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  1. Content type: Research article

    Neuronal ceroid lipofuscinoses type I and type II (NCL1 and NCL2) also known as Batten disease are the commonly observed neurodegenerative lysosomal storage disorder caused by mutations in the PPT1 and TPP1 genes...

    Authors: Jayesh Sheth, Mehul Mistri, Riddhi Bhavsar, Dhairya Pancholi, Mahesh Kamate, Neerja Gupta, Madhulika Kabra, Sanjiv Mehta, Sheela Nampoothiri, Arpita Thakker, Vivek Jain, Raju Shah and Frenny Sheth

    Citation: BMC Neurology 2018 18:203

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  2. Content type: Research article

    Recurrent seizure risks in HIV-positive people with new-onset seizure are largely unknown, making it challenging to offer optimal recommendations regarding antiepileptic drug (AED) initiation. Existing outcome...

    Authors: Melissa A. Elafros, Brent A. Johnson, Omar K. Siddiqi, Jason F. Okulicz, Izukanji Sikazwe, Christopher M. Bositis, Michael J. Potchen, Igor J. Koralnik, William H. Theodore, Lisa Kalungwana and Gretchen L. Birbeck

    Citation: BMC Neurology 2018 18:201

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  3. Content type: Research article

    Cerebrospinal fluid (CSF) biomarkers reflect ongoing processes in the brain. Growth-associated protein 43 (GAP-43) is highly upregulated in brain tissue shortly after experimental ischemia suggesting the CSF G...

    Authors: Åsa Sandelius, Nicholas C. Cullen, Åsa Källén, Lars Rosengren, Crister Jensen, Vesna Kostanjevecki, Manu Vandijck, Henrik Zetterberg and Kaj Blennow

    Citation: BMC Neurology 2018 18:202

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  4. Content type: Research article

    Elevated plasma homocysteine (Hcy) is an independent risk factor for ischemic stroke. This study aimed to evaluate the association between Hcy levels and intracranial plaque characteristics and to investigate ...

    Authors: Shan shan Lu, Jun Xie, Chun qiu Su, Song Ge, Hai bin Shi and Xun ning Hong

    Citation: BMC Neurology 2018 18:200

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  5. Content type: Research article

    In cases showing cerebrospinal fluid (CSF) redistribution as a compensatory mechanism in acute intracranial hypertension, the optic nerve sheath diameter (ONSD) can be used to estimate intracranial pressure (I...

    Authors: Yuzhi Gao, Qiang Li, Chunshuang Wu, Shaoyun Liu and Mao Zhang

    Citation: BMC Neurology 2018 18:199

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  6. Content type: Research article

    Warfarin therapies not only are used to prevent stroke in patients with high risk of cardioembolism such as patients with atrial fibrillation (AF) and rheumatic heart disease (RHD), but also was associated wit...

    Authors: Jiaying Zhu, Mengmeng Ma, Yijia Guo, Muke Zhou, Jian Guo and Li He

    Citation: BMC Neurology 2018 18:194

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  7. Content type: Case report

    The majority of ruptured intracranial aneurysms are combined with subarachnoid hemorrhage, but patients with only intracerebral hematoma without any subarachnoid hemorrhage are extremely rare.

    Authors: Guangyong Chen, Meiling Xu, Long Ma, Yufei Gao, Chengyan He and Jinnan Zhang

    Citation: BMC Neurology 2018 18:197

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  8. Content type: Research article

    Hereditary sensory and autonomic neuropathy type 2 (HSAN2) is an autosomal recessive disorder with predominant sensory dysfunction and severe complications such as limb destruction. There are different subtype...

    Authors: Behrouz Rahmani, Fatemeh Fekrmandi, Keivan Ahadi, Tannaz Ahadi, Afagh Alavi, Abolhassan Ahmadiani and Sareh Asadi

    Citation: BMC Neurology 2018 18:195

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  9. Content type: Case report

    Autosomal recessive hereditary spastic paraplegias (ARHSPs) are a group of clinically and genetically heterogeneous neurodegenerative diseases with progressive spasticity and weakness in the lower limbs. Mutat...

    Authors: Xiaoqian Zhang, Lei Zhang, Yanqing Wu, Gang Li, Shengcai Chen, Yuanpeng Xia and Hongge Li

    Citation: BMC Neurology 2018 18:196

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  10. Content type: Study protocol

    Early and late onset post-stroke cognitive impairment (PCI) contributes substantially to disability following stroke, and is a high priority within stroke research. The aetiology for PCI is complex and related...

