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  1. Biomarkers based on the underlying pathology of Alzheimer’s disease (AD) and Dementia with Lewy Bodies (DLB) have the potential to improve diagnosis and understanding of the substrate for cognitive impairment ...

    Authors: Andrew Siderowf, Michael J Pontecorvo, Holly A Shill, Mark A Mintun, Anupa Arora, Abhinay D Joshi, Ming Lu, Charles H Adler, Douglas Galasko, Carolyn Liebsack, Daniel M Skovronsky and Marwan N Sabbagh
    Citation: BMC Neurology 2014 14:79
    Content type: Research article Published on:

  2. The extent to which MS patients with cognitive dysfunction can accurately self-report outcomes has been a crucial issue. The aim of this study was to quantify and compare the relevance of the quality of life (...

    Authors: Karine Baumstarck, Mohamed Boucekine, Laurent Boyer, Valérie Aghababian, Nathalie Parola, Françoise Reuter, Anderson Loundou, Christophe Lançon, Jean Pelletier and Pascal Auquier
    Citation: BMC Neurology 2014 14:78
    Content type: Research article Published on:

  3. The relationship between circulating microRNA-223 and pathogenesis of acute ischemic stroke is unknown. Here we investigated the roles and possible targets of circulating microRNA-223 in human ischemic stroke ...

    Authors: Yang Wang, Yu Zhang, Jun Huang, Xiaoyan Chen, Xiang Gu, Yongting Wang, Lili Zeng and Guo-Yuan Yang
    Citation: BMC Neurology 2014 14:77
    Content type: Research article Published on:

  4. Rapid eye movement (REM) sleep behavior disorder (RBD) is a common parasomnia in Parkinson’s disease (PD) patients. The current International Classification of Sleep Disorders (ICSD-II) requires a clinical int...

    Authors: Maartje Louter, Johan BAM Arends, Bastiaan R Bloem and Sebastiaan Overeem
    Citation: BMC Neurology 2014 14:76
    Content type: Research article Published on:

  5. Non-ataxic symptoms of spinocerebellar ataxias (SCAs) vary widely and often overlap with various types of SCAs. Duration and severity of the disease and genetic background may play a role in such phenotypic di...

    Authors: Pairoj Boonkongchuen, Sunsanee Pongpakdee, Panitha Jindahra, Chutima Papsing, Powpong Peerapatmongkol, Suppachok Wetchaphanphesat, Supachai Paiboonpol, Charungthai Dejthevaporn, Surat Tanprawate, Angkana Nudsasarn, Chanchai Jariengprasert, Dittapol Muntham, Atiporn Ingsathit and Teeratorn Pulkes
    Citation: BMC Neurology 2014 14:75
    Content type: Research article Published on:

  6. Neurogenic detrusor overactivity (NDO) leads to impaired health-related quality of life (HRQoL), productivity, and greater healthcare resource burden. The humanistic and economic burden may be more apparent in...

    Authors: Derek H Tang, Danielle Colayco, James Piercy, Vaishali Patel, Denise Globe and Michael B Chancellor
    Citation: BMC Neurology 2014 14:74
    Content type: Research article Published on:

  7. Many patients with relapsing-remitting multiple sclerosis (MS) treated with high-dose interferon-β (IFNβ) develop serum binding antibodies (BAb) and neutralizing antibodies (NAb). NAb reduces the biological activ...

    Authors: Edward Fox, Barbara Green, Clyde Markowitz, Ronald Murray, Andrew D Goodman, Stephen J Glenski, Pippa Loupe and Jo Nita Cogburn
    Citation: BMC Neurology 2014 14:73
    Content type: Research article Published on:

  8. In the PREDICT study, a randomised controlled trial comparing dexamethasone with prednisolone in patients with chronic inflammatory demyelinating polyradiculoneuropathy (CIDP), almost a quarter of patients det...

    Authors: Filip Eftimov, Marinus H Liesdek, Camillus Verhamme and Ivo N van Schaik
    Citation: BMC Neurology 2014 14:72
    Content type: Research article Published on:

  10. Teaching people with epilepsy to identify and manage seizure triggers, implement strategies to remember to take antiepileptic drugs, implement precautions to minimize risks during seizures, tell others what to...

