Biyajima, Shunichi Satoh, Takahiro Morikawa, Yuki Morita, Rie Watanabe, Daisuke Matsui, Masataka Konno, Nobutoshi Morimoto, Yuichi Yatsu, Akihito Hirasaki and Hiroyuki Yahikozawa
    Citation: BMC Neurology 2022 22:181
  31. Hereditary spastic paraplegia (HSP) is a group of neurodegenerative diseases characterized by lower-limb spastic paraplegia with highly genetic and clinical heterogeneity. However, the clinical sign of spastic...

    Authors: Jiannan Chen, Zhe Zhao, Hongrui Shen, Qi Bing, Nan Li, Xuan Guo and Jing Hu
    Citation: BMC Neurology 2022 22:180
  32. Disruption of brain functional connectivity has been detected after stroke, but whether it also occurs in moyamoya disease (MMD) is unknown. Impaired functional connectivity is always correlated with abnormal ...

    Authors: Junwen Hu, Yin Li, Zhaoqing Li, Jingyin Chen, Yang Cao, Duo Xu, Leilei Zheng, Ruiliang Bai and Lin Wang
    Citation: BMC Neurology 2022 22:179
  33. Wilson’s disease is a hereditary disorder of copper metabolism resulting mainly in hepatic, neurological, and psychiatric symptoms. Multiple sclerosis (MS) is an immune-mediated demyelinating disease affecting...

    Authors: Katalin Despotov, Péter Klivényi, István Nagy, Attila Pálvölgyi, László Vécsei and Cecília Rajda
    Citation: BMC Neurology 2022 22:178
  34. Regular physical activity is of great relevance in Parkinson's disease (PD). It is part of the inpatient multimodal Parkinson's complex treatment (MKP) in Germany. However, there is often a lack of human resou...

    Authors: Lynn Wagner, Björn Hauptmann, Ann-Kristin Hoffmann, Nicole Jochems, Bastian Schmeier, Andreas Schrader, Thomas Kohlmann and Ruth Deck
    Citation: BMC Neurology 2022 22:176
  35. Many stroke survivors have multiple chronic diseases and complications coupled with various other factors which may affect their functional status. We aimed to investigate the factors associated with poor func...

    Authors: Jing Zhou, Fang Liu, Mingchao Zhou, Jianjun Long, Fubing Zha, Miaoling Chen, Jiehui Li, Qingqing Yang, Zeyu Zhang and Yulong Wang
    Citation: BMC Neurology 2022 22:173
  36. Authors: Derek L. Isenberg, Kevin A. Henry, Adam Sigal, Traci Deaner, Jason T. Nomura, Kathleen A. Murphy, Derek Cooney, Susan Wojcik, Ethan S. Brandler, Alexander Kuc, Gerard Carroll, Chadd K. Kraus, Judy B. Shahan, Joseph Herres, Daniel Ackerman and Nina T. Gentile
    Citation: BMC Neurology 2022 22:171

    The original article was published in BMC Neurology 2022 22:132

  37. Aquatic physiotherapy is becoming a more frequently utilised treatment for people with Parkinson’s Disease (PD). Consumers are increasingly accessing information regarding health choices online, and it is not ...

    Authors: Aan Fleur Terrens, Sze-Ee Soh and Prue Morgan
    Citation: BMC Neurology 2022 22:170
  38. Bupropion, an antidepressant inhibiting the reuptake of dopamine and noradrenaline, should be useful to treat depressive symptoms in patients with Parkinson’s disease (PD). Limited and conflicting literature d...

    Authors: Matteo Vismara, Beatrice Benatti, Gregorio Nicolini, Ilaria Cova, Edoardo Monfrini, Alessio Di Fonzo, Vincenza Fetoni, Caterina A. Viganò, Alberto Priori and Bernardo Dell’Osso
    Citation: BMC Neurology 2022 22:169

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