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  1. Epigenetics underlying refractory epilepsy is poorly understood. DNA methylation may affect gene expression in epilepsy patients without affecting DNA sequences. Herein, we investigated the association between...

    Authors: Yudan Lv, Xiangyu Zheng, Mingchao Shi, Zan Wang and Li Cui

    Citation: BMC Neurology 2019 19:114

    Content type: Research article

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  2. Toxic oligomeric α-synuclein (αS; O-αS) has been suggested to play a central role in the pathogenesis of Lewy body diseases such as Parkinson’s disease (PD). Cerebrospinal fluid (CSF) levels of αS, O-αS, total...

    Authors: Hidetomo Murakami, Takahiko Tokuda, Omar M. A. El-Agnaf, Takuma Ohmichi, Ayako Miki, Hideaki Ohashi, Yoshiyuki Owan, Yu Saito, Satoshi Yano, Tamao Tsukie, Takeshi Ikeuchi and Kenjiro Ono

    Citation: BMC Neurology 2019 19:113

    Content type: Research article

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  3. Likely duration of survival of children described as having cerebral palsy is of considerable interest to individuals with cerebral palsy, their families, carers, health professionals, health economists and in...

    Authors: Eve Blair, Katherine Langdon, Sarah McIntyre, David Lawrence and Linda Watson

    Citation: BMC Neurology 2019 19:111

    Content type: Research article

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  4. Idiopathic rapid eye movement sleep behavior disorder (iRBD) affects 1–2% of people over 60 years of age and presents a high risk of developing a neurodegenerative disorder from the group of synucleinopathies,...

    Authors: Jitka Bušková, Pavla Peřinová, Eva Miletínová, Petr Dušek, Evžen Růžička, Karel Šonka and David Kemlink

    Citation: BMC Neurology 2019 19:110

    Content type: Research article

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  5. Type 2 Diabetes in Mexico has a high prevalence, 16–87% of patients may experience peripheral neuropathy. Early detection can prevent or halt its progression. The performance of Sudoscan in detecting neuropath...

    Authors: Angelica Carbajal-Ramírez, Julián A. Hernández-Domínguez, Mario A. Molina-Ayala, María Magdalena Rojas-Uribe and Adolfo Chávez-Negrete

    Citation: BMC Neurology 2019 19:109

    Content type: Study protocol

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  6. The study is intended to fill the knowledge gap about the neuropsychology and neuromotor developmental outcomes, and identify the perinatal risk factors for late preterm infants (LPIs 34~36 weeks GA) born with...

    Authors: Jia You, Bilal Haider Shamsi, Mei-chen Hao, Chun-Hong Cao and Wu-Yue Yang

    Citation: BMC Neurology 2019 19:108

    Content type: Research article

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  7. Lumbo-sacral radiculopathy (LSR) is a common musculoskeletal disorder for which patients seek medical care and referrals for advanced imaging. However, accurate diagnosis remains challenging. Neuropathic pain ...

    Authors: Nassib Tawa, Ina Diener, Quinette Louw and Anthea Rhoda

    Citation: BMC Neurology 2019 19:107

    Content type: Research article

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  8. Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is a hereditary arteriopathy associated with the NOTCH3 gene. Clinical manifestations include strokes, transien...

    Authors: Chumpol Anamnart, Dittapong Songsaeng and Sirisak Chanprasert

    Citation: BMC Neurology 2019 19:106

    Content type: Case report

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  9. Nutritional status is an important prognostic factor in Amyotrophic Lateral Sclerosis (ALS). We wished to study the safety, tolerability and efficacy of nutritional counseling with or without an mHealth applic...

    Authors: Anne Marie Wills, Jamie Garry, Jane Hubbard, Taylor Mezoian, Christopher T. Breen, Courtney Ortiz-Miller, Paige Nalipinski, Stacey Sullivan, James D. Berry, Merit Cudkowicz, Sabrina Paganoni, James Chan and Eric A. Macklin

    Citation: BMC Neurology 2019 19:104

    Content type: Research article

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  10. endovascular therapy (ET) is the standard of care for anterior circulation acute ischemic stroke (AIS) caused by large vessel occlusion (LVO). The role of adjunctive intravenous thrombolysis (IVT) in these pat...

