Articles

Predictors of post-stroke body temperature elevation

Growing evidence indicates that elevated body temperature after stroke is associated with unfavorable outcome. The aim of the current study was to investigate which factors predict temperature elevation within...

Authors: Rebecca Ruborg, Karin Gunnarsson and Jakob O. Ström

Etiology of isolated pontine infarctions: a study based on high-resolution MRI and brain small vessel disease scores

In this retrospective study, we investigated the main pathogenesis of the two types of isolated pontine infarction: paramedian pontine infarcts (PPIs) and small deep pontine infarcts (SDPIs).

Authors: Cheng Xia, Hui-Sheng Chen, Shi-Wen Wu and Wei-Hai Xu

Secondary pallidonigral degeneration mimicking recurrent acute stroke in clinical presentation and magnetic resonance imaging: a case report

Secondary pallidonigral transneuronal degeneration after a remote primary cerebral infarct can mimic recurrent stroke at clinical presentation. We describe a patient with secondary pallidonigral degeneration f...

Authors: Ruei-Je Tsai, Li-Chun Hsieh, Sho-Jen Cheng and Cheng-Yu Chen

CDKN2BAS gene polymorphisms and the risk of intracranial aneurysm in the Chinese population

CDKN2BAS gene polymorphisms has been shown to correlation with intracranial aneurysm(IA) in the study of foreign people. The study, the author selected the Chinese people as the research object to explore whet...

Authors: Yunchang Chen, Gancheng Li, Haiyan Fan, Shenquan Guo, Ran Li, Jian Yin, Xin Zhang, Xifeng Li, Xuying He and Chuanzhi Duan

Inventory of real world data sources in Parkinson’s disease

Real world data have an important role to play in the evaluation of epidemiology and burden of disease; and in assisting health-care decision-makers, especially related to coverage and payment decisions. Howev...

Authors: Audrey Tanguy, Linus Jönsson and Lianna Ishihara

Anterior sacral meningocele infected with Fusobacterium in a patient with recently diagnosed colorectal carcinoma – a case report

Anterior sacral meningoceles are rare, and usually occur with other malformations of the posterior lower spine. While these are more frequently reported in pediatric cohorts, we report a case in an elderly woman.

Authors: Anne K. Braczynski, Marc A. Brockmann, Torben Scholz, Jan-Philipp Bach, Jörg B. Schulz and Simone C. Tauber

Factors necessary for independent walking in patients with thalamic hemorrhage

Thalamic hemorrhages cause motor paralysis, sensory impairment, and cognitive dysfunctions, all of which may significantly affect walking independence. We examined the factors related to independent walking in...

Authors: Shigenori Hiraoka, Shinichiro Maeshima, Hideto Okazaki, Hirokazu Hori, Shinichiro Tanaka, Sayaka Okamoto, Reisuke Funahashi, Kei Yagihashi, Ikuko Fuse, Naoki Asano and Shigeru Sonoda

Pharmacological targeting of secondary brain damage following ischemic or hemorrhagic stroke, traumatic brain injury, and bacterial meningitis - a systematic review and meta-analysis

The effectiveness of pharmacological strategies exclusively targeting secondary brain damage (SBD) following ischemic stroke, aneurysmal subarachnoid hemorrhage, aSAH, intracerebral hemorrhage (ICH), traumatic...

Authors: Thomas Beez, Hans-Jakob Steiger and Nima Etminan

Widespread enlarged perivascular spaces associated with dementia and focal brain dysfunction: case report

Enlarged perivascular spaces (PVS) are common magnetic resonance imaging (MRI) findings, whereas widespread enlarged PVS are extremely rare. Although most patients with widespread enlarged PVS remain asymptoma...

Authors: Daisuke Taniguchi, Hideki Shimura, Masao Watanabe, Nobutaka Hattori and Takao Urabe

The Turkish validation of the Brief International Cognitive Assessment for Multiple Sclerosis (BICAMS) battery

Cognitive impairment may be seen in as many as 43–70% of patients with multiple sclerosis (MS) and may be observed in all MS subtypes. The Brief International Cognitive Assessment in Multiple Sclerosis (BICAMS...

Authors: Serkan Ozakbas, Pinar Yigit, Bilge Piri Cinar, Hatice Limoncu, Turhan Kahraman and Görkem Kösehasanoğulları

Normothermia after decompressive surgery for space-occupying middle cerebral artery infarction: a protocol-based approach

Moderate hypothermia after decompressive surgery might not be beneficial for stroke patients. However, normothermia may prove to be an effective method of enhancing neurological outcomes. The study aims were t...