    Authors: Ines Kralj-Hans, Laura H Goldstein, Adam J Noble, Sabine Landau, Nicholas Magill, Paul McCrone, Gus Baker, Myfanwy Morgan, Mark Richardson, Stephanie Taylor and Leone Ridsdale
    Citation: BMC Neurology 2014 14:69
    Content type: Study protocol Published on:

  11. Tumefactive demyelinating lesions are a rare manifestation of multiple sclerosis (MS). Differential diagnosis of such space occupying lesions may not be straightforward and sometimes necessitate brain biopsy. ...

    Authors: Sharmilee Gnanapavan, Zane Jaunmuktane, Kelly Pegoretti Baruteau, Sakthivel Gnanasambandam and Klaus Schmierer
    Citation: BMC Neurology 2014 14:68
    Content type: Case report Published on:

  12. Gait ability and cognitive function are interrelated during both normal walking (NW) and dual-task walking (DTW), and gait ability is thus adversely affected by cognitive impairment in both situations. However...

    Authors: Takehiko Doi, Hiroyuki Shimada, Hyuma Makizako, Kota Tsutsumimoto, Kazuki Uemura, Yuya Anan and Takao Suzuki
    Citation: BMC Neurology 2014 14:67
    Content type: Research article Published on:

  13. We investigated levels of the β-amyloid 1–42 (Aβ42), total tau protein (T-tau) and tau phosphorylated at position threonine 181 (P-tau) in cerebrospinal fluid (CSF) of idiopathic normal pressure hydrocephalus ...

    Authors: Tae Sung Lim, Jun Young Choi, Sun Ah Park, Young Chul Youn, Hyun Young Lee, Byung Gon Kim, In Soo Joo, Kyoon Huh and So Young Moon
    Citation: BMC Neurology 2014 14:66
    Content type: Research article Published on:

  14. In patients with relapsing-remitting MS (RRMS) fingolimod prevents disease relapses and delays disability progression. First dose administration of fingolimod is associated with a transient, dose-dependent dec...

    Authors: Alice Laroni, Davide Brogi, Vincenzo Brescia Morra, Leonello Guidi, Carlo Pozzilli, Giancarlo Comi, Alessandra Lugaresi, Renato Turrini, Debora Raimondi, Antonio Uccelli and Giovanni Luigi Mancardi
    Citation: BMC Neurology 2014 14:65
    Content type: Research article Published on:

  15. The Insulin-like Growth Factor (IGF)-related system is implicated in neuroregeneration and cell repair, as well as regulating lifespan. IGF-II, one component of this system, has also been found to affect memor...

    Authors: Joakim Hertze, Katarina Nägga, Lennart Minthon and Oskar Hansson
    Citation: BMC Neurology 2014 14:64
    Content type: Research article Published on:

  16. The aging of the population has led to the increase of chronic diseases, especially dementia and cardiovascular diseases, and it has become necessary for their relatives to dedicate more time in caregiving.

    Authors: Emiliano Rodriguez-Sánchez, José María Criado-Gutiérrez, Sara Mora-Simón, M Paz Muriel-Diaz, Manuel A Gómez-Marcos, José I Recio-Rodríguez, M Carmen Patino-Alonso, Luis F Valero-Juan, José A Maderuelo-Fernandez and Luis García-Ortiz
    Citation: BMC Neurology 2014 14:63
    Content type: Study protocol Published on:

  17. Takayasu arteritis (TA) is an idiopathic large-vessel vasculitis that can result in significant morbidity and mortality secondary to progressive stenosis and occlusion. Monitoring disease progression is crucia...

    Authors: Timothy E O’Connor, Haley E Carpenter, Sharatchandra Bidari, Michael F Waters and Vishnumurthy Shushrutha Hedna
    Citation: BMC Neurology 2014 14:62
    Content type: Case report Published on:

  18. Multiple tasking is an integral part of daily mobility. Patients with Parkinson’s disease have dual tasking difficulties due to their combined motor and cognitive deficits. Two contrasting physiotherapy interv...

    Authors: Carolien Strouwen, Esther ALM Molenaar, Samyra HJ Keus, Liesbeth Münks, Marten Munneke, Wim Vandenberghe, Bastiaan R Bloem and Alice Nieuwboer
    Citation: BMC Neurology 2014 14:61
    Content type: Study protocol Published on:

  19. Women have been reported to show more frequent recanalization and better recovery after intravenous (IV) recombinant tissue plasminogen activator (rt-PA) treatment for acute stroke compared with men. To invest...