    Authors: Massimo Gamba, Nicola Gilberti, Enrico Premi, Angelo Costa, Michele Frigerio, Dikran Mardighian, Veronica Vergani, Raffaella Spezi, Ilenia Delrio, Andrea Morotti, Loris Poli, Valeria De Giuli, Filomena Caria, Alessandro Pezzini, Roberto Gasparotti, Alessandro Padovani…

    Citation: BMC Neurology 2019 19:103

    Content type: Research article

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  11. Exercise has failed to reduce falls in those with chronic stroke. A limitation of traditional exercise is that the motor responses needed to prevent a fall are not elicited (i.e. they lack processing specificity)...

    Authors: Jamie Pigman, Darcy S. Reisman, Ryan T. Pohlig, Tamara R. Wright and Jeremy R. Crenshaw

    Citation: BMC Neurology 2019 19:102

    Content type: Research article

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  12. Apathy is a prominent non-motor symptom in Parkinson’s disease (PD). People with apathy show a lack of emotion, passion, and motivation. Between 17 and 70% of persons with PD have apathy; the extreme heterogen...

    Authors: Bria Mele, Zahra Goodarzi, Heather M. Hanson and Jayna Holroyd-Leduc

    Citation: BMC Neurology 2019 19:101

    Content type: Research article

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  13. A revised classification of cerebellar infarctions (CI) may uncover unrecognized associations with etiologic stroke subtypes. We hypothesized that obliquely oriented small cortical cerebellar infarction (SCCI)...

    Authors: Adrien Ter Schiphorst, Lavinia Tatu, Vincent Thijs, Christophe Demattei, Eric Thouvenot and Dimitri Renard

    Citation: BMC Neurology 2019 19:100

    Content type: Research article

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  14. Cerebral amyloid angiopathy-related inflammation (CAA-ri) is a rare clinical entity, characterized by headaches, seizures, rapidly progressive cognitive decline, behavioral changes and magnetic resonance imagi...

    Authors: Yanjiao Du, Chao Liu, Congmin Ma, Xiaohui Xu, Xufeng Zhou, Haitao Zhou and Chao Huang

    Citation: BMC Neurology 2019 19:97

    Content type: Case report

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  15. Post-stroke lower limb spasticity (PSLLS) has a prevalence of 28–37%. PSLLS can cause difficulty in walking and reduce quality of life (QOL). Post stroke spasticity impairs the ability to intervene to improve ...

    Authors: Anupam Datta Gupta, Renuka Visvanathan, Ian Cameron, Simon A. Koblar, Stuart Howell and David Wilson

    Citation: BMC Neurology 2019 19:96

    Content type: Study protocol

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  16. Gall bladder cancer (GBC) is associated with abdominal pain, lump, nausea, vomiting, and jaundice due to either gall bladder mass or the involved adjacent peritoneal structures. Gall bladder cancer presenting ...

    Authors: Shweta Pandey, Ravindra Kumar Garg, Hardeep Singh Malhotra, Ravi Uniyal and Neeraj Kumar

    Citation: BMC Neurology 2019 19:95

    Content type: Case report

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  17. Recurrent optic neuritis (ON) was previously thought to be associated with multiple sclerosis (MS) and neuromyelitis optica spectrum disorders (NMOSD). Meningoencephalitis has recently been suggested to be a c...

    Authors: Xiaonan Zhong, Yanyu Chang, Sha Tan, Jingqi Wang, Xiaobo Sun, Aimin Wu, Lisheng Peng, Alexander Y. Lau, Allan G. Kermode and Wei Qiu

    Citation: BMC Neurology 2019 19:94

    Content type: Case report

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  18. It was suggested that robot-assisted gait training (RAGT) should not be routinely provided to disabled patients in place of conventional over-ground walking training (CGT). There exist several randomised contr...

