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Association of β-cell function and cognitive impairment in patients with abnormal glucose metabolism
BMC Neurology volume 22, Article number: 232 (2022)
Insulin has been demonstrated to play an important role in the occurrence and development of Alzheimer’s disease, especially in those with diabetes. β cells are important insulin-producing cells in human pancreas. This study aimed to investigate the association between β-cell dysfunction and cognitive impairment among patients over 40-year-old with abnormal glucose metabolism in Chinese rural communities.
A sample of 592 participants aged 40 years or older from the China National Stroke Prevention Project (CSPP) between 2015 and 2017 were enrolled in this study. Abnormal glucose metabolism was defined when hemoglobin Alc ≥ 5.7%. Cognitive function was assessed by the Beijing edition of the Montreal Cognitive Assessment scale. Homeostasis assessment of β-cell function was performed and classified into 4 groups according to the quartiles. A lower value of HOMA-β indicated a worse condition of β-cell function. Multivariate logistic regression was used to analyze the association between β-cell function and cognitive impairment.
In a total of 592 patients with abnormal glucose metabolism, the average age was 60.20 ± 7.63 years and 60.1% patients had cognitive impairment. After adjusting for all potential risk factors, we found the first quartile of β-cell function was significantly associated with cognitive impairment (OR: 2.27, 95%CI: 1.32–3.92), especially at the domains of language (OR: 1.64, 95%CI: 1.01–2.65) and abstraction (OR: 2.29, 95%CI: 1.46–3.58).
Our study showed that worse β-cell function is associated with cognitive impairment of people over 40-year-old with abnormal glucose metabolism in Chinese rural communities, especially in the cognitive domains of abstraction and language.
Alzheimer’s disease (AD), the most common type of dementia, is becoming a major challenge for global health and social care . However, the present understanding of the pathogenesis of AD is limited, and there is currently no effective method for early diagnosis and improvement therapy. Aging is the most important risk factor for AD . With the aggravation of population aging in China, the incidence of AD also increases rapidly, which has posed a considerable burden on society and families . Mild cognitive impairment (MCI), a cognitive state between normal cognition and dementia, usually occurs at the preclinical stage of AD . Patients with MCI have normal ability in daily life and only show cognitive impairment during clinical cognitive scale evaluation. Interventions in MCI stage can effectively alleviate the progression of cognitive deficiency in AD, and improve the prognosis and quality of patients’ life. According to many previous studies [5,6,7], diabetes is one of the adjustable risk factors of MCI, which has been shown in Chinese rural communities in our previous study . There are 12.8% of Chinese adults diagnosed as diabetes, which is currently found as the largest proportion of adults affected by diabetes of any country . The high incidence of diabetes may further adversely aggravate the progression of AD. Therefore, exploring the mechanisms under the association between diabetes and cognitive impairment, exploring effective and timely interventions applied for MCI stage, could significantly prevent the prevalence of AD.
β-cell dysfunction, which means the inability of the pancreas to produce enough insulin in response to glucose stimulation, is a typical pathological mechanism in type 2 diabetes mellitus (T2DM) . Insulin, as well as insulin-related growth factors, plays an important role in the development of central nervous system (CNS) [11, 12]. Impaired signaling through insulin/insulin-like growth factor (IGF) receptors in the brain can damage a range of neural and glial functions, including glucose homeostasis, energy metabolism, and white matter fiber structure and function [13, 14]. As reported, dysfunction of insulin signaling acts the core of the neurodegenerative cascade in AD [13, 14]. AD-associated abnormalities in energy metabolism are also reported to be caused by insulin resistance or reduced insulin actions in the brain . Thus, AD is called as “type 3 diabetes”, which means a type of brain-specific or brain-restricted diabetes . Based on the correlation between impaired insulin signaling and AD, β-cell dysfunction, an important reason for insulin deficiency in brain, may also have adverse effects on cognitive function. Furtherly researching the relationship between β-cell dysfunction and MCI in people with prediabetes or diabetes, will help delay the progression of cognitive impairment, as well as reduce the incidence of AD.
