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  1. Content type: Case report

    Diabetic chorea appears during the course of poorly-controlled diabetes. While chorea associated with diabetes mellitus usually occurs during hyperglycemic episodes, hypoglycemia can also cause diabetic chorea...

    Authors: Eriko Matsushima, Hiroshi Shiota, Kentaro Watanabe, Yuichiro Otsuka, Midori Yamana, Suguru Yamaguchi, Fujiko Egashira, Satoshi Kamei and Hisamitsu Ishihara

    Citation: BMC Neurology 2019 19:131

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  2. Content type: Debate

    Interferon (IFN) beta drugs have been approved for the treatment of relapsing forms of multiple sclerosis (RMS) for more than 20 years and are considered to offer a favourable benefit-risk profile. In July 201...

    Authors: Annette Kolb-Mäurer, Cord Sunderkötter, Borries Kukowski and Sven G. Meuth

    Citation: BMC Neurology 2019 19:130

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  3. Content type: Study protocol

    Multiple sclerosis (MS) is a neurological disease of the central nervous system and is associated with many psychosocial symptoms that are difficult to manage including low mood, anxiety, fatigue and pain, as ...

    Authors: Amy-Lee Sesel, Louise Sharpe, Heidi N. Beadnall, Michael H. Barnett, Marianna Szabo and Sharon L. Naismith

    Citation: BMC Neurology 2019 19:129

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  4. Content type: Research article

    Mood disorder after stroke is common but drug and psychosocial treatments have been assessed with disappointing results. Preventing mood disorder from developing in the first place could be a better approach a...

    Authors: Kate Hill, Allan House, Peter Knapp, Carrie Wardhaugh, John Bamford and Andy Vail

    Citation: BMC Neurology 2019 19:128

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  5. Content type: Research article

    Immune cells are involved in all stages of acute ischaemic stroke (AIS) and possess both neuroprotective and neurodamaging properties. It has been suggested that immune system activation after stroke may be as...

    Authors: Neringa Jucevičiūtė, Paulius Mikužis and Renata Balnytė

    Citation: BMC Neurology 2019 19:127

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  6. Content type: Case report

    Autoimmune encephalitis (AE) is a newly recognized autoimmune disorders in which the targets are proteins or receptors involved in synaptic transmission and neuronal excitability. α-amino-3-hydroxy-5-methyl-4-...

    Authors: Qingyang Luo, Xianghong Wu and Wen Huang

    Citation: BMC Neurology 2019 19:126

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  7. Content type: Case report

    Non-dystrophic myotonias (NDMs) are skeletal muscle disorders involving myotonia distinct from myotonic dystrophy. It has been reported that the muscle pathology is usually normal or comprises mild myopathic c...

    Authors: Takanori Hata, Takamura Nagasaka, Kishin Koh, Mai Tsuchiya, Yuta Ichinose, Haitian Nan, Kazumasa Shindo and Yoshihisa Takiyama

    Citation: BMC Neurology 2019 19:125

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  8. Content type: Research article

    The neurofibromatoses (NF) are a group of genetic disorders that interfere negatively with the quality of life (QoL) and influence physical, emotional and social statuses. Studying the effects of neurofibromat...

    Authors: Akram Sanagoo, Leila Jouybari, Fatemeh Koohi and Fatemeh Sayehmiri

    Citation: BMC Neurology 2019 19:123

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  9. Content type: Research article

    No longitudinal, long-term, follow-up studies have explored the association between presence and severity of variations in extracranial venous anatomy, and clinical outcomes in patients with multiple sclerosis...

    Authors: Sirin Gandhi, Karen Marr, Marcello Mancini, Maria Grazia Caprio, Dejan Jakimovski, Avinash Chandra, Jesper Hagemeier, David Hojnacki, Channa Kolb, Bianca Weinstock-Guttman and Robert Zivadinov

    Citation: BMC Neurology 2019 19:121

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  10. Content type: Research article

    Clinical diagnosis of Parkinson’s disease (PD) has always lagged behind clinical symptoms. The diagnostic latency might be influenced by many factors. The diagnostic latency of Chinese people with PD has been ...

    Authors: Ying Wan, Yingying Zhu, Yi Luo, Xun Han, Yongsheng Li, Jing Gan, Na Wu, Anmu Xie and Zhenguo Liu

    Citation: BMC Neurology 2019 19:120

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  11. Content type: Study protocol

    The use of vestibular rehabilitation principles in the management of gaze and postural stability impairments in people with multiple sclerosis (PwMS) has shown promise in pilot work completed in our lab and in...