    Authors: Martin Sattelmayer, Odile Chevalley, Ruedi Steuri and Roger Hilfiker

    Citation: BMC Neurology 2019 19:93

    Content type: Research article

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  19. Primary periodic paralysis is characterized by recurrent quadriplegia typically associated with abnormal serum potassium levels. The molecular diagnosis of primary PP previously based on Sanger sequencing of h...

    Authors: Sushan Luo, Minjie Xu, Jian Sun, Kai Qiao, Jie Song, Shuang Cai, Wenhua Zhu, Lei Zhou, Jianying Xi, Jiahong Lu, Xiaohua Ni, Tonghai Dou and Chongbo Zhao

    Citation: BMC Neurology 2019 19:92

    Content type: Research article

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  20. Mitochondrial encephalomyopathy, lactic acidosis and stroke-like episodes (MELAS) is a mitochondrial cytopathy caused by mutations in mitochondrial DNA. Clinical manifestation is typically before the age of 40.

    Authors: Tim Sinnecker, Michaela Andelova, Michael Mayr, Stephan Rüegg, Michael Sinnreich, Juergen Hench, Stephan Frank, André Schaller, Christoph Stippich, Jens Wuerfel and Leo H. Bonati

    Citation: BMC Neurology 2019 19:91

    Content type: Case report

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  21. Primary central nervous system lymphoma (PCNSL) is the most prevalent brain, spinal cord, eyes, and leptomeningeal lymphoma. It is often misdiagnosed due to an unspecific presentation or unavailable biopsy and...

    Authors: Hui Zhao, Miao Ma, Limin Zhang, Guanghui Zheng, Hong Lv, Jie Liu, Xiao Li, Bei Song and Guojun Zhang

    Citation: BMC Neurology 2019 19:90

    Content type: Case report

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  22. Missense mutations in SAMD9L gene is associated with ataxia-pancytopenia syndrome (ATXPC), OMIM#159550. Common clinical features in these patients include neurological and hematological symptoms. The phenotype an...

    Authors: Sofia Thunström and Markus Axelsson

    Citation: BMC Neurology 2019 19:89

    Content type: Case report

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  23. Cholinesterase inhibitors remain the first line therapy for people with mild to moderate Alzheimer’s disease (AD). Response is modest and difficult to predict from pre-treatment characteristics. We hypothesise...

    Authors: Peter J. Connelly, Fiona Adams, Ziad I. Tayar and Faisel Khan

    Citation: BMC Neurology 2019 19:88

    Content type: Research article

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  24. Wilson’s disease (WD) is an autosomal recessive disease of impaired copper metabolism. Previous study demonstrated that WD with corpus callosum abnormalities (WD-CCA) was limited to the posterior part (spleniu...

    Authors: Zhi-Hua Zhou, Yun-Fan Wu, Jin Cao, Ji-Yuan Hu, Yong-Zhu Han, Ming-Fan Hong, Gong-Qiang Wang, Shu-Hu Liu and Xue-Min Wang

    Citation: BMC Neurology 2019 19:85

    Content type: Research article

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  25. In clinical practice, a large number of post-stroke survivors require nasogastric tube (NGT) placement and nasal feeding for a relatively long period. However, its impact on the swallowing function remains lar...

    Authors: Zhi-Yong Wang, Jian-Min Chen and Guo-Xin Ni

    Citation: BMC Neurology 2019 19:83

    Content type: Research article

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  26. Warfarin is evidence-based therapy for the prevention of cardioembolic stroke, but has not been studied for its effects on whole blood viscosity (WBV). This study investigated the effect of warfarin versus asp...

    Authors: Chan-Hyuk Lee, Keun-Hwa Jung, Daniel J. Cho and Seul-Ki Jeong

    Citation: BMC Neurology 2019 19:82

    Content type: Research article

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  27. Cerebellar hemorrhage is a potentially life-threatening condition and neurologic deterioration during hospitalization could lead to severe disability and poor outcome. Finds out the factors influencing neurolo...