    Authors: Pernille Thingstad, Torunn Askim, Mona K. Beyer, Geir Bråthen, Hanne Ellekjær, Hege Ihle-Hansen, Anne Brita Knapskog, Stian Lydersen, Ragnhild Munthe-Kaas, Halvor Næss, Sarah T. Pendlebury, Yngve Muller Seljeseth and Ingvild Saltvedt

    Citation: BMC Neurology 2018 18:193

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  11. Content type: Research article

    There is limited data on the effects of medication-related adverse events occurring during inpatient stays for stroke. The objectives of our study were to characterize reasons for acute readmission after acute...

    Authors: James A. G. Crispo, Dylan P. Thibault, Yannick Fortin, Daniel Krewski and Allison W. Willis

    Citation: BMC Neurology 2018 18:192

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  12. Content type: Research article

    Fibromyalgia is a chronic disorder characterized by widespread musculoskeletal pain accompanied by fatigue, sleep, memory, and mood problems. Recently, occipital nerve field stimulation (ONS) has been proposed...

    Authors: Shaheen Ahmed, Mark Plazier, Jan Ost, Gaetane Stassijns, Steven Deleye, Sarah Ceyssens, Patrick Dupont, Sigrid Stroobants, Steven Staelens, Dirk De Ridder and Sven Vanneste

    Citation: BMC Neurology 2018 18:191

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  13. Content type: Case report

    Posterior reversible encephalopathy syndrome (PRES) is described as a clinical-radiological disease entity with good prognosis. In brain MRI, PRES generally presents with vasogenic edema. Although PRES is indu...

    Authors: Yoshitsugu Nakamura, Masakazu Sugino, Akihiro Tsukahara, Hiroko Nakazawa, Naomune Yamamoto and Shigeki Arawaka

    Citation: BMC Neurology 2018 18:190

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  14. Content type: Case report

    Paraneoplastic neurological syndromes (PNS) are rare disorders associated with cancer and are believed to be immune mediated. Patients with autonomic PNS suffer from variable combinations of parasympathetic an...

    Authors: Tatsuya Ueno, Yukihiro Hasegawa, Rie Hagiwara, Tomoya Kon, Jin-ichi Nunomura and Masahiko Tomiyama

    Citation: BMC Neurology 2018 18:189

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  15. Content type: Research article

    Galcanezumab, a humanized monoclonal antibody that selectively binds to the calcitonin gene-related peptide, has demonstrated in previous Phase 2 and Phase 3 clinical studies (≤6-month of treatment) a reductio...

    Authors: Angelo Camporeale, David Kudrow, Ryan Sides, Shufang Wang, Annelies Van Dycke, Katherine J. Selzler and Virginia L. Stauffer

    Citation: BMC Neurology 2018 18:188

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  16. Content type: Study protocol

    Patients with ischaemic stroke or transient ischaemic attack (TIA) are at high risk of future cardiovascular events. Despite compelling evidence about the efficacy of secondary prevention, a substantial gap ex...

    Authors: Thomas Toell, Christian Boehme, Lukas Mayer, Stefan Krebs, Clemens Lang, Karin Willeit, Barbara Prantl, Michael Knoflach, Gerhard Rumpold, Gudrun Schoenherr, Andrea Griesmacher, Peter Willeit, Julia Ferrari, Wilfried Lang, Stefan Kiechl and Johann Willeit

    Citation: BMC Neurology 2018 18:187

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  17. Content type: Research article

    Little is known about whether tolerability and adherence to treatment can be influenced by weather and temperature conditions. The objective of this study was to assess monthly and seasonal adherence to and sa...

    Authors: Spyros N. Deftereos, Evangelos Koutlas, Efrosini Koutsouraki, Athanassios Kyritsis, Panagiotis Papathanassopoulos, Nikolaos Fakas, Vaia Tsimourtou, Nikolaos Vlaikidis, Antonios Tavernarakis, Konstantinos Voumvourakis, Michalis Arvanitis, Dimitrios Sakellariou and Filippo DeLorenzo

    Citation: BMC Neurology 2018 18:186

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  18. Content type: Study protocol

    Parkinson’s disease (PD) is a chronic progressive disorder leading to increasing disability. While the symptoms and needs of patients in the early stages of their disease are well characterized, little informa...

    Authors: Monika Balzer-Geldsetzer, Joaquim Ferreira, Per Odin, Bastiaan R. Bloem, Wassilios G. Meissner, Stefan Lorenzl, Michael Wittenberg, Richard Dodel and Anette Schrag

    Citation: BMC Neurology 2018 18:185

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  19. Content type: Research article

    To determine the association of prior traumatic brain injury (TBI) with subsequent diagnosis of neurodegeneration disease.

