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  2. The level of function of instrumental activities of daily living (IADL) is crucial for a person’s autonomy. A clear understanding of the nature of IADL and its limitations in people with mild cognitive impairm...

    Authors: Marina Bruderer-Hofstetter, Sietske A. M. Sikkes, Thomas Münzer and Karin Niedermann

    Citation: BMC Neurology 2020 20:264

    Content type: Research article

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  3. Level of dependency after a stroke is important for long-term outcome in several aspects, but less is known about important predictors for outcome depending on functional dependency. The aim of the current stu...

    Authors: Emma Westerlind, Daniel Hörsell and Hanna C. Persson

    Citation: BMC Neurology 2020 20:263

    Content type: Research article

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  4. In this study, we explored whether the proposed short-echo-time magnitude (setMag) image derived from quantitative susceptibility mapping (QSM) could resemble NM-MRI image in substantia nigra (SN), by quantita...

    Authors: Xue Ling Liu, Li Qin Yang, Feng Tao Liu, Pu-Yeh Wu, Yong Zhang, Han Zhuang, Yong Hong Shi, Jian Wang, Dao Ying Geng and Yu Xin Li

    Citation: BMC Neurology 2020 20:262

    Content type: Research article

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  5. Although the criteria for acute migraine treatment and prevention have been well described, there are still unmet needs, general underuse and low benefits of preventive drugs.

    Authors: Marianna Delussi, Eleonora Vecchio, Giuseppe Libro, Silvia Quitadamo and Marina de Tommaso

    Citation: BMC Neurology 2020 20:256

    Content type: Research article

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  6. Psychopathology and personality traits may influence the course of autoimmune disorders. With this prospective longitudinal cohort study, we aimed to assess personality, stress and depression in myasthenia pat...

    Authors: Anca Bogdan, Carolina Barnett, Abdulrahman Ali, Mohammed AlQwaifly, Alon Abraham, Shabber Mannan, Eduardo Ng and Vera Bril

    Citation: BMC Neurology 2020 20:261

    Content type: Research article

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  7. Delayed cerebral ischemia is one of the leading causes of death and disability in patients with subarachnoid hemorrhage (SAH). Transluminal balloon angioplasty (TBA) is a therapeutic option for vasospasms affe...

    Authors: Ioannis Tsogkas, Vesna Malinova, Katharina Schregel, Dorothee Mielke, Daniel Behme, Veit Rohde, Michael Knauth and Marios-Nikos Psychogios

    Citation: BMC Neurology 2020 20:260

    Content type: Research article

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  9. Leukodystrophies are familial heterogeneous disorders primarily affecting the white matter, which are defined as hypomyelinating or demyelinating based on disease severity as assessed at MRI. Recently, a group...

    Authors: Rosa Campopiano, Rosangela Ferese, Stefania Zampatti, Emiliano Giardina, Francesca Biagioni, Claudio Colonnese, Diego Centonze, Marianna Storto, Fabio Buttari, Edoardo Fraviga, Vania Broccoli, Mirco Fanelli, Francesco Fornai and Stefano Gambardella

    Citation: BMC Neurology 2020 20:258

    Content type: Case report

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  10. Deep vein thrombosis (DVT) is an important complication of ischemic stroke, although the incidence of DVT is regarded as being lower in Asian than in non-Asian patients. Here, we investigated the incidence and...

    Authors: Sang Hee Ha, Yeon-Jung Kim, Sung Hyuk Heo, Dae-il Chang and Bum Joon Kim

    Citation: BMC Neurology 2020 20:257

    Content type: Research article

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  11. Even though recent research has achieved significant advancement in the development of therapeutic approaches for Wilson’s diseases (WD), the current treatment options available for WD are still limited, espec...

    Authors: Jing Zhang, Lulu Xiao and Wenming Yang

    Citation: BMC Neurology 2020 20:255

    Content type: Research article

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  12. Stroke is a leading cause of long-term disability. Cost-effective post-stroke rehabilitation programs for upper limb are critically needed. Brain-Computer Interfaces (BCIs) which enable the modulation of Elect...