Authors: Jan Rahmig, Matthias Kuhn, Hermann Neugebauer, Eric Jüttler, Heinz Reichmann and Hauke Schneider

Atrial fibrillation is not uncommon among patients with ischemic stroke and transient ischemic stroke in China

Atrial fibrillation (AF) is reported to be a less frequent cause of ischemic stroke in China than in Europe and North America, but it is not clear whether this is due to underestimation. Our aim was to define ...

Authors: Xiaomeng Yang, Shuya Li, Xingquan Zhao, Liping Liu, Yong Jiang, Zixiao Li, Yilong Wang and Yongjun Wang

Selection bias in clinical stroke trials depending on ability to consent

Clinical trials are the hallmark of evidence-based medicine, but recruitment is often challenging, especially in stroke trials investigating patients not being able to give informed consent. In some nations, e...

Authors: Benjamin Hotter, Lena Ulm, Sarah Hoffmann, Mira Katan, Joan Montaner, Alejandro Bustamante and Andreas Meisel

Self-reported physical activity correlates in Swedish adults with multiple sclerosis: a cross-sectional study

The benefits of physical activity in persons with Multiple Sclerosis (MS) are considerable. Knowledge about factors that correlate to physical activity is helpful in order to develop successful strategies to i...

Authors: Elisabeth Anens, Lena Zetterberg, Charlotte Urell, Margareta Emtner and Karin Hellström

Prescription of secondary preventive drugs after ischemic stroke: results from the Malaysian National Stroke Registry

Evaluation of secondary stroke prevention in low and middle-income countries remains limited. This study assessed the prescription of secondary preventive drugs among ischemic stroke patients upon hospital dis...

Authors: Wen Yea Hwong, Zariah Abdul Aziz, Norsima Nazifah Sidek, Michiel L. Bots, Sharmini Selvarajah, L. Jaap Kappelle, Sheamini Sivasampu and Ilonca Vaartjes

The humanistic burden of Pompe disease: are there still unmet needs? A systematic review

Humanistic burden considers the impact of an illness on a patient’s health-related quality of life (HRQoL), activities of daily living (ADL), caregiver health, and caregiver QoL. Humanistic burden also conside...

Authors: Benedikt Schoser, Deborah A. Bilder, David Dimmock, Digant Gupta, Emma S. James and Suyash Prasad

Cognitive rehabilitation and mindfulness in multiple sclerosis (REMIND-MS): a study protocol for a randomised controlled trial

Cognitive problems frequently occur in patients with multiple sclerosis (MS) and profoundly affect their quality of life. So far, the best cognitive treatment options for MS patients are a matter of debate. Th...

Authors: Ilse M. Nauta, Anne E. M. Speckens, Roy P. C. Kessels, Jeroen J. G. Geurts, Vincent de Groot, Bernard M. J. Uitdehaag, Luciano Fasotti and Brigit A. de Jong

The usefulness of chief complaints to predict severity, ventilator dependence, treatment option, and short-term outcome of patients with Guillain-Barré syndrome: a retrospective study

It remains an urgent need for early recognition of disease severity, treatment option and outcome of Guillain-Barré syndrome (GBS). The chief complaint may be quickly obtained in clinic and is one of the candi...

Authors: Ying Wang, Pei Shang, Meiying Xin, Jing Bai, Chunkui Zhou and Hong-Liang Zhang

Predictors of early-onset post-ischemic stroke depression: a cross-sectional study

Post-stroke depression (PSD) seriously affects the rehabilitation of nerve function and quality of life. However, the pathogenesis of PSD is still not clear. This study aimed to investigate the demographic, cl...

Authors: Guilin Meng, Xiaoye Ma, Lei Li, Yan Tan, Xiaohui Liu, Xueyuan Liu and Yanxin Zhao

Parkinson disease polygenic risk score is associated with Parkinson disease status and age at onset but not with alpha-synuclein cerebrospinal fluid levels

The genetic architecture of Parkinson’s Disease (PD) is complex and not completely understood. Multiple genetic studies to date have identified multiple causal genes and risk loci. Nevertheless, most of the ex...

Authors: Laura Ibanez, Umber Dube, Benjamin Saef, John Budde, Kathleen Black, Alexandra Medvedeva, Jorge L. Del-Aguila, Albert A. Davis, Joel S. Perlmutter, Oscar Harari, Bruno A. Benitez and Carlos Cruchaga

EEG dynamical correlates of focal and diffuse causes of coma

Rapidly determining the causes of a depressed level of consciousness (DLOC) including coma is a common clinical challenge. Quantitative analysis of the electroencephalogram (EEG) has the potential to improve D...