    Authors: Chi-Hsien Huang, Chi-Wei Lin, Yi-Che Lee, Chih-Yuan Huang, Ru-Yi Huang, Yi-Cheng Tai, Kuo-Wei Wang, San-Nan Yang, Yuan-Ting Sun and Hao-kuang Wang

    Citation: BMC Neurology 2018 18:184

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  20. Content type: Research article

    Respiratory mechanics affects the effect of positive end-expiratory pressure (PEEP) on intracranial pressure (ICP). Respiratory mechanics of the lung and the chest wall was not differentiated in previous studi...

    Authors: Han Chen, Jing Zhou, Yi-Qin Lin, Jian-Xin Zhou and Rong-Guo Yu

    Citation: BMC Neurology 2018 18:183

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  21. Content type: Research article

    Physical activity (PA) is associated with lower risk of stroke. We tested the hypothesis that lack of pre-stroke PA is an independent predictor of poor outcome after first-ever ischemic stroke.

    Authors: Christian Urbanek, Viola Gokel, Anton Safer, Heiko Becher, Armin J. Grau, Florian Buggle and Frederick Palm

    Citation: BMC Neurology 2018 18:181

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  22. Content type: Case report

    Posterior reversible encephalopathy syndrome (PRES) is a neurotoxic condition which comprises various neurological symptoms. This syndrome could be complicated by intracranial hemorrhage including subarachnoid...

    Authors: Dan Hu, Jing Xiong, Yunfei Zha and Zhaohui Zhang

    Citation: BMC Neurology 2018 18:182

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  23. Content type: Case report

    Posterior reversible encephalopathy syndrome (PRES) is a reversible clinical and neurological entity. There are varieties of comorbid conditions which are associated with PRES. Chronic obstructive pulmonary di...

    Authors: Sushil Khanal and Subhash Prasad Acharya

    Citation: BMC Neurology 2018 18:180

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  24. Content type: Research article

    Deep venous thrombosis (DVT) is a severe complication in longitudinally extensive transverse myelitis (LETM) patients. It may interfere with LETM treatment and delay the recovery of the spinal dysfunction. How...

    Authors: Tian Song, Xindi Li, Yonghong Liu and Xinghu Zhang

    Citation: BMC Neurology 2018 18:179

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  25. Content type: Case report

    Alemtuzumab has been demonstrated to reduce the risks of relapse and accumulation of sustained disability in Multiple Sclerosis (MS) patients compared to β-interferon. It acts against CD52, leading primarily t...

    Authors: A. G. Vakrakou, D. Tzanetakos, S. Valsami, E. Grigoriou, K. Psarra, J. Tzartos, M. Anagnostouli, E. Andreadou, M. E. Evangelopoulos, G. Koutsis, C. Chrysovitsanou, E. Gialafos, A. Dimitrakopoulos, L. Stefanis and C. Kilidireas

    Citation: BMC Neurology 2018 18:178

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  26. Content type: Research article

    Neuromyelitis optica spectrum disorders (NMOSD) often coexist with connective tissue disorders (CTD). The aim of this study was to investigate and compare the features of NMOSD with and without CTD.

    Authors: Chun-Sheng Yang, Qiu Xia Zhang, Sheng Hui Chang, Lin Jie Zhang, Li Min Li, Yuan Qi, Jing Wang, Zhi Hua Sun, Nannan Zhangning, Li Yang and Fu-Dong Shi

    Citation: BMC Neurology 2018 18:177

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  27. Content type: Case report

    Leukoencephalopathy with brainstem and spinal cord involvement and lactate elevation (LBSL, OMIM #611105) is a genetic disease of the central nervous system characterized by lower limb spasticity, cerebellar a...

    Authors: Ashraf Yahia, Liena Elsayed, Arwa Babai, Mustafa A. Salih, Sarah Misbah El-Sadig, Mutaz Amin, Mahmoud Koko, Rayan Abubakr, Razaz Idris, Shaimaa Omer M.A. Taha, Salah A. Elmalik, Alexis Brice, Ammar Eltahir Ahmed and Giovanni Stevanin

    Citation: BMC Neurology 2018 18:175

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  28. Content type: Case report

    Herpes simplex encephalitis is the most common type of sporadic encephalitis worldwide. Frank intracerebral hemorrhage complicating the disease course in herpes simplex encephalitis patients is rare, especiall...