In rural areas of China, due to the more serious condition of population aging and the relatively weak awareness of medical treatment, the control and therapy of diabetes-related cognitive impairment are significantly impeded. Thus, to provide evidence for the prevention and management of cognitive dysfunction in Chinese rural communities, this study was performed to investigate the association between β-cell dysfunction and cognitive decline in people (≥40 years old) with abnormal glucose metabolism. And the study hypothesis was that the β-cell dysfunction may act as a risk factor of cognitive impairment in the specific population of China.
Study design and population
The China National Stroke Prevention Project (CSPP) is a community-based, prospective, long-term follow-up study to promote the management of stroke in Chinese adults. It is supported by the China Ministry of Health and China Ministry of Finance. The protocol of subject enrollment for the CSPP study has been described previously . Residents who aged≥40 years, belonged to the selected communities or lived there for over half a year were invited to join a screening program. The questionnaire, clinical examination and laboratorial evaluation were performed at baseline. This study cohort was a sub-population of 5188 subjects residing in the Beiqijia community and Shunyi district hospital of Beijing between September 2015 and September 2017. Ultimately, we excluded 4596 participants according to the exclusion criteria, and 592 participants were enrolled. The exclusion criteria were shown as follows: (1) with normal glucose metabolism; (2) with history of neurological disease which may affect the cognitive ability, such as transient ischemic attacks (TIA) and stroke; (3) existing factors which may interfere cognitive assessment and other examination, such as hearing or visual impairment, difficulties to cooperate, and mental disorder; (4) with incomplete baseline information.
Assessment of cognitive function
The cognitive function was evaluated by the Beijing edition of the Montreal Cognitive Assessment scale (MoCA). MoCA is a screening tool with high sensitivity and specificity in detecting MCI . It consists of seven cognitive domains including visuospatial/executive functions (5 points), naming (3 points), language (3 points), attention (6 points), abstraction (2 points), delayed recall (5 points) and orientation (6 points). The score of MoCA ranges from 0 to 30, and the total score (if< 30 points) needs to be added 1 point when the subject is educated 12 years or less. According to the original explanation of MoCA results, the highest score was 30, and cognitive impairment was defined when a corrected MoCA score < 26. In this study, all staff responsible for the MoCA test were systematically trained and evaluated by the CSPP.
Assessment of FPI, FPG and other biochemical indexes
Fasting plasma glucose (FPG) was measured by glucometer and glucose test strips (ACCU-CHEKR Active, Roche Diabetes Care GmbH, German) after an overnight fast of the participants. At the same time, superficial venous blood was collected for measurement of the fasting insulin and other biochemical indices. The fasting plasma insulin (FPI) was tested by an automatic light-emitting analyzer (DXI800, Beckman, American), with the technology of microparticle chemiluminescence immunoassay. All blood samples were collected in EDTA tubes and measured with an automated analyzer (Hitachi 747; Hitachi, Tokyo, Japan) in the laboratory at Beiqijia and Shunyi Hospital.
According to the guidelines from the Standards of Medical Care in Diabetes-2019, the abnormal glucose metabolism was defined when hemoglobin Alc (HbAlc) ≥ 5.7% .
Assessment of the index of β-cell function and insulin resistance
The homeostasis model assessment of β-cell function (HOMA-β) was used to evaluate the β-cell function. HOMA-β is an indicator of pancreatic β-cell function based on FPI and FPG levels, which was estimated as follows: HOMA-β = FPI level (μU/ml) × 20/[FPG (mM)-3.5]. For HOMA-β, the lower value means worse β-cell function. In this study, patients were grouped by the quartile of HOMA-β (Q1: HOMA-β ≤ 36.69, Q2: 36.70 ≤ HOMA-β ≤ 56.58, Q3: 56.59 ≤ HOMA-β ≤ 83.29, Q4: HOMA-β ≥ 83.30). The Homeostasis model assessment of insulin resistance (HOMA-IR) was calculated as follows: HOMA-IR = FPI level (μU/ml) x FPG (mM)/22.5 [20, 21]. For HOMA-IR, the higher value indicates a more serious degree of insulin resistance.
Questionnaire of baseline information
Our questionnaire included demographic information (such as age, gender, and education level), lifestyle risk factors (such as smoking and alcohol consumption), medical history (high blood pressure, diabetes, and dyslipidemia), family history, and other necessary information. All relevant staff have been trained and evaluated by CSPP. All questionnaire data were entered into the EpiData 3.0 as an electronic database by two trained staff. Standardized procedures are followed by experienced data managers to check data for integrity and potential errors.