Authors: MohammadMehdi Kafashan, Shoko Ryu, Mitchell J. Hargis, Osvaldo Laurido-Soto, Debra E. Roberts, Akshay Thontakudi, Lawrence Eisenman, Terrance T. Kummer and ShiNung Ching

Neuroprotective effect of neuroserpin in non-tPA-induced intracerebral hemorrhage mouse models

The neuroprotective effects of neuroserpin (NSP) have been well documented in both patients and animal models with cerebral ischemia; however, have never been investigated in hemorrhagic stroke. The aim of thi...

Authors: Wei Li, Tetsuya Asakawa, Sha Han, Baoguo Xiao, Hiroki Namba, Chuanzhen Lu, Qiang Dong and Liang Wang

Application of the 2016 diagnostic approach for autoimmune encephalitis from Lancet Neurology to Chinese patients

A unified clinical approach to diagnose autoimmune encephalitis was published in Lancet Neurology in 2016. Purpose of our study is to examine the feasibility and reasonability of the 2016 “A clinical approach to ...

Authors: Lin Li, Lin Sun, Rong Du, Yuanchu Zheng, Feifei Dai, Qiuying Ma and Jiawei Wang

Ultra high-field SWI of the substantia nigra at 7T: reliability and consistency of the swallow-tail sign

The loss of the swallow-tail sign of the substantia nigra has been proposed for diagnosis of Parkinson’s disease. Aim was to evaluate, if the sign occurs consistently in healthy subjects and if it can be relia...

Authors: Manuel A. Schmidt, Tobias Engelhorn, Franz Marxreiter, Juergen Winkler, Stefan Lang, Stephan Kloska, Philipp Goelitz and Arnd Doerfler

Headache symptoms from migraine patients with and without aura through structure-validated self-reports

Headache symptoms self-reported by migraine patients are largely congruent with the clinician-used diagnostic criteria, but not always so. Patients’ self-reports of headache symptoms might offer additional clu...

Authors: Jiawei Wang, Bingren Zhang, Chanchan Shen, Jinhua Zhang and Wei Wang

Effects of Homocysteine on white matter diffusion parameters in Alzheimer’s disease

The clinical features of Alzheimer’s disease (AD) are related to brain network degeneration, and hyperhomocysteinemia is related to greater white matter hyperintensities. We investigated the changes in four di...

Authors: Chen-Chang Lee, Shih-Wei Hsu, Chi-Wei Huang, Wen-Neng Chang, Sz-Fan Chen, Ming-Kung Wu, Chiung-Chih Chang, Lain-Chyr Hwang and Po-Chou Chen

Identification of VPS35 p.D620N mutation-related Parkinson’s disease in a Taiwanese family with successful bilateral subthalamic nucleus deep brain stimulation: a case report and literature review

Vacuolar protein sorting 35 (VPS35) was recently reported to be a genetic cause for late-onset autosomal dominant Parkinson’s disease (PD). However, VPS35 mutations are rarely reported in Asian populations. Herei...

Authors: Ying-Fa Chen, Yung-Yee Chang, Min-Yu Lan, Pei-Lung Chen and Chin-Hsien Lin

MOG antibody seropositivity in a patient with encephalitis: beyond the classical syndrome

The presence of circulating anti-myelin oligodendrocyte glycoprotein antibodies (MOG-Abs) has been described in sera of patients with different inflammatory conditions of the central nervous system. In adults ...

Authors: Sara Mariotto, Salvatore Monaco, Patrick Peschl, Ilaria Coledan, Romualdo Mazzi, Romana Höftberger, Markus Reindl and Sergio Ferrari

Correction to: Comparison of neuropsychiatric symptoms and diffusion tensor imaging correlates among patients with subcortical ischemic vascular disease and Alzheimer’s disease

Authors: Min-Chien Tu, Wen-Hui Huang, Yen-Hsuan Hsu, Chung-Ping Lo, Jie Fu Deng and Ching-Feng Huang

Assessment of intracranial pressure with ultrasonographic retrobulbar optic nerve sheath diameter measurement

Ultrasonograpic retrobulbar optic nerve sheath diameter (ONSD) measurement is considered to be an alternative noninvasive method to estimate intracranial pressure,but the further validation is urgently needed....

Authors: Dachuan Liu, Zhen Li, Xuxiang Zhang, Liping Zhao, Jianping Jia, Fei Sun, Yaxing Wang, Daqing Ma and Wenbin Wei

Laboratory markers of cardiac and metabolic complications after generalized tonic-clonic seizures

Generalized tonic-clonic seizures (GTCS) frequently lead to emergency inpatient referrals. Laboratory blood values are routinely performed on admission to detect underlying causes and metabolic or cardiac comp...