    Authors: Brian J. Loyd, Annie Fangman, Daniel S. Peterson, Eduard Gappmaier, Michael C. Schubert, Anne Thackery and Lee Dibble

    Citation: BMC Neurology 2019 19:119

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  12. Content type: Research article

    In patients suffering from Chronic Inflammatory Demyelinating Polyneuropathy (CIDP) disease severity is assessed by Medical Research Counsil (MRC) Scale or Inflammatory Neuropathy Cause and Treatment (INCAT) d...

    Authors: Juliane Klehmet, Svenja Beutner, Sarah Hoffmann, Matthias Dornauer, Friedemann Paul, Ralf Reilmann, Alexander U. Brandt and Andreas Meisel

    Citation: BMC Neurology 2019 19:118

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  13. Content type: Research article

    Following spinal cord injury (SCI), family members are often called upon to undertake the caregiving role. This change in the nature of the relationship between the individuals with SCI and their families can ...

    Authors: Gaya Jeyathevan, Jill I. Cameron, B. Catharine Craven, Sarah E. P. Munce and Susan B. Jaglal

    Citation: BMC Neurology 2019 19:117

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  14. Content type: Research article

    STRIVE is a multicenter, observational, open-label, single-arm study of natalizumab in anti–JC virus (JCV) seronegative patients with early relapsing-remitting multiple sclerosis (RRMS). The objective of this ...

    Authors: Jai Perumal, Robert J. Fox, Roumen Balabanov, Laura J. Balcer, Steven Galetta, Shavy Makh, Sourav Santra, Christophe Hotermans and Lily Lee

    Citation: BMC Neurology 2019 19:116

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  15. Content type: Case report

    Fabry disease is rare, and the diagnosis is often delayed. Here, we describe a case of Fabry disease resulting in vasculopathy of the central nervous system. Magnetic resonance (MR) black-blood sequence (three...

    Authors: De-Zheng Kong, Ya-Hui Lian, Lin-Jing Wang, Chun-Mei Wang, Yang-Yang Meng and Hong-Wei Zhou

    Citation: BMC Neurology 2019 19:115

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  16. Content type: Research article

    Epigenetics underlying refractory epilepsy is poorly understood. DNA methylation may affect gene expression in epilepsy patients without affecting DNA sequences. Herein, we investigated the association between...

    Authors: Yudan Lv, Xiangyu Zheng, Mingchao Shi, Zan Wang and Li Cui

    Citation: BMC Neurology 2019 19:114

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  17. Content type: Research article

    Toxic oligomeric α-synuclein (αS; O-αS) has been suggested to play a central role in the pathogenesis of Lewy body diseases such as Parkinson’s disease (PD). Cerebrospinal fluid (CSF) levels of αS, O-αS, total...

    Authors: Hidetomo Murakami, Takahiko Tokuda, Omar M. A. El-Agnaf, Takuma Ohmichi, Ayako Miki, Hideaki Ohashi, Yoshiyuki Owan, Yu Saito, Satoshi Yano, Tamao Tsukie, Takeshi Ikeuchi and Kenjiro Ono

    Citation: BMC Neurology 2019 19:113

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  18. Content type: Case report

    Internal jugular vein stenosis (IJVS), characterized by a series of clinical manifestations, such as head and neck symptoms, visual and ear symptoms, as well as sleep disorder, has been receiving attention in ...

    Authors: Min Li, Yuan Sun, Chong Ching Chan, Chunqiu Fan, Xunming Ji and Ran Meng

    Citation: BMC Neurology 2019 19:112

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  19. Content type: Research article

    Likely duration of survival of children described as having cerebral palsy is of considerable interest to individuals with cerebral palsy, their families, carers, health professionals, health economists and in...

    Authors: Eve Blair, Katherine Langdon, Sarah McIntyre, David Lawrence and Linda Watson

    Citation: BMC Neurology 2019 19:111

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  20. Content type: Research article

    Idiopathic rapid eye movement sleep behavior disorder (iRBD) affects 1–2% of people over 60 years of age and presents a high risk of developing a neurodegenerative disorder from the group of synucleinopathies,...

    Authors: Jitka Bušková, Pavla Peřinová, Eva Miletínová, Petr Dušek, Evžen Růžička, Karel Šonka and David Kemlink

    Citation: BMC Neurology 2019 19:110

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  21. Content type: Study protocol

    Type 2 Diabetes in Mexico has a high prevalence, 16–87% of patients may experience peripheral neuropathy. Early detection can prevent or halt its progression. The performance of Sudoscan in detecting neuropath...

    Authors: Angelica Carbajal-Ramírez, Julián A. Hernández-Domínguez, Mario A. Molina-Ayala, María Magdalena Rojas-Uribe and Adolfo Chávez-Negrete

    Citation: BMC Neurology 2019 19:109

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  22. Content type: Research article

    The study is intended to fill the knowledge gap about the neuropsychology and neuromotor developmental outcomes, and identify the perinatal risk factors for late preterm infants (LPIs 34~36 weeks GA) born with...