    Authors: Fawaz Al-hussain, Muhammad S Hussain, Carlos Molina, Ken Uchino, Ashfaq Shuaib, Andrew M Demchuk, Andrei V Alexandrov and Maher Saqqur
    Citation: BMC Neurology 2014 14:60
    Content type: Research article Published on:

  20. England has one of the highest rates of hospital death in dementia in Europe. How this has changed over time is unknown. This study aimed to analyse temporal trends in place of death in dementia over a recent ...

    Authors: Katherine E Sleeman, Yuen K Ho, Julia Verne, Wei Gao and Irene J Higginson
    Citation: BMC Neurology 2014 14:59
    Content type: Research article Published on:

  21. There are a number of instruments that describe severity and progression of multiple sclerosis and they are increasingly used as endpoints to assess the effectiveness of therapeutic interventions. We examined ...

    Authors: Sandra Meyer-Moock, You-Shan Feng, Mathias Maeurer, Franz-Werner Dippel and Thomas Kohlmann
    Citation: BMC Neurology 2014 14:58
    Content type: Research article Published on:

  23. Month-long daytime Ramadan fasting pose s major challenges to multiple sclerosis (MS) patients in Muslim countries. Physicians should have practical knowledge on the implications of fasting on MS. We present a...

    Authors: Soodeh Razeghi Jahromi, Mohammad Ali Sahraian, Fereshteh Ashtari, Hormoz Ayromlou, Massoud Etemadifar, Majid Ghaffarpour, Ehsan Mohammadianinejad, Shahriar Nafissi, Alireza Nickseresht, Vahid Shaygannejad, Mansoreh Togha, Hamid Reza Torabi and Shadi Ziaie
    Citation: BMC Neurology 2014 14:56
    Content type: Debate Published on:

  24. The proportion of strokes occurring in younger adults has been rising over the past decade. Due to the far longer life expectancy in the young, stroke in this group has an even larger socio-economic impact. Ho...

    Authors: Renate M Arntz, Mayte E van Alebeek, Nathalie E Synhaeve, Paul J Brouwers, Gert W van Dijk, Rob A Gons, Tom den Heijer, Paul LM de Kort, Karlijn F de Laat, Anouk G van Norden, Sarah E Vermeer, Maureen J van der Vlugt, Roy PC Kessels, Ewoud J van Dijk and Frank-Erik de Leeuw
    Citation: BMC Neurology 2014 14:55
    Content type: Study protocol Published on:

  25. Essential tremor (ET) and Parkinson’s disease (PD) are considered distinct disorders. The aim of the study was to look for a link or any distinguishing features by transcranial sonography (TCS), together with ...

    Authors: Kristina Laučkaitė, Daiva Rastenytė, Danguolė Šurkienė, Birutė Vaidelytė, Gabrielė Dambrauskaitė, Andrius Sakalauskas, Antanas Vaitkus and Rymantė Gleiznienė
    Citation: BMC Neurology 2014 14:54
    Content type: Research article Published on:

  26. Statins, due to their well-established pleiotropic effects, have noteworthy benefits in stroke prevention. Despite this, a significant proportion of high-risk patients still do not receive the recommended ther...

    Authors: Isabella Canavero, Anna Cavallini, Patrizia Perrone, Mauro Magoni, Lucia Sacchi, Silvana Quaglini, Giordano Lanzola and Giuseppe Micieli
    Citation: BMC Neurology 2014 14:53
    Content type: Research article Published on:

  27. Assessment of arm-hand use is very important in children with cerebral palsy (CP) who encounter arm-hand problems. To determine validity and reliability of new instruments to assess actual performance, a set o...

    Authors: Ryanne JM Lemmens, Yvonne JM Janssen-Potten, Annick AA Timmermans, Anke Defesche, Rob JEM Smeets and Henk AM Seelen
    Citation: BMC Neurology 2014 14:52
    Content type: Research article Published on:

  29. Some studies reported that cerebral developmental venous anomaly (DVA) is often concurrent with cavernous malformation (CM). But there is lack of statistical evidence and study of bulk cases. The factors assoc...

    Authors: Guolu Meng, Chuanfeng Bai, Tengfei Yu, Zhen Wu, Xing Liu, Junting Zhang and Jizong zhao
    Citation: BMC Neurology 2014 14:50
    Content type: Research article Published on:

  30. Data sources for MS research are numerous but rarely provide an objective measure of drug therapy compliance coupled with patient-reported health outcomes. The objective of this paper is to describe the method...