Authors: Robert D. Nass, Sina Meiling, René P. Andrié, Christian E. Elger and Rainer Surges

Intrafamilial phenotypic heterogeneity in a Taiwanese family with a MAPT p.R5H mutation: a case report and literature review

Frontotemporal degeneration (FTD) is a clinically and genetically heterogeneous neurodegenerative disorder characterized by deficits in executive function that frequently overlaps with parkinsonism and motor n...

Authors: Hui-Chi Lin, Chin-Hsien Lin, Pei-Lung Chen, Shih-Jung Cheng and Pei-Hao Chen

Exercise prescription for patients with multiple sclerosis; potential benefits and practical recommendations

Multiple sclerosis (MS) can result in significant mental and physical symptoms, specially muscle weakness, abnormal walking mechanics, balance problems, spasticity, fatigue, cognitive impairment and depression...

Authors: Farzin Halabchi, Zahra Alizadeh, Mohammad Ali Sahraian and Maryam Abolhasani

Low threshold unmyelinated mechanoafferents can modulate pain

Human, hairy skin contains a subgroup of C-fibers, the C-low threshold mechanoreceptive afferents ((C-LTMR) C-tactile or C-touch (CT) fibers) that are linked with the signaling of affective aspects of human to...

Authors: Kathrin Habig, Anne Schänzer, Wolfgang Schirner, Gothje Lautenschläger, Benjamin Dassinger, Håkan Olausson, Frank Birklein, Elke R. Gizewski and Heidrun H. Krämer

Anatomic mapping of molecular subtypes in diffuse glioma

Tumor location served as an important prognostic factor in glioma patients was considered to postulate molecular features according to cell origin theory. However, anatomic distribution of unique molecular sub...

Authors: Qisheng Tang, Yuxi Lian, Jinhua Yu, Yuanyuan Wang, Zhifeng Shi and Liang Chen

A novel frameshift GRN mutation results in frontotemporal lobar degeneration with a distinct clinical phenotype in two siblings: case report and literature review

Progranulin gene (GRN) mutations are major causes of frontotemporal lobar degeneration. To date, 68 pathogenic GRN mutations have been identified. However, very few of these mutations have been reported in Asians...

Authors: Takashi Hosaka, Kazuhiro Ishii, Takeshi Miura, Naomi Mezaki, Kensaku Kasuga, Takeshi Ikeuchi and Akira Tamaoka

Trial design and rationale for APOLLO, a Phase 3, placebo-controlled study of patisiran in patients with hereditary ATTR amyloidosis with polyneuropathy

Patisiran is an investigational RNA interference (RNAi) therapeutic in development for the treatment of hereditary ATTR (hATTR) amyloidosis, a progressive disease associated with significant disability, morbid...

Authors: David Adams, Ole B. Suhr, Peter J. Dyck, William J. Litchy, Raina G. Leahy, Jihong Chen, Jared Gollob and Teresa Coelho

Supernumerary phantom limb in a patient with basal ganglia hemorrhage - a case report and review of the literature

Supernumerary phantom limb (SPL) is a rare neurologic phenomenon, in which a patient misperceives an extra limb in addition to the original set of limbs. We report a case of SPL in a patient with a right basal...

Authors: Hang-Rai Kim, Jee-young Han, Young Ho Park, Beom Joon Kim, Wookjin Yang and SangYun Kim

Research on advanced intervention using novel bone marrOW stem cell (RAINBOW): a study protocol for a phase I, open-label, uncontrolled, dose-response trial of autologous bone marrow stromal cell transplantation in patients with acute ischemic stroke

Stroke is a leading cause of death and disability, and despite intensive research, few treatment options exist. However, a recent breakthrough in cell therapy is expected to reverse the neurological sequelae o...

Authors: Hideo Shichinohe, Masahito Kawabori, Hiroaki Iijima, Tuyoshi Teramoto, Takeo Abumiya, Naoki Nakayama, Ken Kazumata, Shunsuke Terasaka, Teruyo Arato and Kiyohiro Houkin

Aggregation-prone GFAP mutation in Alexander disease validated using a zebrafish model

Alexander disease (AxD) is an astrogliopathy that predominantly affects the white matter of the central nervous system (CNS), and is caused by a mutation in the gene encoding the glial fibrillary acidic protei...