    Authors: Donatella Mattia, Floriana Pichiorri, Emma Colamarino, Marcella Masciullo, Giovanni Morone, Jlenia Toppi, Iolanda Pisotta, Federica Tamburella, Matteo Lorusso, Stefano Paolucci, Maria Puopolo, Febo Cincotti and Marco Molinari

    Citation: BMC Neurology 2020 20:254

    Content type: Study protocol

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  14. High adherence to a Mediterranean Diet is associated with reduced incidence and mortality of acute ischemic stroke (AIS) but may also be associated with severity. Our purpose was to investigate the association...

    Authors: Pablo M. Lavados, Enrico Mazzon, Alexis Rojo, Alejandro M. Brunser and Verónica V. Olavarría

    Citation: BMC Neurology 2020 20:252

    Content type: Research article

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  15. The purpose of this study was to clarify the effect of asymmetric COW variants on carotid flow changes, and proposed an easy estimate of the representative carotid flow volume for accurate numerical simulation.

    Authors: Te-Chang Wu, Tai-Yuan Chen, Ching-Chung Ko, Jeon-Hor Chen and Ching-Po Lin

    Citation: BMC Neurology 2020 20:251

    Content type: Research article

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  16. Post-stroke depression (PSD) is a mood disorder characterized by depression and anhedonia caused by stroke. Metabolomics identified metabolites associated with PSD, but previous studies are based on gas chroma...

    Authors: Man Wang, Xianwei Gui, Lanxiang Wu, Sheng Tian, Hansen Wang, Liang Xie and Wei Wu

    Citation: BMC Neurology 2020 20:250

    Content type: Research article

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  17. Cerebral venous sinus thrombosis (CVST), a rare cause of cerebral infarction, is often unrecognized at initial presentation. We report the case of a patient with bilateral corpus callosum and corona radiata in...

    Authors: Rui Lan, Yun-zhi Ma, Xiao-ming Shen, Ji-tao Wu, Chun-qing Gu and Yong Zhang

    Citation: BMC Neurology 2020 20:249

    Content type: Case report

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  18. COVID-19 is caused by the severe acute respiratory syndrome virus SARS-CoV-2. It is widely recognized as a respiratory pathogen, but neurologic complications can be the presenting manifestation in a subset of ...

    Authors: Shelli Farhadian, Laura R. Glick, Chantal B. F. Vogels, Jared Thomas, Jennifer Chiarella, Arnau Casanovas-Massana, Jing Zhou, Camila Odio, Pavithra Vijayakumar, Bertie Geng, John Fournier, Santos Bermejo, Joseph R. Fauver, Tara Alpert, Anne L. Wyllie, Cynthia Turcotte…

    Citation: BMC Neurology 2020 20:248

    Content type: Case report

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  19. A unique patient with MELAS syndrome, who initially masqueraded as having acute encephalitis and was eventually diagnosed with MELAS syndrome harboring a mtDNA 14453G → A mutation, is described.

    Authors: Yuki Yokota, Makoto Hara, Takayoshi Akimoto, Tomotaka Mizoguchi, Yu-ichi Goto, Ichizo Nishino, Satoshi Kamei and Hideto Nakajima

    Citation: BMC Neurology 2020 20:247

    Content type: Case report

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  20. KMT2B-related dystonia is a recently described form of childhood onset dystonia that may improve with deep brain stimulation. Prior reports have focused on neurologic features including prominent bulbar involveme...

    Authors: Andrew Ng, Serena Galosi, Lisa Salz, Terence Wong, Caitlin Schwager, Shivarajan Amudhavalli, Rose Gelineau-Morel, Shimul Chowdhury and Jennifer Friedman

    Citation: BMC Neurology 2020 20:246

    Content type: Case report

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  21. Parkinson’s Disease (PD) is a heterogeneous, progressive neurodegenerative disorder which is characterized by a variety of motor and non-motor symptoms. To date, no disease modifying treatment for PD exists. H...