Education level was defined as “elementary education or below”, “middle school education” and “high school education or above”. Age groups were categorized as “40-59 years old” and “≥60 years old”. Body mass index (BMI) was classified into “≥ 25” and “< 25” . Alcohol consumption and smoking were both categorized as “never” or “former or current”, based on the self-provided information of patients. Hypertension was defined when systolic blood pressure ≥ 140 mmHg or diastolic blood pressure ≥ 90 mmHg, or with a self-reported history of hypertension. Hyperhomocysteinemia (High-Hcy) was diagnosed by serum homocysteine (> 15 μmol/L). Dyslipidemia was diagnosed when low-density lipoprotein cholesterol (LDL-C) ≥ 3.37 mmol/L, or high-density lipoprotein cholesterol (HDL-C) < 1.04 mmol/L, or triglycerides (TG) ≥ 1.7 mmol/L, or total cholesterol (TC) ≥ 5.17 mmol/L, or with a self-reported history of dyslipidemia .
Statistical analysis was performed using the IBM SPSS Statistics 23.0. All statistical analyses were two-tailed, and the P value less than 0.05 was considered statistically significant.
During univariate analysis, we used analysis of variance (ANOVA) for normally distributed variables, Wilcoxon or Kruskal–Wallis tests for non-normally distributed variables, and χ2 test for the classification variables. Multivariate logistic regression analysis was used to analyze the relationship between β-cell function and cognitive impairment. The covariates with P < 0.1 in univariate analysis were collected for multivariate models. Some additional variables (suggested to be risk factors of cognitive impairment in previous studies) were also included [24, 25]. Besides, all potential variables were evaluated in subgroups, to assess whether there was any significant interaction between these variables and the relationship between β-cell function and the prevalence of cognitive impairment.
Multivariate ordinal and binary logistic regression analysis were used to analyze the association between β-cell function and specific cognitive domains. After parallel line checking, visuospatial/executive functions, naming, attention, language, and abstraction and recall were found suitable for ordinal logistic regression, but the orientation domain was not. Therefore, the orientation was analyzed by binary logistic regression. For analysis, the orientation was divided into two groups: the maximum was one group, and the rest were the other group.
The mean age of the 592 participants was 60.20 ± 7.63 years, ranging from 40 years to 85 years; 181 (30.6%) were men, and 152 (25.7%) of them had high school education or above. Out of 592 patients, 356 (60.1%) had cognitive impairment. For the entire sample, the mean HOMA-IR was 2.27 ± 2.03, and the mean MoCA score was 23.77 ± 4.27.
Baseline characteristics stratified by the quartile of HOMA-β were shown in Table 1. Patients with higher HOMA-β were more likely to be female, and have higher BMI and lower HDL-C (P < 0.05, Table 1). Insulin resistant levels were different among different quartiles, but the trend was not clear.
Correlation between β-cell function and cognitive impairment
Table 2 showed the association between HOMA-β and cognitive impairment. In univariate analysis (OR: 1.83, 95%CI: 1.14–2.95, P = 0.012), as well as in multivariate logistic regression adjusting for age, and sex and education in Model 1 (OR: 1.81, 95%CI: 1.10–2.99, P = 0.020), the first quartile was associated with cognitive impairment. After further adjusting for BMI, smoking, alcohol assumption, hypertension, dyslipidemia, heart disease, high-hcy and HOMA-IR in Model 2, the significance of the association between the first quartile with cognitive impairment remained (OR: 2.27, 95%CI: 1.32–3.92, P = 0.003).
Stratified analyses showed that age, gender, BMI, education, smoking, alcohol assumption, hypertension, dyslipidemia, heart disease and the prevalence of high-hcy had no interaction effect with β-cell function on cognitive impairment (P > 0.05, Table 3).
Correlation between β-cell function and specific cognitive domains
Table 4 showed the differences of seven specific cognitive domains among 4 quartiles of HOMA-β, respectively. The function of abstraction and language were better in patients with higher HOMA-β (P < 0.05, Table 4). After adjusting for all potential covariates, the first quartile was further significantly related with impairment of language (OR: 1.64, 95%CI: 1.01–2.65, P = 0.045) and abstraction (OR: 2.29, 95%CI: 1.46–3.58, P < 0.001). The results were shown in Table 5.
