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  1. HINT1 mutations cause an autosomal recessive axonal neuropathy with neuromyotonia. This is a first case report of coexistence of myasthenia gravis (MG) and HINT1-related motor axonal neuropathy without neuromyoto...

    Authors: Jia Fang, Hui Huang, Qiang Lei, Yingying Luo, Zhengchu Tang, Xiaoliu Shi and Jian Guang Tang
    Citation: BMC Neurology 2022 22:168
  2. Lysophosphatidic acid (LPA) is a common glycerol phospholipid and an important extracellular signaling molecule. LPA binds to its receptors and mediates a variety of biological effects, including the pathophys...

    Authors: Yaya Wang, Jie Zhang, Liqin Huang, Yanhong Mo, Changyu Wang, Yiyi Li, Yangyang Zhang and Zhaohui Zhang
    Citation: BMC Neurology 2022 22:166
  3. As a debilitating syndrome, paraneoplastic cerebellar degeneration (PCD) remains challenging to treat. Further, anti-Yo antibody (directed against human cerebellar degeneration-related protein 2) detection in ...

    Authors: Takeshi Imai, Kensuke Shinohara, Kenji Uchino, Hirohisa Okuma, Futaba Maki, Kiyoshi Hiruma, Yasushi Ariizumi and Yoshihisa Yamano
    Citation: BMC Neurology 2022 22:165
  4. Idiopathic intracranial hypertension is a rare neurological condition among children. Its manifestations vary from mild headaches to loss of vision. Although rare, COVID-19 infection and high dose cytosine ara...

    Authors: Rim Rakez, Wiem Boufrikha, Sana Lakhal, Amel Boughammoura and Mohamed Adnene Laatiri
    Citation: BMC Neurology 2022 22:163
  5. Duchenne muscular dystrophy (DMD) is the most common muscular dystrophy in the pediatric population. The manifestations of this disease include progressive muscle weakness, gait dysfunction, and motor impairme...

    Authors: Gholamreza Zamani, Sareh Hosseinpour, Mahmoud Reza Ashrafi, Mahmoud Mohammadi, Reza Shervin Badv, Ali Reza Tavasoli, Masood Ghahvechi Akbari, Ali Hosseini Bereshneh, Reza Azizi Malamiri and Morteza Heidari
    Citation: BMC Neurology 2022 22:162
  6. Palliative sedation has become widely accepted as a method to alleviate refractory symptoms in terminally ill patients. Controversies regarding this topic especially concern the use of palliative sedation for ...

    Authors: Laura Salzmann, Bernd Alt-Epping and Alfred Simon
    Citation: BMC Neurology 2022 22:161

    The Correction to this article has been published in BMC Neurology 2022 22:188

  7. Operating an aircraft is associated with a large mental workload; however, knowledge of the mental workload of ROV operators is limited. The purpose of this study was to establish a digital system for assessin...

    Authors: Liya Tang, Juanning Si, Lei Sun, Gengsheng Mao and Shengyuan Yu
    Citation: BMC Neurology 2022 22:160
  8. The KHENERGYC trial will be a phase II, randomised, double-blinded, placebo-controlled (DBPC), parallel-group study in the paediatric population (birth up to and including 17 years). The study will be recruiti...

    Authors: Jan Smeitink, Rob van Maanen, Lonneke de Boer, Gerrit Ruiterkamp and Herma Renkema
    Citation: BMC Neurology 2022 22:158
  9. We assess the impact of prevention strategies regarding type 2 diabetes as a modifiable risk factor for dementia and its consequences for the future number of dementia patients in Germany.

    Authors: Anne Fink, Achim Doerre, Ilja Demuth and Gabriele Doblhammer
    Citation: BMC Neurology 2022 22:157
  10. Hemorrhagic transformation (HT) is the most alarming complication of acute ischemic stroke. We aimed to identify risk factors for HT in Chinese patients and attempted to develop a nomogram to predict individua...

    Authors: Keming Zhang, Jianfang Luan, Changqing Li and Mingli Chen
    Citation: BMC Neurology 2022 22:156
  11. It is common for people with persistent spasticity due to a stroke to receive an injection of botulinum toxin-A in the upper limb, however post-injection intervention varies.

    Authors: Natasha A. Lannin, Louise Ada, Coralie English, Julie Ratcliffe, Steven Faux, Mithu Palit, Senen Gonzalez, John Olver, Emma Schneider, Maria Crotty and Ian D. Cameron
    Citation: BMC Neurology 2022 22:154
  12. Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis is the most frequent autoimmune paraneoplastic encephalitis, and is primarily associated with ovarian teratomas. Here, we report the first case of a pati...