    Authors: Jeffrey M. Boertien, Sygrid van der Zee, Asterios Chrysou, Marleen J. J. Gerritsen, Nomdo M. Jansonius, Jacoba M. Spikman and Teus van Laar

    Citation: BMC Neurology 2020 20:245

    Content type: Study protocol

    Published on:

  23. Cerebral palsy (CP), which is the leading cause of motor disability during childhood, can produce sensory and cognitive impairments at different degrees. Most recent therapeutic interventions for these patient...

    Authors: Rodrigo Araneda, Stephane V. Sizonenko, Christopher J. Newman, Mickael Dinomais, Gregoire Le Gal, Daniela Ebner-Karestinos, Julie Paradis, Anne Klöcker, Geoffroy Saussez, Josselin Demas, Rodolphe Bailly, Sandra Bouvier, Emmanuel Nowak, Andrea Guzzetta, Inmaculada Riquelme, Sylvain Brochard…

    Citation: BMC Neurology 2020 20:243

    Content type: Study protocol

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  24. Lowering vascular risk is associated with a decrease in the prevalence of cardiovascular disease and dementia. However, it is still unknown whether lowering of vascular risk with pharmacological treatment pres...

    Authors: Marlise E. A. van Eersel, Sipke T. Visser, Hanneke Joosten, Ron T. Gansevoort, Joris P. J. Slaets and Gerbrand J. Izaks

    Citation: BMC Neurology 2020 20:242

    Content type: Research article

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  25. Increasing evidence supports the role of soluble inflammatory mediators in the pathogenesis of refractory temporal lobe epilepsy (TLE). Hippocampal sclerosis (HS) is a well-described pathohistological abnormal...

    Authors: Pabitra Basnyat, Marko Pesu, Mikael Söderqvist, Anna Grönholm, Suvi Liimatainen, Maria Peltola, Jani Raitanen and Jukka Peltola

    Citation: BMC Neurology 2020 20:241

    Content type: Research article

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  26. The onset of myasthenia (MG) gravis with anti-muscle-specific tyrosine kinase (MuSK) antibodies most commonly peaks in the fourth decade of life, and MG with MuSK antibodies (MuSK-MG) rarely coexists with a ma...

    Authors: Shoko Sakano, Hirofumi Matsuyama, Hidehiro Ishikawa, Akihiro Shindo, Yuichiro Ii, Keita Matsuura, Minoru Mizutani, Norikazu Kawada and Hidekazu Tomimoto

    Citation: BMC Neurology 2020 20:240

    Content type: Case report

    Published on:

  27. Thrombolysis with recombinant tissue plasminogen activator (rtPA) improves outcome for patients with acute ischemic stroke (AIS), but many of them still have substantial disability. Glibenclamide (US adopted n...

    Authors: Kaibin Huang, Zhong Ji, Yongming Wu, Yunqiang Huang, Guangning Li, Saijun Zhou, Zhi Yang, Wenguo Huang, Guoshuai Yang, Guohu Weng, Pingyan Chen and Suyue Pan

    Citation: BMC Neurology 2020 20:239

    Content type: Study protocol

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  28. It is well demonstrated that immunosuppressants can reduce, but not eliminate the risk of generalized development in ocular myasthenia gravis (OMG). In this study, we aimed to explore the predictive factors of...

    Authors: Jiaqi Ding, Sijia Zhao, Kaixi Ren, Dan Dang, Hongzeng Li, Fang Wu, Min Zhang, Zhuyi Li and Jun Guo

    Citation: BMC Neurology 2020 20:238

    Content type: Research article

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  29. Myositis is a recognised complication of numerous systemic viral infections including influenza. In adults the typical pattern is characterised by myalgia and marked proximal muscle weakness in upper and lower...

    Authors: Jakub Scaber, Adam J Molyneux, Camilla Buckley and Alastair J S Webb

    Citation: BMC Neurology 2020 20:237

    Content type: Case report

    Published on:

  30. Diffusion tensor imaging (DTI) is an effective method to identify subtle changes to normal-appearing white matter (WM). Here we analyzed the DTI data with other examinations, including motor evoked potentials ...