    Authors: Yu-Ni Ho, Shih-Yuan Hsu, Yu-Tsai Lin, Fu-Chang Cheng, Yu-Jun Lin, Nai-Wen Tsai, Cheng-Hsien Lu and Hung-Chen Wang

    Citation: BMC Neurology 2019 19:81

    Content type: Research article

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  28. This pilot study was to examine the feasibility and tolerance of whole body vibration therapy (WBVT) for children and adults with moderate severity of cerebral palsy (CP) being graded as levels III or IV on th...

    Authors: Tamis W. Pin, Penelope B. Butler and Sheila Purves

    Citation: BMC Neurology 2019 19:80

    Content type: Research article

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  29. Patients with severe brain injury is usual at high risk of extubation failure, despite of those with no/minor primary respiratory problem, majority of them still needs long term respiratory support and has sev...

    Authors: Meiling Dong, Yongfang Zhou, Jing Yang, Jie Yang, Xuelian Liao and Yan Kang

    Citation: BMC Neurology 2019 19:79

    Content type: Research article

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  30. Huntington’s disease (HD) is a rare, genetic neurodegenerative disorder often presenting with emotional, cognitive and behavioral abnormalities before manifestation of disease defining motor symptoms. Cognitiv...

    Authors: Sebastian Michels, Hans-Georg Buchholz, Florian Rosar, Isabel Heinrich, Manuela A. Hoffmann, Susann Schweiger, Oliver Tüscher and Mathias Schreckenberger

    Citation: BMC Neurology 2019 19:78

    Content type: Case report

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  31. Rett syndrome (RTT) is a severe neurodevelopmental disorder mainly affecting females. One of the main clinical manifestations is hand stereotypies, which is presumed to based on dysfunction rather than on stru...

    Authors: Xiaoqing Luo, Cheng Li, Xiaolu Wang, Xiaoli Yu and Jun Jiang

    Citation: BMC Neurology 2019 19:77

    Content type: Case report

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  32. Neuroendocrine tumors represent an expansive group of neoplasms that share an etiology of epithelial origin with neuroendocrine differentiation. Poorly-differentiated neuroendocrine carcinomas behave similarly...

    Authors: Julie R. Bloom, Arlen Brickman, Fan J. Yang, Ji-Weon Park and Jonathan Cheponis

    Citation: BMC Neurology 2019 19:76

    Content type: Case report

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  33. Complex brain arteriovenous malformations (bAVMs) in ≥3 Spetzler-Martin grades have long been challenges among cerebrovascular diseases. None of the traditional methods, such as microsurgical operation, endova...

    Authors: Mingze Wang, Yuming Jiao, Yong Cao, Shuo Wang and Jizong Zhao

    Citation: BMC Neurology 2019 19:75

    Content type: Study protocol

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  34. Spontaneous isolated posterior inferior cerebellar artery (PICA) dissection has been reported more frequently since high-resolution vessel wall magnetic resonance imaging (HR vw-MRI) was introduced to the fiel...

    Authors: Yong Soo Cho, Pahn Kyu Choi, Hyun Ju Seon, Dong Hun Kim, Byoung-Soo Shin and Hyun Goo Kang

    Citation: BMC Neurology 2019 19:74

    Content type: Case report

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  35. Several studies have suggested that migraineurs suffer from neurocognitive abnormalities, but this phenomenon and exact mechanisms remain controversial. In this study, we aimed to reevaluate visual spatial att...

    Authors: Yunliang Guo, Qiang Tian, Song Xu, Mimi Han, Yue Sun, Yan Hong, Xunyao Hou and Xueping Liu

    Citation: BMC Neurology 2019 19:73

    Content type: Research article

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  36. Riluzole is the only approved oral drug for amyotrophic lateral sclerosis (ALS). We performed a retrospective study including ALS patients treated with riluzole, focusing on adverse events.