    Authors: Yoon Hwan Byun, Eun Jin Ha, Sang-Bae Ko and Kyung Hyun Kim

    Citation: BMC Neurology 2018 18:176

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  29. Content type: Case report

    DNA methyltransferase 1 (EC 2.1.1.37), encoded by DNMT1 gene, is one of key enzymes in maintaining DNA methylation patterns of the human genome. It plays a crucial role in embryonic development, imprinting and...

    Authors: Wenxia Zheng, Zhenxing Yan, Rongni He, Yaowei Huang, Aiqun Lin, Wei Huang, Yuying Su, Shaoyuan Li, Victor Wei Zhang and Huifang Xie

    Citation: BMC Neurology 2018 18:174

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  30. Content type: Case report

    Progressive encephalomyelitis with rigidity and myoclonus (PERM) syndrome is a rare neurological condition. Its clinical characteristics include axial and limb muscle rigidity, myoclonus, painful spasms and hy...

    Authors: Aurélie Degeneffe, Marie Dagonnier, Alain D’hondt and Jose Antonio Elosegi

    Citation: BMC Neurology 2018 18:173

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  31. Content type: Research article

    Headache management is common within chiropractic clinical settings; however, little is yet known about how this provider group manage headache sufferers. The aim of this study is to report on the prevalence o...

    Authors: Craig Moore, Andrew Leaver, David Sibbritt and Jon Adams

    Citation: BMC Neurology 2018 18:171

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  32. Content type: Research article

    The validation of international cognitive batteries in different multiple sclerosis (MS) populations is essential. Our objective was to obtain normative data for the Portuguese population of the Brief Internat...

    Authors: Cláudia Sousa, Mariana Rigueiro-Neves, Telma Miranda, Paulo Alegria, José Vale, Ana Margarida Passos, Dawn Langdon and Maria José Sá

    Citation: BMC Neurology 2018 18:172

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  33. Content type: Research article

    Migraine and Attention Deficit and Hyperactivity Disorder (ADHD) have been found to be associated in child and adolescent cohorts; however, the association has not been assessed in adults or otherwise healthy ...

    Authors: Thomas Folkmann Hansen, Louise K. Hoeffding, Lisette Kogelman, Thilde Marie Haspang, Henrik Ullum, Erik Sørensen, Christian Erikstrup, Ole Birger Pedersen, Kaspar René Nielsen, Henrik Hjalgrim, Helene M. Paarup, Thomas Werge and Kristoffer Burgdorf

    Citation: BMC Neurology 2018 18:147

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  34. Content type: Research article

    About 30% of stroke patients suffer from aphasia. As aphasia strongly affects daily life, most patients request a prediction of outcome of their language function. Prognostic models provide predictions of outc...

    Authors: Femke Nouwens, Evy G. Visch-Brink, Hanane El Hachioui, Hester F. Lingsma, Mieke W. M. E. van de Sandt-Koenderman, Diederik W. J. Dippel, Peter J. Koudstaal and Lonneke M. L. de Lau

    Citation: BMC Neurology 2018 18:170

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  35. Content type: Research article

    Currently, it is challenging to detect the awareness of patients who suffer disorders of consciousness (DOC). Brain-computer interfaces (BCIs), which do not depend on the behavioral response of patients, may s...

    Authors: Qiuyou Xie, Jiahui Pan, Yan Chen, Yanbin He, Xiaoxiao Ni, Jiechun Zhang, Fei Wang, Yuanqing Li and Ronghao Yu

    Citation: BMC Neurology 2018 18:144

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  36. Content type: Case report

    Besides CSF-flow obstruction, syringomyelia is associated with inflammatory spinal cord lesions. However, syringomyelia-like syndrome concomitant with neuromyelitis optica spectrum disorder (NMOSD) and primary...

    Authors: Xiangling Li, Zhengqi Lu and Yanqiang Wang

    Citation: BMC Neurology 2018 18:168

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  37. Content type: Research article

    Recent studies have shown conflicting results regarding the effect of hydrogel coils for treating intracranial aneurysm compared to bare platinum coils. We implemented a meta-analysis to assess the value of hy...

    Authors: Tao Xue, Zhouqing Chen, Weiwei Lin, Jiayi Xu, Xuming Shen and Zhong Wang

    Citation: BMC Neurology 2018 18:167

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  38. Content type: Case report

    Herpes zoster ophthalmicus (HZO) is an inflammation related to reactivation of the latent varicella zoster virus (VZV), involving the ophthalmic branch of the trigeminal nerve. Optic neuritis (ON), a rare ocul...