In our study, lower β-cell function defined by HOMA-β was found associated with an increased risk of cognitive impairment (especially in language and abstraction) in middle aged and elderly people (≥40 years) with abnormal glucose metabolism in Chinese rural communities. β cells are important insulin-secreting cells in human islet. The dysfunction of them may lead to significant insulin deficiency and impaired insulin signaling in brain. A lot of studies have shown that dysfunction of insulin signaling forms the core of neurodegeneration in Alzheimer’s disease (AD) [13, 26, 27]. β-cell dysfunction is common in people with prediabetes or diabetes . Thus, great attention should be paid to the β-cell dysfunction related cognitive impairment in middle-aged and old people with abnormal glucose metabolism.
There are some potential mechanisms that may explain the relationship between β-cell dysfunction and cognitive impairment. Firstly, the insulin deficiency caused by β-cell dysfunction can influence cognition by affecting brain energy metabolism. Studies have reported that in the early stages of AD, cerebral glucose utilization may reduce by up to 45% . And the decrease in brain energy metabolism predates the cognitive decline. It is also reported that cerebral glucose metabolism increased after the restoration of basal insulin levels in metabolically healthy participants . Besides, insulin deficiency also damages vascular function through effects on vasoreactivity, lipid metabolism, and inflammation . As reported, lower β-cell function may lead to elevated intima-media thickness  and increased risk of recurrent stroke , both of which have been found associated with cognitive impairment [33, 34]. In addition, insulin plays an important role in synaptic plasticity of hippocampus. In insulin-deficient diabetic rats, hippocampal synaptic plasticity such as long-term enhancement (LTP) was found inhibited . Insulin can also modulate some neurotransmitters in the brain that are involved in cognitive function, such as N-methyl-D-aspartate (NMDA) , acetylcholine and norepinephrine [37, 38]. Based on the importance of insulin in AD, transnasal insulin therapy is suggested for AD therapy now. The therapeutic effects have also been demonstrated in some clinical trials of patients , as well as in animal models .
In people of rural communities, which account for 50.32% of the Chinese population , due to the large and aging population, and relatively backward medical level, there may exist some difficulties in the screening and therapy of initial β-cell dysfunction and MCI. Therefore, promoting early screening of those abnormalities, and searching for convenient and accurate screening methods, are necessary for the arrangement of β-cell dysfunction related dementia in old people of Chinese rural communities. In this study, the MoCA scale was used to test the cognitive function, and HOMA-β was used to evaluate the function of β cells. Compared with some complex scales, MoCA is more easily promoted and operated by physicians, and more comprehensible for old people. In addition, MoCA has higher sensitivity and specificity in the detection of MCI . HOMA is a mathematical model for calculating the steady-state glucose and insulin concentrations. Compared to the hyperglycemic clamp technique, the gold standard for evaluation of β-cell function, HOMA-β is more inexpensive and easier to operate. Moreover, HOMA-β was well correlated with hyperglycemic clamp under different glucose tolerance conditions . Thus, due to their convenience and accuracy, the method of MoCA scale and HOMA-β can be widely used in rural communities in China, as well as some clinical large-scale epidemiological studies.
Notably, the influence of insulin resistance was corrected in the exploration of correlation between β-cell dysfunction and cognitive impairment. Insulin resistance is defined as a failure of target tissues to exhibit a normal response to insulin . It usually coexists with β-cell dysfunction in diabetic patients . Since the influence of insulin resistance on the value of FPG and FPI, HOMA-β may underestimate the decline of β-cell function . In our study, after adjustment for HOMA-IR, the association of β-cell dysfunction and cognitive impairment remained. This result suggests that, in people with dysglycemia of Chinese rural communities, the association between insulin secretion and cognitive impairment is independent of insulin sensitivity.
In addition, in this study, the impairment of language was found associated with β-cell function in people over 40-year-old with abnormal glucose metabolism. For old diabetic patients, language function was particularly important for their social functioning, which was closely associated with the psychological states and disease management. The elderly with language dysfunction may fail to communicate well with their families or doctors, resulting in emotional distress and some diseases due to delayed detection. As time goes by, patients may develop diabetes aggravation, depression, and some related complications, such as dyslipidemia and hypertension . Therefore, timely detection and therapy of β -cell disorder can effectively improve the quality of life of old diabetic patients.