    Authors: Beike Chen, Qiang Tan, Weikang Zhao, Qiming Yang, Hongyan Zhang, Fabao Gao, Xin Liu, Hua Feng and Dianming Jiang

    Citation: BMC Neurology 2020 20:236

    Content type: Research article

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  31. Mesial temporal lobe epilepsy (MTLE) is the most common form of focal epilepsy, which is frequently characterized by hippocampal sclerosis (HS). Accumulating studies have suggested widespread cortico-cortical ...

    Authors: Dongyan Wu, Feiyan Chang, Dantao Peng, Sheng Xie, Xiaoxuan Li and Wenjing Zheng

    Citation: BMC Neurology 2020 20:235

    Content type: Research article

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  32. Mechanical ventilation (MV) with positive end-expiratory pressure (PEEP) is commonly applied in patients with severe traumatic brain injury (sTBI). However, the individual responsiveness of intracranial pressu...

    Authors: Hong Peng Li, Ying Ni Lin, Zhi Hui Cheng, Wei Qu, Liu Zhang and Qing Yun Li

    Citation: BMC Neurology 2020 20:234

    Content type: Research article

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  33. Interictal epileptiform discharges (IEDs) have been proven to impair cognitive function. However, it is not clear whether IEDs disrupt academic performance in children with idiopathic epilepsy, and the contrib...

    Authors: Dazhi Cheng, Xiuxian Yan, Keming Xu, Xinlin Zhou and Qian Chen

    Citation: BMC Neurology 2020 20:233

    Content type: Research article

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  34. Partially thrombosed giant aneurysms at the basilar apex (BA) artery are challenging lesions with a poor prognosis if left untreated. Here we describe a rare case of extensive brain edema after growth of a sur...

    Authors: Daniel García-Pérez, Irene Panero, Carla Eiriz, Luis Miguel Moreno, Pablo M. Munarriz, Igor Paredes, Alfonso Lagares and José F. Alén

    Citation: BMC Neurology 2020 20:232

    Content type: Case report

    Published on:

  35. By 2050, the prevalence of Alzheimer’s disease (AD) in the United States is predicted to reach 13.8 million. Despite worldwide research efforts, a cure for AD has not been identified. Thus, it is critical to i...

    Authors: Kyoung Shin Park, Alexis B. Ganesh, Nathaniel T. Berry, Yashonda P. Mobley, William B. Karper, Jeffrey D. Labban, Christopher N. Wahlheim, Tomika M. Williams, Laurie Wideman and Jennifer L. Etnier

    Citation: BMC Neurology 2020 20:231

    Content type: Study protocol

    Published on:

  36. Intracranial necrotizing granulomatous space-occupying lesions are sparsely reported in literature. Variability in presenting symptomatology and radiographic features makes diagnostic work-up difficult.

    Authors: Kerilyn N. Godbe, Brian F. Saway, Evin L. Guilliams, John J. Entwistle and Robert W. Jarrett Jr

    Citation: BMC Neurology 2020 20:230

    Content type: Case report

    Published on:

  37. Arterial thoracic outlet syndrome is a rare condition characterized by a subclavian artery pathology associated with a bone abnormality. It is rarely associated with thromboembolic stroke. The mechanism of cer...

    Authors: Adam Celier, Simon Chabay, Aurélien Maurizot, Frédéric Cochennec, Daniela Stanciu and Fernando Pico

    Citation: BMC Neurology 2020 20:229

    Content type: Case report

    Published on:

  38. Recent studies have examined hypertrophic pachymeningitis as an IgG4-RD. However, there are no reports of immunoglobulin G4 (IgG4)-related hypertrophic pachymeningitis with polycystic subdural hygroma.

    Authors: Kazumichi Ota, Yoshihiko Nakazato, Risa Okuda, Ryu Yokoyama, Hitoshi Kawasaki, Naotoshi Tamura and Toshimasa Yamamoto

    Citation: BMC Neurology 2020 20:228

    Content type: Case report

    Published on:

  41. The aim of this study was to assess the cognitive function of patients over 60 years old with meningioma using a domain-specific neuropsychological test and to investigate the relevant factors affecting pre-op...