    Authors: Kavin Vanikieti, Anuchit Poonyathalang, Panitha Jindahra, Piyaphon Cheecharoen, Patchalin Patputtipong and Tanyatuth Padungkiatsagul

    Citation: BMC Neurology 2018 18:165

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  39. Content type: Research article

    We systematically reviewed the comparative effectiveness of injectable beta-interferons (IFN-β) and glatiramer acetate (GA) on annualised relapse rate (ARR), progression and discontinuation due to adverse even...

    Authors: G. J. Melendez-Torres, Xavier Armoiry, Rachel Court, Jacoby Patterson, Alan Kan, Peter Auguste, Jason Madan, Carl Counsell, Olga Ciccarelli and Aileen Clarke

    Citation: BMC Neurology 2018 18:162

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  40. Content type: Research article

    Neurodegenerative processes in the elderly damage the brain, leading to progressive, incapacitating cognitive, behavioral, and motor dysfunctions which culminate in dementia. Fully manifest dementia is likely ...

    Authors: Lorenzo Pasquini, Jorge Llibre Guerra, Martin Prince, Kia-Chong Chua and A. Matthew Prina

    Citation: BMC Neurology 2018 18:163

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  41. Content type: Research article

    Studying the impact of demographic changes and progress in the management of stroke patients is necessary in order to organize care structures for the coming years. Consequently, we analyzed the prognostic tre...

    Authors: Emilio Rodríguez-Castro, Iria López-Dequit, María Santamaría-Cadavid, Susana Arias-Rivas, Manuel Rodríguez-Yáñez, José Manuel Pumar, Pablo Hervella, Esteban López-Arias, Andrés da Silva-Candal, Ana Estany, María Piñeiro-Lamas, Tomás Sobrino, Francisco Campos, Manuel Portela, Manuel Vázquez-Lima, José Castillo…

    Citation: BMC Neurology 2018 18:164

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  42. Content type: Case report

    Crohn’s disease (CD) is associated with a variety of extra-intestinal manifestations. Most commonly these involve the eye, skin, joints, coagulation system and liver. Cerebral manifestations of CD have been re...

    Authors: Konrad Whittaker, Konstanze Guggenberger, Nils Venhoff, Soroush Doostkam, Hans-Eckart Schaefer and Brita Fritsch

    Citation: BMC Neurology 2018 18:161

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  43. Content type: Case report

    Catheter-related blood stream infection (CRBSI) is one of the most common intractable healthcare-associated infections because catheters can be easily contaminated by resistant bacteria, and is associated with...

    Authors: Nobuhiko Arai, Yutaka Mine, Hiroshi Kagami and Makoto Inaba

    Citation: BMC Neurology 2018 18:158

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  44. Content type: Case report

    Cerebral venous sinus thrombosis or stenosis (here collectively referred to as cerebral venous sinus occlusion, CVSO) can cause chronically-elevated intracranial pressure (ICP). Patients may have no neurologic...

    Authors: Tongtao Zhao, Gang Wang, Jiaman Dai, Yong Liu, Yi Wang and Shiying Li

    Citation: BMC Neurology 2018 18:159

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  45. Content type: Research article

    To investigate visual recovery after treatment of acute optic neuritis (ON) with either oral or intravenous high-dose methylprednisolone, in order to establish the best route of administration.

    Authors: Magdalena Naumovska, Rafi Sheikh, Boel Bengtsson, Malin Malmsjö and Björn Hammar

    Citation: BMC Neurology 2018 18:160

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  46. Content type: Case report

    The computed tomography (CT) finding of a pseudo-subarachnoid hemorrhage (SAH) may lead the treating physician into a diagnostic dilemma. We present a case of a pseudo-SAH in a patient with post-resuscitative ...

    Authors: Mohamad Syafeeq Faeez Md Noh and Anna Misyail Abdul Rashid

    Citation: BMC Neurology 2018 18:157

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  47. Content type: Research article

    Though genetic and environmental determinants of systemic haemodynamic have been reported, surprisingly little is known about their influences on cerebral haemodynamics. We assessed the potential geographical ...

    Authors: Angela S. M. Salinet, Ronney B. Panerai, Juliana Caldas, Ricardo C. Nogueira, Adriana B. Conforto, Manoel J. Texeira, Edson Bor-Seng-Shu and Thompson G. Robinson

    Citation: BMC Neurology 2018 18:156

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