    Authors: Patricia K Coyle, Bruce A Cohen, Thomas Leist, Clyde Markowitz, MerriKay Oleen-Burkey, Marc Schwartz, Mark J Tullman and Howard Zwibel
    Citation: BMC Neurology 2014 14:49
    Content type: Research article Published on:

  31. Current evidence has suggested the need for increased self-management support efforts in spinal cord injury (SCI) to reduce secondary complications. However, current self-management programs may not be suitabl...

    Authors: Sarah EP Munce, Fiona Webster, Michael G Fehlings, Sharon E Straus, Eunice Jang and Susan B Jaglal
    Citation: BMC Neurology 2014 14:48
    Content type: Research article Published on:

  32. The editors of BMC Neurology would like to thank all our reviewers who have contributed to the journal in Volume 13 (2013).

    Authors: Tim Shipley
    Citation: BMC Neurology 2014 14:28
    Content type: Reviewer acknowledgement Published on:

  33. There is increasing research that examines gender-issues in multiple sclerosis (MS), but little focus has been placed on gender-issues regarding physical activity. The aim of the present study was to describe ...

    Authors: Elisabeth Anens, Margareta Emtner, Lena Zetterberg and Karin Hellström
    Citation: BMC Neurology 2014 14:47
    Content type: Research article Published on:

  35. Translating knowledge derived from medical research into the clinical setting is dependent on the representativeness of included patients. Therefore we compared baseline data of patients included in a recent l...

    Authors: Christian Tanislav, Ulrike Grittner, Bjoern Misselwitz, Gerhard Jan Jungehuelsing, Christian Enzinger, Bettina von Sarnowski, Jukka Putaala, Manfred Kaps, Peter Kropp, Arndt Rolfs, Turgut Tatlisumak, Franz Fazekas, Edwin Kolodny and Bo Norrving
    Citation: BMC Neurology 2014 14:45
    Content type: Research article Published on:

  36. Cognitive disorders, such as memory disturbances, are often observed following a subarachnoid hemorrhage. We present a very rare case where rupture of a posterior cerebral artery aneurysm caused restricted dam...

    Authors: Shinichiro Maeshima, Aiko Osawa, Fumitaka Yamane, Hidetoshi Shimaguchi, Ikuo Ochiai, Tomoyuki Yoshihara, Nahoko Uemiya, Ryuzaburo Kanazawa and Shoichiro Ishihara
    Citation: BMC Neurology 2014 14:44
    Content type: Case report Published on:

  37. The contribution of cerebrovascular function to cognitive performance is gaining increased attention. Transcranial doppler (TCD) is portable, reliable, inexpensive and extremely well tolerated by young and cli...

    Authors: Mireille J Bakker, Jessica Hofmann, Owen F Churches, Nicholas A Badcock, Mark Kohler and Hannah AD Keage
    Citation: BMC Neurology 2014 14:43
    Content type: Research article Published on:

  38. Pain is a troublesome non-motor symptom of Parkinson’s disease (PD). The RECOVER (Randomized Evaluation of the 24-hour Coverage: Efficacy of Rotigotine; Clintrials.gov: NCT00474058) study demonstrated signific...

    Authors: Jan Kassubek, Kallol Ray Chaudhuri, Theresa Zesiewicz, Erwin Surmann, Babak Boroojerdi, Kimberly Moran, Liesbet Ghys and Claudia Trenkwalder
    Citation: BMC Neurology 2014 14:42
    Content type: Research article Published on:

  39. Acute ischemic stroke (AIS) has a biphasic effect on the peripheral immune system. The initial inflammatory response is followed by systemic immunosuppression, referred to as stroke-induced immunosuppression (...

    Authors: András Folyovich, Enikő Biró, Csaba Orbán, Anna Bajnok, Viktória Varga, Anna K Béres-Molnár, Barna Vásárhelyi and Gergely Toldi
    Citation: BMC Neurology 2014 14:41
    Content type: Research article Published on:

  40. Tinnitus is a result of hyper-activity/hyper-synchrony of auditory neurons coding the tinnitus frequency, which has developed to synchronous mass activity owing the lack of inhibition. We assume that removal o...