    Authors: Jia You, Bilal Haider Shamsi, Mei-chen Hao, Chun-Hong Cao and Wu-Yue Yang

    Citation: BMC Neurology 2019 19:108

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  23. Content type: Research article

    Lumbo-sacral radiculopathy (LSR) is a common musculoskeletal disorder for which patients seek medical care and referrals for advanced imaging. However, accurate diagnosis remains challenging. Neuropathic pain ...

    Authors: Nassib Tawa, Ina Diener, Quinette Louw and Anthea Rhoda

    Citation: BMC Neurology 2019 19:107

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  24. Content type: Case report

    Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is a hereditary arteriopathy associated with the NOTCH3 gene. Clinical manifestations include strokes, transien...

    Authors: Chumpol Anamnart, Dittapong Songsaeng and Sirisak Chanprasert

    Citation: BMC Neurology 2019 19:106

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  25. Content type: Research article

    Nutritional status is an important prognostic factor in Amyotrophic Lateral Sclerosis (ALS). We wished to study the safety, tolerability and efficacy of nutritional counseling with or without an mHealth applic...

    Authors: Anne Marie Wills, Jamie Garry, Jane Hubbard, Taylor Mezoian, Christopher T. Breen, Courtney Ortiz-Miller, Paige Nalipinski, Stacey Sullivan, James D. Berry, Merit Cudkowicz, Sabrina Paganoni, James Chan and Eric A. Macklin

    Citation: BMC Neurology 2019 19:104

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  26. Content type: Research article

    endovascular therapy (ET) is the standard of care for anterior circulation acute ischemic stroke (AIS) caused by large vessel occlusion (LVO). The role of adjunctive intravenous thrombolysis (IVT) in these pat...

    Authors: Massimo Gamba, Nicola Gilberti, Enrico Premi, Angelo Costa, Michele Frigerio, Dikran Mardighian, Veronica Vergani, Raffaella Spezi, Ilenia Delrio, Andrea Morotti, Loris Poli, Valeria De Giuli, Filomena Caria, Alessandro Pezzini, Roberto Gasparotti, Alessandro Padovani…

    Citation: BMC Neurology 2019 19:103

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  27. Content type: Research article

    Exercise has failed to reduce falls in those with chronic stroke. A limitation of traditional exercise is that the motor responses needed to prevent a fall are not elicited (i.e. they lack processing specificity)...

    Authors: Jamie Pigman, Darcy S. Reisman, Ryan T. Pohlig, Tamara R. Wright and Jeremy R. Crenshaw

    Citation: BMC Neurology 2019 19:102

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  28. Content type: Research article

    Apathy is a prominent non-motor symptom in Parkinson’s disease (PD). People with apathy show a lack of emotion, passion, and motivation. Between 17 and 70% of persons with PD have apathy; the extreme heterogen...

    Authors: Bria Mele, Zahra Goodarzi, Heather M. Hanson and Jayna Holroyd-Leduc

    Citation: BMC Neurology 2019 19:101

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  29. Content type: Research article

    A revised classification of cerebellar infarctions (CI) may uncover unrecognized associations with etiologic stroke subtypes. We hypothesized that obliquely oriented small cortical cerebellar infarction (SCCI)...

    Authors: Adrien Ter Schiphorst, Lavinia Tatu, Vincent Thijs, Christophe Demattei, Eric Thouvenot and Dimitri Renard

    Citation: BMC Neurology 2019 19:100

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  30. Content type: Case report

    Cerebral amyloid angiopathy-related inflammation (CAA-ri) is a rare clinical entity, characterized by headaches, seizures, rapidly progressive cognitive decline, behavioral changes and magnetic resonance imagi...

    Authors: Yanjiao Du, Chao Liu, Congmin Ma, Xiaohui Xu, Xufeng Zhou, Haitao Zhou and Chao Huang

    Citation: BMC Neurology 2019 19:97

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  31. Content type: Study protocol

    Post-stroke lower limb spasticity (PSLLS) has a prevalence of 28–37%. PSLLS can cause difficulty in walking and reduce quality of life (QOL). Post stroke spasticity impairs the ability to intervene to improve ...

    Authors: Anupam Datta Gupta, Renuka Visvanathan, Ian Cameron, Simon A. Koblar, Stuart Howell and David Wilson

    Citation: BMC Neurology 2019 19:96

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  32. Content type: Case report

    Gall bladder cancer (GBC) is associated with abdominal pain, lump, nausea, vomiting, and jaundice due to either gall bladder mass or the involved adjacent peritoneal structures. Gall bladder cancer presenting ...