    Authors: Aya Inoue-Shibui, Masaaki Kato, Naoki Suzuki, Junpei Kobayashi, Yoshiki Takai, Rumiko Izumi, Yuuko Kawauchi, Hiroshi Kuroda, Hitoshi Warita and Masashi Aoki

    Citation: BMC Neurology 2019 19:72

    Content type: Research article

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  37. Parkinson’s disease is a complex neurological disorder characterized by a variety of motor- as well as non-motor symptoms. Video-based technology (using continuous home monitoring) may bridge the gap between t...

    Authors: N. M. de Vries, K. Smilowska, J. Hummelink, B. Abramiuc, M. M. van Gilst, B. R. Bloem, P. H. N. de With and S. Overeem

    Citation: BMC Neurology 2019 19:71

    Content type: Research article

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  38. Albeit the few resting-state fMRI neuroimaging studies in frontal lobe epilepsy (FLE) patients, these studies focused on functional connectivity. The aim of this current study was to examine the effective conn...

    Authors: Benjamin Klugah-Brown, Cheng Luo, Rui Peng, Hui He, Jianfu Li, Li Dong and Dezhong Yao

    Citation: BMC Neurology 2019 19:70

    Content type: Research article

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  39. Intermittent theta burst stimulation (iTBS) is a form of repetitive transcranial stimulation that has been used to enhance upper limb (UL) motor recovery. However, only limited studies have examined its effica...

    Authors: Yu-Jen Chen, Ying-Zu Huang, Chung-Yao Chen, Chia-Ling Chen, Hsieh-Ching Chen, Ching-Yi Wu, Keh-Chung Lin and Tzu-ling Chang

    Citation: BMC Neurology 2019 19:69

    Content type: Research article

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  40. To evaluate the utility of the revised coma remission scale (CRS-r), together with other clinical variables, in predicting emergence from disorders of consciousness (DoC) during intensive rehabilitation care.

    Authors: Lucia Francesca Lucca, Danilo Lofaro, Loris Pignolo, Elio Leto, Maria Ursino, Maria Daniela Cortese, Domenico Conforti, Paolo Tonin and Antonio Cerasa

    Citation: BMC Neurology 2019 19:68

    Content type: Research article

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  41. Stroke is a serious cardiovascular disease and is also the leading cause of long-term disability in developing and developed countries. Because matrix metalloproteinase-9 (MMP-9) is associated with the risk of ma...

    Authors: Ning Gao, Tie Guo, Han Luo, Guolong Tu, Fanglin Niu, Mengdan Yan and Ying Xia

    Citation: BMC Neurology 2019 19:67

    Content type: Research article

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  42. Gait Initiation (GI) is a functional task that challenges the balance control requiring weight shift and a transition from standing to walking. Individuals with Down Syndrome (DS) walk with low velocity, prolo...

    Authors: Carolina Corsi, Veronica Cimolin, Paolo Capodaglio, Claudia Condoluci and Manuela Galli

    Citation: BMC Neurology 2019 19:66

    Content type: Research article

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  43. Embolectomy is the standard of care in acute ischemic stroke (AIS) caused by large vessel occlusion (LVO). Aim of this study was to compare two techniques: A Direct Aspiration First Pass Technique (ADAPT) and ...

    Authors: Alex Brehm, Volker Maus, Ioannis Tsogkas, Ruben Colla, Amélie Carolina Hesse, Roland Gerard Gera and Marios-Nikos Psychogios

    Citation: BMC Neurology 2019 19:65

    Content type: Research article

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  44. The effect of the blood urea nitrogen (BUN) to creatinine (Cr) ratio (henceforth BUN/Cr) on haemorrhagic transformation (HT) of acute ischaemic stroke (AIS) patients is unclear.

    Authors: Linghui Deng, Shi Qiu, Changyi Wang, Haiyang Bian, Lu Wang, Yuxiao Li, Bo Wu and Ming Liu

    Citation: BMC Neurology 2019 19:63

    Content type: Research article

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