There were also some limitations in this study. First, large parts of patients in our study with missing data were excluded from the current analysis. The effect of this on the results is unclear, although the differences between baseline characteristics of included and excluded patients are not statistically significant (data not shown). Second, due to the large missing data, the detailed medication information was not included in the final analysis in this study, which was important for diabetes management and should be furtherly analyzed in the further studies. Third, due to the lack of follow-up data, the measurements of the influence of β-cell function on subsequent cognitive function in several years after baseline were unavailable. Further research with a large sample size and a long-term follow-up is required to examine the association between β-cell function and cognitive impairment in people with abnormal glucose metabolism of Chinese rural communities.
β-cell dysfunction may be an independent risk factor of cognitive impairment, especially in the domains of language and abstraction, among the middle-aged and elderly population (≥40 years) with abnormal glucose metabolism in rural communities of China.
Availability of data and materials
The datasets used and analyzed during the current study are available from the corresponding author on reasonable request.
Mild cognitive impairment
Type 2 diabetes mellitus
Central nervous system
Insulin-like growth factor
Transient ischemic attacks
Montreal Cognitive Assessment scale
Fasting plasma glucose
Fasting plasma insulin
Homeostasis assessment model, insulin resistance
Homeostasis assessment model, β-cell
Low-density lipoprotein cholesterol
High-density lipoprotein cholesterol
Analysis of variance
Body mass index
Joe E, Ringman JM. Cognitive symptoms of Alzheimer's disease: clinical management and prevention. BMJ. 2019;367:l6217.
Trevisan K, Cristina-Pereira R, Silva-Amaral D, Aversi-Ferreira TA. Theories of aging and the prevalence of Alzheimer's disease. Biomed Res Int. 2019;2019:9171424.
Jia J, Wei C, Chen S, Li F, Tang Y, Qin W, et al. The cost of Alzheimer's disease in China and re-estimation of costs worldwide. Alzheimers Dement. 2018;14(4):483–91.
Lin SY, Lin PC, Lin YC, Lee YJ, Wang CY, Peng SW, et al. The clinical course of early and late mild cognitive impairment. Front Neurol. 2022;13:685636.
Lotan R, Ganmore I, Livny A, Itzhaki N, Waserman M, Shelly S, et al. Effect of advanced glycation end products on cognition in older adults with type 2 diabetes: results from a pilot clinical trial. JAD. 2021;82(4):1785–95.
Zhang Z, Zhang B, Wang X, Zhang X, Yang QX, Qing Z, et al. Olfactory dysfunction mediates adiposity in cognitive impairment of type 2 diabetes: insights from clinical and functional neuroimaging studies. Diabetes Care. 2019;42(7):1274–83.
Guzmán-Ramos K, Osorio-Gómez D, Bermúdez-Rattoni F. Cognitive impairment in alzheimer's and metabolic diseases: a catecholaminergic hypothesis. Neuroscience. 2022;S0306–4522(22):00271–8.
Guo M, Kang K, Wang A, Jia J, Zhang J, Wang Y, et al. Association of diabetes status with cognitive impairment in two Chinese rural communities. J Neurol Sci. 2020;415:116894.
Li Y, Teng D, Shi X, Qin G, Qin Y, Quan H, et al. Prevalence of diabetes recorded in mainland China using 2018 diagnostic criteria from the American Diabetes Association: national cross sectional study. BMJ. 2020;369:m997.
Hudish LI, Reusch JE, Sussel L. н╡ cell dysfunction during progression of metabolic syndrome to type 2 diabetes. J Clin Invest. 2019;129(10):4001–8.
Blázquez E, Hurtado-Carneiro V, LeBaut-Ayuso Y, Velázquez E, García-García L, Gómez-Oliver F, et al. Significance of brain glucose Hypometabolism, altered insulin signal transduction, and insulin resistance in several neurological diseases. Front Endocrinol. 2022;13:873301.
Pignatelli J, de Sevilla MEF, Sperber J, Horrillo D, Medina-Gomez G, Aleman IT. Insulin-like growth factor I couples metabolism with circadian activity through hypothalamic orexin neurons. Int J Mol Sci. 2022;23(9):4679.