    Authors: Ying Yu, Jun-Li Liu and Dai-Shi Tian
    Citation: BMC Neurology 2022 22:153
  13. The Guillain-Barre Syndrome (GBS), also known as acute idiopathic polyneuritis, is a critical acquired condition associated with preceding nonspecific infection or triggering factors like trauma, surgery, or v...

    Authors: Priyank Patel, Darshil Shah, Chinmay Jani, Jui Shah, Ruchi Jani, Arjun Kelaiya, Jinal Pandya, Harpreet Singh, Omar Al Omari, Dhara Roy, Irmgard Behlau and Ami Parikh
    Citation: BMC Neurology 2022 22:151
  14. Neuronal intranuclear inclusion disease (NIID) is a rare neurodegenerative disease characterized by eosinophilic hyaline intranuclear inclusions in cells in the central and peripheral nervous system. High-inte...

    Authors: Hongfen Wang, Feng Feng, Jiajin Liu, Jianwen Deng, Jiongming Bai, Wei Zhang, Luning Wang, Baixuan Xu and Xusheng Huang
    Citation: BMC Neurology 2022 22:150
  15. We do not yet know whether or the extent to which multimodal therapy changes the health behaviors and health service use of chronic headache patients in the long term. Associations are expected between pain sy...

    Authors: Carolin Donath, Katharina Luttenberger, Christa Geiß, Patricia Albert and Britta Fraunberger
    Citation: BMC Neurology 2022 22:149
  16. A variety of management options (e.g., disease-modifying therapy, lifestyle interventions, rehabilitation) are available for persons with relapsing-remitting multiple sclerosis (MS). Besides coping with the di...

    Authors: Anna Sippel, Jutta Scheiderbauer, Désirée Eklund, Sigrid Arnade, Stephan Schmidt, Ingo Kleiter, Rebecca Morrison, Christopher Kofahl and Christoph Heesen
    Citation: BMC Neurology 2022 22:146
  17. The use of patient reported outcomes measures (PROMs) may offer utility that are important for stroke survivors. This study assessed the PROMIS-10, which contains Mental health (MH) and Physical Health (PH) do...

    Authors: Amber E. Corrigan, Ben Carter, Alexander Smith, Anna Pennington and Jonathan Hewitt
    Citation: BMC Neurology 2022 22:145
  18. As a chronic, disabling disease, multiple sclerosis (MS) has challenged healthcare systems in many ways. MS adversely affects patients’ quality of life and self-efficacy and results in psychological stress. Th...

    Authors: Mostafa Bijani, Maryam Niknam, Shanaz Karimi, Zeinab Naderi and Azizallah Dehghan
    Citation: BMC Neurology 2022 22:144
  19. Fingolimod, an oral sphingosine 1-phosphate receptor immunomodulator, is approved in Europe for people with multiple sclerosis (pwMS) with highly active disease despite a full and adequate course of treatment ...

    Authors: Veronika Tichá, Zuzana Počíková, Josef Vytlačil and Radka Štěpánová
    Citation: BMC Neurology 2022 22:143
  20. Hyperintense Acute Reperfusion Marker (HARM) is a hyperintense subarachnoid signal on FLAIR MRI sequence caused by gadolinium contrast leakage into the subpial space. While, on FLAIR, HARM may mimic subarachno...

    Authors: Luigi Francesco Saccaro, Imen Bekri, Maxime De Malherbe, Intissar Hmida and Fernando Pico
    Citation: BMC Neurology 2022 22:142
  21. We previously characterized hemisphere-specific motor control deficits in the ipsilesional, less-impaired arm of unilaterally lesioned stroke survivors. Our preliminary data indicate these deficits are substan...

    Authors: Candice Maenza, Robert L. Sainburg, Rini Varghese, Brooke Dexheimer, Marika Demers, Lauri Bishop, Shanie A. L. Jayasinghe, David A. Wagstaff and Carolee Winstein
    Citation: BMC Neurology 2022 22:141
  22. People with amyotrophic lateral sclerosis (ALS) are at high risk for severe outcomes from Covid-19 infection. Researchers exploring ALS and Covid-19 have focused primarily on system response and adaptation. Us...

    Authors: Shelagh K. Genuis, Westerly Luth, Tania Bubela and Wendy S. Johnston
    Citation: BMC Neurology 2022 22:140
  23. Glioblastoma multiforme (GBM) is the most common aggressive malignant brain tumor. However, the molecular mechanism of glioblastoma formation is still poorly understood. To identify candidate genes that may be...