    Authors: Min Ju Kang, Jung-Min Pyun, Min Jae Baek, Kihwan Hwang, Jung Ho Han, Young Ho Park, Chae-Yong Kim and SangYun Kim

    Citation: BMC Neurology 2020 20:225

    Content type: Research article

    Published on:

  42. New evidence on the efficacy and safety of dual antiplatelet therapy for secondary stroke prevention have been realized in the recent years. An updated meta analysis was done to determine the effect of the var...

    Authors: Christessa Emille Que Albay, Frederick Gavril D. Leyson and Federick C. Cheng

    Citation: BMC Neurology 2020 20:224

    Content type: Research article

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  43. We evaluated severe pain-related adverse events (SAE) during the percutaneous dilatational tracheostomy (PDT) procedure performed by a neurointensivist and compared the outcomes with that of conventional surgi...

    Authors: Yong Oh Kim, Chi Ryang Chung, Chi-Min Park, Gee Young Suh and Jeong-Am Ryu

    Citation: BMC Neurology 2020 20:223

    Content type: Research article

    Published on:

  44. Palato-pharyngo-laryngeal myoclonus, a variant of palatal myoclonus, is characterized by involuntary rhythmic movements of palatal, pharyngeal, and laryngeal muscles. Symptomatic palatal myoclonus is classical...

    Authors: Jamie L. Fleet, Ronelle Calver, Gihan C. Perera and Zhihui Deng

    Citation: BMC Neurology 2020 20:222

    Content type: Case report

    Published on:

  45. Surgery is usually the treatment of choice for patients with cervical compressive myelopathy (CCM). Motor evoked potential (MEP) has proved to be helpful tool in evaluating intraoperative cervical spinal cord ...

    Authors: Shujie Wang, Zhifu Ren, Jia Liu, Jianguo Zhang and Ye Tian

    Citation: BMC Neurology 2020 20:221

    Content type: Research article

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  46. Thrombocytopenia (TP) has been shown to be an independent predictor of mortality in the intensive care unit (ICU) patients. Studies are lacking in the neurological ICU (NICU) population. The aim was to evaluat...

    Authors: Dawei Zhou, Zhimin Li, Lei Wu, Guangzhi Shi and Jianxin Zhou

    Citation: BMC Neurology 2020 20:220

    Content type: Research article

    Published on:

  47. Almost half of the stroke patients admitted to geriatric rehabilitation has persisting problems after discharge. Currently, there is no evidence based geriatric rehabilitation programme available for older str...

    Authors: Tom P. M. M. Vluggen, Jolanda C. M. van Haastregt, Jeanine A. Verbunt, Caroline M. van Heugten and Jos M. G. A. Schols

    Citation: BMC Neurology 2020 20:219

    Content type: Research article

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  48. Several studies have reported the association between polymorphisms in Matrix metalloproteinases (MMPs) gene family and risk of Multiple sclerosis (MS). However, the results have been inconsistent and inconclu...

    Authors: Mina Mohammadhosayni, Arezou Khosrojerdi, Keivan Lorian, Saeed Aslani, Danyal Imani, Bahman Razi, Farhad Babaie and Shahram Torkamandi

    Citation: BMC Neurology 2020 20:218

    Content type: Research article

    Published on:

  49. Poststroke depression can lead to functional dependence, cognitive impairment and reduced quality of life. The aim of this study was to evaluate the effects of a percutaneous mastoid electrical stimulator (PME...

    Authors: Taoli Lu, Lanying He, Bei Zhang, Jian Wang, Lili Zhang, Wei Wei Dong and Hao Yang

    Citation: BMC Neurology 2020 20:217

    Content type: Research article

    Published on:

  50. Spastic ataxia of Charlevoix-Saguenay is a neurodegenerative condition due to mutations in the SACS gene and without a cure. Attempts to treatments are scarce and limited to symptomatic drugs.

    Authors: Ivana Ricca, Alessandra Tessa, Rosanna Trovato, Giacomo Maria Bacci and Filippo Maria Santorelli

    Citation: BMC Neurology 2020 20:215

    Content type: Case report

    Published on:

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