Kellar D, Craft S. Brain insulin resistance in Alzheimer's disease and related disorders: mechanisms and therapeutic approaches. Lancet Neurol. 2020;19(9):758–66.
Tumminia A, Vinciguerra F, Parisi M, Frittitta L. Type 2 diabetes mellitus and Alzheimer's disease: role of insulin Signalling and therapeutic implications. Int J Mol Sci. 2018;19(11):3306.
Hoyer S. Glucose metabolism and insulin receptor signal transduction in Alzheimer disease. Eur J Pharmacol. 2004;490(1–3):115–25.
Kandimalla R, Thirumala V, Reddy PH. Is Alzheimer's disease a type 3 diabetes? A critical appraisal. Biochim Biophys Acta Mol basis Dis. 2017;1863(5):1078–89.
Longde W, Ling Y, Yang H, Yi Z, Yongjun W, Xunming J, et al. Fixed-dose combination treatment after stroke for secondary prevention in China: a national community-based study. Stroke. 2015;46(5):1295–300.
Pinto TCC, Machado L, Bulgacov TM, Rodrigues-Júnior AL, Costa MLG, Ximenes RCC, et al. Is the Montreal cognitive assessment (MoCA) screening superior to the Mini-mental state examination (MMSE) in the detection of mild cognitive impairment (MCI) and Alzheimer's disease (AD) in the elderly? Int Psychogeriatr. 2019;31(4):491–504.
2. Classification and Diagnosis of Diabetes. Standards of medical Care in Diabetes-2019. Diabetes Care. 2019;42(Suppl 1):S13–s28.
Priya MM, Amutha A, Pramodkumar TA, Ranjani H, Jebarani S, Gokulakrishnan K, et al. н╡-cell function and insulin sensitivity in Normal glucose-tolerant subjects stratified by 1-hour plasma glucose values. Diabetes Technol Ther. 2016;18(1):29–33.
Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC. Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia. 1985;28(7):412–9.
Hashimoto M, Tashiro H, Kobayashi T, Kuroda S, Hamaoka M, Ohdan H. Influence of higher BMI for hepatitis B- and C-related hepatocellular carcinomas. Langenbecks Arch Surg. 2017;402(5):745–55.
Wang J, Liu Y, Zhang L, Li N, Wang C, Gao X, et al. Associations of high sensitivity C-reactive protein levels with the prevalence of asymptomatic intracranial arterial stenosis. Eur J Neurol. 2014;21(3):512–8.
Warren JD, Bamiou DE. Prevention of dementia by targeting risk factors. Lancet. 2018;391(10130):1575.
Kuźma E, Hannon E, Zhou A, Lourida I, Bethel A, Levine DA, et al. Which risk factors causally influence dementia? A systematic review of Mendelian randomization studies. JAD. 2018;64(1):181–93.
Burillo J, Marqués P, Jiménez B, González-Blanco C, Benito M, Guillén C. Insulin resistance and diabetes mellitus in Alzheimer's disease. Cells. 2021;10(5):1236.
Thankappan S, Sen S, Subramanian S, Sinha P, Purushottam M, Bharath S. Insulin resistance in patients with Alzheimer's dementia: a controlled study from India. Asian J Psychiatr. 2018;38:33–4.
Hoyer S, Nitsch R. Cerebral excess release of neurotransmitter amino acids subsequent to reduced cerebral glucose metabolism in early-onset dementia of Alzheimer type. J Neural Transm. 1989;75(3):227–32.
Bingham EM, Hopkins D, Smith D, Pernet A, Hallett W, Reed L, et al. The role of insulin in human brain glucose metabolism: an 18fluoro-deoxyglucose positron emission tomography study. Diabetes. 2002;51(12):3384–90.
Anfossi G, Russo I, Doronzo G, Trovati M. Contribution of insulin resistance to vascular dysfunction. Arch Physiol Biochem. 2009;115(4):199–217.
Roussel R, Natali A, Balkau B, Højlund K, Sánchez G, Nolan JJ, et al. Beta-cell function is associated with carotid intima-media thickness independently of insulin resistance in healthy individuals. J Hypertens. 2016;34(4):685–91.
Zhou M, Pan Y, Jing J, Wang Y, Zhao X, Liu L, et al. Association between н╡-cell function estimated by HOMA-н╡ and prognosis of non-diabetic patients with ischaemic stroke. Eur J Neurol. 2018;25(3):549–55.