    Authors: Jianmin Li, Zhao Zhang, Ke Guo, Shuhua Wu, Chong Guo, Xinfan Zhang and Zi Wang
    Citation: BMC Neurology 2022 22:139
  24. Growing evidence suggests that vascular risk factors, especially hypertension, relate not only to cardiovascular disease but also to cognitive impairment. However, the impact of pulse pressure on cognitive fun...

    Authors: Ryo Mizuhara, Shingo Mitaki, Masahiro Takamura, Satoshi Abe, Keiichi Onoda, Shuhei Yamaguchi and Atsushi Nagai
    Citation: BMC Neurology 2022 22:137
  25. Extracorporeal circulation (ECC) is now being increasingly used in critical care settings. Epileptic seizures are a recognized but under reported complication in patients receiving this care. Acute symptomatic...

    Authors: Matteo Pugnaghi, Francesco Cavallieri, Mauro Zennaro, Marialuisa Zedde, Romana Rizzi, Davide Gabbieri and Franco Valzania
    Citation: BMC Neurology 2022 22:136
  26. Meningiomas and unruptured cerebral aneurysms (UCAs) rarely coexist. However, the treatment strategy remains to be fully elucidated. This report is a first report that UCA related to the tumor feeder intraoper...

    Authors: Shingo Tanaka, Masaaki Kobayashi, Toshiya Ichinose, Nozomu Oikawa, Masashi Kinoshita, Akifumi Yoshikawa, Naoyuki Uchiyama and Mitsutoshi Nakada
    Citation: BMC Neurology 2022 22:135
  27. We report a rare case of Godtfredsen syndrome caused by clival chondrosarcoma and perform a review of literatures. This article also explains the clinico-anatomical correlation of this rare neurological syndrome.

    Authors: Yong Zheng Wai, Yong Yuin Chong, Noraini Mohd Dusa, Yin Peng Lai and Lik Thai Lim
    Citation: BMC Neurology 2022 22:134
  28. Diabetic striatopathy is a rare neurological manifestation of nonketotic hyperglycemia that presents with contralateral hemichorea-hemiballismus. Presentation with concurrent seizures is rarely reported.

    Authors: Abeer Sabry Safan, Omna Sharma, Muna Almasri, Ashton Ian D’Souza and Omer Suliman
    Citation: BMC Neurology 2022 22:133
  29. Large vessel occlusion (LVO) strokes are best treated with rapid endovascular therapy (EVT). There are two routes that LVO stroke patients can take to EVT therapy when transported by EMS: primary transport (am...

    Authors: Derek L. Isenberg, Kevin A. Henry, Adam Sigal, Traci Deaner, Jason T. Nomura, Kathleen A. Murphy, Derek Cooney, Susan Wojcik, Ethan S. Brandler, Alexander Kuc, Gerard Carroll, Chadd K. Kraus, Judy B. Shahan, Joseph Herres, Daniel Ackerman and Nina T. Gentile
    Citation: BMC Neurology 2022 22:132

    The Correction to this article has been published in BMC Neurology 2022 22:171

  30. Post herpes simplex virus (HSV) autoimmune encephalitis has been reported mainly in association with NMDA receptor antibodies, however, never with Caspr2 antibodies.

    Authors: Klaus Berek, Ronny Beer, Astrid Grams, Raimund Helbok, Anna Lindner, Bettina Pfausler, Alois Schiefecker, Florian Deisenhammer and Harald Hegen
    Citation: BMC Neurology 2022 22:131
  31. Type 2 diabetes mellitus (T2DM) affects the occurrence and prognosis of acute ischemic stroke (AIS). However, the impact of diabetes on thrombus characteristics is unclear. The relationship between the composi...

    Authors: Qun Gao, Peng Qi, Junjie Wang, Shen Hu, Ximeng Yang, Jingwen Fan, Ling Li, Yao Lu, Jun Lu, Juan Chen and Daming Wang
    Citation: BMC Neurology 2022 22:130
  32. The COVID-19 pandemic has forced lockdowns and declarations of states of emergency, resulting in marked changes to daily life such as dietary habits in many countries. Though serum omega-3 polyunsaturated fatt...