    Authors: Shweta Pandey, Ravindra Kumar Garg, Hardeep Singh Malhotra, Ravi Uniyal and Neeraj Kumar

    Citation: BMC Neurology 2019 19:95

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  33. Content type: Case report

    Recurrent optic neuritis (ON) was previously thought to be associated with multiple sclerosis (MS) and neuromyelitis optica spectrum disorders (NMOSD). Meningoencephalitis has recently been suggested to be a c...

    Authors: Xiaonan Zhong, Yanyu Chang, Sha Tan, Jingqi Wang, Xiaobo Sun, Aimin Wu, Lisheng Peng, Alexander Y. Lau, Allan G. Kermode and Wei Qiu

    Citation: BMC Neurology 2019 19:94

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  34. Content type: Research article

    It was suggested that robot-assisted gait training (RAGT) should not be routinely provided to disabled patients in place of conventional over-ground walking training (CGT). There exist several randomised contr...

    Authors: Martin Sattelmayer, Odile Chevalley, Ruedi Steuri and Roger Hilfiker

    Citation: BMC Neurology 2019 19:93

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  35. Content type: Research article

    Primary periodic paralysis is characterized by recurrent quadriplegia typically associated with abnormal serum potassium levels. The molecular diagnosis of primary PP previously based on Sanger sequencing of h...

    Authors: Sushan Luo, Minjie Xu, Jian Sun, Kai Qiao, Jie Song, Shuang Cai, Wenhua Zhu, Lei Zhou, Jianying Xi, Jiahong Lu, Xiaohua Ni, Tonghai Dou and Chongbo Zhao

    Citation: BMC Neurology 2019 19:92

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  36. Content type: Case report

    Mitochondrial encephalomyopathy, lactic acidosis and stroke-like episodes (MELAS) is a mitochondrial cytopathy caused by mutations in mitochondrial DNA. Clinical manifestation is typically before the age of 40.

    Authors: Tim Sinnecker, Michaela Andelova, Michael Mayr, Stephan Rüegg, Michael Sinnreich, Juergen Hench, Stephan Frank, André Schaller, Christoph Stippich, Jens Wuerfel and Leo H. Bonati

    Citation: BMC Neurology 2019 19:91

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  37. Content type: Case report

    Primary central nervous system lymphoma (PCNSL) is the most prevalent brain, spinal cord, eyes, and leptomeningeal lymphoma. It is often misdiagnosed due to an unspecific presentation or unavailable biopsy and...

    Authors: Hui Zhao, Miao Ma, Limin Zhang, Guanghui Zheng, Hong Lv, Jie Liu, Xiao Li, Bei Song and Guojun Zhang

    Citation: BMC Neurology 2019 19:90

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  38. Content type: Case report

    Missense mutations in SAMD9L gene is associated with ataxia-pancytopenia syndrome (ATXPC), OMIM#159550. Common clinical features in these patients include neurological and hematological symptoms. The phenotype an...

    Authors: Sofia Thunström and Markus Axelsson

    Citation: BMC Neurology 2019 19:89

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  39. Content type: Research article

    Cholinesterase inhibitors remain the first line therapy for people with mild to moderate Alzheimer’s disease (AD). Response is modest and difficult to predict from pre-treatment characteristics. We hypothesise...

    Authors: Peter J. Connelly, Fiona Adams, Ziad I. Tayar and Faisel Khan

    Citation: BMC Neurology 2019 19:88

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  40. Content type: Research article

    Wilson’s disease (WD) is an autosomal recessive disease of impaired copper metabolism. Previous study demonstrated that WD with corpus callosum abnormalities (WD-CCA) was limited to the posterior part (spleniu...

    Authors: Zhi-Hua Zhou, Yun-Fan Wu, Jin Cao, Ji-Yuan Hu, Yong-Zhu Han, Ming-Fan Hong, Gong-Qiang Wang, Shu-Hu Liu and Xue-Min Wang

    Citation: BMC Neurology 2019 19:85

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  41. Content type: Case report

    Huntington’s disease (HD) is a rare, genetic neurodegenerative disorder often presenting with emotional, cognitive and behavioral abnormalities before manifestation of disease defining motor symptoms. Cognitiv...

    Authors: Sebastian Michels, Hans-Georg Buchholz, Florian Rosar, Isabel Heinrich, Manuela A. Hoffmann, Susann Schweiger, Oliver Tüscher and Mathias Schreckenberger

    Citation: BMC Neurology 2019 19:78

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  42. Content type: Case report

    Rett syndrome (RTT) is a severe neurodevelopmental disorder mainly affecting females. One of the main clinical manifestations is hand stereotypies, which is presumed to based on dysfunction rather than on stru...

    Authors: Xiaoqing Luo, Cheng Li, Xiaolu Wang, Xiaoli Yu and Jun Jiang

    Citation: BMC Neurology 2019 19:77

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