    Authors: Christo Pantev, Claudia Rudack, Alwina Stein, Robert Wunderlich, Alva Engell, Pia Lau, Andreas Wollbrink and Alex Shaykevich
    Citation: BMC Neurology 2014 14:40
    Content type: Study protocol Published on:

  41. The Oxfordshire Community Stroke Project (OCSP) classification is a simple stroke classification system with value in predicting clinical outcomes. We investigated whether and how the addition of OCSP classifi...

    Authors: Sheng-Feng Sung, Solomon Chih-Cheng Chen, Huey-Juan Lin, Chih-Hung Chen, Mei-Chiun Tseng, Chi-Shun Wu, Yung-Chu Hsu, Ling-Chien Hung and Yu-Wei Chen
    Citation: BMC Neurology 2014 14:39
    Content type: Research article Published on:

  42. De-escalating natalizumab (NTZ) to interferon beta 1b (IFN B 1B) is a possible treatment option in multiple sclerosis (MS) patients interrupting NTZ because of increased risk of progressive multifocal leukoenc...

    Authors: Chiara Zecca, Gianna C Riccitelli, Pasquale Calabrese, Emanuele Pravatà, Ursula Candrian, Charles RG Guttmann and Claudio Gobbi
    Citation: BMC Neurology 2014 14:38
    Content type: Research article Published on:

  43. Prediction of clinical outcome in the acute stage of ischaemic stroke can be difficult when based on patient characteristics, clinical findings and on non-contrast CT. CT perfusion and CT angiography may provi...

    Authors: Tom van Seeters, Geert Jan Biessels, Irene C van der Schaaf, Jan Willem Dankbaar, Alexander D Horsch, Merel JA Luitse, Joris M Niesten, Willem PTM Mali, L Jaap Kappelle, Yolanda van der Graaf and Birgitta K Velthuis
    Citation: BMC Neurology 2014 14:37
    Content type: Study protocol Published on:

  44. Obstructive sleep apnea is a common sleep disorder in stroke patients. Obstructive sleep apnea is associated with stroke severity and poor functional outcome. Continuous positive airway pressure seems to impro...

    Authors: Justine A Aaronson, Coen AM van Bennekom, Winni F Hofman, Tijs van Bezeij, Joost G van den Aardweg, Erny Groet, Wytske A Kylstra and Ben A Schmand
    Citation: BMC Neurology 2014 14:36
    Content type: Study protocol Published on:

  45. Current clinical assessments of motor function in Huntington’s Disease (HD) rely on subjective ratings such as the Unified Huntington’s Disease Rating scale (UHDRS). The ability to track disease progression us...

    Authors: Lucy M Collins, Stanley E Lazic and Roger A Barker
    Citation: BMC Neurology 2014 14:35
    Content type: Research article Published on:

  47. A number of reports have described the presence of tuberculosis (TB) in neuromyelitis optica (NMO) patients. However, a definite association between the two conditions has not been conclusively demonstrated.

    Authors: Rui Li, Xiaonan Zhong, Wei Qiu, Aimin Wu, Yongqiang Dai, Zhengqi Lu and Xueqiang Hu
    Citation: BMC Neurology 2014 14:33
    Content type: Research article Published on:

  48. Meningioangiomatosis (MA) is a rare hamartomatous lesion. Only six cases of cystic MA have been reported in the literature.

    Authors: Peifeng Li, Guangbin Cui, Yingmei Wang, Ming Geng and Zhe Wang
    Citation: BMC Neurology 2014 14:32
    Content type: Case report Published on:

  49. Although common and often disabling in multiple sclerosis (MS), visual dysfunction is currently not adequately accounted for in both clinical routine and MS trials. Sloan low contrast letter acuity (SLCLA) is ...

    Authors: Johann Schinzel, Hanna Zimmermann, Friedemann Paul, Klemens Ruprecht, Katrin Hahn, Alexander U Brandt and Jan Dörr
    Citation: BMC Neurology 2014 14:31
    Content type: Research article Published on:

  50. Cerebrovascular complications (CVCs) frequently occur in patients with acute infective endocarditis (IE). The aim of this study is to describe the clinical findings of CVCs and to evaluate the impact of CVCs o...

    Authors: Seung-Jae Lee, Sam-Sae Oh, Dal-Soo Lim, Chan-Young Na and Jae-Hyun Kim
    Citation: BMC Neurology 2014 14:30
    Content type: Research article Published on:
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BMC Neurology

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