    Authors: Kenichiro Hira, Yuji Ueno, Nobukazu Miyamoto, Sho Nakajima, Chikage Kijima and Nobutaka Hattori
    Citation: BMC Neurology 2022 22:128
  33. Patients with brain tumours often present with non-specific symptoms. Correctly identifying who to prioritise for urgent brain imaging is challenging. Brain tumours are amongst the commonest cancers diagnosed ...

    Authors: Karolis Zienius, Mio Ozawa, Willie Hamilton, Will Hollingworth, David Weller, Lorna Porteous, Yoav Ben-Shlomo, Robin Grant and Paul M. Brennan
    Citation: BMC Neurology 2022 22:127
  34. Migraine patients have musculoskeletal disorders and pain in the cervical. And, despite the pathophysiology demonstrating the relationship between migraine and the cervical spine, the effectiveness of cranioce...

    Authors: Mariana Tedeschi Benatto, Lidiane Lima Florencio, Marcela Mendes Bragatto, Fabíola Dach, César Fernández-de-las-Peñas and Débora Bevilaqua-Grossi
    Citation: BMC Neurology 2022 22:126
  35. Previous studies have revealed that low frequency repeated transcranial magnetic stimulation (rTMS) on the contralesional primary motor cortex (cM1) is less effective in severe stroke patients with poor neural...

    Authors: Jiali Li, Hewei Wang, Yujian Yuan, Yunhui Fan, Fan Liu, Jingjing Zhu, Qing Xu, Lan Chen, Miao Guo, Zhaoying Ji, Yun Chen, Qiurong Yu, Tianhao Gao, Yan Hua, Mingxia Fan and Limin Sun
    Citation: BMC Neurology 2022 22:125
  36. To study the effects of subthalamic nucleus-deep brain stimulation (STN-DBS) on autonomic dysfunctions in Parkinson’s disease (PD) patients.

    Authors: Feng Zhang, Feng Wang, Cong-Hui Li, Ji-Wei Wang, Chun-Lei Han, Shi-Ying Fan, Dong-Mei Gao, Yu-Jing Xing, Chen Yang, Jian-Guo Zhang and Fan-Gang Meng
    Citation: BMC Neurology 2022 22:124
  37. The current multi-center, randomized, double-blind study was conducted among children with cerebral palsy (CP) to assess the safety and efficacy of umbilical cord blood mononuclear cell (UCB-MNC). We performed...

    Authors: Morteza Zarrabi, Masood Ghahvechi Akbari, Man Amanat, Anahita Majmaa, Ali Reza Moaiedi, Hadi Montazerlotfelahi, Masoumeh Nouri, Amir Ali Hamidieh, Reza Shervin Badv, Hossein Karimi, Ali Rabbani, Ali Mohebbi, Shahram Rahimi-Dehgolan, Rosa Rahimi, Ensieh Dehghan, Massoud Vosough…
    Citation: BMC Neurology 2022 22:123
  38. Biallelic pathogenic variants in the SCARB2 gene have been associated with action myoclonus-renal failure (AMRF) syndrome. Even though SCARB2 associated phenotype has been reported to include typical neurological...

    Authors: Burcu Atasu, Ayse Nur Ozdag Acarlı, Basar Bilgic, Betül Baykan, Erol Demir, Yasemin Ozluk, Aydin Turkmen, Ann-Kathrin Hauser, Gamze Guven, Hasmet Hanagasi, Hakan Gurvit, Murat Emre, Thomas Gasser and Ebba Lohmann
    Citation: BMC Neurology 2022 22:122
  39. Approximately half (55%) of anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis is known to show abnormal brain images, including high signal intensity in T2 or fluid attenuated inversion recovery (FLAIR) ...

    Authors: Dong Keun Son, Seong Min Cho, Han Uk Ryu, Byoung-Soo Shin and Hyun Goo Kang
    Citation: BMC Neurology 2022 22:121
  40. Multiple sclerosis (MS) is an inflammatory chronic disease that is characterized by an increased prevalence of adverse mental health outcomes in patients with MS (pwMS). The main aim of this study is to invest...

    Authors: Safanah AlSaeed, Nuha M. Alkhawajah, Mohsen Ayyash, Salman Aljarallah, Rola Alarieh and Amani Abu-Shaheen
    Citation: BMC Neurology 2022 22:120
  41. Transcranial direct current stimulation (tDCS) is a noninvasive brain stimulation to modulate cortical activity for improving motor function. However, the different tDCS applications for modulating cortical ac...

    Authors: Pei-Ling Wong, Yea-Ru Yang, Shun-Chang Tang, Shi-Fong Huang and Ray-Yau Wang
    Citation: BMC Neurology 2022 22:119

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