Nath M, Misra S, Nair P, Kumar P. Carotid intima-media thickness and risk of mild cognitive impairment: a systematic review and meta-analysis. Acta Neurol Scand. 2022;145(2):139–50.
Ojagbemi A, Bello T, Owolabi M, Baiyewu O. Cognitive decline before and after a first-ever stroke in Africans. Acta Neurol Scand. 2021;144(3):266–74.
Biessels GJ, Kamal A, Ramakers GM, Urban IJ, Spruijt BM, Erkelens DW, et al. Place learning and hippocampal synaptic plasticity in streptozotocin-induced diabetic rats. Diabetes. 1996;45(9):1259–66.
Skeberdis VA, Lan J, Zheng X, Zukin RS, Bennett MV. Insulin promotes rapid delivery of N-methyl-D- aspartate receptors to the cell surface by exocytosis. Proc Natl Acad Sci U S A. 2001;98(6):3561–6.
Figlewicz DP, Szot P, Israel PA, Payne C, Dorsa DM. Insulin reduces norepinephrine transporter mRNA in vivo in rat locus coeruleus. Brain Res. 1993;602(1):161–4.
Kopf SR, Baratti CM. Effects of posttraining administration of insulin on retention of a habituation response in mice: participation of a central cholinergic mechanism. Neurobiol Learn Mem. 1999;71(1):50–61.
Craft S, Raman R, Chow TW, Rafii MS, Sun CK, Rissman RA, et al. Safety, efficacy, and feasibility of intranasal insulin for the treatment of mild cognitive impairment and Alzheimer disease dementia: a randomized clinical trial. JAMA Neurol. 2020;77(9):1099–109.
Barone E, Tramutola A, Triani F, Calcagnini S, Di Domenico F, Ripoli C, et al. Biliverdin reductase-a mediates the beneficial effects of intranasal insulin in Alzheimer disease. Mol Neurobiol. 2019;56(4):2922–43.
Nasreddine ZS, Phillips NA, Bédirian V, Charbonneau S, Whitehead V, Collin I, et al. The Montreal cognitive assessment, MoCA: a brief screening tool for mild cognitive impairment. J Am Geriatr Soc. 2005;53(4):695–9.
Lee SH, Park SY, Choi CS. Insulin resistance: from mechanisms to therapeutic strategies. Diabetes Metab J. 2022;46(1):15–37.
Wang T, Lu J, Shi L, Chen G, Xu M, Xu Y, et al. Association of insulin resistance and н╡-cell dysfunction with incident diabetes among adults in China: a nationwide, population-based, prospective cohort study. Lancet Diabetes Endocrinol. 2020;8(2):115–24.
Festa A, Haffner SM, Wagenknecht LE, Lorenzo C, Hanley AJ. Longitudinal decline of н╡-cell function: comparison of a direct method vs a fasting surrogate measure: the insulin resistance atherosclerosis study. J Clin Endocrinol Metab. 2013;98(10):4152–9.
Biessels GJ, Despa F. Cognitive decline and dementia in diabetes mellitus: mechanisms and clinical implications. Nat Rev Endocrinol. 2018;14(10):591–604.
We thank all staff and participants of the China National Stroke Prevention Project for their important contributions.
This work was supported by the Ministry of Finance of the People’s Republic of China [issued by Finance and Social Security  Document No. 82 and  Document No. 50, Ministry of Finance], CAMS Innovation Fund for Medical Sciences (2019-I2M-5-029), Beijing Municipal Committee of Science and Technology (Z201100005620010), and Beijing key clinical specialty.
Ethics approval and consent to participate
This study was performed according to the Helsinki Declaration and was approved by the Ethics Committees of Beijing Xuanwu (2015–024) and Beijing Tiantan hospital (KY 2019–019-02). Written informed consent was obtained from each participant or his/her legal representatives.
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Guo, M., Jia, J., Zhang, J. et al. Association of β-cell function and cognitive impairment in patients with abnormal glucose metabolism. BMC Neurol 22, 232 (2022). https://doi.org/10.1186/s12883-022-02755-6
- β-Cell function
- Cognitive impairment
- Alzheimer’s disease (AD)