Authors: So-Hyun Lee, Tai-Seung Nam, Kun-Hee Kim, Jin Hee Kim, Woong Yoon, Suk-Hee Heo, Min Jung Kim, Boo Ahn Shin, Ming-Der Perng, Hyon E. Choy, Jihoon Jo, Myeong-Kyu Kim and Seok-Yong Choi

Caught in a no-win situation: discussions about CCSVI between persons with multiple sclerosis and their neurologists – a qualitative study

In recent years, shared decision making (SDM) has been promoted as a model to guide interactions between persons with MS and their neurologists to reach mutually satisfying decisions about disease management –...

Authors: S. Michelle Driedger, Ryan Maier, Ruth Ann Marrie and Melissa Brouwers

The hemorrhagic transformation index score: a prediction tool in middle cerebral artery ischemic stroke

We aimed to develop a tool, the hemorrhagic transformation (HT) index (HTI), to predict any HT within 14 days after middle cerebral artery (MCA) stroke onset regardless of the intravenous recombinant tissue pl...

Authors: Mikhail N. Kalinin, Dina R. Khasanova and Murat M. Ibatullin

Phenotypic expressions of hereditary Transthyretin Ala97Ser related Amyloidosis (ATTR) in Taiwanese

The disease course and early signs specific to ATTR Ala97Ser, the most common endemic mutation in Taiwan, have not been well described. Since new medications can slow down the rate of disease progression, the ...

Authors: Hui-Ching Hsu, Ming-Feng Liao, Jung-Lung Hsu, Ai-Lun Lo, Hung-Chou Kuo, Rong-Kuo Lyu, Victor Chien-Chia Wu, Chih-Wei Wang and Long-Sun Ro

Amyotrophic lateral sclerosis modifies progenitor neural proliferation in adult classic neurogenic brain niches

Adult neurogenesis persists through life at least in classic neurogenic niches. Neurogenesis has been previously described as reduced in neurodegenerative diseases. There is not much knowledge about is adult n...

Authors: Lucía Galán, Ulises Gómez-Pinedo, Antonio Guerrero, Jose Manuel García-Verdugo and Jorge Matías-Guiu

Adherence, satisfaction and functional health status among patients with multiple sclerosis using the BETACONNECT® autoinjector: a prospective observational cohort study

Maintaining patient adherence to disease modifying drugs in multiple sclerosis is a challenge, which can be improved by autoinjectors. The BETACONNECT® is a fully electronic autoinjector for the injection of i...

Authors: Ingo Kleiter, Michael Lang, Judith Jeske, Christiane Norenberg, Barbara Stollfuß and Markus Schürks

Automated segmentation of cerebral deep gray matter from MRI scans: effect of field strength on sensitivity and reliability

The cerebral subcortical deep gray matter nuclei (DGM) are a common, early, and clinically-relevant site of atrophy in multiple sclerosis (MS). Robust and reliable DGM segmentation could prove useful to evalua...

Authors: Renxin Chu, Shelley Hurwitz, Shahamat Tauhid and Rohit Bakshi

Subjective patient-reported versus objective adherence to subcutaneous interferon β-1a in multiple sclerosis using RebiSmart®: the CORE study

Patient adherence to treatment is key to preventing the worsening of neurological disability in multiple sclerosis (MS). The RebiSmart® autoinjector facilitates self-administration of subcutaneous interferon β...

Authors: Chiara Zecca, Giulio Disanto, Sarah Mühl and Claudio Gobbi

Neurogranin and tau in cerebrospinal fluid and plasma of patients with acute ischemic stroke

While neurogranin has no value as plasma biomarker for Alzheimer’s disease, it may be a potential blood biomarker for traumatic brain injury. This evokes the question whether there are changes in neurogranin l...

Authors: Ann De Vos, Maria Bjerke, Raf Brouns, Naomi De Roeck, Dirk Jacobs, Lien Van den Abbeele, Kaat Guldolf, Henrik Zetterberg, Kaj Blennow, Sebastiaan Engelborghs and Eugeen Vanmechelen

Cilostazol improves endothelial function in acute cerebral ischemia patients: a double-blind placebo controlled trial with flow-mediated dilation technique

In order to evaluate the impact of cilostazol on endothelial function, we compared the changes of flow-mediated dilation (FMD) between aspirin and cilostazol groups in patients with acute cerebral ischemia.

Authors: Seong-Joon Lee, Jin Soo Lee, Mun Hee Choi, Sung Eun Lee, Dong Hoon Shin and Ji Man Hong

Are the anomalous vertebral arteries more hypoplastic?: retrospective linear mixed model approach

Small or hypoplastic vertebral artery (VA) is one of the risk factor for posterior circulation stroke. We assess whether various types of VA anomaly contribute to its diameter.

Authors: Chulho Kim, Jong-Hee Sohn and Hui-Chul Choi